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Predictors of survival in autoimmune liver disease overlap syndromes

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(P<0.05)in patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates

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Pediatric Investigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Sebastian Acosta Rohit S.Loomba Claire Rizk gary E.Stapleton David Faraoni Fabio Savorgnan Department of Pediatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA Department of Anesthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The standard of care in the management of d-transposition of the great arteries(TGA)includes the arterial switch operation(ASO).1,2 Although some institutions have begun to publish the results of performing the ASO within the first few hours of life,most centers continue to"electively"delay ASO for several days to allow for a reduction in pulmonary vascular resistance and the stabilization of renal and liver function.1,2 The early initiation of prostaglandin E1(PGE)infusion to maintain ductal patency is a nearly universal component of therapy in order to maintain adequate arterial oxygen saturation and systemic oxygen delivery during the pre-operative period via intercirculatory mixing at the atrial septal and patent ductus arteriosus levels1,3.

关键词： balloon maintain stabilization

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The Dallas Donation after Circulatory Death Transplantation Summit:expanding donation after circulatory death procedures through process improvement,broader utilization,and innovation

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 824-836,I0009页

作者： Michele Finotti Anji Wall Anthony D’Alessandro gary Schwartz Chris Sonnenday David Goldberg Ashish Shah Peter Friend Jeff P.Orlowski Greg McKenna Steve Newton Brad Adams William C.Chapman Amit Mathur Marwan Abouljoud Tim Pruett Amelia Hessheimer James F.Trotter Sumeet K.Asrani Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Hepatobiliary and General Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaPaduaItaly Division of Transplantation Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA Department of Thoracic Surgery and Lung Transplantation Baylor University Medical CenterCenter for Advanced Heart and Lung DiseaseDallasTXUSA Department of Surgery University of MichiganAnn ArborMIUSA Division of Digestive Health and Liver Diseases Department of MedicineUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Cardio-Thoracic Surgery Vanderbilt University Medical CenterNashvilleTNUSA Nuffield Department of Surgical Sciences University of OxfordOxfordUK LifeShare Transplant Donor Services of Oklahoma Oklahoma CityOKUSA Administration Baylor University Medical CenterDallasTXUSA Southwest Transplant Alliance DallasTXUSA Department of Surgery/Transplantation Washington UniversitySt.LouisMOUSA Division of Transplant Surgery Department of SurgeryMayo Clinic ArizonaAlix School of MedicinePhoenixAZUSA Divisions of Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMIUSA Department of Surgery University of MinnesotaMinneapolisMNUSA General and Digestive Surgery Hospital Universitario La PazIdiPAZMadridSpain

Despite a significant increase in utilization over the past decade,the number of donation after circulatory death(DCD)organs that are procured and transplanted in the United States(US)remains well below its *** is still room for expansion,as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in *** convened a multidisciplinary transplantation summit to examine various aspects of DCD,with faculty members from around the world with clinical and academic interest in DCD donation and transplantation,including abdominal and cardiothoracic surgeons,organ procurement organization directors,hepatologists,and *** conference focused on identifying barriers to DCD organ utilization and strategies to overcome these *** divide the barriers to DCD utilization into three mains categories:(Ⅰ)policy and process variation;(II)logistical and transportation challenges;and(Ⅲ)higher risk perceptions related to DCD *** each barrier,we proposed a variety of solutions,providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of *** is a specific focus on ex situ machine perfusion,normothermic regional perfusion,and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

关键词： Donation after circulatory death donation(DCD donation) marginal graft donor pool machine perfusion(MP)

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不锈钢薄管折弯成型与回弹有限元模拟分析

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机械制造与自动化 2024年第3期53卷 155-157,180页

作者：褚艺光周圣何统统王丙旭 gary Barber 杭州佐帕斯工业有限公司浙江杭州310018 浙江理工大学机械与自动控制学院浙江杭州310018 奥克兰大学汽车摩擦学中心美国罗彻斯特48309

基于Simufact Forming软件建立不锈钢薄管折弯成型的有限元仿真模型,模拟薄管折弯成型过程并分析接触面摩擦因数和折弯速度对薄管折弯后回弹程度的影响。结果表明:随着薄管折弯角度的不断增大,折弯区域的等效应力逐渐增大,局部高应力区... 详细信息

基于Simufact Forming软件建立不锈钢薄管折弯成型的有限元仿真模型,模拟薄管折弯成型过程并分析接触面摩擦因数和折弯速度对薄管折弯后回弹程度的影响。结果表明:随着薄管折弯角度的不断增大,折弯区域的等效应力逐渐增大,局部高应力区域增大,外侧壁厚逐渐减小,内侧壁厚逐渐增大;薄管折弯后回弹量随摩擦因数的增大或折弯速度的减小呈现先增大后减小的趋势;当摩擦因数为0.2或折弯速度为2 s内190°时,薄管的回弹量最大。该结果能够为薄管折弯成型模拟仿真和回弹量预测提供一定的参考。

关键词：不锈钢薄管折弯成型回弹有限元模型模拟分析

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264米的美国魔鬼塔为什么全球登顶者不足百人？

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环球人文地理 2024年第13期 90-97页

作者：李嘉麟 Dan gary GRP Imagery kellyvandellen Kyle samantha Jacob WOLFGANG flickr

在美国怀俄明州，有一座不足300米的“矮山”。别看它不高，论起攀登难度，就连珠峰登顶者都对它望洋兴叹。在美国怀俄明州东北部，有一座由火山岩和沉积岩构成的圆柱形岩石塔——魔鬼塔。它矗立在一望无际的草原上，显得格外突兀。谁...

