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Taking care of volunteers in a stroke trial: a new assisted-management strategy

Stroke & Vascular Neurology 2016年第3期1卷 108-114页

作者： Amber C Stuart Jason J Sico Catherine M Viscoli Ashis H Tayal Silvio E Inzucchi gary a ford Karen L Furie Robert Cote J David Spence David Tanne Walter N Kernan on behalf of the IRIS Trial Investigators Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Service Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Neuroscience Institute Allegheny Health NetworkPittsburghPennsylvaniaUSA Lewis Katz School of Medicine at Temple University PhiladelphiaPennsylvaniaUSA Division of Medical Sciences Oxford UniversityOxfordUK The Warren Alpert Medical School of Brown University ProvidenceRhode IslandUSA Department of Neurology Neurosurgery and MedicineMcGill UniversityMontrealQuebecCanada University of Western Ontario LondonOntarioCanada 10Sheba Medical CenterTel Aviv UniversityTel AvivIsrael 不详

Background and purpose:Providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke *** optimal strategy,however,is *** report the performance of a new approach for delivering preventive care to trial ***:Participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic *** care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback *** studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressure<140/90 mm Hg,lowdensity lipoprotein(LDL)cholesterol<2.59 mmol/L and antithrombotic ***:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and LDL(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given ***,only 22%of participants achieved all 3 goals in each ***:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over *** registration number:NCT00091949.

关键词： prevention annually goals

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2004年世界电子业--快乐日子又来了!

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电子产品世界 2004年第2期11卷 18-20页

作者： Dale ford gary Grandbois

2003年:半导体业重返好时光iSuppli公司预计,2003年世界半导体市场销售将增长13.9%,与2002年的增长1.6%不可同日而语.

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Substrate topography as a powerful tool to modify glial cell biology and interactions

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Neural Regeneration Research 2025年第5期20卷 1390-1391页

作者： Pascal Achenbach Haktan Altinova gary A.Brook Institute of Neuropathology RWTH Aachen University Hospital Department of Neurosurgery RWTH Aachen University Hospital Aachen Germany Berlin State Office for Health and Social Affairs(LAGeSo) BerlinGermany

Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal *** normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.

关键词： injuries topography system

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实时LWD：随钻测井

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国外测井技术 2002年第1期17卷 34-49页

作者： Saad Bargach lan Falconer Garlos Maeso John Rasmus Ted Bomemann Richard Plumb Daniel Codazzi Kyel Hondenfield gary ford John Harner Bill Grether Hendrik Rohler 美国得克萨斯州SugarLand 得克萨斯州休斯敦法国Clamart Anadarko石油公司美国阿拉斯加州Anchorage 阿拉斯加石油技术资源公司阿拉斯加州Anchorage RWE-DEA AG么司德国汉堡

石油和天然气工业界正在努力寻求更有效、成本效益更高的建井方法.第三代随钻测井仪器的出现正实现目标拓展一个新的领域,能力提高可以提供更准确井位并降低风险.为钻井服务的实时测井技术由此将迅速成为现实.

关键词：实时LWD 随钻测井随钻测量 MWD 井位准确性

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血管性认知损害诊断的进一步规范化：血管性认知损害分类共识研究组指南

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国际脑血管病杂志 2018年第4期26卷 241-250页

作者： Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti gary A. ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂徐俊 Translational Health Sciences University of Bristol Bristol UK Sunnybrook Research Institute University of Toronto Ontario Canada Department of Pharmacology National University of Singapore Singapore Department of Neurology and Center for Neuroscience University of California at Davis Sacramento California USA Neurology University of Helsinki and Helsinki University Hospital Helsinki Finland Divison of Medical Sciences Oxford University Oxford UK Institute of Neuroscience Newcastle University Newcastle UK Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK NEUROFARBA Department University of FlorenceFlorence Italy Inserm U1171 University of Lille Lille France Methodist Neurological Institute Houston Texas USA Memory Clinic at Department of Neuropsychiatry Sahlgrenska University Hospital Molndal Sweden Institute of Neuroscience and Physiology Sahlgrenska AcademyUniversity of Gothenburg Sweden School of Psychiatry University of New South WalesSydney Australia Neuropsychiatric Institute Prince of Wales Hospital Randwick New South WalesAustralia Population Health Sciences University of Bristol Bristol UK Institute of Institute of Clinical Sciences Block B Queens University Belfast Belfast UK 116044 大连医科大学 116044 苏北人民医院神经内科扬州225001 首都医科大学附属北京天坛医院神经内科北京100069

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impair... 详细信息

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impairment of Cognition Classification Consensus Study,VICCCS）,旨在就VCI的诊断原则（VICCCS-1）和诊断方案（VICCCS-2）达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲（Delphi）调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65～79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网（National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN）发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作.

关键词：血管性认知损害血管性痴呆指南标准共识德尔菲法

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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The relationship between sleep disorders and testosterone in men

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Asian Journal of Andrology 2014年第2期16卷 262-265,I0009,I0010页

作者： gary Wittert Discipline of Medicine and Freemasons Foundation Centre for Men's Health University of Adelaide Adelaide South Australia Australia.

