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Catatonia:A deep dive into its unfathomable depths

World Journal of Psychiatry 2024年第2期14卷 210-214页

作者： Peter Phiri gayathri delanerolle Oliver Hope Tharangini Murugaiyan Geoffrey Dimba Shanaya Rathod Zukiswa Zingela Research&Innovation Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJHampshireUnited Kingdom Acute Inpatients Services Southern Health NHS Foundation TrustBasingstoke RG249RHUnited Kingdom Home Treatment Team South WestSurrey and Borders Partnerships NHS Foundation TrustGuildford GU27XLSurreyUnited Kingdom Faculty of Health Sciences Nelson Mandela UniversitySummerstrand 6001GqeberhaSouth Africa

This editorial addresses catatonia,a complex neuropsychiatric syndrome characterised by a spectrum of psychomotor *** editorial seeks to clarify the ambiguous aspects of catatonia,integrating recent research findings,including global studies and diagnostic *** discusses catatonia’s clinical manifestations,prevalence,and associated psychiatric and medical conditions,with particular emphasis on its frequent co-occurrence with schizophrenia and mood *** prevalence of catatonia,which varies across psychiatric populations,is illustrated by a significant study conducted in Nelson Mandela Bay,South *** study provides valuable insights into the effectiveness of the Bush-Francis Screening Instrument compared to the Diagnostic and Statistical Manual 5 criteria in diagnosing *** editorial evaluates treatment approaches,primarily focusing on benzodiazepines and electroconvulsive therapy,and discusses emerging therapeutic *** underscores the importance of robust diagnostic frameworks and early intervention in managing catatonia,as recommended by the latest evidence-based consensus ***,it suggests future research directions,particularly in exploring the neurobiological and genetic factors of catatonia,to enhance our understanding and improve treatment *** editorial succinctly aims to demystify catatonia and provide valuable insights for clinicians and researchers in mental health care.

关键词： Catatonia Schizophrenia Neuropsychiatry Benzodiazepines Electroconvulsive therapy Bush-Francis screening instrument Diagnosis

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Tree: Reducing the use of restrictive practices on psychiatric wards through virtual reality immersive technology training

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World Journal of Psychiatry 2024年第10期14卷 1521-1537页

作者： Peter Phiri Laura Pemberton Yang Liu Xiaojie Yang Joe Salmon Isabel Boulter Sana Sajid Jackie Clarke Andy McMillan Jian Qing Shi gayathri delanerolle Department of Research&Innovation Southern Health National Health Service Foundation TrustSouthampton SO303JBUnited Kingdom Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221Yunnan ProvinceChina Virti Healthcare KeynshamBristol BS311SNUnited Kingdom Neuromodulation Centre Southern Health National Health Service Foundation TrustSouthampton SO140YGUnited Kingdom National Health Service Talking Therapies Southern Health National Health Service Foundation TrustSouthampton SO509FHUnited Kingdom

BACKGROUND Restrictive practices(RPs)are defined by measures linked to physical and chemical restraints to reduce the movement or control behaviours during any *** is an equal part of RPs intended to isolate and reduce the sensory stimulation to safeguard the patient and those within the *** interventions by way of virtual reality(VR)could assist with reducing the need for RPs as it could help reduce anxiety or agitation by way of placing users into realistic and immersive *** could also aid staff to and change current *** To assess the feasibility and effectiveness of using a VR platform to provide reduction in RP *** A randomised controlled feasibility study,accompanied by evaluations at 1 month and 6 months,was conducted within inpatient psychiatric wards at Southern Health National Health Service Foundation Trust,United *** VR scenarios were used on VR headsets to provide training on reducing RPs in 3 inpatient psychiatric *** measures included general self-efficacy scale,generalised anxiety disorder assessment 7(GAD-7),Burnout Assessment Tool 12,the Everyday Discrimination Scale,and the Compassionate Engagement and Action *** Findings revealed statistically significant differences between the VR and treatment as usual groups,in the Everyday Discrimination Scale items Q8 and Q9:P=0.023 and P=0.040 respectively,indicating higher levels of perceived discrimination in the VR *** were no significant differences between groups in terms of general self-efficacy,generalised anxiety disorder assessment 9,and Burnout Assessment Tool 12 scores.A significant difference was observed within the VR group for compassionate engagement from others(P=0.005)over *** respondents recorded System Usability Scale scores above 70,with an average score of *** was a significant reduction in rates of RPs in the VR group vs treatment as usual group with a fluctuating variability ob

