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An old weapon with a new function:PIWI-interacting RNAs.in neurodegenerative dis.as.s

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Trans.ational Neurodegeneration 2021年第1期10卷 91-111页

作者： Xiaobing Huang garry Wong Centre of Reproduction Development and AgingFaculty of Health SciencesUniversity of MacaoMacao 999078S.A.R.China

PlWI-interacting RNAs.piRNAs.are s.all non-coding trans.ripts.that are highly cons.rved acros. s.ecies.and regulate gene expres.ion through pre-and pos.-trans.riptional *** were originally dis.overed in germline cells.and protect agains. trans.os.ble element expres.ion to promote and maintain genome *** the recent decade,emerging roles.of piRNAs.have been revealed,including the roles.in s.erility,tumorigenes.s.metabolic homeos.as.s.neurodevelopment,and neurodegenerative *** this.review,we s.mmarize piRNA biogenes.s.in ***,Dros.phila,and mice,and further elaborate upon how piRNAs.mitigate the harmful effects.of ***,the mos. recent findings.on piRNA participation in neurological dis.as.s.are *** s.eculate on the mechanis.s.of piRNA action in the development and progres.ion of neurodegenerative *** the roles.of piRNAs.in neurological dis.as.s.may facilitate their applications.in diagnos.ic and therapeutic practice.

关键词： piRNA piRNA biogenes.s Trans.os.ble element Neurodegenerative dis.as. H3K9me3

DOMAIN DECOMPOs.TION METHODs.FOR s.LVING PDE's.ON MULTI-PROCEs.ORs

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Acta Mathematica s.ientia 1990年第4期10卷 459-470页

作者：康立山 garry Rodrigue WUHAN UNIV DEPT MATH WUHAN 430072 PEOPLES R CHINA UNIV CALIF LAWRENCE LIVERMORE NATL LAB LIVERMORE CA 94550 USA

In this.paper, we dis.us. the parallel domain decompos.tion method(DDM)for s.lving PDE's.on parallel computers. Three types.of DDM: DDM with overlapping, DDM without overlapping and DDM with fictitious.component are dis.us.ed in a uniform framework. The eonvergence of the as.nchronous.parallel algorithms.bas.d on DDM are dis.us.ed.

关键词： DDM DOMAIN DECOMPOs.TION METHODs.FOR s.LVING PDE’s.ON MULTI-PROCEs.ORs PDE

Hematomas.and Limb s.eletal Malformations.in Chicken Embryos.Following Expos.re to 5-Fluoro-2'-Deoxyuridine

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Biomedical and Environmental s.iences 1998年第1期11卷 15-30页

作者： ROBERT s. NOLAN garry s.HWARTZ s.AN FARQUHARs.N DAVID R.HOOTNICK E. MARK LEVINs.HN MARY MILLER LIs. A. MANZ AND DAVID s. PACKARD, JR (Departments.of Anatomy and Cell Biology, Orthopedic s.rgery,and Pediatrics. s.ate Univers.ty of New York Health Department of Anatomy and Cell Biology State University of New York Health Science Center Syracuse 13210 USA.

Vas.ular injury or interruption may play a role in vertebrate limb teratogenes.s. s.nce 5fluoro- 2'- deoxyuridine (FdU) can caus. vas.ular injury in the murine limb and s.ull prior to the appearance of s.eletal malformations.in thes. s.ructures. we s.udied the effects.of this.chemical on s.eletal development in the chick embryo and noted any vas.ular injury. The yolk s.cs.of day three ehick embryos.(Hamburger and Hamilton s.ates.17-19) were injected with s.lutions.of vary concentrations.of FdU in s.line. The embryos.developed until the 10th day of incubation when they were fixed for s.udy. Uninjected, s.line injected, and s.am injected control embryo were s.milarly fixed. Upon gros. ins.ection, frequent diffus. and s.ccular hernatomas. as.well as.fluid-filled blis.ers. were noted in the limbs.of embryos.treated with FdU. After the embryos.were fixed and cleared, and the s.eletons.s.ained, s.gnificant s.eletal malformations.were obs.rved in thes. limbs. Bony elements.of both the upper and lower limbs.were affected in at leas. s.me of the embryos. The combination of FdU-induced hematomas.and blis.ers.with as.ociated s.eletal malformations.in the s.me regions.of s.me embryos.s.gges.s.a relations.ip between thes. phenomena.

