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Acta Pharmaceutica Sinica B 2023年第2期13卷 897-898页

作者： Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu gary d.lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren department of Emergency Shanghai Tenth People's HospitalSchool of Medicine Tongji UniversityShanghai 200072China Shanghai University School of Medicine Shanghai 200044China University of Wyoming College of Health Sciences LaramieWY 82071USA department of Cardiovascular Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510000China Medprime Health Services LLC ParisTX 75460USA department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan Hospital Fudan UniversityShanghai 200032China department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001China Cardiovascular Research Centre University of AlbertaEdmontonAlberta T6G 2S2Canada Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Endocrinology and MetabolismZhongshan Hospital Fudan UniversityShanghai 200032China department of Laboratory Medicine and Pathology University of WashingtonSeattleWA 98195USA

The authors of the above-mentioned paper noticed an error in Fig.5a as reported.H&E staining was shown in wrong color during figure processing and dKO-LF group was accidently copied and pasted *** H&E images have been replaced with the correct color with the accurate grouping *** text content in figure legend or conclusion is affected by this *** authors sincerely apologize for any inconvenience caused to the journal and readers.

关键词： correction journal mentioned

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3508-3526页

Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic ***2–Ampkα2 double knockout(dKO)mice were placed on high fat diet for 5 *** metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were *** mice were lean without anthropometric *** fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in dKO but not Akt2^(-/-) and Ampkα2^(-/-) *** fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT *** effects were eliminated in dKO but not Akt2^(-/-) and Ampkα2^(-/-) *** diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in dKO *** intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCd-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(dGAT1),the effect was absent in dKO but not Akt2^(-/-) and Ampkα2^(-/-) *** diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by *** of Parkin effectively nullified dKO-induced metabolic benefits against high fat *** samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human *** data suggest that concurrent de

关键词： Akt2 AMPK Parkin High fat intake Obesity Steatosis Mitophagy FoxO1

Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International Journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： Jin Xu Lingfeng Wang Peilin Yang Haoqing Jiang Huai Zheng Licong An Xingtao Liu gary J Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2d plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(NPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform NPs into densely packed,uniform,and ultrafine NPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine NP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral Line Receivers

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Research in Astronomy and Astrophysics 2024年第6期24卷 315-322页

作者： Bing-Ru Wang di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Rudolf Schieder gary J.Melnick National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China KOSMA I.Physik.InstitutUniversität zu KölnZülpicher Str.7750937 KölnGermany Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetMS 66CambridgeMA 02138USA

The Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral *** have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit *** CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were *** present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).The noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise *** noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

关键词： telescopes space vehicles:instruments instrumentation:miscellaneous ISM:lines and bands

Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates

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Pediatric Investigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Sebastian Acosta Rohit S.Loomba Claire Rizk gary E.Stapleton david Faraoni Fabio Savorgnan department of Pediatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA department of Pediatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA department of Pediatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA department of Anesthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The standard of care in the management of d-transposition of the great arteries(TGA)includes the arterial switch operation(ASO).1,2 Although some institutions have begun to publish the results of performing the ASO within the first few hours of life,most centers continue to"electively"delay ASO for several days to allow for a reduction in pulmonary vascular resistance and the stabilization of renal and liver function.1,2 The early initiation of prostaglandin E1(PGE)infusion to maintain ductal patency is a nearly universal component of therapy in order to maintain adequate arterial oxygen saturation and systemic oxygen delivery during the pre-operative period via intercirculatory mixing at the atrial septal and patent ductus arteriosus levels1,3.

关键词： balloon maintain stabilization

Electronic properties of 2d materials and their junctions

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Nano Materials Science 2024年第1期6卷 1-23页

作者： Taposhree dutta Neha Yadav Yongling Wu gary J.Cheng Xiu Liang Seeram Ramakrishna Aoussaj Sbai Rajeev Gupta Aniruddha Mondal Zheng Hongyu Ashish Yadav department of Chemistry Indian Institute of Engineering Science and TechnologyShibpurWest Bengal711103India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Industrial Engineering Purdue University315 N.Grant St.West LafayetteIN47907United States Birck Nanotechnology Center Purdue University1205 W State St.West LafayetteIN47907United States Advanced Materials Institute Qilu University of TechnologyShandong Academy of SciencesJinan250014PR China Nanoscience and Nanotechnology Initiative National University of Singapore10 Kent Ridge Crescent119260Singapore Faculty of Applied Phsyics and Mathematics Gdansk University of Technology Narutowicza 11/1280233GdanskPoland department of Physics School of EngineeringUniversity of Petroleum&Energy StudiesDehradun248007UttarakhandIndia department of Physics National Institute of Technology DurgapurDurgapur713209West BengalIndia

With an extensive range of distinctive features at nano meter-scale thicknesses,two-dimensional(2d)materials drawn the attention of the scientific *** tremendous advancements in exploratory research on 2d materials,knowledge of 2d electrical transport and carrier dynamics still in its ***,here we highlighted the electrical characteristics of 2d materials with electronic band structure,electronic transport,dielectric constant,carriers *** atomic thinness of 2d materials makes substantially scaled field-effect transistors(FETs)with reduced short-channel effects conceivable,even though strong carrier mobility required for high performance,low-voltage device *** also discussed here about factors affecting 2d materials which easily enhanced the activity of those materials for various ***,Those 2d materials used in state-of-the-art electrical and optoelectronic devices because of the extensive nature of their electronic band structure.2d materials offer unprecedented freedom for the design of novel p-n junction device topologies in contrast to conventional bulk *** also,describe the numerous 2d p-n junctions,such as homo junction and hetero junction including mixed dimensional ***,we talked about the problems and potential for the future.

