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Crohn’s strictures open with anti-mycobacterial antibiotic therapy:A retrospective review

World Journal of Gastrointestinal Endoscopy 2020年第12期12卷 542-554页

作者： Rhys Collyer Annabel Clancy gaurav agrawal Thomas J Borody Centre for Digestive Diseases Five Dock 2046NSWAustralia

BACKGROUND Medical therapy for strictures is limited and first-line treatment consists of endoscopic balloon dilatation,strictureplasty or surgical *** tuberculosis,Helicobacter pylori and Streptococcus can all cause stenosis,for which antibiotic treatment achieves stricture *** avium *** is a suspected causative agent in Crohn’s disease(CD).Thus,specialized antimicrobial treatment,in particular,anti-mycobacterial antibiotic therapy(AMAT)has been proposed as a potential treatment *** our knowledge,the opening of CD strictures has not been recorded using any form of antibiotic *** hypothesized that AMAT would resolve strictures in patients with *** To investigate the effect and outcomes of AMAT in a cohort of CD patients with an ileal *** A single center,retrospective,medical record case review was conducted on an observational cohort of patients with CD who had an ileal stricture on colonoscopy and were treated with *** patients meeting the inclusion criteria were identified from the internal medical ***(75%)patients had follow-up colonoscopy and clinical data *** AMAT regimen was prescribed after the initial colonoscopy for a duration of at least six months until follow-up colonoscopy with the attending *** demographics,symptoms,colonoscopy reports,inflammatory serum markers and concurrent medications were recorded at pre-treatment and follow-up between January 1995 and June *** Of the patients that returned for follow-up after>24 mo of AMAT,twenty(67%)had complete resolution(CR)of their ileal strictures,three(10%)had partial resolution and seven(23%)had no *** of stricture outcome,21 patients(70%)demonstrated clinical response to AMAT and there was a statistically significant reduction in inflammatory serum markers C-reactive protein(P<0.0001)and erythrocyte sedimentation rate(P=0.04)from pretreatm

关键词： Antibiotics Colonoscopy Crohn’s disease Ileum Inflammatory bowel disease Stricture

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Carcinoma bladder and sliding bladder hernia: Unusual association of paramount significance

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Asian Journal of Urology 2020年第2期7卷 186-187页

作者： Manav agrawal gaurav Garg Sunny Goel Manoj Kumar Department of Urology King George’s Medical UniversityLucknowUttar PradeshIndia

A 60-year-old man,a diagnosed case of inguinal hernia was referred for evaluation of voiding lower urinary tract symptoms(LUTS).There was no history of *** local examination,he had right-sided-direct inguinal hernia with right *** biochemical parameters were within normal *** routine microscopy revealed presence of field full of red blood *** uroflowmetry there was presence of decreased peak flow rate(12 mL/s)and average flow rate(8 mL/s).

关键词： bladder hernia Carcinoma

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A transient shift in equatorial hydrology and vegetation during the Eocene Thermal Maximum 2

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Geoscience Frontiers 2024年第5期15卷 174-181页

作者： gaurav Srivastava Harshita Bhatia Poonam Verma Yogesh P.Singh Shailesh agrawal Torsten Utescher R.C.Mehrotra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India Senckenberg Research Institute and Natural History Museum Frankfurt/M.Senckenberg Research Station of Quaternary PalaeontologyWeimerGermany Institute for Geosciences University of BonnNussallee 853115 BonnGermany

The equatorial evergreen forests nourish the world’s biodiversity hotspots and are considered the lungs of the ***,their future survival is uncertain,due to anthropogenically increased carbon emissions and changes in the hydrological *** the changes in the hydrological cycle in the equatorial region due to an increase in carbon emission is of prime *** early Paleogene hyperthermal events are potential analogs to understand the consequences of high carbon emission on the hydrological *** this communication,we quantify the terrestrial seasonal climate using the plant proxy and infer that during the Eocene Thermal Maximum 2 when atmospheric carbon dioxide concentration was>1000 ppmv near the palaeo-equator(~0.6°N),the rainfall decreased significantly,leading to the expansion of deciduous *** study raises important questions about the future survival of equatorial rainforests and biodiversity hotspots under increased carbon emissions.

关键词： Coexistence approach Climate ETM-2 Global warming Hyperthermal Paleogene

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Transcatheter interventions for severe tricuspid regurgitation:a literature review

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Journal of Geriatric Cardiology 2022年第7期19卷 539-550页

作者： Pramod Kumar Ponna Stephen Patin Naga Sai Shravan Turaga Dominika M Zoltowska Vishal Devarkonda Ramya Krishna Botta Yashwant agrawal gaurav Dhar Internal Medicine Louisiana State University Health Sciences CenterShreveportLAUSA Division of Cardiology University of Arkansas for Medical SciencesLittle RockARUSA Division of Cardiology University of FloridaJacksonvilleFLUSA Division of Infectious Diseases Vanderbilt University Medical CenterNashvilleTNUSA Division of Cardiology Chandler Region Medical CenterChandlerArizonaUSA

The prevalence of tricuspid regurgitation(TR)increases with age,affecting 65%-85%of *** TR is caused by a congenital or acquired abnormality of the tricuspid valve apparatus(leaflets,chordae,papillary muscles,or annulus).Secondary TR is due to insufficient coaptation from dilation of tricuspid valve annulus due to the right ventricle(RV)or right at-rium(RA)remodeling and increased RV *** TR is without increased RV pressures and is associated with atrial *** TR is a benign *** to severe tricuspid regurgitation has independently been associated with in-creased *** of these patients are treated medically due to poor outcomes with surgical repair of isolated *** in-hospital mortality rate is 8.8%,and the median length of stay in hospital is 11 days resulting in higher healthcare *** if the patients undergo surgical repair or replacement,available data do not show improvement in *** a more detailed un-derstanding of the complex anatomy and physiology of the tricuspid valve and significant complications from untreated tricusp-id valve disease,the approach to the management of TR has shifted from a conservative approach to a process of prevention and *** the past decade,transcatheter tricuspid valve interventions and tricuspid annuloplasty rings have been de-veloped,contributing to decreased mortality from surgical *** tricuspid valve intervention techniques have im-proved survival,quality of life,and reduced heart failure *** review summarizes normal anatomy,types of TR,etiology and different mechanisms of TR,echocardiographic assessment of the severe TR,and highlights various percu-taneous transcatheter techniques for tricuspid valve repair.

关键词： anatomy tricuspid regurgitation

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