Plasma testosterone levels display circadian variation, peaking during sleep, and reaching a nadir in the late afternoon, with a superimposed ultradian rhythm with pulses every 90 min reflecting the underlying rhythm of pulsatile luteinizing hormone （LH） secretion. The increase in testosterone is sleep, rather than circadian rhythm, dependent and requires at least 3h of sleep with a normal architecture. Various disorders of sleep including abnormalities of sleep quality, duration, circadian rhythm disruption, and sleep-disordered breathing may result in a reduction in testosterone levels. The evidence, to support a direct effect of sleep restriction or circadian rhythm disruption on testosterone independent of an effect on sex hormone binding globulin （SHBG）, or the presence of comorbid conditions, is equivocal and on balance seems tenuous. Obstructive sleep apnea （OSA） appears to have no direct effect on testosterone, after adjusting for age and obesity. However, a possible indirect causal process may exist mediated by the effect of OSA on obesity. Treatment of moderate to severe OSA with continuous positive airway pressure （CPAP） does not reliably increase testosterone levels in most studies. In contrast, a reduction in weight does so predictably and linearly in proportion to the amount of weight lost. Apart from a very transient deleterious effect, testosterone treatment does not adversely affect OSA. The data on the effect of sleep quality on testosterone may depend on whether testosterone is given as replacement, in supratherapeutic doses, or in the context abuse. Experimental data suggest that testosterone may modulate individual vulnerability to subjective symptoms of sleep restriction. Low testosterone may affect overall sleep quality which is improved by replacement doses. Large doses of exogenous testosterone and anabolic/androgenic steroid abuse are associated with abnormalities of sleep duration and architecture.

关键词： obesity obstructive sleep apnea shift work sleep restriction testosterone

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Turbulence modelling of the aerodynamic interaction ofOGV wakes and diffuser flow

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航空动力学报 2011年第10期26卷 2302-2312页

作者： Page gary McGuirk Jim Department of Aeronautical and Automotive Engineering Loughborough University

Different turbulence closures were used to predict the flow interaction between the wakes created by compressor outlet guide vanes(OGVs) and a downstream annular *** statistical turbulence models were tested based on the classical Reynolds-averaged Navier-Stokes(RANS) *** high-Re and low-Re(Launder-Sharma) versions of the k-ε model were applied to a selected test problem for OGV wake/diffuser *** test problem was specifically chosen because experimentally determined inlet conditions and both profile and performance data were available to validate predictions.A preliminary study was also reported of the more advanced large eddy simulation(LES) *** LES sub-grid-scale(SGS) model was the basic Smagorinsky eddy viscosity assumption,with a Van-Driest damping function for improved capture of near-wall viscous *** between the two RANS models showed little difference in terms of velocity contours at OGV trailing edge and diffuser *** terms of overall diffuser performance(static pressure recovery and total pressure loss coefficients),the high-Re model was shown to agree well with experimental *** preliminary LES study indicates the highly unsteady character of the OGV wake flow,but requires improved treatment of inlet conditions.

关键词： outlet guide vane(OGV) wakes diffuser flow interaction Reynolds-averaged Navier-Stokes(RANS) modelling large eddy simulation(LES) modelling

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NON SPURIOUS SPECTRAL-LIKE ELEMENT METHODS FOR MAXWELL'S EQUATIONS

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Journal of Computational Mathematics 2007年第3期25卷 282-304页

作者： gary Cohen Marc Duruflé INRIA Domaine de VoluceauRocquencourt-BP 10578153 Le Chesnay CedexFrance

In this paper, we give the state of the art for the so called “mixed spectral elements” for Maxwell＇s equations. Several families of elements, such as edge elements and discon-tinuous Galerkin methods （DGM） are presented and discussed. In particular, we show the need of introducing some numerical dissipation terms to avoid spurious modes in these methods. Such terms are classical for DGM but their use for edge element methods is novel approach described in this paper. Finally, numerical experiments show the fast and low-cost character of these elements.

关键词： Maxwell's equations Discontinuous Galerkin methods Edge elements Masslumping.

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Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions

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Chinese Journal of Mechanical Engineering 2009年第1期22卷 27-35页

作者： SHAN Songqing WANG G gary Department of Mech. and Manufacturing Engineering the University of Manitoba Winnipeg MB R3T 5 V6 Canada School of Engineering Science Simon Fraser University Surrey BC V3T OA3 Canada

Reliability-based design optimization （RBDO） is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop procedure, the computational expense of RBDO is normally very high. Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients. This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive. These computation intensive functions are often considered as a ＂black-box＂ and their gradients are not available or not reliable. On the basis of the reliable design space （RDS） concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing （RSP） approach, in which RDS is first identified and then gradually refined while optimization is performed. It fundamentally avoids the nested optimization and probabilistic assessment loop. Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method.

关键词： Reliability based design optimization black-box function reliable design space

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