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Time trends and disparities of obesity and related national policies and programs in Nepal:a systematic review

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Global Health Journal 2024年第2期8卷 46-57页

作者： Junxiang Wei Peng Nie Liwang gao {2. Mi Youfa wang Department of Obstetrics Northwest Women's and Children's HospitalXi'anShaanxiChina School of Economics and Finance Xi'an Jiaotong UniversityXi'anShaanxiChina Center for Non-Communicable Disease Management Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Global Health Institute No.21 Hongren BuildingWest China Science and Technology lnnovation Harbour(iHarbour)Xi'anShaanxiChina School of Public Health Xi'an Jiaotong UniversityXi'anShaanxiChina

Objective Overweight and obesity prevalence has increased in low-income *** study systematically reviewed the obesity trend,disparities,and prevention and control efforts in *** We searched PubMed and Google Scholar for articles and reports published between January 1,2.04 and December 31,*** information on National policies and programs related to obesity prevention was retrieved from governmental websites and consultation with relevant *** and obesity were defined using the World Health Organization body mass index cut ***-two studies and reports were *** Overall,overweight and obesity rates increased in all groups in Nepal although nationally representative data remained *** combined overweight and obesity(OW/OB)and obesity rates in women aged 15-49 years increased from 8.5%to 2..2.and from 0.9%to 5.1%between 2.06 and 2.16,***/OB and obesity rates in men were 17.1%and 2.5%based on data from the 2.16 Demographic and Health ***/OB rate in under-five children increased from 0.6%to 2.8%between 2.06 and *** rates for school-age(5-9 years)boys and girls in 2.16 were 2.4%and 2.8%,respectively,and were 1.1%and 1.4%for male and female adolescents aged 10-19 years,***/OB prevalence was much higher among women,residents in urban areas and central provinces,and in higher socioeconomic status *** prevalence of OW/OB and obesity for 2.30 in adults aged 15-49 was 44.7%and 8.3%,respectively,while it was 2.2.for OW/OB in preschool *** and direct interventions that specifically focused on obesity prevention and control are *** OW/OB prevalence in Nepal has increased during the past 1.8 decades,disproportionately affecting population *** interventions mostly focused on undernutrition with some indirect implications for obesity *** the future,Nepal needs to develop population-based programs for obesity

关键词： Nutrition transition Overweight Obesity Obesity prevention Systematic review Nepal

Transport network and flow mechanism of shallow ore-bearing magma in Tongling ore cluster area

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science china Earth sciences 2006年第4期49卷 397-407页

作者： DENG Jun1,2. wang Qingfei1,2., HUANG Dinghua3 , WAN Li4, yang Liqiang1,2.& {2. Bangfei1,2.1. State Key Laboratory of Geological Processes and Mineral Resources, china university of Geosciences, beijing 100083, china 2. Key Laboratory of Lithosphere Tectonics and Lithoprobing Technology of Ministry of Education, china university of Geo- sciences, beijing 100083, china 3. Faculty of Earth sciences, china university of Geosciences, Wuhan 430074, china 4. School of Mathematics and Information science, Guangzhou university, Guangzhou 510405, china 1. State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China 2. Key Laboratory of Lithosphere Tectonics and Lithoprobing Technology of Ministry of Education China University of Geosciences Beijing 100083 China 3. Faculty of Earth sciences China University of Geosciences Wuhan 430074 China 4. School of Mathematics and Information science Guangzhou University Guangzhou 510405 China

Abundant studies revealed that shallow intrusions of the Yanshanian epoch resulted in the mass mineralization of the Tongling region. Various evidences showed there existed a concealed magma chamber at ?10 km depth in the middle part of this region during Yanshanian epoch, from which the ore-forming magma was generated and then transported to the superficial layer. Yet the transport network and flow mechanism of the shallow ore-bearing magma, the key problem associ- ated with ore-forming process, was relatively little focused on. Integrate analysis of structural me- chanics, statistical fractal and geological facts suggested that NE trending high-angle fold-related thrust faults and the tessellated basement ones served as the main pathways for the shallow magma’s transporting, moreover, the saddle void spaces among adjacent strata in the folds upon this fault system provided the place for magma’s emplacement. So the folds in the upper part and faults in the lower part of the upper crust constituted the fluid’s transport and emplacement network. During the deformation of geologic body with multi-layer structure, the layers in the upper part tended to fold when received the jacking stress from the lower part, while the lower one inclined to fault undergoing loads of the upper part. And the producing probability of this structure assemblage was highly in- creased in the condition, such as in the Tongling area, that the mechanic rigidity of the lower layers was stronger than that of the upper ones. For the pre-existence of fluid-conducting network, the top magma with high volatile in the magma chamber transported rapidly to the superficial layer in dyking pattern, located in the void spaces of folds, filled and reconstructed them. The sudden drop of pres- sure caused the fluid unmixing from the magma and mass ore-forming elements concentration. Pulse activity of the dyking may be the principal reason why magmatic bodies in the Tongling area were spatially-temporally con

关键词： Tongling, structural network, magma intrusion, fractal, dyke.

