检索结果-南通市图书馆

Contra.ting the a.nesic Effects of Tempora.y Ina.tiva.ion with Lesions of the Hippoca.pus on Context Memory

Journa. of Beha.iora. a.d Bra.n Science 2016年第4期6卷 184-198页

作者： gavin a. scott Debora. M. Sa.cier Hugo Lehma.n Fa.ulty of Science University of Ontario Institute of Technology Oshawa Canada Psychology Depa.tment Trent University Peterborough Canada

Lesions a.d tempora.y ina.tiva.ion of the hippoca.pus (HPC) in rodents occa.iona.ly lea. to discrepa.t a.nesic effects. We directly compa.ed a.d contra.ted the retrogra.e a.nesic effects tha. sma.l HPC lesions (~50% da.a.e), la.ge HPC lesions (~80% da.a.e), a.d combined dorsa. a.d ventra. HPC ina.tiva.ion using the sodium cha.nel blocker tetrodotoxin (TTX) ha. on contextua. fea. conditioning. Compa.ed to control ra.s, la.ge HPC lesions significa.tly reduced freezing during retention testing, a.beha.iour consistent with retrogra.e a.nesia. In contra.t, neither the sma.l lesions nor the TTX ina.tiva.ion significa.tly reduced freezing. The extent of da.a.e wa. significa.tly a.d nega.ively correla.ed with retention performa.ce (r(9) = -0.896, p a. 70% or more of the HPC needed to be da.a.ed to observe deficits. Importa.tly, TTX ina.tiva.ion disrupted spa.ia. memory in the Morris Wa.er Ta.k, confirming tha. our ina.tiva.ion procedure did impa.r one form of HPC-dependent memory. To a.sess the extent of the TTX ina.tiva.ion, immedia.e ea.ly gene expression wa. qua.tified in the HPC following the Morris Wa.er Ta.k. However, despite the beha.ioura. impa.rment, we did not find a.significa.t reduction in expression. We conclude tha. tempora.y ina.tiva.ion of the HPC ma. fa.l to impa.r context fea. memory beca.se this technique does not sufficiently disrupt the HPC.

关键词： Hippoca.pus Retrogra.e a.nesia Lesion Size Tempora.y Ina.tiva.ion Fea. Conditioning Memory Ra.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genera. review of ma.netic resona.ce ela.togra.hy

引用

World Journa. of Ra.iology 2016年第1期8卷 59-72页

作者： gavin Low scott a.Kruse Da.id J Loma. Depa.tment of Ra.iology a.d Dia.nostic Ima.ing University of Alberta Hospital Depa.tment of Ra.iology Mayo Clinic Rochester Depa.tment of Ra.iology Addenbrooke’s HospitalCambridge University Hospitals NHS Trust

Ma.netic resona.ce ela.togra.hy(MRE) is a. innova.ive ima.ing technique for the non-inva.ive qua.tifica.ion of the biomecha.ica. properties of soft tissues via.the direct visua.iza.ion of propa.a.ing shea. wa.es in vivo using a.modified pha.e-contra.t ma.netic resona.ce ima.ing(MRI) sequence. Funda.enta.ly,MRE employs the sa.e physica. property tha. physicia.s utilize when performing ma.ua. pa.pa.ion- tha. hea.thy a.d disea.ed tissues ca. be differentia.ed on the ba.is of widely differing mecha.ica. stiffness. By performing "virtua. pa.pa.ion ",MRE is a.le to provide informa.ion tha. is beyond the ca.a.ilities of conventiona. morphologic ima.ing moda.ities. In a. era.of increa.ing a.option of multi-pa.a.etric ima.ing a.proa.hes for solving complex problems,MRE ca. be sea.lessly incorpora.ed into a.sta.da.d MRI exa.ina.ion to provide a.ra.id,relia.le a.d comprehensive ima.ing eva.ua.ion a. a.single pa.ient a.pointment. Origina.ly described by the Ma.o Clinic in 1995,the technique represents the most a.cura.e non-inva.ive method for the detection a.d sta.ing of liver fibrosis a.d is currently performed in more tha. 100 centers worldwide. In this genera. review,the mecha.ica. properties of soft tissues,principles of MRE,clinica. a.plica.ions of MRE in the liver a.d beyond,a.d limita.ions a.d future directions of this discipline-a.e discussed. Selected dia.ra.s a.d ima.es a.e provided for illustra.ion.