在美国怀俄明州，有一座不足300米的“矮山”。别看它不高，论起攀登难度，就连珠峰登顶者都对它望洋兴叹。在美国怀俄明州东北部，有一座由火山岩和沉积岩构成的圆柱形岩石塔——魔鬼塔。它矗立在一望无际的草原上，显得格外突兀。谁能相信，近百年来，能够登上264米塔顶的登山者不足百人。那么，魔鬼塔是怎么形成的呢？这个问题，让好事者争论了一百多年。

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The relationship between sleep disorders and testosterone in men

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Asian Journal of Andrology 2014年第2期16卷 262-265,I0009,I0010页

作者： gary Wittert Discipline of Medicine and Freemasons Foundation Centre for Men's Health University of Adelaide Adelaide South Australia Australia.

Plasma testosterone levels display circadian variation, peaking during sleep, and reaching a nadir in the late afternoon, with a superimposed ultradian rhythm with pulses every 90 min reflecting the underlying rhythm of pulsatile luteinizing hormone （LH） secretion. The increase in testosterone is sleep, rather than circadian rhythm, dependent and requires at least 3h of sleep with a normal architecture. Various disorders of sleep including abnormalities of sleep quality, duration, circadian rhythm disruption, and sleep-disordered breathing may result in a reduction in testosterone levels. The evidence, to support a direct effect of sleep restriction or circadian rhythm disruption on testosterone independent of an effect on sex hormone binding globulin （SHBG）, or the presence of comorbid conditions, is equivocal and on balance seems tenuous. Obstructive sleep apnea （OSA） appears to have no direct effect on testosterone, after adjusting for age and obesity. However, a possible indirect causal process may exist mediated by the effect of OSA on obesity. Treatment of moderate to severe OSA with continuous positive airway pressure （CPAP） does not reliably increase testosterone levels in most studies. In contrast, a reduction in weight does so predictably and linearly in proportion to the amount of weight lost. Apart from a very transient deleterious effect, testosterone treatment does not adversely affect OSA. The data on the effect of sleep quality on testosterone may depend on whether testosterone is given as replacement, in supratherapeutic doses, or in the context abuse. Experimental data suggest that testosterone may modulate individual vulnerability to subjective symptoms of sleep restriction. Low testosterone may affect overall sleep quality which is improved by replacement doses. Large doses of exogenous testosterone and anabolic/androgenic steroid abuse are associated with abnormalities of sleep duration and architecture.

关键词： obesity obstructive sleep apnea shift work sleep restriction testosterone

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Turbulence modelling of the aerodynamic interaction ofOGV wakes and diffuser flow

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航空动力学报 2011年第10期26卷 2302-2312页

作者： Page gary McGuirk Jim Department of Aeronautical and Automotive Engineering Loughborough University

Different turbulence closures were used to predict the flow interaction between the wakes created by compressor outlet guide vanes(OGVs) and a downstream annular *** statistical turbulence models were tested based on the classical Reynolds-averaged Navier-Stokes(RANS) *** high-Re and low-Re(Launder-Sharma) versions of the k-ε model were applied to a selected test problem for OGV wake/diffuser *** test problem was specifically chosen because experimentally determined inlet conditions and both profile and performance data were available to validate predictions.A preliminary study was also reported of the more advanced large eddy simulation(LES) *** LES sub-grid-scale(SGS) model was the basic Smagorinsky eddy viscosity assumption,with a Van-Driest damping function for improved capture of near-wall viscous *** between the two RANS models showed little difference in terms of velocity contours at OGV trailing edge and diffuser *** terms of overall diffuser performance(static pressure recovery and total pressure loss coefficients),the high-Re model was shown to agree well with experimental *** preliminary LES study indicates the highly unsteady character of the OGV wake flow,but requires improved treatment of inlet conditions.

关键词： outlet guide vane(OGV) wakes diffuser flow interaction Reynolds-averaged Navier-Stokes(RANS) modelling large eddy simulation(LES) modelling

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NON SPURIOUS SPECTRAL-LIKE ELEMENT METHODS FOR MAXWELL'S EQUATIONS

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Journal of Computational Mathematics 2007年第3期25卷 282-304页

作者： gary Cohen Marc Duruflé INRIA Domaine de VoluceauRocquencourt-BP 10578153 Le Chesnay CedexFrance

In this paper, we give the state of the art for the so called “mixed spectral elements” for Maxwell＇s equations. Several families of elements, such as edge elements and discon-tinuous Galerkin methods （DGM） are presented and discussed. In particular, we show the need of introducing some numerical dissipation terms to avoid spurious modes in these methods. Such terms are classical for DGM but their use for edge element methods is novel approach described in this paper. Finally, numerical experiments show the fast and low-cost character of these elements.

关键词： Maxwell's equations Discontinuous Galerkin methods Edge elements Masslumping.

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Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions

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Chinese Journal of Mechanical Engineering 2009年第1期22卷 27-35页

作者： SHAN Songqing WANG G gary Department of Mech. and Manufacturing Engineering the University of Manitoba Winnipeg MB R3T 5 V6 Canada School of Engineering Science Simon Fraser University Surrey BC V3T OA3 Canada

Reliability-based design optimization （RBDO） is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop procedure, the computational expense of RBDO is normally very high. Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients. This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive. These computation intensive functions are often considered as a ＂black-box＂ and their gradients are not available or not reliable. On the basis of the reliable design space （RDS） concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing （RSP） approach, in which RDS is first identified and then gradually refined while optimization is performed. It fundamentally avoids the nested optimization and probabilistic assessment loop. Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method.

关键词： Reliability based design optimization black-box function reliable design space

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