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Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade

World Journal of Gastrointestinal Oncology 2017年第9期9卷 354-362页

作者： Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman gary n mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center Department of Medical Oncology at the University of Texas MD Anderson Cancer Center Department of Radiology at the University of Texas MD Anderson Cancer Center Department of Pathology at the University of Texas MD Anderson Cancer Center Department of SurgicalOncology at the University of Texas MD Anderson Cancer Center

AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards *** There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P nd 0%, respectively(P ndependent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P nd peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. COnCLUSIOn Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms.

关键词： Hyperthermic intraperitoneal chemotherapy Pseudomyxoma peritonei Histology Grade Prognostic Outcomes

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz J.T.Huber Stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(Inn)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate Inn leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution nanoparticle morphology Particle size distribution

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Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International Journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： Jin Xu Lingfeng Wang Peilin Yang Haoqing Jiang Huai Zheng Licong An Xingtao Liu gary J Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(nPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform nPs into densely packed,uniform,and ultrafine nPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine nP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

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Leflunomide: A versatile additive for defect reduction, enhanced optoelectronic properties and environmental stability of perovskite films

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nano Research 2024年第4期17卷 2628-2637页

作者： Dingyue Sun Ming Peng Taijin Wang Longju Yi Shizuo Zhang Feng Liu gary J.Cheng The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906USA

The development of perovskite photoelectric devices with excellent performance is largely dependent on the defects in the perovskite *** address this issue,a specific drug,leflunomide(LF,C_(12)H_(9)F_(3)n_(2)O_(2)),was incorporated into the perovskite to reduce defects and improve its photoelectric *** is believed that the C=O bond on LF molecule can interact with the uncoordinated Pb2+of the perovskite,thereby reducing non-radiative *** novel approach of incorporating LF into perovskite films has the potential to revolutionize the development of high-performance perovskite photoelectric *** trifluoromethyl functional(–CF_(3))group on LF can form a protective layer on the surface of the perovskite film,shielding it from water ***,LF can be utilized to alter the nucleation position of perovskite,thus minimizing the number of defects and optimizing the film ***,the LF-doped perovskite film displays low trap density and high photoelectric *** LF-doped perovskite film showed a trap density of 8.28×10^(11),which is notably lower than the 2.04×10^(12) of the perovskite film without *** responsivity and detectivity of the LF-doped perovskite photodetector were 0.771 A/W and 2.81×10^(11) Jones,respectively,which are much higher than the 0.23 A/W and 1.06×10^(10) Jones of the LF-undoped perovskite ***,the LF-doped photodetector maintained an initial photocurrent of 86%after 30 days of storage in air,indicating drastically increased environmental *** strongly suggests that LF is an effective additive for perovskites utilized in optoelectronic devices with high performance.

关键词： leflunomide additive engineering defect passivation perovskite

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new insights into nitric oxide biosynthesis underpin lateral root development

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Molecular Plant 2024年第5期17卷 691-693页

作者： Kapuganti Jagadis Gupta nidhi Yadav Aprajita Kumari gary J.Loake national Institute for Plant Genome Research Aruna Asaf Ali MargNew Delhi 110070India Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK Centre for Engineering Biology School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK

In recent years,nitric oxide(nO)has emerged as a key redox signaling molecule in plants functioning in the regulation of key developmental programs and the orchestration of responses to a plethora of environmental cues(Kolbert et al.,2019).The predominant route for the transfer of nO bioactivity is through S-nitrosylation,the addition of an nO moiety to a protein cysteine thiol to form an S-nitrosothiol(Yun et al.,2011).Specificity for this process is established by the structural constraints imposed by tertiary protein structure in gating access to given cysteine redox switches and associated proteins that can either facilitate the addition or removal of the nO moiety at these residues(Umbreen et al.,2018).

