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Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai GUO Chang-ya liU gao-hui li Jian-ping XIANG Xiao-chang LENG Yi-ke CAI Xue-bin HU Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

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Material flow behavior and microstructural evolution during refill friction stir spot welding of alclad 2A12-T4 aluminum alloy

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International Journal of Minerals,Metallurgy and Materials 2021年第1期28卷 131-141页

作者： gao-hui li li Zhou ling-yun Luo Xi-ming Wu Ning Guo State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology(WeihaiWeihai)264209China

In this study, we used the stop-action technique to experimentally investigate the material flow and microstructural evolution of alclad 2A12-T4 aluminum alloy during refill friction stir spot *** are two material flow components, i.e., the inward-or outward-directed spiral flow on the horizontal plane and the upward-or downward-directed flow on the vertical *** the plunge stage, the flow of plasticized metal into the cavity is similar to that of a stack, whereby the upper layer is pushed upward by the lower *** the refill stage, this is process *** such, there is no obvious vertical plasticized metal flow between adjacent *** leads to the coarsening of S(Al2CuMg) in the thermo-mechanically affected zone and the diminishing of S in the stir *** dynamic recrystallization results in the formation of fine equiaxed grains in the stir zone, but this process becomes difficult in the thermo-mechanically affected zone due to the lower deformation rate and the pinning action of S precipitates on the dislocations and sub-grain boundaries, which leads to a high fraction of low-angle grain boundaries in this zone.

关键词： refill friction stir spot welding aluminum alloy material flow behavior precipitate evolution dislocation configuration

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Effect of tool plunge depth on the microstructure and fracture behavior of refill friction stir spot welded AZ91 magnesium alloy joints

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 699-709页

作者： Hai-feng Zhang li Zhou Wen-lin li gao-hui li Yi-tang Tang Ning Guo Ji-cai Feng Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology at WeihaiWeihai 264209China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

We used refill friction stir spot welding(RFSSW)to join 2-mm-thick AZ91D-H24 magnesium alloy sheets,and we investigated in detail the effect of tool plunge depth on the microstructure and fracture behavior of the joints.A sound joint surface can be obtained using plunge depths of 2.0 and 2.5 *** depth was found to significantly affect the height of the hook,with greater plunge depths corresponding to more severe upward bending of the hook,which compromised the tensile-shear properties of the *** hardness reached a minimum at the thermo-mechanically affected zone due to the precipitation phases of this zone as it dissolved into theα-matrix during the welding *** fracture modes of RFSSW joints can be divided into three types:shear fracture,plug fracture,and shear–plug *** these,the joint with a shear–plug fracture exhibited the best tensile-shear load of 6400 N.

关键词： refill friction stir spot welding AZ91 magnesium alloy microstructure fracture behavior

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拉贝洛尔配合硝苯地平治疗妊娠期高血压的效果

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中国现代药物应用 2024年第5期18卷 11-15页

作者：胡坤盛晓斌高慧丽胡愔北京市石景山医院妇产科 100042

目的观察在妊娠期高血压的治疗中实施拉贝洛尔配合硝苯地平治疗所取得的临床效果。方法 78例妊娠期高血压患者,随机分为对照组和观察组,各39例。对照组给予拉贝洛尔治疗,观察组给予拉贝洛尔联合硝苯地平治疗。比较两组新生儿不良结局... 详细信息

目的观察在妊娠期高血压的治疗中实施拉贝洛尔配合硝苯地平治疗所取得的临床效果。方法 78例妊娠期高血压患者,随机分为对照组和观察组,各39例。对照组给予拉贝洛尔治疗,观察组给予拉贝洛尔联合硝苯地平治疗。比较两组新生儿不良结局、不良妊娠结局、药物不良反应发生情况、临床疗效以及治疗前后血液流变学(全血低切粘度、全血高切粘度、血浆粘度)、血压[收缩压(SBP)、舒张压(DBP)]、24 h尿蛋白定量。结果观察组新生儿不良结局发生率7.69%低于对照组的25.64%(P<0.05)。观察组患者不良妊娠结局发生率10.26%低于对照组的28.21%(P<0.05)。治疗后,观察组患者SBP(120.56±6.65)mm Hg(1 mm Hg=0.133 kPa)、DBP(86.25±6.52)mm Hg、24 h尿蛋白定量(1.04±0.32)g/24 h低于对照组的(132.45±9.23)mm Hg、(98.45±7.12)mm Hg、(1.63±0.39)g/24 h(P<0.05)。观察组药物不良反应发生率5.13%低于对照组的23.08%(P<0.05)。观察组患者全血高切粘度(3.05±0.26)mPa·s、全血低切粘度(11.10±1.25)mPa·s、血浆粘度(1.32±0.12)mPa·s低于对照组的(4.99±0.44)、(14.87±2.05)、(1.88±0.21)mPa·s(P<0.05)。观察组患者生理功能评分(22.59±1.32)分、心理功能评分(23.65±2.64)分、躯体功能评分(22.46±1.45)分、社会功能评分(22.63±1.45)分均高于对照组的(17.56±1.41)、(18.45±3.52)、(15.96±1.52)、(17.52±1.36)分(P<0.05)。观察组患者治疗总有效率94.87%高于对照组的79.49%(P<0.05)。结论在妊娠期高血压治疗中实施拉贝洛尔配合硝苯地平治疗效果突出,推荐应用于临床。

关键词：妊娠期高血压拉贝洛尔硝苯地平血压不良反应

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Weyl Type Theorem for Bounded linear Operator and Its Functional Calculus

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Acta Mathematica Sinica,English Series 2024年第2期40卷 528-536页

作者： gao hui Zi FENG Peng Tong li School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

Let H be a complex infinite dimensional Hilbert space and B(H)be the algebra of all bounded linear operators on *** this paper,we mainly study the operators that satisfy both a-Weyl's theorem and property(R).Also,the operators whose functional calculus satisfies the two properties are also *** give the features for the operator or its functional calculus for which both a-Weyl's theorem and property(R)hold.

