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城市公交管理的Stackelberg博弈模型

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交通运输系统工程与信息 2009年第3期9卷 121-127页

作者：孙连菊高自友北京交通大学轨道交通控制与安全国家重点实验室北京100044 曲阜师范大学运筹与管理学院山东日照276826

公交市场上运营者之间的自由竞争往往会走入"囚徒困境",即所达到的Nash平衡不是Pareto最优.针对此,本文引入公交管理者进行宏观调控使运营者走出困境.本文首先建立了描述管理者与运营者之间的动态调整过程的Stackelberg博弈模型.鉴于该... 详细信息

公交市场上运营者之间的自由竞争往往会走入"囚徒困境",即所达到的Nash平衡不是Pareto最优.针对此,本文引入公交管理者进行宏观调控使运营者走出困境.本文首先建立了描述管理者与运营者之间的动态调整过程的Stackelberg博弈模型.鉴于该双层模型的复杂性,文中将下层广义Nash均衡博弈模型转化成变分不等式问题,并讨论了博弈均衡解的存在性.然后给出了增广Lagrange罚函数算法及其收敛性结论.最后给出具体算例.

关键词：公共交通 Stackelberg博弈间隙函数增广Lagrange罚函数

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彩色身份证件照片的混合压缩算法

计算机学报 2000年第3期23卷 334-334,F003页

作者：郭田德高自友北方交通大学交通运输学院北京100044

提出了一个彩色身份证件照片的混合压缩算法 .该算法把 FC2 VQ(Feature Correction tow- stage VectorQuantization)算法和著名的 EZW类算法结合在一起 ,充分利用这两类算法的优点对彩色身份证件照片进行压缩 ,得到一幅视觉效果最好的... 详细信息

提出了一个彩色身份证件照片的混合压缩算法 .该算法把 FC2 VQ(Feature Correction tow- stage VectorQuantization)算法和著名的 EZW类算法结合在一起 ,充分利用这两类算法的优点对彩色身份证件照片进行压缩 ,得到一幅视觉效果最好的压缩照片 .在个人身份证件实验系统中 ,用这种算法将一幅 96× 12 8的 2 4- b彩色照片连同两枚指纹的特征数据及必要的个人信息存储在一个 PDF417二维条形码 (存储空间为 10 2 4个字节 )中 ,照片的重建质量可以接受 .

关键词：彩色照片压缩混合算法图像处理身份证件照片

Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity

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Science China(Life Sciences) 2024年第1期67卷 51-66页

作者： Yonghui Jiang Xueying gao Yue Liu Xueqi Yan Huangcong Shi Rusong Zhao zi-Jiang Chen Fei gao Han Zhao Shigang Zhao Center for Reproductive Medicine Shandong UniversityJinan 250012China Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250012China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250012China National Research Center of Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215000China Center for reproductive medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200127China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of ScienceBeijing 100101China

Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive *** ovary,as one of the primary regulators of female fertility,is a complex organ comprised of heterogeneous cell types that work together to maintain a normal ovarian microenvironment(OME).Despite its importance,the effect of obesity on the entire ovary remains poorly *** this study,we performed ovary single-cell and nanoscale spatial RNA sequencing to investigate how the OME changed under different kinds of obesity,including high-fat diet(HFD)induced obesity and Leptin ablation induced obesity(OB).Our results demonstrate that OB,but not HFD,dramatically altered the proportion of ovarian granulosa cells,theca-interstitial cells,luteal cells,and endothelial ***,based on the spatial dynamics of follicular development,we defined four subpopulations of granulosa cell and found that obesity drastically disrupted the differentiation of mural granulosa cells from small to large antral ***,HFD enhanced follicle-stimulating hormone(FSH)sensitivity and hormone conversion,while OB caused decreased sensitivity,inadequate steroid hormone conversion,and impaired follicular *** differences can be explained by the differential expression pattern of the transcription factor ***,our study provides a powerful and high-resolution resource for profiling obesity-induced OME and offers insights into the diverse effects of obesity on female reproductive disorders.

关键词： obesity ovarian microenvironment snRNA-seq Stereo-seq Foxo1

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城市混合交通条件下路段阻抗函数的研究

交通运输系统工程与信息 2008年第1期8卷 68-73页

作者：四兵锋钟鸣高自友北京交通大学轨道交通控制与安全国家重点实验室北京100044 加拿大新布瑞克大学土木工程系加拿大

在充分分析了城市混合交通网络中主要交通方式(包括小汽车、公交车以及自行车)的运行特性,包括运行速度、平均乘客人数以及道路资源的占用率等的基础上,从出行者的出行需求的角度出发,考虑了不同道路条件下不同流量之间相互影响的因素,... 详细信息

在充分分析了城市混合交通网络中主要交通方式(包括小汽车、公交车以及自行车)的运行特性,包括运行速度、平均乘客人数以及道路资源的占用率等的基础上,从出行者的出行需求的角度出发,考虑了不同道路条件下不同流量之间相互影响的因素,构造了城市混合交通网络的路段阻抗函数形式,并对其中的相关参数的标定方法进行了说明.