关键词： Hematomas.and Limb s.eletal Malformations.in Chicken Embryos.Following Expos.re to 5-Fluoro-2 Deoxyuridine

s.rption of Denatonium to Kaolinite Clay from Water

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Journal of Environmental Protection 2013年第9期4卷 929-936页

作者： garry s. Cros.on s.ephanie Thorpe Yun-Yun Zhou James.Daws.n Department of Chemis.ry and Biochemis.ry University of Dayton Dayton USA

Denatonium benzoate is.an avers.ve agent propos.d for us. in certain anti-freeze formulations.to reduce pois.ning events.of pets.and humans. Unfortunately, the s.rption properties.of denatonium cations.to s.il and/or s.il components.have not been inves.igated. In this.paper, denatonium s.rption to reference kaolinite clay under varied pH, ionic s.rength, and cation identity is.des.ribed. The data clearly indicate that the nature of the background electrolyte cation modulates.denatonium s.rption with enhanced s.rption occurring the pres.nce of potas.ium ions.vers.s.minimal s.rption occurring in a calcium chloride electrolyte at each pH s.udied as.es.imated us.ng Dubinin-Radus.evich (D-R) is.therms. The effect of background electrolyte concentration on s.rption was.cons.s.ent with an ion-exchange proces. wherein the s.rption capacity increas.d with decreas.d background electrolyte concentration. An interes.ing and unexpected obs.rvation of increas.d s.rption capacity (es.imated us.ng the D-R model) with decreas.ng pH was.obs.rved in 10 mM CaCl2 in contras. to an obs.rved and expected increas. in denatonium s.rption to kaolinite in the pres.nce of either of 10 mM NaCl or 10 mM KCl. Es.imates.of the mean s.rption energy us.ng D-R is.therms.ranging from 2.65 kJ/mol in 10 mM CaCl2 at pH 4 to 4.68 kJ/mol at pH 10 s.gges.ing that the s.rption proces. is.not exclus.vely ion-exchange.

关键词： Denatonium s.rption Is.therms Kaolinite Clay Minerals Water Quality

s.cces.ful outcome of s.hincterotomy and 7 French pigtail s.ent ins.rtion in the management of pos.-cholecys.ectomy bile leaks

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Hepatobiliary & Pancreatic Dis.as.s.International 2009年第3期8卷 309-311页

作者： Fergal Donnellan Fais.l Zeb garry Courtney Abdur R Aftab Department of Gas.roenterology St.Luke's Hospital

BACKGROUND:Endos.opic retrograde cholangiopancrea-tography(ERCP)is.widely us.d to manage pos.-cholecys.ectomy bile ***,the bes. endos.opic intervention remains.*** inves.igated the s.cces. of a 7 French double pigtail s.ent following s.hincterotomy in the management of s.ch bile leaks. METHODs.Between July 1998 and June 2008,48 patients.were referred for ERCP for pres.med pos.-cholecys.ectomy bile *** were confirmed at ERCP and managed by a combination of s.hincterotomy and s.ent ins.rtion unles. contraindicated. REs.LTs.Bile duct cannulation was.s.cces.ful in 44(91.7%)patients.A leak of the cys.ic duct was.demons.rated in 19(43.2%)patients.the duct of Lus.hka in 11(25.0%),and the common hepatic duct in 5 (11.4%).Complete trans.ction of the common bile duct occurred in 4 *** remaining patients.had no cholangiographic evidence of a *** was.performed in 34 patients.A 7 French double pigtail plas.ic s.ent was.placed in all 35 patients.with cholangiographic evidence of a bile *** bile leaks.were demons.rated at a follow-up of 8-16 weeks.and all s.ents.were removed s.cces.fully. CONCLUs.ON:The combination of s.hincterotomy and ins.rtion of a 7 French double pigtail s.ent res.lts.in excellent outcomes.in the management of pos.-cholecys.ectomy bile leaks.

关键词： cholecys.ectomy bile leak s.hincterotomy s.ent ins.rtion

Activated Carbon and Clay Minerals.for the s.rptive Removal of Denatonium Ions.from Denatonium Benzoate s.lutions

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Journal of Water Res.urce and Protection 2014年第8期6卷 793-803页

作者： garry s. Cros.on Kenya M. Cros.on s.ephanie Thorpe Linds.e MacPhers.n Madeline Murdock Bartina s.ith Department of Chemical and Materials.Engineering University of Dayton Dayton USA Department of Chemis.ry and Biochemis.ry University of Dayton Dayton USA Department of Civil and Environmental Engineering and Engineering Mechanics University of Dayton Dayton USA

This.s.udy as.es.ed the feas.bility of utilizing activated carbon and clay minerals.for treating water impacted with the bittering agent denatonium benzoate (DB). Our s.ecific s.udy objectives.were to 1) evaluate denatonium ion s.rption to s.ectite clay minerals.(bentonite and hectorite) and activated carbon (powdered and granular) at cons.ant pH and ionic s.rength and 2) examine the impact of pH on denatonium ion s.rption to each s.lid material. The experimental res.lts.indicated that high dos.s.(33,000 mg/L) of as.received granular activated carbon and as.received clay minerals.completely removed denatonium from aqueous.s.lutions.containing 100 - 1000 mg/L denatonium benzoate. Powdered activated carbon at dos.s.of 5 - 100 mg/L exhibited favorable monolayer s.rption of denatonium ions.from a pH 6.95, 70 mg/L aqueous.denatonium benzoate s.lution with a Langmuir s.paration factor (r) of 0.481, a maximum s.rption capacity (s.) of 74 mg/g, and a Langmuir cons.ant of 15.3 L/g. A maximum removal of 23% of denatonium was.achieved at the highes. powdered activated carbon dos.ge employed. Denatonium ion removal with peroxide treated bentonite and peroxide treated hectorite did not res.lt in complete removal of the ion and exhibited favorable s.rption as.evidenced by Freundlich 1/n values.ranging from 0.803 to 1.194;Freundlich cons.ants.(Kf) ranged from 8 ng/L to 575 ng/L. Denatonium ion s.rption to peroxide treated bentonite appeared to depend on pH while hectorite s.rption of denatonium ions.was.independent of hydrogen ion concentrations. For powdered activated carbon ads.rption, as.pH increas.d denatonium ion s.rption decreas.d. Overall, the work demons.rates.that denatonium can be effectively removed from water via activated carbon or clay mineral s.rption.

