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Expression of TRAIL and TRAIL receptors in normal and malignant tissues

Cell Research 2005年第6期15卷 430-438页

作者： Raymond A DANIELS,Helen TURLEY,Fiona C KIMBERLEY,Juthathip MONGKOLSAPAYA,Paul CH’EN,Francesco PEZZELLA,gavin R SCREATON Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford OX3 9DS UK Nuffield Department of Clinical Laboratory Sciences University of Oxford John Radcliffe Hospital Oxford OX3 9DS UK Hammersmith Hospital Du Cane Road London W12 0NN UK Hammersmith Hospital Du Cane Road London W12 0NN UK Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford OX3 9DS UK Nuffield Department of Clinical Laboratory Sciences University of Oxford John Radcliffe Hospital Oxford OX3 9DS UK Hammersmith Hospital Du Cane Road London W12 0NN UK

TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, is a member of the TNF family of *** cells were initially found to have increased sensitivity to TRAIL compared with normal cells, raising hopes thatTRAIL would prove useful as an anti-tumor agent. The production of reliable monoclonal antibodies against TRAIL andits receptors that can stain fixed specimens will allow a thorough analysis of their expression on normal and malignanttissues. Here we report the generation of monoclonal antibodies against TRAIL and its four membrane-bound receptors(TR1–4), which have been used to stain a range of normal and malignant cells, as routinely fixed specimens. Low levelsof TRAIL expression were found to be limited mostly to smooth muscle in lung and spleen as well as glial cells in thecerebellum and follicular cells in the thyroid. Expression of the TRAIL decoy receptors (TR3 and 4) was not aswidespread as indicated by Northern blotting, suggesting that they may be less important for the control of TRAILcytotoxicity than previously thought. TR1 and TR2 expression increases significantly in a number of malignant tissues,but in some common malignancies their expression was low, or patchy, which may limit the therapeutic role of *** together, we have a panel of monoclonal antibodies that will allow a better assessment of the normal role ofTRAIL and allow assessment of biopsy material, possibly allowing the identification of tumors that may be amenable toTRAIL therapy.

关键词： apoptosis immunohistochemistry monoclonal antibodies tumor markers.

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Phosphate Glass Fibre Composites for Bone Repair

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Journal of Bionic Engineering 2009年第4期6卷 318-323页

作者： Andrew J.Parsons Ifty Ahmed Papia Haque Ben Fitzpatrick Muhammad I.K.Niazi gavin S.Walker Chris D.Rudd Division of Materials Mechanics & StructuresFaculty of EngineeringUniversity of NottinghamNottingham NG7 2RDUK

We investigate high-modulus degradable materials intended to replace metals in biomedical *** are typically composites comprising a polylactide(PLA)matrix reinforced with phosphate glass fibres,which provide reinforcement similar to E-glass but are entirely degradable in water to produce,principally,calcium *** have made composites using a variety of fibre architectures,from non-woven random mats to unidirectional fibre *** properties in the region of 30 GPa modulus and 350 MPa strength have been achieved-directly comparable to quoted values for human cortical *** collaboration with other groups we have begun to consider the development of foamed systems with structures mimicking cancellous bone and this has shown significant *** fibres in these foamed structures provide improved creep resistance and reinforcement of the pore *** date the materials have exhibited excellent cellular responses in vitro and further studies are due to include consideration of the surface character of the materials and the influence of this on cell interaction, both with the composites and the glass fibres themselves,which show promise as a standalone porous scaffold.

关键词： biocomposites phosphate glass PLA porous bone repair

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Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

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npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao Kobayashi Eriko Watanabe Yu-ya Ohnishi Hajime Nakamura Naoki Yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

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Common Core State Standards＂ What＇s Next？

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Journal of Literature and Art Studies 2014年第11期4卷 1007-1014页

作者： Rose Campbell Kirk gavin Florida A&M University Tallahassee Florida USA

Common Core Assessment is a national initiate that is designed to provide P-12 students with results that could be used to help prepare them for work and college readiness. Emphasis is also placed on rigor will also be identified while raising the curriculum standards in the United States to a competitive international level. The purpose of this research is to examine the results from the Common Core Assessment completed in the States of New York and Kentucky. The Common Core Assessment resulting from these states were selected because a review of the literature determined that these were the two States in the United States that have reported test results. Specifically, this paper will review assessment results and provide an opinion on the future implementation of Common Core Standards in the United States.

