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中国环保产业 2001年第5期 32-32页

作者：孙青霞亓宝艳葛玉兴山东省蓬莱市环境监测站山东蓬莱265600 山东省蓬莱市煊煜机械有限公司山东蓬莱265600

文章介绍了CLHH环保型锅炉的工作原理和结构设计,它即使燃烧含硫量及挥发份均很高的煤,直接排放时,烟气指标也可达到国家标准。

关键词：锅炉研制技术前景分析 CLHH环保型燃煤锅炉

Improved artificial bee colony algorithm with mutual learning

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Journal of Systems Engineering and Electronics 2012年第2期23卷 265-275页

作者： yu Liu Xiaoxi Ling yu Liang Guanghao Liu School of Software Dalian University of Technology Dalian 116024 P. R. China Civil Aviation Flight University of China Guanghan 618307 E R. China

The recently invented artificial bee colony （ABC） al- gorithm is an optimization algorithm based on swarm intelligence that has been used to solve many kinds of numerical function optimization problems. It performs well in most cases, however, there still exists an insufficiency in the ABC algorithm that ignores the fitness of related pairs of individuals in the mechanism of find- ing a neighboring food source. This paper presents an improved ABC algorithm with mutual learning （MutualABC） that adjusts the produced candidate food source with the higher fitness between two individuals selected by a mutual learning factor. The perfor- mance of the improved MutualABC algorithm is tested on a set of benchmark functions and compared with the basic ABC algo- rithm and some classical versions of improved ABC algorithms. The experimental results show that the MutualABC algorithm with appropriate parameters outperforms other ABC algorithms in most experiments.

关键词： artificial bee colony (ABC) algorithm numerical func- tion optimization swarm intelligence mutual learning.

Experimental study on the gas-stripping chamber of an E//B neutral particle analyzer

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Nuclear Science and Techniques 2024年第11期35卷 98-107页

作者： Long Ma De-Hao Xie Yan-Xi Wang Shuo Wang Ji-Feng Han Wei-Ping Lin Jian-Li Liu Xing-Quan Liu yu-Guo Liu Xiao-Bing Luo yuan Luo Guo-Feng Qu yu-Fan Qu Pei-Pei Ren Roy Wada Lin-ge Zang Jing-Jun Zhu Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southwestern Institute of Physics Chengdu 610218China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA

Stripping units take a key role in the neutral particle analyzer(NPA).A renovated gas-stripping unit was constructed for the newly designed E//B *** H_(2)as the working gas,we measured the gas inlet pressure(P_(0))and vacuum chamber pressure(P_(3)).The pressure distribution inside the gas-stripping room was calculated with Ansys Fluent,using the measured P_(0)and P_(3)as boundary *** stripping efficiency of the stripping unit was then simulated utilizing the geant4 Monte Carlo code for the H and D *** pressure P_(0)=40 Pa,which is one-sixth of what found in the previous design and corresponds to a thickness of 1.27×10^(17)atoms∕cm^(2),was obtained as the optimum working pressure for the upgraded stripping *** 50 kV electron cyclotron resonance(ECR)ion source platform was designed and constructed for E//B NPA calibration,and its performance has been *** the ECR ion source platform,we measured the efficiency of the stripping unit through an inverse experiment with proton *** compared the current ratios of measurements with and without H_(2)gas to geant4 simulation *** found adequate agreement between the overall trends of the experiment and the *** significant deviation for incident energies below 20 keV may result from the scattering effects of low-energy protons,leading to reduced accuracy in single-scattering physics in geant4 *** the scattering corrections observed in the reverse experiments obtains more accurate stripping efficiencies for H and D atoms in the energy range of 20–200 keV and the global efficiency with the maximum values of 95.0%for H atoms and 78.9%for D atoms at 200 keV.

关键词： NPA Gas-stripping ECR ion source Stripping efficiency geant4

generation of Spontaneous Synchronized Rhythm and its Role in Information Processing

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Chinese Physics Letters 2001年第2期18卷 295-297页

作者： yu yu-Guo WANG Wei National Laboratory of Solid State Microstructure and Department of Physics Nanjing UniversityNanjing 210093

The generation of spontaneous synchronized rhythm and its role are studied by using a globally coupled excitable stochastic neuronal *** the coupling strength exceeds a critical value,the neurons with a suitable noise in the network exhibit a strong tendency to synchronize and display a spontaneous *** coherence of the network can be enhanced by a suitable noise and a coupling of the *** spontaneous rhythm enhances the ability of the network in processing weak periodic signals.

