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Passive activity enhances residual control ability in patients with complete spinal cord injury

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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ras癌基因与肺癌

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昆明医学院学报 2000年第3期21卷 73-77页

作者：高金莉金克炜昆明医学院病理学教研室昆明650031

就目前ras癌基因突变与肺癌的关系方面的国内外研究进展作一简要综述

关键词： ras癌基因肺癌基因突变

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基于降维理论的本体映射算法

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西北师范大学学报（自然科学版） 2011年第4期47卷 52-55页

作者：徐天伟甘健侯高丽金高炜云南师范大学信息学院云南昆明650092 苏州大学数学科学学院江苏苏州215006

通过建立多本体间的映射,实现多本体间的相互操作.将多本体图中每个顶点对应的信息用一个向量表示,通过计算多本体图中每对顶点的欧式距离建立一个连通的本体图,利用谱聚类降维方法将本体图中每个顶点的数据信息降为一维,从而通过顶点... 详细信息

通过建立多本体间的映射,实现多本体间的相互操作.将多本体图中每个顶点对应的信息用一个向量表示,通过计算多本体图中每对顶点的欧式距离建立一个连通的本体图,利用谱聚类降维方法将本体图中每个顶点的数据信息降为一维,从而通过顶点对应的实数间的差值判断来自不同本体顶点间的相似程度,进而建立本体映射.实验结果表明,新算法能较好解决已有文献中存在的问题,在结构存在差异的本体间建立映射是有效的.

关键词：本体映射概念相似度降维理论欧式距离拉普拉斯Beltrami算子

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脑脊液神经蛋白质对临床拟诊Creutzfeldt—Jakob病的早期诊断价值

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中华神经科杂志 2007年第4期40卷 253-256页

作者：林世和于雪凡孙瑞红高金立吉林大学第一医院神经科长春130021

目的探讨和比较数种神经蛋白质对 Creutzfeldt-Jakob 病(CJD)的早期诊断价值。方法对14例发病2个月内 CJD 取脑脊液,采用蛋白捕捉法和酶联免疫试验对总 tau 蛋白(t-tau)、磷酸化 tau 蛋白(p-tau)、t-tau 蛋白与 p-tau 蛋白比值(t-tau/p-... 详细信息

目的探讨和比较数种神经蛋白质对 Creutzfeldt-Jakob 病(CJD)的早期诊断价值。方法对14例发病2个月内 CJD 取脑脊液,采用蛋白捕捉法和酶联免疫试验对总 tau 蛋白(t-tau)、磷酸化 tau 蛋白(p-tau)、t-tau 蛋白与 p-tau 蛋白比值(t-tau/p-tau)、S-100β蛋白、14-3-3蛋白及14-3-2蛋白进行定量检测,同时设非 CJD 痴呆(OD,11例)和无痴呆(ND,18例)的对照组。结果 (1)t-tau蛋白:CJD 组、OD 组和 ND 组分别是8295、300、161 pg/ml。p-tau/t-tau 值分别是0.0092、0.2258、0.2471。(2)S-100β蛋白:CJD 组、OD 组、ND 组分别是1.576、0.639、0.239 ng/ml。(3)14-3-3蛋白:CJD 组、OD 组、ND 组分别是40.00、2.65、3.10 ng/ml。(4)14-3-2蛋白:CJD 组、OD 组与 ND 组分别是48.43、14.00、20.50 ng/ml。(5)t-tau≥500 pg/ml 为阈值点,敏感度为84.6%,特异度87.5%,p-tau 无诊断意义;(6)S-100B 蛋白≥1.626 ng/ml 为阈值点,敏感度为92.3%,特异度为83.8%;(7)14-3-3蛋白以≥9 ng/ml 为阈值点,敏感度为86.7%,特异度为86.4%;(8)14-3-2蛋白以≥24 ng/ml 为阈值点,其敏感度为78.6%,特异度为77.3%。结论脑脊液神经蛋白质检测对散发性 Creutzfeldt-Jakob病的早期诊断有一定价值。

关键词：克-亚综合征 14-3-3蛋白质类 tau蛋白质类 S100蛋白质类早期诊断

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水下运动体体效应内波理论分析研究

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水动力学研究与进展（A辑） 2012年第4期27卷 471-477页

作者：洪方文姚志崇高丽瑾王小青中国船舶科学研究中心无锡214082 中国科学院电子学研究所北京100190

基于势流理论对分层流中运动物体产生的内波进行了分析,其中采用线性自由面条件,通过傅里叶变换法,建立了体效应内波的预报模型,并对跃变分层中水下卵形体的内波进行了计算和分析。计算结果与文献理论结果吻合良好,表明了本研究建立的... 详细信息

基于势流理论对分层流中运动物体产生的内波进行了分析,其中采用线性自由面条件,通过傅里叶变换法,建立了体效应内波的预报模型,并对跃变分层中水下卵形体的内波进行了计算和分析。计算结果与文献理论结果吻合良好,表明了本研究建立的体效应内波预报模型的正确性。

关键词：水下运动体体效应内波理论分析

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RE-SEGNN:recurrent semantic evidence-aware graph neural network for temporal knowledge graph forecasting

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Science China(Information Sciences) 2025年

作者： Wenyu CAI Mengfan li Xuanhua SHI Yuanxin FAN Quntao ZHU Hai jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and Technology

Temporal knowledge graph(TKG) reasoning, has seen widespread use for modeling real-world events, particularly in extrapolation settings. Nevertheless, most previous studies are embedded models, which require both entity and relation embedding to make predictions, ignoring the semantic correlations among different entities and relations within the same timestamp. This can lead to random and nonsensical predictions when unseen entities or relations occur. Furthermore, many existing models exhibit limitations in handling highly correlated historical facts with extensive temporal depth. They often either overlook such facts or overly accentuate the relationships between recurring past occurrences and their current counterparts. Due to the dynamic nature of TKG, effectively capturing the evolving semantics between different timestamps can be *** address these shortcomings, we propose the recurrent semantic evidenceaware graph neural network(RE-SEGNN), a novel graph neural network that can learn the semantics of entities and relations simultaneously. For the former challenge, our model can predict a possible answer to missing quadruples based on semantics when facing unseen entities or relations. For the latter problem, based on an obvious established force, both the recency and frequency of semantic history tend to confer a higher reference value for the current. We use the Hawkes process to compute the semantic trend, which allows the semantics of recent facts to gain more attention than those of distant facts. Experimental results show that RE-SEGNN outperforms all SOTA models in entity prediction on 6 widely used datasets, and 5 datasets in relation prediction. Furthermore, the case study shows how our model can deal with unseen entities and relations.

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