关键词： Common Core Assessment State Standards Student Achievement P-12 College Readiness workforceready

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2008年,让我们一起说中文——《Steven视线》专访英国领事馆文化处文化领事gavin Anderson(英文)

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英语沙龙（高中） 2008年第12期 50-52页

作者： Steven gavin Anderson 沪江英语

奥运圣火在北京缓缓熄灭,开始了走向英伦的另一段精彩旅程。身为怀着满腔热血和浓浓爱国情的中华儿女,我们每个人都有义务成为一名传承中国传统文化、促进中英两国青年交流的使者。语言是我们深入了解一个国家、一个民族文化底蕴最基本... 详细信息

奥运圣火在北京缓缓熄灭,开始了走向英伦的另一段精彩旅程。身为怀着满腔热血和浓浓爱国情的中华儿女,我们每个人都有义务成为一名传承中国传统文化、促进中英两国青年交流的使者。语言是我们深入了解一个国家、一个民族文化底蕴最基本的沟通工具。本期Steven专访为我们带来英国文化领事对语言学习和交流的独到见解。

关键词：专访领事馆英国文化中国传统文化文化底蕴每个人中文视线中英两国交流

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Walking-friendly built environments and objectively measured physical function in older adults

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Journal of Sport and Health Science 2020年第6期9卷 651-656页

作者： Mohammad Javad Koohsari gavin R.McCormack Tomoki Nakaya Ai Shibata Kaori Ishii Akitomo Yasunaga Yung Liao Koichiro Oka Faculty of Sport Sciences Waseda UniversityTokorozawa 359-1192Japan Behavioural Epidemiology Laboratory Baker Heart and Diabetes InstituteMelbourneVIC 3004Australia Melbourne School of Population and Global Health The University of MelbourneMelbourneVIC 3010Australia Department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlberta T2N 4Z6Canada Faculty of Kinesiology University of CalgaryCalgaryAlberta T2N 4Z6Canada School of Architecture Planning and LandscapeUniversity of CalgaryCalgaryAlberta T2N 4Z6Canada Graduate School of Environmental Studies Tohoku UniversitySendai 980-0845Japan Faculty of Health and Sport Sciences University of TsukubaTsukuba 305-8574Japan Faculty of Liberal Arts and Sciences Bunka Gakuen UniversityTokyo 151-8523Japan

Background:Few studies have examined the associations between urban design attributes and older adults’physical ***,it is not well known how built-environment attributes may influence physical function in Asian *** aim of this study was to examine associations between objectively measured environmental attributes of walkability and objectively assessed physical function in a sample of Japanese older ***:Cross-sectional data collected in 2013 from 314 older residents(aged 65-84 years)living in Japan were *** function was estimated from objectively measured upper-and lower-body function,mobility,and balance by a trained research team member.A comprehensive list of built-environment attributes,including population density,availability of destinations,intersection density,and distance to the nearest public transport station,were objectively *** Score as a composite measure of neighborhood walkability was also ***:Among men,higher population density,availability of destinations,and intersection density were significantly associated with better physical function performance(1-legged stance with eyes open).Higher Walk Score was also marginally associated with better physical function performance(1-legged stance with eyes open).None of the environmental attributes were associated with physical function in elderly ***:Our findings indicate that environmental attributes of walkability are associated with the physical function of elderly men in the context of ***-friendly neighborhoods can not only promote older adults’active behaviors but can also support their physical function.

