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Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

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Journal of Traditional Chinese Medicine 2024年第4期44卷 670-679页

作者： LIU Tongtong ZHANG Xi YANG Hui LIN Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI Chang LONG Hongping LUO Yan XIANG Yun ge jinwen WANG Yuhong MENG Pan Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China the Second People's Hospital of Hunan Province Changsha 410007China The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410007China Hunan Academy of Chinese Medicine Changsha 410013China

OBJECTIVE:To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons,and to elucidate the mechanism behind the ***:The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal *** vivo,novelty suppressed feeding,open-field and sucrose preference tests as well as Morris water maze were *** content of brain derived neurotrophic factor(BDNF),5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA)in serum were detected by enzyme-linked immunosorbent *** mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis,and *** of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU),the expression of BDNF,neurotrophin-3(NT-3),and nerve growth factor(NGF)in hippocampus dentate gyrus region were measured by *** vitro,BDNF,NT-3,tropomyosin receptor kinase B(TrkB),and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)were detected through the high content analysis(HCA)to investigate neurotrophin and ***:Induction of CUMS in rats induced depressive symptoms,while luteolin significantly enhanced sucrose consumption,decreased feeding latency,increased locomotor activity,escape latency,distance of target quadrant and regulated the content of depressive-like *** analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU,BrdU+neuronal nuclear antigen,and BrdU+doublecortin in septo-temporal axis of S2(mid-septal)and T3(mid-temporal).Moreover,expression of BDNF,NT-3,and NGF increased significantly in the septo-temporal axis of S2 and *** showed increased expression of BDNF,NT-3,TrkB and p-CREB in primary hippocampal ***:The results provided direct ev

关键词： fetal rats Survival

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基于气阳濡动学说的脑小血管病气虚血瘀证的病机与治疗

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中华中医药杂志 2024年第2期39卷 561-565页

作者：方锐周月李玉丽谢乐杜麒麟谢瑶葛金文湖南省中医药研究院中药临床药理研究所长沙410006 湖南省中西医结合医院(湖南省中医药研究院附属医院) 长沙410006 湖南省中医药研究院中医药文献信息研究所长沙410013 湖南中医药大学中西医结合学院长沙410208 湖南省中医药研究院长沙410013

脑小血管病(CSVD)即累及颅内小/微动脉、毛细血管、小/微静脉等引起的一系列临床常见的综合征,以卒中(深部小梗死、脑出血)、认知功能下降和情感障碍等为主要临床表现。围绕老年病及脑病的辨证论治方法,葛金文教授创新性提出气阳濡动学... 详细信息

脑小血管病(CSVD)即累及颅内小/微动脉、毛细血管、小/微静脉等引起的一系列临床常见的综合征,以卒中(深部小梗死、脑出血)、认知功能下降和情感障碍等为主要临床表现。围绕老年病及脑病的辨证论治方法,葛金文教授创新性提出气阳濡动学说,认为气阳不足,温化濡养或运动总摄失司,脑之元神失去濡养,总司五脏六腑、四肢百骸、气血精津、经脉血脉失常,故导致情感、记忆认知障碍,躯体功能异常等。气阳不足、血脉瘀滞为CSVD发生发展核心病机。文章从CSVD的发病机制出发,基于气阳濡动学说,提出CSVD气虚血瘀证的病机演变进程为气阳不足、阴津亏虚、气郁血瘀、痰湿内生、神明失养等,治疗当以益气(阳)活血为主要治则,灵活配伍益气(阳)养阴、调畅气机、温阳固摄、化痰袪湿、活血祛瘀、养魂安神等之品,为本病的临床辨证施治提供了不同视角的诊疗思路。