Status of study on biological and toxicological effects of nanoscale materials

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science china Chemistry 2005年第5期48卷 385-394页

作者： wang Bing1, FENG Weiyue1, ZHAO Yuliang1, XING Gengmei1, CHAI Zhifang1, wang Haifang2.& JIA Guang3 1. Laboratory for Bio-Environmental Health {2.s of Nanoscale Materials (Nanosafety Lab), Institute of High Energy Physics, Chi-nese Academy of {2.s, beijing 100049, china 2. college of Chemistry and Molecular Engineering, Peking university, beijing 100871, china 3. Department of Occupational and Environmental Health {2.s, School of Public Health, Peking university,{12., china 1. Laboratory for Bio-Environmental Health sciences of Nanoscale Materials (Nanosafety Lab) Institute of High Energy Physics Chinese Academy of Sciences 100049 Beijing China 2. college of Chemistry and Molecular Engineering Peking University 100871 Beijing China 3. Department of Occupational and Environmental Health sciences School of Public Health Peking University 100083 Beijing China

Because the physical and chemical properties of nanosized materials mostly differ from the existing microsized materials, their potential impacts on human health and the envi-ronment will be topics under the serious discussions in press and in a number of international scientific journals. We analyze and summarize the existing data of the experimental study on the biological activities and adverse effects of nanoscale materials/particles including single wall carbon nanotubes, multi wall carbon nanotubes, titanium oxide and iron powders. Though some biological behaviors of nanoscale materials observed cannot be understood on the basis of the current knowledge, as the existing data are mostly preliminary, it is too early to make some ex-clusive conclusions on biological activities (or the toxicity) of any of nanoscale materials. The experimental techniques, the current topics, and the future research directions for this new re-search field are also discussed.

关键词： nanomaterials, single wall carbon nanotubes, multi wall carbon nanotubes, titanium oxide and iron, biological activity and toxicological effect.

PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han Zhang Kai gao Shuang wang Yue-Hua Zhang Zhi-Xian {2. Ye Wu Yu-Wu Jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2.related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(2..7%,8/30),and levetiracetam(2.%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***2.3Trp and PACS2.*** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:10582.380-106107443,2.6 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2.were quite limited but located in different regions.A CNV destroying part of the PACS2.gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2

Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor

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science china Chemistry 2007年第5期50卷 665-674页

作者： HU JianPing1,2. CHANG Shan1, CHEN WeiZu1 & wang CunXin1 1 college of Life {2. and Bioengineering, beijing university of Technology, beijing 10002., china 2.Department of Chemistry & Life {2.s, Leshan Normal university, Leshan 614004, china college of Life science and Bioengineering Beijing University ofTechnologyBeijing 100022China Department of Chemistry & Life sciences Leshan NormalUniversityLeshan 614004China

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the lifecycle of this virus and also an important target for the study of anti-HIV drugs. The binding mode of the wild type IN core domain and its G140S mutant with L-Chicoric acid (LCA) inhibitor were investigated by using multiple conformation molecular docking and molecular dynamics (MD) simulation. Based on the binding modes, the drug resistance mechanism was explored for the G140S mutant of IN with LCA. The results indicate that the binding site of the G140S mutant of IN core domain with LCA is different from that of the core domain of the wild type IN, which leads to the partial loss of inhibition potency of LCA. The flexibility of the IN functional loop region and the interactions between Mg2. ion and the three key residues (i.e., D64, D116, E152. stimulate the biological operation of IN. The drug resistance also lies in several other important effects, such as the repulsion between LCA and E152.in the G140S mutant core domain, the weakening of K159 binding with LCA and Y143 pointing to the pocket of the G140S mutant. All of the above simulation results agree well with experimental data, which provide us with some helpful information for designing the drug of anti-HIV based on the structure of IN.

关键词： molecular docking, MD simulation, HIV-1 IN, drug design

Analysis and Key Parameter Optimization Design of Leningrader Seal Performance

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Wuhan university Journal of Natural sciences 2024年第2期29卷 177-192页

作者： yang Dongya wang Xuelin wang Feng ZHANG Hailong gao Gui college of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050Gansu China Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325000ZhejiangChina State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000GansuChina

In order to improve the performance and service life of the Leningrader seal of the Stirling engine piston rod,interference,pre-load and friction coefficient were taken as influencing factors,and the curved surface response method was adopted to reduce the contact stress of sealing surface and von Mises stress of the sealing sleeve as the response index,with the optimization goal of reducing wear and extending *** above three key parameters are analyzed and optimized,the influence of each parameter on the sealing performance and service life is obtained,and the best combination scheme of the three is *** results show that the interaction between pre-tightening force and interference fit has the greatest impact on contact *** interaction between interference fit and friction coeffi-cient has the most significant effect on von Mises *** optimized parameters can reduce the maximum contact stress and maximum von Mises stress of the sealing sleeve by 2..3%and 2..6%,respectively,under a media pressure of 5-9 *** bench verification shows that the leakage of the optimized sealing device in 12.h is reduced by 0.44 cc·min^(-1)(1 cc=1 cm^(3)).The wear rate of the sealing sleeve is 1.08%before optimization and 0.45%after optimization,indicating that the optimized parameters in this paper are effective.

