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西班牙高危患者的血压控制和心血管预后:来自INVe.T(国际性维拉帕米缓释片/群多普利)研究的发现

世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 8-9页

作者： Coope.-De.off R.M. Aranda Jr. J.M. gaxiola e. 韩瑞娟 Unive.sity of Florida Colle.e.of Me.icine Gainesville FL United States

Background: Pe.ple.of Hispanic origin are.the.faste.t growing e.hnic minority in the.Unite. State. and ofte. have.hype.te.sion and othe. comorbiditie. which incre.se.the.risk associate. with coronary arte.y dise.se.CAD). Me.hods and Re.ults: An analysis of the.8045 Hispanic patie.ts e.rolle. in INVe.T was conducte., and comparisons we.e.made.to the.14 531 non-Hispanic patie.ts. INVe.T was a prospe.tive. randomize., ope., blinde. e.d point study in CAD patie.ts with hype.te.sion. Afte. 61 835 patie.t-ye.rs of follow-up, tre.tme.t with e.the. a ve.apamil sustaine. re.e.se.SR) or ate.olol antihype.te.sive.strate.y re.ulte. in gre.te. blood pre.sure.control in Hispanic patie.ts, and Hispanic patie.ts we.e.at significantly lowe. risk of e.pe.ie.cing a nonfatal myocardial infarction, nonfatal stroke. or de.th(hazard ratio[HR] 0.87, 95%CI 0.78-0.97). Hispanic e.hnicity was associate. with an incre.se.HR 1.19, 95%CI 1.04-1.36), and randomization to the.ve.apamil SR strate.y was associate. with a de.re.se.HR 0.85, 95%CI 0.76-0.95), in the.risk of ne.-onse. diabe.e.. Use.of trandolapril in the.ve.apamil SR strate.ywas associate. with re.uce. risk of ne.-onse. diabe.e., whe.e.s incre.sing dose. of ate.olol and hydrochlorothiazide.in the.ate.olol strate.y we.e.associate. with incre.se. risk of ne.-onse. diabe.e.. Conclusions: The.Hispanic cohort of INVe.T had be.te. blood pre.sure.control and lowe. risk of adve.se.cardiovascular outcome. compare. with the.non-Hispanic cohort. A ve.apamil SR strate.y is an alte.native.to an ate.olol strate.y for the.tre.tme.t of Hispanic patie.ts with hype.te.sion and CAD and can re.uce.the.risk of ne.-onse. diabe.e..

关键词：群多普利 INVe.T 维拉帕米非致死性抗高血压药物新发糖尿病阿替洛尔风险降低增长速度

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Oxidative.stre.s indicators in human and bottle.ose.dolphin le.kocyte. in re.ponse.to a pro-inflammatory challe.ge

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BIOCe.L 2021年第6期45卷 1621-1630页

作者： TARYN e.SYMON RAMÓN gaxiola-ROBLe. CLAUDIA J.He.NÁNDe.-CAMACHO TANIA Ze.Te.O-SAVÍN Ce.tro de.Inve.tigacione. Biológicas de. Noroe.te La Paz23096México Hospital Ge.e.al de.Zona No.1 Instituto Mexicano del Seguro SocialLa Paz23000México Ce.tro Inte.disciplinario de.Cie.cias Marinas Instituto Politécnico NacionalLa Paz23096México

Marine.mammals unde.go cycle. of tissue.ische.ia and re.e.fusion during the.dive.*** injury can re.ult in oxidative.tissue.damage.and the.activation of a pro-inflammatory immune.*** risk of oxidative.damage.is re.uce. by *** hypothe.is is that the.re.orte. highe. antioxidant de.e.se. within marine.mammal tissue. provide.additional prote.tion in situations that produce.oxidative.stre.s,like.inflammation,in comparison to te.re.trial mammal *** we.e.isolate. from the.whole.blood of Pacific bottle.ose.dolphins(Tursiops truncatus gilli)and humans(Homo sapie.s)and we.e.e.pose. to lipopolysaccharide.(LPS,10μg/mL)in vitro to simulate.a pro-inflammatory *** stre.s indicators,including supe.oxide.radical(O_(2)^(•−))production,activitie. of supe.oxide.dismutase.SOD),catalase.CAT),glutathione.pe.oxidase.GPx),glutathione.re.uctase.GR),and glutathione.S-transfe.ase.GST),as we.l as oxidative.prote.n damage.we.e.quantifie. by *** 48 h unde. e.pe.ime.tal conditions,bottle.ose.dolphin le.kocyte. produce. 1.9 time. more.O_(2)^(•−)but displaye. 2.0 time. lowe. prote.n carbonyl conce.trations compare. to human *** 48 h unde. e.pe.ime.tal conditions,bottle.ose.dolphin le.kocyte. displaye. 7.9,2.0,11.1,and 3.3 time. more.activitie. of CAT,GPx,GR,and GST,re.pe.tive.y,compare. to human *** re.ults sugge.t that,unde. ce.l culture.conditions,the.antioxidant de.e.se. in bottle.ose.dolphin le.kocyte. provide.additional prote.tion against pro-inflammatory challe.ge. in comparison to human le.kocyte.,like.y as an adaptive.advantage.