关键词：混合交通阻抗函数流量分配网络

Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao you Yue XU Shu-juan ZHANG Ye-hao CHEN Yuan-yuan XIN gao-jie LIU zi-xin REN Jun-guo CAO Ce LI Ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing Key Laboratory of Chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–160 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-18, IL-1β, monocyte chemotactic protein 1(MCP-1), tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1(Caspase-1), GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β, MCP-1, TNF-α and IL-6(P<0.01 or P<0.05). At the same time, by inhibiting NLRP3/Caspase-1/GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1, GSDMD and GSDMD-N proteins(P<0.01). Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： Chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

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Petroleum Science 2024年第4期21卷 2625-2637页

作者： Zhi-Qiang He He-Ping Xie Ling Chen Jian-Ping Yang Bo Yu zi-Jie Wei Ming-Zhong gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and Hydropower Sichuan University Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green Energy College of Civil and Transportation Engineering Shenzhen University School of Mechanical Engineering Sichuan University College of Polymer Science and Engineering Sichuan University

Deep oil and gas reservoirs are under high-temperature conditions, but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability, resulting in distorted resource assessments. The development of in situ temperaturepreserved coring(ITP-Coring) technology for deep reservoir rock is urgent, and thermal insulation materials are key. Therefore, hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) were proposed as thermal insulation materials. The materials properties under coupled hightemperature and high-pressure(HTHP) conditions were tested. The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased; additionally,increasing temperature accelerated the process. High temperatures directly caused the thermal conductivity of the materials to increase; additionally, the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity. High temperatures weakened the matrix, and high pressures destroyed the HGM, which resulted in a decrease in the tensile mechanical properties of the materials. The materials entered the high elastic state at 150.C, and the mechanical properties were weakened more obviously, while the pressure led to a significant effect when the water absorption was above 10%. Meanwhile, the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86% at 100.C and 100 MPa, respectively, which meet the application requirements of the self-designed coring device. Finally, K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100.C and 100 MPa. To further improve the materials properties, the interface layer and EP matrix should be optimized. The results can provide references for the optimization and engineering application of materials and thus technical su

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring (ITP-Coring) Hollow glass microsphere/epoxy resin thermal insulation materials (HGM/EP materials) High-temperature and high-pressure (HTHP) Physical and mechanical properties

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同一尺寸货物三维装箱问题的一种启发式算法

信息与控制 2005年第4期34卷 490-494页

作者：隋树林邵巍高自友北京交通大学交通运输学院北京100044 青岛科技大学自主导航与智能控制研究所山东青岛266042

给出了集装箱装载同一尺寸长方体货物问题的一种启发式算法.该算法解决了许多三维装箱算法计算量大、排列不规则等缺点,同时用计算机编程实现该算法,并与国内主要装箱软件作了对比,最后给出了该算法的可行性与优势.

关键词：集装箱启发式算法三维装箱问题

基于不确定旅客需求的高速铁路鲁棒列车开行方案研究

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交通运输系统工程与信息 2022年第1期22卷 115-123页

作者：张春田戚建国杨立兴高原高自友北京交通大学交通运输学院北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044 北京理工大学管理与经济学院北京100081

针对现实中旅客需求的不确定性,将旅客需求划分为必须满足的确定性旅客需求和可适当满足的波动性旅客需求,以极小化铁路运营公司总运营成本为目标,利用轻鲁棒技术,构建不确定旅客需求下高速铁路鲁棒列车开行方案优化模型。本文所提出的... 详细信息

针对现实中旅客需求的不确定性,将旅客需求划分为必须满足的确定性旅客需求和可适当满足的波动性旅客需求,以极小化铁路运营公司总运营成本为目标,利用轻鲁棒技术,构建不确定旅客需求下高速铁路鲁棒列车开行方案优化模型。本文所提出的优化模型无需事先给出线路备选集,只需提前输入铁路走廊相关参数和旅客需求分布,即可得到旅客需求驱动的列车开行方案,避免了备选集合设置不合理对列车开行方案质量的影响。另外,通过引入线性化技术将模型转化为整数线性规划模型,利用MATLAB平台调用GUROBI进行求解。最后,将模型应用到武汉-广州高速铁路走廊上,验证了其有效性。结果表明,优化后的方案能更好地处理旅客出行需求的不确定性,为编制高速铁路鲁棒列车开行方案提供一定的理论依据。

关键词：铁路运输列车开行方案不确定旅客需求轻鲁棒技术

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时变网络环境下旅行商问题研究

系统工程学报 2010年第5期25卷 585-591页

作者：李妍峰李军高自友北京交通大学系统科学研究所北京100044 西南交通大学经济管理学院四川成都610031

对时变旅行商问题进行描述,提出处理一般跨时段的新方法,并建立数学模型.在求解方法上构造动态搜索优化算法ds-k-opt(k=2,2.5,3)求解该问题.通过实验仿真,大部分动态搜索优化算法解质量优于动态规划启发式算法,且求解规模更大.动态搜索... 详细信息

对时变旅行商问题进行描述,提出处理一般跨时段的新方法,并建立数学模型.在求解方法上构造动态搜索优化算法ds-k-opt(k=2,2.5,3)求解该问题.通过实验仿真,大部分动态搜索优化算法解质量优于动态规划启发式算法,且求解规模更大.动态搜索优化算法解随k值增大而更优,算法运行时间也随之增加.

关键词：时变旅行商问题跨时段动态搜索优化算法动态规划启发式