关键词： a-Weyl's theorem property(R) functional calculus

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Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 35-42页

作者： li-li Miao Jing-Wen Wang hui-hui liu Shuai gao Yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Hepatology Shandong UniversityJinan 250012China

Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC). Methods: We enrolled 197 patients, 111 with HBV-HCC, 51 with chronic hepatitis B(CHB), and 35 healthy controls(HCs). The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs) was identified by methylation specific polymerase chain reaction(MSP). The mRNA expression was examined using real-time quantitative polymerase chain reaction(q PCR). Results: The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0%) compared to that in CHB patients(68.6%) and HCs(74.3%)( P < 0.001). The methylated group had lower alanine aminotransferase level( P = 0.035) and lower rates of tumor node metastasis(TNM) Ⅲ/Ⅳ( P = 0.043) and T3/T4( P = 0.026). TNM stage was identified to be an independent factor for GLDC promoter methylation. GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients( P = 0.022 and P < 0.001, respectively). GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters( P = 0.003). The diagnostic accuracy of alpha-fetoprotein(AFP) combined with GLDC promoter methylation for HBV-HCC was improved compared with that of AFP alone(AUC: 0.782 vs. 0.630, P < 0.001). In addition, GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients( P = 0.038). Conclusions: The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs. The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.

关键词： Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells

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Research on a Monte Carlo global variance reduction method based on an automatic importance sampling method

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Nuclear Science and Techniques 2024年第5期35卷 200-215页

作者： Yi-Sheng Hao Zhen Wu Shen-Shen gao Rui Qiu hui Zhang Jun-li li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging of Ministry of Education Beijing 100084China Nuctech Company limited Beijing 100084China

Global variance reduction is a bottleneck in Monte Carlo shielding *** global variance reduction problem requires that the statistical error of the entire space is *** study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program *** proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation *** results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% *** demonstrates that the grid-AIS method is effective in addressing global *** results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational ***,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.

关键词： Monte Carlo Global variance reduction Reactor shielding Automatic importance sampling

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Effect of TiO_(2) addition on microstructures and properties of Mgo-Cao refractory aggregates

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Journal of Iron and Steel Research International 2024年第6期31卷 1547-1554页

作者： Shuai Zhang Jing-ran Wang Yuan-gao li Feng-you li Wen Yan hui-ying Shi The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Joint International Research Laboratory of Refractories and Metallurgy Wuhan 430081HubeiChina Shanxi Luweibao Taigang Refractory Co. Ltd.Taiyuan 030003ShanxiChina

MgO-CaO(40 wt.%CaO)refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO_(2) as *** effect of TiO_(2) on their phase composition,microstructures and properties was investigated by X-ray diffraction and scanning electron *** properties such as bulk density,apparent porosity,relative aggregate tube strength and hydration resistance were also *** results showed that the CaTiO_(3) generated by the reaction between CaO and TiO_(2) was distributed around the CaO grain boundaries and intermittently distributed with MgO,which formed an isolation layer around CaO and greatly improved the hydration ***,the introduction of TiO_(2) promoted sintering and increased the grain size,further improving the strengths and hydration resistance of the *** addition,the most significant enhancement in the hydration resistance and strengths of the samples was achieved when 1.0-2.0 wt.%TiO_(2) was *** this case,the relative strength of aggregate increased from 33.3% to 37.3%-43.1%,and the mass gain after the hydration test decreased from 3.13% to 1.26%-1.45%.

关键词： MgO-CaO refractory aggregate TiO_(2)addition Phase composition Microstructure Hydration resistance

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Difference schemes on non-uniform mesh and their application

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Progress in Natural Science:Materials International 2004年第10期14卷 8-14页

作者： MA Yanwen ,gao hui,FU Dexun and li Xinliang (Laboratory of Nonlinear Mechanics,Institute of Mechanics,Chinese Academy of Sciences,Beijing100080,China) Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

High order accurate schemes are needed to simulate the multi-scale complex flow fields to get fine structures in simula-tion of the complex flows with large gradient of fluid parameters near the wall,and schemes on non-uniform mesh are desirable for many CFD(computational fluid dynamics)*** construction methods of difference approximations and several difference approxima-tions on non-uniform mesh are *** accuracy of the methods and the influence of stretch ratio of the neighbor mesh increment on accuracy are *** comments on these methods are given,and comparison of the accuracy of the results obtained by schemes based on both non-uniform mesh and coordinate transformation is made,and some numerical examples with non-uniform mesh are present-ed.

关键词： scheme on non-uniform mesh high order accurate scheme compact difference approximation

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Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental Sciences 2024年第2期37卷 133-145页

作者： liU Xiao CAO Ying liN Xiao Wan gao Dan Yang MIAO hui hui li Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ***,the underlying mechanism is yet *** study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive *** Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control *** tests were conducted 24 h before surgery and 6,9,and 24 h after *** C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala *** In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for *** changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of *** Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of *** identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker

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