关键词：脑小血管病气阳濡动学说气虚血瘀证病机治则治法

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基于《中风病良方大全》探讨中药治疗出血性中风成方规律

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湖南中医杂志 2024年第3期40卷 19-27页

作者：杜晓霞周德生苏啟后葛金文湖南中医药大学第一附属医院湖南长沙410007 深圳市宝安区中医院广东深圳518000 湖南省中医药研究院湖南长沙410013

目的:分析《中风病良方大全》中治疗出血性中风的方剂成方规律。方法:搜集《中风病良方大全》一书中治疗出血性中风的方剂,通过Microsoft Excel 2010软件统计中药频次,SPSS Modeler 18.0软件进行关联规则分析及决策树分析,SPSS Statisti... 详细信息

目的:分析《中风病良方大全》中治疗出血性中风的方剂成方规律。方法:搜集《中风病良方大全》一书中治疗出血性中风的方剂,通过Microsoft Excel 2010软件统计中药频次,SPSS Modeler 18.0软件进行关联规则分析及决策树分析,SPSS Statistics 25.0软件进行聚类分析、因子分析。结果:得到有效方剂355首,涉及中药267味,核心药物为当归、红花、川芎、桃仁,常用药物功效分别为活血化瘀(22.49%)、平肝息风(17.31%)、补虚(14.72%)、清热(11.77%)、化痰止咳平喘(7.65%),药性主要涉及寒(40.36%)、温(32.24%)、平(22.30%),药味主要涉及苦(32.03%)、甘(28.68%)、辛(23.25%),归经主要为肝(23.56%)、心(14.56%)、脾(14.26%)经。关联规则分析得到12个药组,聚类分析得到8个药组,因子分析提取15个公因子,大黄为因变量的决策树筛选出大黄、三七两味中药。结论:数据挖掘技术全面探究出中药治疗出血性中风的成方规律大多是以活血化瘀、平肝息风、补虚清热、化痰开窍为配伍原则,有助于开发相关药物和指导中医临床实践。

关键词：出血性中风《中风病良方大全》成方规律数据挖掘

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湖湘古代中医药文献的类型与特点述略

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湖南中医药大学学报 2024年第1期44卷 158-162页

作者：许盈葛金文湖南中医药大学湖南长沙410208 湖南省马王堆医学研究中心湖南长沙410006 湖南省中医药研究院湖南长沙410006

湖湘中医药文献既是湖湘先人认识疾病的重要途径,又是湖湘地区中医药知识的重要宝库。从早期的口头传承到简帛、竹木简牍,再到纸质文献,湖湘中医药文献呈现了丰富多样的类型和独特的发展轨迹。周秦两汉时期,湖湘中医药文献开始萌芽,主... 详细信息

湖湘中医药文献既是湖湘先人认识疾病的重要途径,又是湖湘地区中医药知识的重要宝库。从早期的口头传承到简帛、竹木简牍,再到纸质文献,湖湘中医药文献呈现了丰富多样的类型和独特的发展轨迹。周秦两汉时期,湖湘中医药文献开始萌芽,主要以简帛文献为主;魏晋隋唐时期,文献载体逐渐向竹木简牍转变,且养生文献得到发展;宋金元时期,方书集合文献占据主导地位,中医药知识体系更趋完善;明清时期,见证了湖湘中医药文献的鼎盛,特别是处理时疫的文献得到广泛流传。通过厘清湖湘古代中医药文献的类型与特点,展示和挖掘湖湘中医药知识和理论的构建历程,从而促进湖湘中医药及其文献的研究利用。

关键词：湖湘文化中医药文献文献载体文献类型地域医学特色

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A novel efficient energy absorber with free inversion of a metal foam-filled circular tube

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 1-14页

作者： Jianxun ZHANG jinwen BAI State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong UniversityXi'an 710049China

