检索结果-南通市图书馆

Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions:a systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第5期23卷 495-500页

作者： yu Zhou Cun-Can Deng Wu-Jiang Liu Huang Liu Hou-Bin Zheng yun-ge Tang Xin-Zong Zhang Jun-Hong Deng Department of Urology The First Affiliated HospitalJinan UniversityGuangzhou 510630China NHC Key Laboratory of Male Reproduction and genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China Digestive Diseases Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Andrology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China

Studies have explored the assisted reproductive technology(ART)outcomes of y-chromosome azoospermia factor c(AZFc)microdeletions,but the effect of sperm source on intracytoplasmic sperm injection(ICSI)remains *** determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions,we searched Embase,Web of Science,and PubMed to conduct a systematic review and *** first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group(risk ratio:0.97,95%confidence interval[CI]:0.73-1.28,P=0.82).The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group(risk ratio:1.06,95%Cl:0.54-2.06,P=0.87).The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group(risk ratio:1.24,95%Cl:0.66-2.34,P=0.50).Inevitable heterogeneity weakened our ***,our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes,representing a meaningful result for clinical *** properly designed studies are needed to further confirm our conclusions.

关键词： assisted reproductive technology azoospermia factor c microdeletions ejaculated sperm live birth rate testicular sperm

1961-2005年中国霾日气候特征及变化分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地理学报 2008年第7期63卷 761-768页

作者：高歌国家气候中心中国气象局气候研究开放实验室北京100081

利用1961-2005年中国霾日统计资料,对中国霾的时空气候分布特征、变化趋势进行了详细分析,并探讨了霾变化的可能原因及其与太阳总辐射、日照时数变化的关系。结果表明:近45年来,中国年和四季霾日的空间分布特征均呈现东多西少的空间分... 详细信息

利用1961-2005年中国霾日统计资料,对中国霾的时空气候分布特征、变化趋势进行了详细分析,并探讨了霾变化的可能原因及其与太阳总辐射、日照时数变化的关系。结果表明:近45年来,中国年和四季霾日的空间分布特征均呈现东多西少的空间分布态势,东部地区集中在三个多发区,分别为长江中下游、华北和华南;季节变化,除东北地区、青藏高原、西北西部四季霾日均很少且变化不明显外,其余大部分地区均呈现为冬季多,夏季少,春秋季居中的特点。近45年,全国平均年霾日数呈现明显的增加趋势,2004年为最高值。我国东部大部地区主要呈现增加趋势,尤其霾多发地区,如长江中下游、珠江流域及河南西部等地,霾日增加幅度大,趋势显著,人类活动造成的大气污染物增加及天气气候变化是这些地区霾日呈现增加趋势的可能原因,我国西部地区和东北大部地区则以减少趋势为主。华北、长江中下游地区、华南地区霾日变化趋势与日照时数变化趋势相反,霾的增加是造成太阳总辐射减少的主要原因之一。东北地区、西北地区、西南地区、青藏高原霾日变化和日照时数变化均呈现不明显的减少趋势,但由于这些地区霾日发生少,其变化不会对日照时数和太阳总辐射变化造成很大的影响。

关键词：中国霾大气污染日照时数太阳总辐射

Levitation and lateral forces between a point magnetic dipole and a superconducting sphere

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2016年第5期25卷 453-456页

作者： H M Al-Khateeb M K Alqadi F y Alzoubi B Albiss M K Hasan (Qaseer) N y Ayoub Department of Physics Jordan University of Science and Technology School of Basic Sciences and Humanities German Jordanian University

The dipole–dipole interaction model is employed to investigate the angular dependence of the levitation and lateral forces acting on a small magnet in an anti-symmetric magnet/superconducting sphere system. Breaking the symmetry of the system enables us to study the lateral force which is important in the stability of the magnet above a superconducting sphere in the Meissner state. Under the assumption that the lateral displacement of the magnet is small compared to the physical dimensions of our proposed system, analytical expressions are obtained for the levitation and lateral forces as a function of the geometrical parameters of the superconductor as well as the height, the lateral displacement, and the orientation of the magnetic moment of the magnet. The dependence of the levitation force on the height of the levitating magnet is similar to that in the symmetric magnet/superconducting sphere system within the range of proposed lateral displacements. It is found that the levitation force is linearly dependent on the lateral displacement whereas the lateral force is independent of this displacement. A sinusoidal variation of both forces as a function of the polar and azimuthal angles specifying the orientation of the magnetic moment is observed. The relationship between the stability and the orientation of the magnetic moment is discussed for different orientations.