关键词： moiety addition redox

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numerical Analysis on the Effect of n-Si on Cu(In, Ga)Se₂ Based Thin-Films for High-Performance Solar Cells by 1D-SCAPS

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Open Journal of Applied Sciences 2024年第5期14卷 1315-1329页

作者： Rasika n. Mohottige Micheal Farndale gary S. Coombs Shahnoza Saburhhojayeva Department of natural Sciences Waldorf University Forest City IA USA

We report the performances of a chalcopyrite Cu(In, Ga)Se2 CIGS-based thin-film solar cell with a newly employed high conductive n-Si layer. The data analysis was performed with the help of the 1D-Solar Cell Capacitance Simulator (1D-SCAPS) software program. The new device structure is based on the CIGS layer as the absorber layer, n-Si as the high conductive layer, i-In2S3, and i-ZnO as the buffer and window layers, respectively. The optimum CIGS bandgap was determined first and used to simulate and analyze the cell performance throughout the experiment. This analysis revealed that the absorber layer’s optimum bandgap value has to be 1.4 eV to achieve maximum efficiency of 22.57%. Subsequently, output solar cell parameters were analyzed as a function of CIGS layer thickness, defect density, and the operating temperature with an optimized n-Si layer. The newly modeled device has a p-CIGS/n-Si/In2S3/Al-ZnO structure. The main objective was to improve the overall cell performance while optimizing the thickness of absorber layers, defect density, bandgap, and operating temperature with the newly employed optimized n-Si layer. The increase of absorber layer thickness from 0.2 - 2 µm showed an upward trend in the cell’s performance, while the increase of defect density and operating temperature showed a downward trend in solar cell performance. This study illustrates that the proposed cell structure shows higher cell performances and can be fabricated on the lab-scale and industrial levels.

关键词： n-Si p-CIGS 1D-SCAPS Thin-Films In2S3

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Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi Wang gary J.Melnick Jin-Zeng Li gary A.Fuller Jinjin Xie national Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsinghua University Beijing 100084China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center for Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite(SWAS)*** obtained an averaged O_(2)spectrum based on this sample using the(SWAS)survey data(O_(2),487.249 GHz,n=3-1,J=3-2).no emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m *** a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O_(2)abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM:molecules galaxies:abundances ISM:lines and bands Galaxy:abundances

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Electronic properties of 2D materials and their junctions

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nano Materials Science 2024年第1期6卷 1-23页

作者： Taposhree Dutta neha Yadav Yongling Wu gary J.Cheng Xiu Liang Seeram Ramakrishna Aoussaj Sbai Rajeev Gupta Aniruddha Mondal Zheng Hongyu Ashish Yadav Department of Chemistry Indian Institute of Engineering Science and TechnologyShibpurWest Bengal711103India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Industrial Engineering Purdue University315 N.Grant St.West LafayetteIN47907United States Birck nanotechnology Center Purdue University1205 W State St.West LafayetteIN47907United States Advanced Materials Institute Qilu University of TechnologyShandong Academy of SciencesJinan250014PR China nanoscience and nanotechnology Initiative National University of Singapore10 Kent Ridge Crescent119260Singapore Faculty of Applied Phsyics and Mathematics Gdansk University of Technology Narutowicza 11/1280233GdanskPoland Department of Physics School of EngineeringUniversity of Petroleum&Energy StudiesDehradun248007UttarakhandIndia Department of Physics National Institute of Technology DurgapurDurgapur713209West BengalIndia

With an extensive range of distinctive features at nano meter-scale thicknesses,two-dimensional(2D)materials drawn the attention of the scientific *** tremendous advancements in exploratory research on 2D materials,knowledge of 2D electrical transport and carrier dynamics still in its ***,here we highlighted the electrical characteristics of 2D materials with electronic band structure,electronic transport,dielectric constant,carriers *** atomic thinness of 2D materials makes substantially scaled field-effect transistors(FETs)with reduced short-channel effects conceivable,even though strong carrier mobility required for high performance,low-voltage device *** also discussed here about factors affecting 2D materials which easily enhanced the activity of those materials for various ***,Those 2D materials used in state-of-the-art electrical and optoelectronic devices because of the extensive nature of their electronic band structure.2D materials offer unprecedented freedom for the design of novel p-n junction device topologies in contrast to conventional bulk *** also,describe the numerous 2D p-n junctions,such as homo junction and hetero junction including mixed dimensional ***,we talked about the problems and potential for the future.

关键词： 2D materials Electrical properties p-n junctions Mixed hereto junctions Homo junctions Electrical transport

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Management of obstructed colorectal carcinoma in an emergency setting:An update

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： Efstathios T Pavlidis Ioannis n Galanis Theodoros E Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(CT),CT colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed since it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficulties in dissecting the distended colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma Emergency surgery Colectomy Intraluminal metal stents

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Predictors of survival in autoimmune liver disease overlap syndromes

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World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUnD Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(Pn patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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