关键词： Leningrader seal Stirling engine performance analysis optimized design parameter configuration

Reduced analysis and confirmatory research on co-adaptability theoretical solution to conflicting events in construction engineering projects

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science china(Technological sciences) 2010年第2期53卷 480-485页

作者： HOU XueLiang1 , LU Mei2.& wang Kai3 1 School of Business Administration, North china Electric Power {2., beijing 102.06, china 2.Department of Construction Management, Tsinghua {2., beijing 100084, china 3 college of Management, beijing Jiaotong {2., beijing 100084, china 1. School of Business Administration North China Electric Power University Beijing 102206 China2. Department of Construction Management Tsinghua University Beijing 100084 China3. College of Management Beijing Jiaotong University Beijing 100084 China

The co-adaptability theoretical solution to conflicting events in construction engineering projects has three problems. First, the transformation of constraint conditions of theoretical solution is very difficult in practical engineering applications; second, some coefficients are difficult to be determined; third, there are overfull circular arithmetic operations involved in it. To resolve these problems, a new method to reduce the theoretical solution complications is proposed. By analyzing the operating mechanism of theoretical solution model, redundancies in the theoretical solution can be eliminated, and the ISM mapping with the co-adaptability solution can be set up. Based on this approach, a procedure to solve practical conflicting events in construction projects is established by replacing characteristic variables with mathematic variables. The research results show that the procedure can replace the co-adaptability theoretical solution effectively and solve practical conflicting events in construction projects.

关键词： construction project conflict theoretical solution reduced analysis ISM confirmatory research

Spectral observation of symmetry-protected selection rules for dynamical high-dimensional parity in alignment magnetic resonance

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science china(Physics,Mechanics & Astronomy) 2024年第10期67卷 1-11页

作者： Xu-Xing Geng Kai Jin Lu Zhou wang-wang Tang Guoqing {2. Shangqing Liang Shao-Ping Wu Guang-Ming Huang gao-Xiang Li Department of Physics Huazhong Normal UniversityWuhan 430079China college of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

Multidimensional Floquet-driven alignment systems with dynamical symmetry present various exotic phenomena and ***,there are challenges in directly characterizing large-spin dynamical symmetry from ***,we first observe the symmetry-protected selection rules of dynamical high-dimensional parity in a large-spin(F=4)*** theoretically construct a Floquet-driven alignment system that can be used to reveal high-dimensional spatiotemporal *** the experiment,the system is implemented in Cs atomic gas subjected to two-dimensional Floquet-modulated magnetic resonance *** developing Floquet detection protocols of alignment double-sided spectra,we directly verify symmetry-protected selection rules of dynamical high-dimensional parity for large-spin *** work advances the exploration of dynamical symmetry to large spins,and unravels a universal Floquet scheme for the investigation of symmetry-protected selection rules.

关键词： dynamical high-dimensional symmetry symmetry-protected selection rules large-spin alignment magnetic resonance,Floquet two-mode detection

Atomistic origin of high grain boundary resistance in solid electrolyte lanthanum lithium titanate

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Journal of Materiomics 2024年第6期10卷 1214-1221页

作者： Shang Peng Yongjin Chen Xuefeng Zhou Mingxue Tang Jianbo wang Hua wang Lin Guo Lujun Huang Wenge {2. Xiang gao Center for High Pressure science and Technology Advanced Research(HPSTAR) Beijing100094China School of Physics and Technology Center for Electron MicroscopyMOE Key Laboratory of Artificial Micro-and Nano-structuresand Institute for Advanced StudiesWuhan UniversityWuhan430072China School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100191China School of Materials science and Engineering Harbin Institute of TechnologyP.O.Box 433Harbin150001China

Lanthanum lithium titanate is one of the promising electrolytes for solid-state lithium-ion batteries due to its high bulk ionic conductivity up to∼10^(−3) S/***,the practical application of this material has been bottlenecked by high grain boundary(GB)resistance,while the underlying mechanism is still under *** we report a comprehensive study with direct evidence to reveal the origin of high GB resistance in La_(2.3)–xLi_(3x)TiO_(3)(LLTO).Atomic-scale observations via advanced scanning transmission electron microscopy show that the GBs are uniformly subject to subsurface segregation of La atoms to compensate for the excess surface *** La segregation leads to an abrupt decrease of charge carrier concentration neighboring GBs and hence is supposed to have deleterious effect on GB *** findings suggest a novel mechanism of space-charge-induced cation segregation,which shed lights on the intrinsic origin of low GB ionic conductivity in LLTO.

关键词： Space-charge layer Cation segregation Intergranullar glassy film Solid-state electrolyte Ionic conductivity