关键词： lateral and levitation forces Meissner effect dipole–dipole interaction model superconductor

Clinical characteristics and outcomes of primary intracranial alveolar soft-part sarcoma: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第1期10卷 296-303页

作者： Jun-yu Chen Bo Cen Fei Hu yong Qiu Guo-Min Xiao Jun-ge Zhou Fang-Cheng Zhang Department of Neurosurgery General Hospital of the Yangtze River ShippingWuhan 430010Hubei ProvinceChina Department of Neurosurgery Wuhan Union HospitalWuhan 430010Hubei ProvinceChina

BACKGROUND Primary intracranial alveolar soft-part sarcoma(PIASPS)is a rare *** aimed to investigate the clinical profiles and outcomes for *** SUMMARy We firstly reported five consecutive cases from our ***,the cases from previous studies were pooled and analyzed to delineate the characteristics of this *** cohort included two males and three *** median age was 21-years-old(range:8-54-years-old).All the patients received surgical *** total resection(GTR),radiotherapy,and chemotherapy were administered in 3 patients,4 patients,and 1 patient,*** a median follow-up of 36 mo,tumor progression was noticed in 4 patients;and 3 patients died of the *** data(n=14)contained 5 males and 9 females with a median age of 19 *** log-rank tests showed that GTR(P=0.011)could prolong progression-free survival,and radiotherapy(Pger overall *** Patients with PIASPS suffer from poor *** treatment is the first choice,and GTR should be achieved when the tumor is *** with PIASPS benefit from radiotherapy,which should be considered as a part of treatment therapies.

关键词： Primary intracranial alveolar soft-part sarcoma Surgery Radiotherapy Progression-free survival Overall survival Case report

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第12期8卷 5631-5656页

作者： Zhi-Qiang Wang Zhao-Cong Zhang yu-yang Wu ya-Nan Pi Sheng-Han Lou Tian-Bo Liu ge Lou Chang yang Department of Gynecology Oncology Harbin Medical University Cancer HospitalHarbin 150086China School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical UniversityWenzhouChina Department of Colorectal Surgery Harbin Medical University Cancer HospitalHarbinChina

BET proteins,which influence gene expression and contribute to the development of cancer,are epigenetic ***,BET inhibitors represent a novel form of epigenetic anticancer *** preliminary clinical trials have shown the anticancer potential of BET inhibitors,it appears that these drugs have limited effectiveness when used ***,given the limited monotherapeutic activity of BET inhibitors,their use in combination with other drugs warrants attention,including the meaningful variations in pharmacodynamic activity among chosen drug *** this paper,we review the function of BET proteins,the preclinical justification for BET protein targeting in cancer,recent advances in small-molecule BET inhibitors,and preliminary clinical trial *** elucidate BET inhibitor resistance mechanisms,shed light on the associated adverse events,investigate the potential of combining these inhibitors with diverse therapeutic agents,present a comprehensive compilation of synergistic treatments involving BET inhibitors,and provide an outlook on their future prospects as potent antitumor *** conclude by suggesting that combining BET inhibitors with other anticancer drugs and innovative next-generation agents holds great potential for advancing the effective targeting of BET proteins as a promising anticancer strategy.

关键词： drugs holds meaningful

THE CONVERgeNCE OF MULTIGRID METHODS FOR SOLVING FINITE ELEMENT EQUATIONS IN THE PRESENCE OF SINGULARITIES

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 1995年第4期13卷 315-324页

作者： y.Q. Huang y.X. Li(Depariment of Mathematics, Xiangtan University, Hunan, China) XIANGTAN UNIV DEPT MATHXIANGTANHUNANPEOPLES R CHINA

We analyze the convergence of multigrid methods applied to finite elementequations of second order with singularities caused by reentrant angles and abruptchanges in the boundary conditions. Provided much more weaker demand of clas-sical multigrid proofs, it is shown in this paper that, for symmetric and positivedefinite problems in the presence of singularities, multigrid algorithms with evenone smoothing step converge at a rate which is independent of the number of lev-els or unknowns. Furthermore, we extend this result to the nonsymmetric andindefinite problems.

