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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han Bo Yan Pan Liao Zhenyu Yin Xintong ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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超级街区路网模式在中西方的发展与演变

城市建筑 2025年第1期22卷 78-84页

作者：葛欣韩雨晨东南大学建筑设计研究院有限公司东南大学建筑学院

超级街区是二元分化规划思想的产物,体现为边界干道和内部道路在规划、建设、管控上的强烈对比,继而呈现为形态和功能上的内外差异。在中西方,超级街区由于成因和发展历程的不同,产生了诸多形态、功效各异的范式。然而,既有研究对于超... 详细信息

超级街区是二元分化规划思想的产物,体现为边界干道和内部道路在规划、建设、管控上的强烈对比,继而呈现为形态和功能上的内外差异。在中西方,超级街区由于成因和发展历程的不同,产生了诸多形态、功效各异的范式。然而,既有研究对于超级街区普遍采取批判的态度,忽略了其在超越街区的尺度上组织城市形态与功能的价值和潜力。本研究剖析了超级街区的定义,梳理了中西方超级街区的发展演变历程,提炼出各阶段路网的典型范式及变体。

关键词：超级街区路网中西方范式变体

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BIOLUMINESCENCE TOMOGRAPHY:BIOMEDICAL BACKGROUND,MATHEMATICAL THEORY,AND NUMERICAL APPROXIMATION

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Journal of Computational Mathematics 2008年第3期26卷 324-335页

作者： Weimin han ge Wang Department of Mathematics University of Iowa Iowa City IA 52242 USA Division of Biomedical Imaging Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 USA

Over the last couple of years molecular imaging has been rapidly developed to study physiological and pathological processes in vivo at the cellular and molecular levels. Among molecular imaging modalities, optical imaging stands out for its unique advantages, especially performance and cost-effectiveness. Bioluminescence tomography （BLT） is an emerging optical imaging mode with promising biomedical advantages. In this survey paper, we explain the biomedical significance of BLT, summarize theoretical results on the analysis and numerical solution of a diffusion based BLT model, and comment on a few extensions for the study of BLT.

关键词： Biomedical imaging Bioluminescence tomography (BLT) Inverse problem,Regularization Numerical approximation Error analysis

Numerical simulation of viscous flows with adaptively refined Cartesian grid

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航空动力学报 2014年第2期29卷 467-474页

作者： han Yu-qi GAO ge National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Energy and Power EngineeringBeijing University of Aeronautics and Astronautics

Quadtree-based Cartesian grid was automatically generated from specified *** refinements were performed according to geometric parameters and solution of flow *** altered CCST(curvature corrected symmetry technique)approach was proposed to apply solid wall boundary conditions. Driven flows in a square cavity and flows around NACA0012airfoil were simulated and compared with the result of published structured grid and stretched Cartesian *** results show that solid wall boundary condition are accurately applied by current altered CCST approach,while incompressible/compressible subsonic, transonic and supersonic viscous flows are adequately simulated with adaptively refined Cartesian grid.

关键词： adaptively refined Cartesian grid viscous flow CCST(curvature corrected symmetry technique) boundary condition

Performance Analysis and Multi-Objective Optimization of Two Organic Rankine Cycles with Different Fluids for Low Grade Waste Heat Recovery

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Journal of Thermal Science 2022年第3期31卷 650-662页

作者： ge Yi han Jitian ZHU Xiaoxuan School of Energy and Power Engineering Shandong UniversityJi’nan250061China

The basic organic Rankine cycle(BORC)and ORC with an internal heat exchanger(IHORC)are studied with different working fluids under a given heat source condition to analyse the thermodynamic performances and net power *** results demonstrate that the external exergy efficiency of IHORC is lower than that of BORC while the internal exergy efficiency is on the opposite with the same overall exergy efficiencies.A multi-objective optimization model with inlet pressure and temperature of expander as independent parameters and exergy and heat recovery efficiencies as objective functions is solved by NSGA-II(the second non-dominated sorting genetic algorithm).The Pareto optimal solutions are obtained by the optimization *** calculation with the optimum conditions,it is determined that R236ea has the best comprehensive performance with exergy efficiencies being 40.69%and 41.38%,and heat recovery efficiencies being 83.2%and 75.6%in IHORC and BORC,*** evaporators occupy the maximum exergy destruction,which can be reduced by decreasing pinch point temperatures and increasing evaporation pressures.

关键词： ORC working fluids exergy analysis multi-objective optimization exergy destruction

Flocking Effects of the Stochastic Cucker-Smale System with Noise

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Journal of Systems Science & Complexity 2024年第5期37卷 1978-1994页

作者： han Ning ge Bin LI Lin School of Mathematical Sciences Harbin Engineering UniversityHarbin 150001China

In this paper,the flocking behavior of a Cucker-Smale model with a leader and noise is studied in a finite *** authors present a Cucker-Smale system with two nonlinear controls for a complex network with stochastic synchronization in *** on the finite-time stability theory of stochastic differential equations,the sufficient conditions for the flocking of stochastic systems in a finite time are obtained by using the Lyapunov function ***,the numerical simulation of the particle system is carried out for the leader and noise,and the correctness of the results is verified.