关键词： coupling globally stochastic

Factors affecting occurrence of gastric varioliform lesions: A case-control study

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World Journal of Gastroenterology 2016年第22期22卷 5228-5236页

作者： Tian-Hui Zou Ru-Hua Zheng Qin-Yan Gao Xuan Kong Xiao-yu Chen Zhi-Zheng ge Ying-Xuan Chen Xiao-Ping Zou Jing-yuan Fang Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Division of Gastroenterology and Hepatology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM: To investigate the factors influencing the occurrence of gastric varioliform lesions(GVLs) and their possible link with gastric ***: A 1:1 matched case-control study was performed to retrospectively analyze data from 1638 chronic gastritis patients who had undergone gastroscopy at one of two Chinese hospitals between 2009 and 2014. Patients with GVLs(cases) were compared to those without such lesions(controls). Endoscopic and pathological findings were recorded, along with interview information on Helicobacter pylori(H. pylori) infection, medical, drug and family histories, lifestyle and eating habits. The association between each factor and the occurrence of GVLs was estimated, and then multivariate conditional logistic regression was used to evaluate the independent ***: The frequency and severity of glandular atrophy, intestinal metaplasia(IM) and low-grade intraepithelial neoplasia were significantly increased in the GVL group(P getable consumption [0.491(0.311, 0.776), P = 0.002] was negatively correlated. CONCLUSION: Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities.

关键词： Gastric cancer Gastric varioliform lesions Precancerous lesion Risk factor Varioliform gastritis

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新型鼠疫疫苗F1抗原原液性质的研究

微生物学免疫学进展 2020年第3期48卷 15-20页

作者：王婷吴智远李朋伟张婷婷戈钰雯高明刘月萍孙田华焦磊王秉翔兰州生物制品研究所有限责任公司第三研究室甘肃省疫苗工程技术研究中心甘肃兰州730046

目的新型鼠疫疫苗包含鼠疫减毒菌EV株培养提取的天然F1抗原。研究生理氯化钠溶液中F1抗原的生物与理化性质、结构概况及聚合状态等特性,以期对F1抗原的制备、质量控制及其免疫原性研究提供理论依据。方法①过碘酸-希夫(PAS)染色法、糖... 详细信息

目的新型鼠疫疫苗包含鼠疫减毒菌EV株培养提取的天然F1抗原。研究生理氯化钠溶液中F1抗原的生物与理化性质、结构概况及聚合状态等特性,以期对F1抗原的制备、质量控制及其免疫原性研究提供理论依据。方法①过碘酸-希夫(PAS)染色法、糖蛋白碳水化合物估测试剂盒鉴定F1抗原是否为糖蛋白,蒽酮-硫酸法定量测定F1抗原中多糖含量,基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)技术测定F1抗原单体相对分子质量并与理论值差异比对,间接证明F1抗原是否糖基化;②高效分子排阻色谱法联用多角度激光散射(HPSEC-MALLS)法研究保存于生理氯化钠溶液中F1抗原的天然聚集状态;③搜索geneBank获得鼠疫菌F1抗原的核苷酸序列,经DNAStar软件翻译出氨基酸序列,并通过肽段覆盖率验证成熟F1抗原的氨基酸序列,以圆二色谱试验结合K2D2软件推测二级结构,MALDI-TOF-MS测定单体相对分子质量。结果①鉴定出F1抗原单体相对分子质量为15 500的蛋白质,不含有多糖成分;②F1抗原的相对分子质量分布范围在10~6~10~7之间,呈现聚集状态;③F1抗原由149个氨基酸组成,单体相对分子质量为15 500,F1抗原的二级结构以β-sheet为主。结论新型鼠疫疫苗中F1抗原为不含多糖成分的蛋白质,天然状态下F1抗原以高分子聚集态存在,F1抗原单体相对分子质量为15 500,抗原结构性质稳定,与理论结果一致。在制造、检定和免疫学研究中应参考F1抗原的这些特性。

关键词：新型鼠疫疫苗 F1抗原性质糖聚集

Theranostic nanomedicine by surface nanopore engineering

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Science China Chemistry 2018年第10期61卷 1243-1260页

作者： Zhenli Li Luodan yu Tian Yang yu Chen Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences

Theranostic nanomedicine that integrates diagnostic and therapeutic agents into one nanosystem has gained considerable momentum in the field of cancer treatment. Among diverse strategies for achieving theranostic capabilities, surface-nanopore engineering based on mesoporous silica coating has attracted great interest because of their negligible cytotoxicity and chemically active surface that can be easily modified to introduce various functional groups(e.g.,-COOH,-NH_2,-SH, etc.) via silanization, which can satisfy various requirements of conjugating biological molecules or functional nanoparticles. In addition,the nanopore-engineered biomaterials possess large surface area and high pore volume, ensuring desirable loading of therapeutic guest molecules. In this review, we comprehensively summarize the synthetic procedure/paradigm of nanopore engineering and further broad theranostic applications. Such nanopore-engineering strategy endows the biocompatible nanocomposites(e.g., Au,Ag, graphene, upconversion nanoparticles, Fe_3O_4, MXene, etc.) with versatile functional moieties, which enables the development of multifunctional nanoplatforms for multimodal diagnostic bio-imaging, photothermal therapy, photodynamic therapy,targeted drug delivery, synergetic therapy and imaging-guided therapies. Therefore, mesoporous silica-based surface-nanopore engineering integrates intriguing unique features for broadening the biomedical applications of the single mono-functional nanosystem, facilitating the development and further clinical translation of theranostic nanomedicine.