关键词： Pro THE CONVERgeNCE OF MULTIGRID METHODS FOR SOLVING FINITE ELEMENT EQUATIONS IN THE PRESENCE OF SINGULARITIES

Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms

在线全文

学校读者我要写书评

暂无评论

genes & Diseases 2019年第3期6卷 276-281页

作者： Qi Zhang Qi Han Jie Zi Jinlong Ma Huihui Song yulu Tian Mary McGrath Chunhua Song Zheng ge Department of Hematology Zhongda Hospital Southeast UniversityInstitute of Hematology Southeast UniversityNanjing 210009China Department of Pediatrics Pennsylvania State University College of MedicineHersheyPA 17033USA

EZH2 is a component of the polycomb repressive complex 2(PRC2),which is a highly conserved histone methyltransferase that methylates lysine 27 of histone ***2 mutations are associated with oncogenesis and progression of ***,the relationship between the clinical outcome of patients with myeloid malignancies and EZH2 mutations is ***,we performed a meta-analysis of 8 studies(n Z 2243 patients)that evaluates the correlation between EZH2 mutations and overall survival(OS)in patients with myeloid ***2 mutations were associated with significantly worse OS(hazard ratio[HR]Z 2.37,95%confidential interval(CI),1.48e3.79).In a word,EZH2 mutations indicate a poor prognosis for patients with myeloid neoplasms.

关键词： EZH2 Meta-analysis Mutations Myeloid neoplasms Prognostic

A Study on the Wear Resistance of Nano-Material/E51

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2004年第3期20卷 340-343页

作者： yan GAO Zhenjia WANG Quanyu MA ge TANG Ji LIANG State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China Lab. of Tribology Dept. of Mech. Eng. Tsinghua Univ. Beijing 100084 China

Epoxy resin modified by nanometric γ-alumina or multi-walled carbon nanotubes (MCNTs) was prepared with solution mixingmethod, and the wear resistance of the composite was studied. The results show that when an optimum amount of nanometricalumina or MCNTs is filled in epikote51 (E51), the wear resistance of the composite will increase. When 8 wt pct nanometricγ-alumina is filled in E51, the wear resistance of the composite increases to 230%. When 10% MCNTs is filled in E51, thewear resistance of the composite increases to 226%. When nanometric alumina is filled in, the wear resistance of modifiedepikote51 will increase as the cure temperature is heightened.

关键词： Epoxy resin Nanometric γ-alumina Multi-walled carbon nanotubes (MCNTs) Wear resistance

Near-Field Thermal Splitter Based on Magneto-Optical Nanoparticles

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2023年第11期40卷 66-72页

作者：葛文宣胡杨高雷吴小虎 School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China School of Optical and Electronic Information Suzhou City UniversitySuzhou 215104China Jiangsu Key Laboratory of Thin Films Soochow UniversitySuzhou 215006China Shandong Institute of Advanced Technology Jinan 250100China School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China

Based on the many-body radiative heat transfer theory,we investigate a thermal splitter based on three magneto-optical In Sb *** system comprises a source with adjustable parameters and two drains with fixed *** leveraging the temperature and magnetic field dependence of the permittivity of In Sb,the direction of heat flux in the system can be controlled by adjusting the magnetic field or temperature at the *** magnetic field control,the coupling between the separated modes,and the suppression of the zero-field mode induced by the magnetic field,are utilized to achieve a thermal splitting ratio within the modulation range of 0.15–***,temperature control results in a thermal splitting ratio ranging from 0.15 to 0.99,as a result of the suppression of the zero-field mode by the magnetic field and the blue shift effect of the zero-field mode frequency increasing with ***,the gap distance between nanoparticles does not significantly affect the splitting *** findings provide valuable theoretical guidance for utilizing magneto-optical nanoparticles as thermal splitters and lay the groundwork for implementing complex heat flux networks using In Sb for energy collection and heat transfer control.

关键词： splitting thermal system