关键词： 2d materials Electrical properties p-n junctions Mixed hereto junctions Homo junctions Electrical transport

Recovery rates of persistent post-COVId-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson Brandon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.gary david A.Gudis Paule V.Joseph d.P.devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(Od)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent Od predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent Od beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent Od in post-COVId-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for Od evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVId-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived Od,74.5%had confirmed psychophysical Od at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TdI)score improved by+3.25 points in the cohort with psychophysical Od(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:Od persists in a significant number of patients who fail to acutely recovery their sense of smell after COVId-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVId olfaction post-COVId condition smell dysfunction

Numerical Analysis on the Effect of n-Si on Cu(In, Ga)Se₂ Based Thin-Films for High-Performance Solar Cells by 1d-SCAPS

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Open Journal of Applied Sciences 2024年第5期14卷 1315-1329页

作者： Rasika N. Mohottige Micheal Farndale gary S. Coombs Shahnoza Saburhhojayeva department of Natural Sciences Waldorf University Forest City IA USA

We report the performances of a chalcopyrite Cu(In, Ga)Se2 CIGS-based thin-film solar cell with a newly employed high conductive n-Si layer. The data analysis was performed with the help of the 1d-Solar Cell Capacitance Simulator (1d-SCAPS) software program. The new device structure is based on the CIGS layer as the absorber layer, n-Si as the high conductive layer, i-In2S3, and i-ZnO as the buffer and window layers, respectively. The optimum CIGS bandgap was determined first and used to simulate and analyze the cell performance throughout the experiment. This analysis revealed that the absorber layer’s optimum bandgap value has to be 1.4 eV to achieve maximum efficiency of 22.57%. Subsequently, output solar cell parameters were analyzed as a function of CIGS layer thickness, defect density, and the operating temperature with an optimized n-Si layer. The newly modeled device has a p-CIGS/n-Si/In2S3/Al-ZnO structure. The main objective was to improve the overall cell performance while optimizing the thickness of absorber layers, defect density, bandgap, and operating temperature with the newly employed optimized n-Si layer. The increase of absorber layer thickness from 0.2 - 2 µm showed an upward trend in the cell’s performance, while the increase of defect density and operating temperature showed a downward trend in solar cell performance. This study illustrates that the proposed cell structure shows higher cell performances and can be fabricated on the lab-scale and industrial levels.

关键词： n-Si p-CIGS 1d-SCAPS Thin-Films In2S3

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph d.Tan gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique d.domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines department of Ophthalmology Manila Doctors HospitalManila 1000Philippines department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pd those from the Visayas(Pd on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Effects of a poly(hydroxyalkanoate)elastomer and kraft pulp fibres on biocomposite properties and three-dimensional(3d)printability of filaments for fused deposition modelling

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Journal of Bioresources and Bioproducts 2022年第3期7卷 161-172页

作者： Sandra Rodríguez-Fabià gary Chinga-Carrasco RISE PFI Høgskoleringen 6bTrondheim 7491Norway

Three-dimensional(3d)printing is a useful technique that allows the creation of objects with complex structures by deposition of successive layers of *** materials are often from fossil ***,efforts are being made to produce environmentally friendly materials for 3d *** addition of lignocellulosic fibres to a polymer matrix is one of the alternatives to replace,for instance,glass fibres in composites as reinforcing *** fields of biocom-posites and 3d printing open innovative application areas for pulp fibres from the pulp and paper *** this work,biocomposites of poly(lactic acid)(PLA),poly(hydroxyalkanoate)(PHA)and kraft pulp fibres were prepared in order to find a suitable formulation for filaments for 3d *** effect of two different types of kraft fibres(bleached(B)and unbleached(U))and of PHA on the mechanical and thermal properties of the biocomposites was *** addition of 30%kraft fibres to PLA resulted in an increase of the tensile modulus from 3074 to∼4800 *** the case of biocomposites containing PHA(50%PLA/20%PHA/30%kraft)the increase in modulus was more moderate(PLA+PHA+U:3838 MPa,and PLA+PHA+B:3312 MPa).The tensile strength of PLA(66 MPa)increased to 77 MPa in PLA+kraft biocomposites,while a reduc-tion in strength was observed for PLA+PHA+U(43 MPa)and PLA+PHA+B(32 MPa).Filaments prepared with PLA,PHA and bleached and unbleached pulp fibres showed similar printability of complex geometries,demonstrating that unbleached pulp fibres could also be utilized in the preparation of biocomposites with good mechanical performance and 3d printing properties.

关键词： biocomposites 3d printing Poly(lactic acid) Kraft pulp