In this paper, a novel efficient energy absorber with free inversion of a metal foam-filled circular tube(MFFCT) is designed, and the axial compressive behavior of the MFFCT under free inversion is studied analytically and numerically. The theoretical analysis reveals that the energy is mainly dissipated through the radial bending of the metal circular tube, the circumferential expansion of the metal circular tube, and the metal filled-foam compression. The principle of energy conservation is used to derive the theoretical formula for the minimum compressive force of the MFFCT over free inversion under axial loading. Furthermore, the free inversion deformation characteristics of the MFFCT are analyzed numerically. The theoretical steady values are found to be in good agreement with the results of the finite element(FE) analysis. The effects of the average diameter of the metal tube, the wall thickness of the metal tube, and the filled-foam strength on the free inversion deformation of the MFFCT are considered. It is observed that in the steady deformation stage, the load-carrying and energy-absorbing capacities of the MFFCT increase with the increase in the average diameter of the metal tube, the wall thickness of the metal tube, or the filled-foam strength. The specific energy absorption(SEA) of free inversion of the MFFCT is significantly higher than that of the metal tube alone.

关键词： metal foam-filled circular tube(MFFCT) free inversion load-carrying capacity energy absorption

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葛金文从寒疫论治新冠病毒奥密克戎感染经验

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湖南中医杂志 2023年第1期39卷 42-47页

作者：杨丽谢乐葛安琪方锐葛金文湖南省中医药研究院湖南长沙410006 北京中医药大学国学院北京102401 湖南省中西医结合医院湖南长沙410006 湖南中医药大学第一附属医院湖南长沙410007

从病因病机、证候表现、治则治法、方剂和加减变化等方面介绍葛金文教授对新冠病毒奥密克戎感染的学术观点及临证经验。葛教授认为新冠病毒奥密克戎感染属于中医学疫病范畴,病名为“寒疫”,病因以寒性疫毒为主,兼有风、燥之性;病机及证... 详细信息

从病因病机、证候表现、治则治法、方剂和加减变化等方面介绍葛金文教授对新冠病毒奥密克戎感染的学术观点及临证经验。葛教授认为新冠病毒奥密克戎感染属于中医学疫病范畴,病名为“寒疫”,病因以寒性疫毒为主,兼有风、燥之性;病机及证候表现以外感寒邪六经传变特征为主;治疗当基于伤寒六经理法,观其脉证,随证治之;通过典型病案分析体现基本方剂的灵活运用,处方精巧,疗效显著,可为新冠病毒感染的治疗提供可借鉴的方法与思路。

关键词：新冠病毒奥密克戎寒疫六经传变名医经验葛金文

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Effect of Sintering Temperature on the Microstructure and Mechanical Properties of Nanocrystalline Cemented Carbide

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 664-672页

作者：陈先富刘颖 YE jinwen WANG Lu School of Materials Science and Engineering Sichuan UniversityChengdu 610065China Key Laboratory of Advanced Special Ma-terial&Technology Ministry of EducationChengdu 610065China

WC-Co nanocrystalline nitrogen-containing cemented carbides were prepared by vacuum sintering and low pressure *** sintering processes of Cr_(2)(C,N)doped nano WC-Co powders were studied by using thermogravimetric analysis(TGA)and differential scanning calorimetry(DSC).The effect of sintering temperature on the microstructure and mechanical properties of nanocrystalline cemented carbide was studied by scanning electron microscope(SEM),high resolution transmission electron microscope(HRTEM)and mechanical property *** results showed that the nano WC grains began to grow in the solid phase sintering stage.A high-performance nano-nitrogen-containing cemented carbide with uniform microstructure and good interfacial bonding can be obtained by increasing the sintering temperature to 1380℃.It has a transverse rupture strength(TRS)of 5057 MPa and a hardness of 1956 HV30.