关键词： Antioxidant de.e.se. Marine.mammals Oxidative.stre.s Re.ctive.oxyge. spe.ie. White.blood ce.ls

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Plant H^＋-PPase.： Re.e.sible.e.zyme. with Contrasting Functions De.e.de.t on Me.brane.e.vironme.t

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Mole.ular Plant 2016年第3期9卷 317-319页

作者： Robe.to A. gaxiola Kame.h Re.mi Julio Pae.-Vale.cia Gaston Pizzio Shangji Zhang School of Life.Scie.ce. Arizona State University 427 E. Taylor Mall Tempe AZ 852872 USA De.artme.t of Botany University of Wisconsin Madison WI 53706 USA Ce.tre.de.Re.e.ca e. Agrige.omica (CRAG) Consorcio CSIC-IRTA-UAB-UB Parc de Recerca de la UAB C/de la Vail Moronta Edifici CRAG Bellaterra (Cerdanyola del Valles) 08193 Barcelona Spain

Plant proton-translocating pyrophosphatase. （H^＋-PPase.） are.ge.e.ally thought of as tonoplast-localize. proton pumps that utilize.the.e.e.gy re.e.se. by hydrolysis of the.phosphoanhydride.bond of pyrophosphate.（PPi） to assist in the.acidification of the.*** has be.n sugge.te. that H^＋-PPase. function as an additional acidification me.hanism to comple.e.t the.ubiquitous V-ATPase.e.pe.ially in young,growing tissue. whe.e.PPi is abundant and ATP is de.le.e. （Shiratake.e. al.,1997）.

关键词： additional e.pe.ially conse.ve.

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Glutamate.de.ydroge.ase.and Na^+-K^+ ATPase.e.pre.sion and growth re.ponse.of Litope.ae.s vanname. to diffe.e.t salinitie. and die.ary prote.n le.e.s

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Chine.e.Journal of Oce.nology and Limnology 2011年第2期29卷 343-349页

作者：李二超 Le.icia ARe.A Gabrie. LIZAMA Gabrie.a gaxiola Ge.ard CUZON Carlos ROSAS 陈立侨 Alain VAN WORMHOUDT School of Life.Scie.ce East China Normal University UMR5178 Station de Biologie Marine du Musum National d'Histoire NaturelleBP225Concarneau 29900France Unidad Multidisciplinaria de.Doce.cia e.Inve.tigación Facultad de CienciasUniversidad Nacional Autónoma de MxicoPuerto de abrigo s/nSisal C.P.97350HunucmYucatnMexico IFRe.e. TahitiFrench Polynesia

Improve.e.t in the.osmore.ulation capacity via nutritional supplie. is vitally important in shrimp *** e.fe.ts of die.ary prote.n le.e.s on the.osmore.ulation capacity of the.Pacific white.shrimp(***) we.e.*** involve. an e.amination of growth pe.formance.glutamate.de.ydroge.ase.GDH) and Na+-K+ ATPase.mRNA e.pre.sion,,and GDH activity in muscle. and *** e.pe.ime.tal die.s we.e.formulate.,containing 25%,40%,and 50% die.ary prote.n,and fe. to the.shrimp at a salinity of *** 20 days,no significant diffe.e.ce.was obse.ve. in we.ght gain,though GDH and Na+-K+ ATPase.ge.e.e.pre.sion and GDH activity incre.se. with highe. die.ary prote.n ***,shrimp fe. die.s with 25% and 50% die.ary prote.n we.e.transfe.re. into tanks with salinitie. of 38 and 5,re.pe.tive.y,and sample. at we.ks 1 and *** fe. with 40% prote.n at 25 in salinity(optimal conditions) we.e.use. as a *** of the.salinitie.,shrimp fe. with 50% die.ary prote.n had significantly highe. growth pe.formance.than othe. die.s;no significant diffe.e.ce. we.e.found in comparison with the.*** fe. with 25% die.ary prote.n and maintaine. at salinitie. of 38 and 5 had significantly lowe. we.ght gain value. afte. 2 *** salinity change.also stimulate. the.he.atosomatic inde.,which incre.se. in the.first we.k and the. re.ove.e. to a re.ative.y normal le.e.,as in the.control,afte. 2 *** findings indicate.that in white.shrimp,the.spe.ific prote.n nutrie.t and e.e.gy de.ands re.ate. to ambie.t salinity change.are.associate. with prote.n *** die.ary prote.n le.e. could improve.the.osmore.ulation capacity of *** with more.e.e.gy re.ource. allocate. to GDH activity and e.pre.sion.

关键词：饲料蛋白水平谷氨酸脱氢酶盐度变化对虾养殖 ATP酶生长性能 Na 日粮蛋白质水平

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