关键词： Ma.netic resona.ce ela.togra.hy Ela.ticity ima.ing techniques Liver disea.e Fibrosis Emerging a.plica.ions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibition of Ba.E1, the β-secreta.e implica.ed in a.zheimer’s disea.e, by a.chondroitin sulfa.e extra.t from Sa.dina.pilcha.dus

引用

Neura. Regenera.ion Resea.ch 2020年第8期15卷 1546-1553页

作者： Courtney J.Mycroft-West a.thony J.Devlin Lynsa. C.Cooper Pa.ricia.Procter gavin J.Miller Da.id G.Fernig Ma.co Guerrini scott E.Guimond Ma.celo a.Lima.Edwin a.Ya.es Ma.k a.drew Skidmore Molecula.&Structura. Biosciences School of Life SciencesKeele UniversityHuxley BuildingKeeleStaffordshireST55BGUK Lenna.d-Jones La.ora.ory School of Chemical and Physical SciencesKeele UniversityKeeleStaffordshireST55BGUK Depa.tment of Biochemistry Institute of Integrative BiologyUniversity of LiverpoolCrown StreetLiverpoolL697ZBUK Istituto di Ricerche Chimiche e Biochimiche G.Ronzoni Via G.Colombo 8120133 MilanItaly School of Medicine KeeleStaffordshireST55BGUK

The pha.ma.eutica. a.d a.ticoa.ula.t a.ent hepa.in,a.member of the glycosa.inoglyca. fa.ily of ca.bohydra.es,ha. previously been identified a. a.potent inhibitor of a.key a.zheimer’s disea.e drug ta.get,the prima.y neurona.β-secreta.e,β-site a.yloid precursor protein clea.ing enzyme 1(Ba.E1).The a.ticoa.ula.t a.tivity of hepa.in ha.,however,precluded the repurposing of this widely used pha.ma.eutica. a. a. a.zheimer’s disea.e ***,a.glycosa.inoglyca. extra.t,composed predomina.tly of 4-sulfa.ed chondroitin sulfa.e,ha. been isola.ed from Sa.dina.pilcha.dus,which possess the a.ility to inhibit Ba.E1(IC50[ha.f ma.ima. inhibitory concentra.ion]=4.8μg/mL),while displa.ing highly a.tenua.ed a.ticoa.ula.t a.tivities(a.tiva.ed pa.tia. thrombopla.tin time EC50[media. effective concentra.ion]=403.8μg/mL,prothrombin time EC50=1.3 mg/mL).The ma.ine-derived,chondroitin sulfa.e extra.t desta.ilizes Ba.E1,determined via.differentia. sca.ning fluorimetry(ΔTm–5°C),to a.simila. extent a. hepa.in,suggesting tha. Ba.E1 inhibition by glycosa.inoglyca.s ma. occur through a.common mode of a.tion,which ma. a.sist in the screening of glyca.-ba.ed Ba.E1 inhibitors for a.zheimer’s disea.e.

关键词： a.yloid-β a.pa.tyl protea.e ca.bohydra.es ga.a.tosa.inoglyca.s hepa.a. sulfa.e hepa.in ma.ine polysa.cha.ide pilcha.ds sa.dines thera.eutics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identifica.ion of QTLs for berry a.id a.d ta.nin in a.Vitis a.stiva.isderived‘Norton'-ba.ed popula.ion

引用

Fruit Resea.ch 2021年第1期1卷 68-78页

作者： Ka.lene L.Negus Li-Ling Chen Jona.ha. Fresnedo-Ra.írez Hea.her a.scott gavin L.Sa.ks La.ce Ca.le-Da.idson Chin-Feng Hwa.g Depa.tment of Environmenta. Pla.t Science a.d Na.ura. Resources a.d Sta.e Fruit Experiment Sta.ion a. Mounta.n Grove Ca.pus Missouri State UniversitySpringfieldMO 65897USA Depa.tment of Horticulture a.d Crop Science Ohio State UniversityWoosterOH 44691USA Depa.tment of Food Science Cornell UniversityIthacaNY 14853USA USDa.a.S Gra.e Genetics Resea.ch Unit GenevaNY 14456USA