关键词： nano nitrogen cemented carbide sintering temperature microstructure mechanical properties

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Effect of(Cr,V)_(2)(C,N)on the Microstructure and Mechanical Properties of WC-10Co Cemented Carbides

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1138-1148页

作者： LI Xiangkun WANG Lu YE jinwen School of Materials Science and Engineering Sichuan UniversityChengdu 610065China

WC-10Co cemented carbides with finer WC and narrower grain size distributions are produced by using(Cr,V)_(2)(C,N)as grain growth *** a result,with the increase of(Cr_(0.9),V_(0.1))_(2)(C,N)and(V_(0.9),Cr_(0.1))_(2)(C,N),the grains size of WC and mean free path of Co phase decrease,and adjacency of WC *** and homogenization of grains enhance the transverse rupture strength(TRS)and the ***,the deflection and bridging of cracks keep the fracture toughness at a respectable *** WC-10Co-0.6(Cr_(0.9),V_(0.1))_(2)(C,N)-0.025(V_(0.9),Cr_(0.1))_(2)(C,N)cemented carbides exhibit excellent comprehensive mechanical properties with the TRS of 4602.6 MPa,hardness of 1835 kg/mm^(2),and fracture toughness of 10.39 MPa·m^(1/2),***,the large pores are caused by excess N larger than 0.03 wt%and deteriorates the mechanical *** provide a new approach to WC-Co cemented carbides preparation with a narrow grain size distribution by adding novel grain growth inhibitors.

关键词： (Cr,V)_(2)(C,N) nutrient content WC grains size microstructure mechanical properties

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《黄帝内经》身体观之四层次说

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中医杂志 2019年第18期60卷 1531-1534页

作者：杨丽葛金文湖南中医药大学中西医结合学院湖南省长沙市410208

身体是医学的基本研究对象,身体观是医学的基本命题,不同的医学体系奠基于特定的身体观,对身体的研究有助于深入认识各医学体系。主要从道的身体、神的身体、气的身体、形的身体四个层面对《黄帝内经》身体观予以阐述,认为道之身体为万... 详细信息

身体是医学的基本研究对象,身体观是医学的基本命题,不同的医学体系奠基于特定的身体观,对身体的研究有助于深入认识各医学体系。主要从道的身体、神的身体、气的身体、形的身体四个层面对《黄帝内经》身体观予以阐述,认为道之身体为万物之本源,但病由乎形气,故汤药及针灸主要作用在神、气、形三个层次。

关键词：黄帝内经身体观道神气形

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Battery pack capacity estimation for electric vehicles based on enhanced machine learning and field data

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Journal of Energy Chemistry 2024年第5期92卷 605-618页

作者： Qingguang Qi Wenxue Liu Zhongwei Deng jinwen Li Ziyou Song Xiaosong Hu College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

Accurate capacity estimation is of great importance for the reliable state monitoring,timely maintenance,and second-life utilization of lithium-ion *** numerous works on battery capacity estimation using laboratory datasets,most of them are applied to battery cells and lack satisfactory fidelity when extended to real-world electric vehicle(EV)battery *** challenges intensify for large-sized EV battery packs,where unpredictable operating profiles and low-quality data acquisition hinder precise capacity *** fill the gap,this study introduces a novel data-driven battery pack capacity estimation method grounded in field *** proposed approach begins by determining labeled capacity through an innovative combination of the inverse ampere-hour integral,open circuit voltage-based,and resistance-based correction ***,multiple health features are extracted from incremental capacity curves,voltage curves,equivalent circuit model parameters,and operating temperature to thoroughly characterize battery aging behavior.A feature selection procedure is performed to determine the optimal feature set based on the Pearson correlation ***,a convolutional neural network and bidirectional gated recurrent unit,enhanced by an attention mechanism,are employed to estimate the battery pack capacity in real-world EV ***,the proposed method is validated with a field dataset from two EVs,covering approximately 35,000 *** results demonstrate that the proposed method exhibits better estimation performance with an error of less than 1.1%compared to existing *** work shows great potential for accurate large-sized EV battery pack capacity estimation based on field data,which provides significant insights into reliable labeled capacity calculation,effective features extraction,and machine learning-enabled health diagnosis.

关键词： Electricvehicle Lithium-ion battery pack Capacity estimation Machine learning Field data

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