关键词： Cucker-Smale model flocking behavior leader noise

Decentralized Dynamic Event-Triggered Communication and Active Suspension Control of In-Wheel Motor Driven Electric Vehicles with Dynamic Damping

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IEEE/CAA Journal of Automatica Sinica 2021年第5期8卷 971-986页

作者： Iftikhar Ahmad Xiaohua ge Qing-Long han the School of Software and Electrical Engineering Swinburne University of TechnologyMelbourneVIC 3122Australia

This paper addresses the co-design problem of decentralized dynamic event-triggered communication and active suspension control for an in-wheel motor driven electric vehicle equipped with a dynamic damper. The main objective is to simultaneously improve the desired suspension performance caused by various road disturbances and alleviate the network resource utilization for the concerned in-vehicle networked suspension system. First, a T-S fuzzy active suspension model of an electric vehicle under dynamic damping is established. Second,a novel decentralized dynamic event-triggered communication mechanism is developed to regulate each sensor's data transmissions such that sampled data packets on each sensor are scheduled in an independent manner. In contrast to the traditional static triggering mechanisms, a key feature of the proposed mechanism is that the threshold parameter in the event trigger is adjusted adaptively over time to reduce the network resources occupancy. Third, co-design criteria for the desired event-triggered fuzzy controller and dynamic triggering mechanisms are derived. Finally, comprehensive comparative simulation studies of a 3-degrees-of-freedom quarter suspension model are provided under both bump road disturbance and ISO-2631 classified random road disturbance to validate the effectiveness of the proposed co-design approach. It is shown that ride comfort can be greatly improved in either road disturbance case and the suspension deflection, dynamic tyre load and actuator control input are all kept below the prescribed maximum allowable limits, while simultaneously maintaining desirable communication efficiency.

关键词： Active suspension control decentralized eventtriggered control dynamic damper dynamic eventtriggered communication in-wheel motor driven electric vehicle

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近70年黄河潼关站以下河段冲淤特征分析

水土保持研究 2025年第1期32卷 48-56页

作者：韩超王飞戈文艳陈昊史尚渝刘元昊西北农林科技大学水土保持科学与工程学院中国科学院水利部水土保持研究所

[目的]揭示黄河潼关以下河段冲淤变化过程及分布特征，为未来黄河下游水土保持和调水调沙工作提供参考。[方法]对1952—2022年来潼关—花园口段、下游游荡型河段、过渡型河段、弯曲型河段输沙特征和冲淤过程进行分析，采用趋势分析、突... 详细信息

[目的]揭示黄河潼关以下河段冲淤变化过程及分布特征，为未来黄河下游水土保持和调水调沙工作提供参考。[方法]对1952—2022年来潼关—花园口段、下游游荡型河段、过渡型河段、弯曲型河段输沙特征和冲淤过程进行分析，采用趋势分析、突变检验与回归分析等方法，确定了不同河段的输沙、冲淤变化特征及其相互影响。[结果]潼关以下河段年输沙量在显著减少(p<0.01),1996年后各站输沙量大幅降低，近20年来沙系数均低于0.01,表现冲刷特征。各河段年淤积量呈下降趋势，潼关—花园口段和弯曲型河段仍在持续淤积，花园口—艾山段近20年淤积量则为负值。研究时段内，潼关以下河段累计淤积泥沙186.84亿t,潼关—花园口段、游荡型河段、过渡型河段和弯曲型河段分别淤积了86.75亿t, 49.45亿t, 17.14亿t, 33.49亿t。另外，输沙量和来沙系数变化分别对潼关—花园口、游荡型河段和花园口以下河段淤积影响明显(p<0.01)。[结论]小浪底水利枢纽运行及调水调沙实施后，潼关以下河段年淤积量大幅减少，潼关—花园口和弯曲型河段承载了更多泥沙，花园口—艾山段则已由淤转冲。

关键词：水沙变化黄河下游冲淤过程淤积现状

Establishment of a three-dimensional particle library for graded crushed stone based on a new aggregate morphology characterization method

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 117-130页

作者： Haitao ge Aimin Sha Zhenqiang han School of Future Transportation Chang'an UniversityXi'an 710064China University of Strasbourg INSA StrasbourgCNRSICubeUMR 7357Strasbourg F-67000France School of Highway Chang'an UniversityXi'an 710064China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China

The morphology of graded crushed stone(GCS)particles has an essential influence on the performance of aggregate *** impact of particle shape is a comprehensive effect that cannot be considered separately,leading to difficulties in establishing the relationship between the mixture properties and the aggregate morphology by using laboratory *** discrete element method(DEM)is an effective way widely adopted to reconstruct the morphology of particles and simulate performance tests of granular ***,selecting limited particles characterizing a real particle-assembly for simulation is still a challenge in current research due to the inherent rich variability of particle *** this study,based on the acquisition of three-dimensional(3D)aggregate shapes by using laser scanning,ellipsoid index(EDI)translating the particle shape as a function of surface area,volume,and contour length is proposed to comprehensively evaluate aggregate ***,a particle library capable of characterizing aggregate morphology distribution is established based on the statistics of the corresponding morphological characteristics of particle *** model reliability is validated by carrying out a series of experimental and numerical penetration tests with nine different *** established particle library can be used to model aggregate mixtures and the proposed simulation framework is promising for optimizing the mixture gradation design numerically.

关键词： Particle library Discrete element method 3D laser scanning Coarse aggregate Morphology characterization Gradation design