关键词： Virtual reality Restrictive practices Inpatient wards Restraint Isolation Rapid tranquilisation Covert medication Procedural restrictions Health professions training

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Associated mortality risk of atypical antipsychotic medication in individuals with dementia

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World Journal of Psychiatry 2022年第2期12卷 298-307页

作者： Peter Phiri Tomas Engelthaler Hannah Carr gayathri delanerolle Clive Holmes Shanaya Rathod Research&Innovation Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Primary Care Population Sciences and Medical EducationFaculty of MedicineUniversity of SouthamptonSouthampton SO165STUnited Kingdom Oxford Centre for Innovation Akrivia HealthOxford OX1 BYUnited Kingdom Department of Psychology University of SouthamptonSouthampton SO165STUnited Kingdom Nuffield Department of Primary Care Health Sciences University of OxfordOxford OX26GGUnited Kingdom Clinical and Experimental Sciences University of SouthamptonSouthampton SO165STUnited Kingdom Research&Innovation Department Memory Assessment&Research CentreSouthern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom

BACKGROUND Antipsychotic medications such as risperidone,olanzapine and aripiprazole are used to treat psychological and behavioural symptoms among dementia *** evidence indicate prescription rates for antipsychotics vary and wider consensus to evaluate clinical epidemiological outcomes is *** To investigate the potential impact of atypical antipsychotics on the mortality of patients with *** A retrospective clinical cohort study was developed to review United Kingdom Clinical Record Interactive Search system based data between January 1,2013 to December 31,2017.A descriptive statistical method was used to analyse the *** Mental State Examination(MMSE)scores were used to assess the severity and stage of disease progression.A cox proportional hazards model was developed to evaluate the relationship between survival following diagnosis and other *** A total of 1692 patients were identified using natural language processing of which,587 were prescribed olanzapine,quetiapine or risperidone(common group)whilst 893(control group)were not prescribed any *** prescribed olanzapine showed an increased risk of death[hazard ratio(HR)=1.32;95%confidence interval(CI):1.08-1.60;P<0.01],as did those with risperidone(HR=1.35;95%CI:1.18-1.54;P<0.001).Patients prescribed quetiapine showed no significant association(HR=1.09;95%CI:0.90-1.34;P=0.38).Factors associated with a lower risk of death were:High MMSE score at diagnosis(HR=0.72;95%CI:0.62-0.83;P<0.001),identifying as female(HR=0.73;95%CI:0.64-0.82;P<0.001),and being of a White-British ethnic group(HR=0.82;95%CI:0.72-0.94;P<0.01).CONCLUSION A significant mortality risk was identified among those prescribed olanzapine and risperidone which contradicts previous findings although the study designs used were *** research should be conducted to better assess clinical epidemiological outcomes associated with diagnosis and therapies to improve c

关键词： Dementia Antipsychotics Mortality Vascular Alzheimer’s disease Frontotemporal dementia Lewy bodies Parkinson’s and mixed

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Rapid commentary:Ethical implications for clinical trialists and patients associated with COVID-19 research

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World Journal of Psychiatry 2021年第3期11卷 58-62页