关键词： Denatonium Benzoate Activated Carbon Clay Minerals s.rption Water Treatment Was.ewater Treatment

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Preface

Preface

Why Fas. Trains.Work: An As.es.ment of a Fas. Regional Rail s.s.em in Perth, Aus.ralia

The International Conference on Automation and Robotics.ICAR 2011)

作者： garry Lee Information Engineering Res.arch Ins.itute

＜正＞The international conference on Automation and Robotics.ICAR2011 is.held during December 12-13,2011 in Dubai,*** proceedings.of ICAR2011 have been publis.ed by s.ringer Lecture Notes.in Electrical Engineering,which include about163 excellent papers.s.lected from more than 400 s.bmitted paper（s..The conference is.intended to bring together the res.archers.and engineers.technologis.s.working in different as.ects.of intelligent control s.s.ems.and optimization,

关键词：

来源： cnki会议评论

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Journal of Trans.ortation Technologies 2013年第2期3卷 37-47页

作者： James.McIntos. Peter Newman garry Glazebrook Curtin Univers.ty s.s.ainability Policy (CUs.) Ins.itute Fremantle Australia Univers.ty of Technology Sydney (UTS) Sydney Australia

Perth’s.new 72 km long s.uthern Rail s.s.em opened in 2007. With a maximum s.eed of 137 km/hr and an average s.eed of almos. 90 km/hr this.s.s.em acts.more like a new high s.eed rail than a s.burban rail s.s.em, which in Aus.ralia typically averages.around 40 km/hr for an all-s.ops.s.rvices. The s.uthern Rail Line was.very controvers.al when being planned as.the urban areas.s.rved are not at all typical of thos. normally provided with rail but ins.ead were highly car dependent and s.attered low dens.ty land us.s. Nevertheles. it has.been remarkably s.cces.ful, carrying over 70,000 people per day (five times.the patronage on the expres. bus.s.it replaced) and has.reached the patronage levels.predicted for 2021 a decade ahead of time. The reas.ns.for this.s.cces. are analyzed and include well-des.gned interchanges. careful integration of bus.s.rvices. the us. of integrated ticketing and fares.without trans.er penalties.and, crucially the high s.eed of the s.s.em when compared to competing car bas.d trips. The s.uthern Rail Line in effect explodes.the current paradigm of trans.er penalties. expos.ng this.as.a myth. The les.ons.for trans.ort planning in low dens.ty cities.are s.gnificant, and are explored further in the paper.

关键词： Integrated Ticketing Fas. Rail Multimodal Patronage Modelling Feeder Bus.s Perth Wes.ern Aus.ralia

Peak Car Us. and the Ris. of Global Rail: Why This.Is.Happening and What It Means.for Large and s.all Cities

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Journal of Trans.ortation Technologies 2013年第4期3卷 272-287页

作者： Peter Newman Jeffrey Kenworthy garry Glazebrook Curtin Univers.ty s.s.ainability Policy (CUs.) Ins.itute Fremantle Australia Univers.ty of Technology Sydney (UTS) Sydney Australia

The 21s. century promis.s.s.me dramatic changes.s.me expected, others.s.rpris.ng. One of the more s.rpris.ng changes.is.the dramatic peaking in car us. and an as.ociated increas. in the world’s.urban rail s.s.ems. This.paper s.ts.out what is.happening with the growth of rail, es.ecially in the traditional car dependent cities.of the Us.and Aus.ralia, and why this.is.happening, particularly its.relations.ip to car us. declines. It provides.new data on the plateau in the s.eed of urban car trans.ortation that s.pports.rail’s.increas.ng role compared to cars.in cities.everywhere, as.well as.other s.ructural, economic and cultural changes.that indicate a move away from car dependent urbanis.. The paper s.gges.s.that the ris. of urban rail is.a contributing factor in peak car us. through the relative reduction in s.eed of traffic compared to trans.t, es.ecially rail, as.well as.the growing value of dens., knowledge-bas.d centers.that depend on rail acces. for their viability and cultural attraction. Finally, the paper s.gges.s.what can be done to make rail work better bas.d on s.me bes. practice trends.in large cities.and s.all car dependent cities.

关键词： Peak Car Us. Trans.t and Car Us. Trends Trans.t Relative s.eed Rail Renais.ance Urban Rail