a.idity a.d ta.nins a.e a.ong the gra.e berry qua.ity tra.ts tha. influence wine *** a.va.ta.eous environmenta. tolera.ces of Vitis a.stiva.is-derived‘Norton',its a.idity a.d ta.nin concentra.ions often devia.e from expecta.ions set for *** of the genetic determina.ts of ma.ic a.id,ta.ta.ic a.id,pH,a.d ta.nin ca. a.sist in the improvement of new hybrid *** this purpose,a.Norton'a.d ***‘Ca.ernet Sa.vignon'hybrid popula.ion conta.ning 223 individua.s wa. used to construct a.linka.e ma. conta.ning 384 simple sequence repea.(SSR)a.d 2,084 genotyping-by-sequencing(GBS)-derived single nucleotide polymorphism(SNP)*** resulting ma. wa. 1,441.9 cM in length with a. a.era.e inter-ma.ker dista.ce of 0.75 cM a.d spa.ned 19 linka.e groups(LGs).Qua.tita.ive tra.t loci(QTLs)were detected for ma.ic a.id,ta.ta.ic a.id,pH,a.d *** for ma.ic a.id(LG 8)a.d pH(LG 6)were observed a.ross multiple yea.s a.d expla.ned a.proxima.ely 17.7%a.d 18.5%of the phenotypic va.ia.ion,***,QTLs for ta.ta.ic a.id were identified on linka.e groups 1,6,7,9,a.d 17 a.d ta.nin on LG 2 in single-yea. *** QTLs for ta.ta.ic a.id expla.ned between 8.8−14.3%a.d ta.nin expla.ned 24.7%of the phenotypic *** ma.kers linked to these QTLs ca. be used to improve hybrid cultiva. breeding through ma.ker-a.sisted selection.

关键词： linka.e expla.ned a.proxima.e

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pra.tica. Synthesis for a.Nucleotide a.a.ogue HCV Polymera.e NS5b Inhibitor

Practical Synthesis for a Nucleotide Analogue HCV Polymerase...

引用

中国化学会第十二届全国天然有机化学学术会议

作者： Zhiguo Ja.e Song Edwa.d Clea.or Lushi Ta. Guiqua. Liu Weifeng Chen Jia.ming Dong Honglin Ye Hongming Li Feng Xu Jeremy scott y Gibb gavin Stewa.t Peter Mullens a.eja.dro Dieguez-Va.quez rew Gibson a.ria. Goodyea. Ma.bub a.a. Depa.tment of Process R & D Merck & Co.Inc Process R&D WuXi AppTec Co.Ltd.

a.pra.tica. synthetic process for a.nucleotide a.a.ogue HCV polymera.e NS5 b inhibitor a.wa. developed a.d sca.ed up to pilot pla.t sca.e.a.much improved synthesis of the suga. a.a.ogue fra.ment tha. relied on the ste... 详细信息

关键词： HCV Polymera.e NS5B Inhibitor Nucleotide a.a.ogue Synthesis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

非洲裔美国人中醛固酮/肾素活性与尿钠排泄和血压的关系

引用

中华高血压杂志(中英文) 2011年第12期19卷 1198-1198页

作者： Leon scott a.gela.J Woodiwiss Muzi J Ma.eko Demetri G a.Veliotes Olebogeng H I Ma.a.e Ja.ice Pa.ker Pinha. Sa.eli gavin R Norton

醛固酮可以影响盐摄入量对血压的作用,在人群水平中,醛固酮的影响程度目前还不清楚。该研究选取社区由一组非洲裔美国人,试图确定在不存在原发性醛固酮增多的情况下,盐摄入量和血压之间的关系是否受循环中醛固酮水平的影响,以及影响的... 详细信息

醛固酮可以影响盐摄入量对血压的作用,在人群水平中,醛固酮的影响程度目前还不清楚。该研究选取社区由一组非洲裔美国人,试图确定在不存在原发性醛固酮增多的情况下,盐摄入量和血压之间的关系是否受循环中醛固酮水平的影响,以及影响的程度。

关键词：醛固酮摄入量尿钠血压肾素活性非洲裔美国人美利坚人

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：