关键词： Elderly Functional test Neighborhood Urban design Walkability

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Maintenance of Species Differences in Closely Related Tetraploid Parasitic Euphrasia (Orobanchaceae) on an Isolated Island

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Plant Communications 2020年第6期1卷 85-99页

作者： Hannes Becher Max R.Brown gavin Powell Chris Metherell Nick J.Riddifordand Alex D.Twyford University of Edinburgh School of Biological SciencesInstitute of Evolutionary BiologyCharlotte Auerbach RoadEdinburgh EH93FLUK Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK Botanical Society of Britain and Ireland 4 High Firs CrescentHarpendenHertfordshire AL51NAUK Schoolton Fair IsleShetland ZE29JUUK

Polyploidy is pervasive in angiosperm evolution and plays important roles in adaptation and ***,polyploid groups are understudied due to complex sequence homology,challenging genome assembly,and taxonomic ***,we study adaptive divergence in taxonomically complex eyebrights(Euphrasia),where recent divergence,phenotypic plasticity,and hybridization blur species *** focus on three closely related tetraploid species with contrasting ecological preferences that are sympatric on Fair Isle,a small isolated island in the British *** a common garden experiment,we show a genetic component to the morphological differences present between these *** wholegenome sequencing and a novel k-mer approach we call“Tetmer”,we demonstrate that the species are of allopolyploid origin,with a sub-genome divergence of approximately 5%.Using2 million SNPs,we show sub-genome homology across species,with a very low sequence divergence characteristic of recent *** genetic variation is broadly structured by species,with clear divergence of Fair Isle heathland Euphrasia micrantha,while grassland Euphrasia arctica and coastal Euphrasia foulaensis are more closely ***,we show that tetraploid Euphrasia is a system of allopolyploids of postglacial species divergence,where adaptation to novel environments may be conferred by old variants rearranged into new genetic lineages.

关键词： incipient speciation k-mer spectrum allopolyploidy tetraploid divergence with gene flow taxonomic complexity

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Technical Design for Holistic Wireless Communication in Smart Buildings

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第S1期35卷 81-87页

作者： Sean Rhys Jones Mark Gillott Rabah Boukhanouf gavin Walker David Tetlow Faculty of Engineering Department of Architecture and Built EnvironmentUniversity of Nottingham

This paper presents the design of a wireless building monitoring network implemented at the University of Nottingham's Creative Energy Homes test *** network is installed in seven smart buildings with the aim of holistically collecting energy *** will be used to inform a central control algorithm to optimise the energy flows between buildings,in turn promoting the smart cities *** and meters measuring temperature,humidity,CO_2,heat energy,power,and stratified tank temperature are ***,the communication protocols utilised are also discussed,which include wireless MBus and *** paper also covers the methods used for ensuring the reliability of data signals and the system controls.

关键词： smart cities smart buildings communication network building monitoring

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研发被忽视和新发传染病疫苗新型冠状病毒肺炎疫苗的成功研发为此提供了蓝图

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英国医学杂志中文版 2021年第6期24卷 301-302页

作者： gavin Yamey 张啸飞(译) Center for Policy Impact in Global Health Duke Global Health InstituteDuke UniversityDurhamNCUSA 清华大学附属北京清华长庚医院临床流行病和生物统计中心

在不到一年的时间内,安全高效的新型冠状病毒肺炎(COVID-19)疫苗被迅速研制成功是近年来最伟大的科学成就之一。这让人们乐观地认为,一场疫苗革命已经到来。如果知道疾病的保护性抗原,那么COVID-19疫苗成功研发的思路和经验或许可以被... 详细信息

在不到一年的时间内,安全高效的新型冠状病毒肺炎(COVID-19)疫苗被迅速研制成功是近年来最伟大的科学成就之一。这让人们乐观地认为,一场疫苗革命已经到来。如果知道疾病的保护性抗原,那么COVID-19疫苗成功研发的思路和经验或许可以被转移到新发传染病和一些被忽视的疾病中去,如结核病。

关键词：新发传染病保护性抗原肺炎疫苗结核病科学成就 ID 被忽视

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Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 126-129页

作者： gavin O'Brien Conor J Shields Desmond C Winter John P Dillon Department Of Academic Surgery Cork University Hospital and National University of Ireland Cork Ireland William O Kirwan and H. Paul RedmondCork Ireland

BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.

关键词： cyclooxygenase-2 pancreatitis genesis lung injury

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