作者： gayathri delanerolle Shanaya Rathod Kathryn Elliot Rema Ramakrishnan Tony Thayanandan Natasha Sandle Nyla Haque Vanessa Raymont Peter Phiri Department of Psychiatry University of OxfordOxford OX37JXUnited Kingdom Research and Development Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Nuffield Department of Women's and Reproductive Health University of OxfordOxford OX37JXUnited Kingdom Primary Care Population Sciences and Medical EducationFaculty of MedicineUniversity of SouthamptonSouthampton SO165STUnited Kingdom

Pandemics disrupt clinical trials worldwide,with lasting effects on *** can severely impact clinical trialists ability to conduct safe and ethically uncompromised ***,the mounting pressure results in ethically and morally distressing decisions faced by clinical trial professionals during pandemic *** clinical trialists attempt to think about preparedness and responses during a pandemic,the need to have an ethical framework that has real-world applicability is *** are a challenging time for all,however,the safety and access to support for clinical trialists and patients within clinical trials should be at the forefront for their organisations and the government.

关键词： COVID-19 Pandemic Ethics Clinical trials Patients Trialists

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Mental health impact on Black,Asian and Minority Ethnic populations with preterm birth:A systematic review and meta-analysis

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World Journal of Psychiatry 2022年第9期12卷 1233-1254页

作者： gayathri delanerolle Yutian Zeng Peter Phiri Thuan Phan Nicola Tempest Paula Busuulwa Ashish Shetty Vanessa Raymont Shanaya Rathod Jian-Qing Shi Dharani K Hapangama Nuffield Department of Primary Care Health Science University of OxfordOxford OX37JXUnited Kingdom Research and Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Southern University of Science and Technology Shenzhen 518055Guangdong ProvinceChina Psychology Department Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Department of Women's and Children's Health University of LiverpoolLiverpool L78TXUnited Kingdom Gynaecology Directorate and Hewitt Centre for Reproductive Medicine Liverpool Women's NHS FoundationLiverpool L87SSUnited Kingdom National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation TrustLondon W1T 4AJUnited Kingdom Department of Psychiatry University of OxfordOxford OX37JXUnited Kingdom National Centre for Applied Mathematics Shenzhen Shenzhen 518055Guangdong ProvinceChina Department of Statistics Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina

BACKGROUND Preterm birth(PTB)is one of the main causes of neonatal deaths globally,with approximately 15million infants are born *** from the Black,Asian,and Minority Ethnic(BAME)populations maybe at higher risk of PTB,therefore,the mental health impact on mothers experiencing a PTB is particularly important,within the BAME *** To determine the prevalence of mental health conditions among BAME women with PTB as well as the methods of mental health assessments used to characterise the mental health *** A systematic methodology was developed and published as a protocol in PROSPERO(CRD420-20210863).Multiple databases were used to extract relevant data.I2 and Egger's tests were used to detect the heterogeneity and publication bias.A trim and fill method was used to demonstrate the influence of publication bias and the credibility of *** Thirty-nine studies met the eligibility criteria from a possible *** prevalence rates of depression among PTB-BAME mothers were significantly higher than full-term mothers with a standardized mean difference of 1.5 and a 95%confidence interval(CI)29%-74%.The subgroup analysis indicated depressive symptoms to be time *** within the very PTB category demonstrated a significantly higher prevalence of depression than those categorised as non-very *** prevalence rates of anxiety and stress among PTB-BAME mothers were significantly higher than in full-term mothers(odds ratio of 88%and 60%with a CI of 42%-149%and 24%-106%,respectively).CONCLUSION BAME women with PTB suffer with mental health *** studies did not report on specific mental health outcomes for BAME ***,the impact of PTB is not accurately represented in this population,and thus could negatively influence the quality of maternity services they receive.