关键词： mesoporous silica nanopore engineering theranostic cancer nanomedicine

Response Sensitivity to Design Parameters of RV Reducer

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Chinese Journal of Mechanical Engineering 2018年第3期31卷 115-127页

作者： yu-Hu Yang Chuan Chen Shi-yu Wang School of Mechanical Engineering Tianjin University

Dynamic characteristic significantly a ects performance of RV reducer. The current researches mainly pay attention to free vibration properties of RV reducer. In order to satisfy the increasing demand on high performance,response sensi?tivity is analytically studied on the basis of cyclic symmetry structure. Based on the structure characteristics,a dynamic model is developed by taking into account the influence of bearing sti ness,crankshaft bending sti ness and mesh sti ness within planetary and cycloidal stages. For the model,governing equation of motion is derived and solved by Fourier series method. The solution revealed that forced vibrations at primary frequency are well defined structural. There exist three typical forced vibration modes: rotational,translational and planetary component modes. Response sensitivity to basic design parameters is obtained as closed?form expressions by di erential method. With the typical vibration modes,response sensitivity is simplified and classified into three types. Calculation of sensitivity implies that vibrations of the output wheel are sensitive to eccentricity. As eccentricity increases,sensitivity of translation decreases first and then increases,but sensitivity of rotation always increases. The proposed method for analyzing response sensi?tivity provides some principles for selecting parameters for RV reducer from the point of view of forced vibration.

关键词： RV reducer Mesh phasing Vibration modes Sensitivity

Novel mutations in PDE6B causing human retinitis pigmentosa

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1094-1099页

作者： Lu-Lu Cheng Ru-Yi Han Fa-yu Yang Xin-Ping yu Jin-Ling Xu Qing-Jie Min Jie Tian Xiang-Lian ge Si-Si Zheng Ye-Wen Lin Yi-Han Zheng Jia Qu Feng Gu School of Ophthalmology and Optometry Eye HospitalWenzhou Medical University State Key Laboratory Cultivation Base and Key Laboratory of Vision ScienceMinistry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Institute of genomic Medicine Wenzhou Medical University

AIM: To identify the genetic defects of a Chinese patient with sporadic retinitis pigmentosa (RP). METHODS: Ophthalmologic examinations were performed on the sporadic RP patient, 144 genes associated with retinal diseases were scanned with capture next generation sequencing (CNGS) approach. Two heterozygous mutations in PDE6B were confirmed in the pedigree by Sanger sequencing subsequently. The carrier frequency of PDE6B mutations of reported PDE5B mutations based on the available two public exome databases (1000 genomes Project and ESP6500 genomes Project) and one in-house exome database was investigated. RESULTS: We identified compound heterozygosity of two novel nonsense mutations c.1133G>A (p.W378X) and c.2395C>T (p.R799X) in PDE6B, one reported causative gene for RP. Neither of the two mutations in our study was presented in three exome databases. Two mutations (p.R74C and p.T6041) in PDE5B have relatively high frequencies in the ESP6500 and in-house databases, respectively, while no common dominant mutation in each of the database or across all databases. CONCLUSION: We demonstrates that compound heterozygosity of two novel nonsense mutations in PDE6B could lead to RP. These results collectively point to enormous potential of next-generation sequencing in determining the genetic etiology of RP and how various mutations in PDE9B contribute to the genetic heterogeneity of RP.

关键词： compound heterozygosity retinitis pigmentosa mutation capture next generation sequencing PDE6B

Tuning spin reorientation in Er1–xYxFeO3 single crystal family

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Frontiers of physics 2019年第1期14卷 105-110页

作者： Ning yuan Ru-Bin Li You-Shuang yu Zheng-Jie Feng Bao-Juan Kang Shi-Yi Zhuo Jun-Yi ge Jin-Cang Zhang Shi-Xun Cao Department of Physics International Center of Quantum and Molecular Structures Shanghai University Shanghai 200444 China Materials genome Institute Shanghai University Shanghai 200444 China Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

A temperature-induced spin reorientation transition between Г4 (Gx, Ay, Fz) and Г2 (Fx, Cy, Gz) has been studied in the family of Er1–xYxFeO3 (x = 0, 0.25, 0.5, 0.75, 1) single crystals. By doping nonmagnetic Y3+, we tuned the spin reorientation temperature to low temperature with increasing x. Moreover, the typical compensation point and spin flip transition of ErFeO3 also decreases with doping, and disappears above x = 0.75. We also report the Rietveld refinements and Raman spectroscopy of Er1–xYxFeO3, where some Raman peaks are shifted to low frequency with increasing doping. Our results shed light on the understanding of the interaction between two magnetic sub-lattices of rare earth (R3+) and iron (Fe3+) ions, and will also contribute to the materials design and potential applications.

关键词： Er1–xYxFeO3 single crystal growth magnetic measurements