关键词： Preterm labor Preterm birth Black Asian and Minority Ethnic Mental health Women's health Wellbeing

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Evaluation of a culturally adapted cognitive behavior therapy-based,third-wave therapy manual

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World Journal of Psychiatry 2023年第1期13卷 15-35页

作者： Peter Phiri Isabel Clarke Lydia Baxter Yu-Tian Zeng Jian-Qing Shi Xin-Yuan Tang Shanaya Rathod Mustafa G Soomro gayathri delanerolle Farooq Naeem Research&Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Department of Italk Southern Health NHS Foundation TrustSouthampton SO509FHUnited Kingdom Department of Italk Step 3 Southern Health NHS Foundation TrustSouthampton SO519FHUnited Kingdom Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina National Center for Applied Mathematics Shenzhen Shenzhen 518055Guangdong ProvinceChina Nuffield Department of Primary Health Care Science University of OxfordOxford OX37JXUnited Kingdom Centre for Addition and Mental Health University of TorontoToronto ON M5SCanada

BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United *** use of CBT for severe mental illness is now more common *** To investigate the feasibility and acceptability of a culturally adapted,CBT-based,third-wave therapy manual using the Comprehend,Cope,and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare *** A pilot study was used to assess the feasibility and acceptability of the manualised *** measures were evaluated at baseline,post-intervention and 12 wk-follow up.32 participants with mental health conditions aged 20-53 years were *** were completed at three time points,using Clinical Outcomes in Routine Evaluation(CORE),Hospital Anxiety and Depression Scale(HADS),Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0(WHODAS).The Patient Experience Questionnaire was completed *** Repeated measures of analysis of variance associated with HADS depression,F(2,36)=12.81,P<0.001,partialη^(2)=0.42 and HADS anxiety scores,F(2,26)=9.93,P<0.001,partialη^(2)=0.36;CORE total score and WHODAS both showed significant effect F(1.25,18.72)=14.98,P<0.001,partialη^(2)=*** F(1.29,14.18)=6.73,P<0.001,partialη^(2)=0.38 *** These results indicate the effectiveness and acceptability of the culturally adapted,CBT-based,third-wave therapy manual intervention among minoritized groups with moderate effect *** levels and acceptability were highly *** viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.

关键词： Cognitive behavioral therapy Comprehend Cope Connect Ethnicity Culture

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Mental health impact of the Middle East respiratory syndrome,SARS,and COVID-19:A comparative systematic review and metaanalysis

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World Journal of Psychiatry 2022年第5期12卷 739-765页

作者： gayathri delanerolle Yutian Zeng Jian-Qing Shi Xuzhi Yeng Will Goodison Ashish Shetty Suchith Shetty Nyla Haque Kathryn Elliot Sandali Ranaweera Rema Ramakrishnan Vanessa Raymont Shanaya Rathod Peter Phiri Nuffield Department of Primary Health Care Science University of OxfordOxford OX26EDUnited Kingdom Southern University of Science and Technology Shenzhen 518055Guangdong ProvinceChina The Alan Turing Institute London NW12DBUnited Kingdom University College London Hospital NHS Foundation Trust London NW12PGUnited Kingdom University College London London WC1E 6BTUnited Kingdom Department of Research and Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Department of Psychiatry University of OxfordOxford OX26EDUnited Kingdom Department of BioSystems Technology University of Sri JayewardenepuraNugegoda 10100Sri Lanka National Perinatal Epidemiology Unit University of OxfordOxford OX37JXUnited Kingdom Faculty of Environmental and Life Sciences Psychology DepartmentUniversity of SouthamptonSouthampton SO171PSUnited Kingdom

BACKGROUND Over the last few decades,3 pathogenic pandemics have impacted the global population;severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV)and *** global disease burden has attributed to millions of deaths and morbidities,with the majority being attributed to *** such,the evaluation of the mental health(MH)impact across healthcare professionals(HCPs),patients and the general public would be an important facet to evaluate to better understand short,medium and long-term *** To identify and report:(1)MH conditions commonly observed across all 3 pandemics;(2)Impact of MH outcomes across HCPs,patients and the general public associated with all 3 pandemics;and(3)The prevalence of the MH impact and clinical epidemiological *** A systematic methodology was developed and published on PROSPERO(CRD42021228697).The databases PubMed,EMBASE,ScienceDirect and the Cochrane Central Register of Controlled Trials were used as part of the data extraction process,and publications from January 1,1990 to August 1,2021 were *** terms and keywords used included Mood disorders,PTSD,Anxiety,Depression,Psychological stress,Psychosis,Bipolar,Mental Health,Unipolar,Self-harm,BAME,Psychiatry disorders and Psychological *** terms were expanded with a‘snowballing’***-regression and the Monte-Carlo simulation method was used in addition to I2 and Egger’s tests to determine heterogeneity and publication *** In comparison to MERS and SARS-CoV,it is evident SAR-CoV-2 has an ongoing MH impact,with emphasis on depression,anxiety and post-traumatic stress *** It was evident MH studies during MERS and SARS-CoV was limited in comparison to SARS-CoV-2,with much emphasis on reporting symptoms of depression,anxiety,stress and sleep *** lack of comprehensive studies conducted during previous pandemics have introduced limitations to the

关键词： COVID-19 Middle East respiratory syndrome SARS-CoV SARS-CoV-2 Mental health Wellbeing Psychiatry Healthcare professionals Patients Physical health Public health Outbreaks and pandemics

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Exploratory systematic review and meta-analysis on period poverty

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World Journal of Meta-Analysis 2023年第5期11卷 196-217页

作者： gayathri delanerolle Xiao-Jie Yang Heitor Cavalini Om P Kurmi Camilla Mørk Røstvik Ashish Shetty LuckySaraswat Julie Taylor Sana Sajid Shanaya Rathod Jian-Qing Shi Peter Phiri Department of Research&Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Nuffield Department of Medicine University of OxfordOxford OX37JXUnited Kingdom School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221Yunnan ProvinceChina University College London London WC1E 6BTUnited Kingdom Centre for Intelligent Healthcare Institute of Health and WellbeingCoventry UniversityCoventry CV15LBUnited Kingdom Centre for Contemporary Art University of St AndrewsScotland KY169AJUnited Kingdom Pain Management Centre University College London Hospitals NHS Foundation TrustLondon W1T 4AJUnited Kingdom Aberdeen Centre for Women’s Health University of AberdeenAberdeen AB243FXUnited Kingdom School of Nursing University of BirminghamBirmingham B152TTUnited Kingdom Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom

BACKGROUNDPeriod poverty is a global health and social issue that needs to be *** has been reported that many females compromise their education,employment,and social commitments during their menstruation days due to a number of reasons,including lack of access to toilets or menstrual *** To provide a comprehensive understanding on period poverty,including outcomes associated with *** All observational and randomised clinical trials reporting menstruation challenges,menstrual poverty and menstrual products were *** search strategy included multiple electronic databases of PubMed,Web of Science,ScienceDirect,ProQuest and *** published in a peer review journal in English between the 30th of April 1980 and the 30th of April 2022 were *** Newcastle-Ottawa Scale was used to assess the risk of bias of the systematic included *** odds ratios(ORs)together with 95%confidence intervals(CIs)are reported overall and for *** A total of 80 studies were systematically selected,where 38 were included in the *** the 38 studies,28 focused on children and young girls(i.e.,10-24 years old)and 10 included participants with a wider age range of 15-49 *** prevalence of using disposable sanitary pads was 45%(95%CI:0.35-0.58).The prevalence of menstrual education pre-menarche was 68%(95%CI:0.56-0.82).The prevalence of good menstrual hygiene management(MHM)was 39%(95%CI:0.25-0.61).Women in rural areas(OR=0.30,95%CI:0.13-0.69)were 0.70 times less likely to have good MHM practices than those living in urban *** There was a lack of evidence,especially from low-and middle-income *** research to better understand the scope and prevalence of period poverty should be *** will enable the development of improved policies to increase access to menstrual products and medical support where necessary.

关键词： Period poverty Menstruation Mental health Menstrual education Menstrual hygiene

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