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Chinese Medical Journal 2024年第7期137卷 871-873页

作者： Zhenfa Hu Kai Su Huihui Miao xue gao Fushan xue Ming Tian Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Airway management is closely related to the safety and quality of *** 2015,the Difcult Airway Society suggested that endotracheal intubation should beberoptic bronchoscope(FOB)-guided and blind intubation should be *** supraglottic airway device(SAD)BlockBuster^(TM)with matched tracheal tube(Block-Buster^(TM)tracheal tube,BTT;Tuoren Medical Instrument Co.,Ltd.,Changyuan,Henan,China)is an improved second-generation SAD with intubation function.[1,2]Theberscope-monitored intubation via SAD BlockBuster^(TM)can make the whole process ***,we investigated the feasibility,success rate,and complications of the new intubation technique in a well-positioned SAD BlockBuster^(TM)by sequential case observation.

关键词： intubation airway supra

Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

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Journal of Bionic Engineering 2024年第3期21卷 1397-1411页

作者： Jiaqi Liu Guiwei Li He Liu Jincheng Wang Hui Wang xue gao Qingping Liu Chenyu Wang Department of Plastic and Reconstructive Surgery The First Hospital of Jilin UniversityChangchun130021China Department of Orthopaedics The Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130022China

The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient ***,there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional(4D)*** groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external ***,implants crafted using 4D printing offer significant potential for dynamic *** by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation *** choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human *** attribute allowed for temperature-responsive intraoperative self-deformation and postoperative *** chosen animal model for experimentation was *** into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior *** prostheses were then surgically implanted in a minimally invasive manner into the rabbit ***,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days *** histological evaluations confirmed the practical viability of these prostheses in a living *** research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

关键词： 4D printing Shape memory polyurethane Rhinoplasty Self-deformation Dynamic aesthetic adjustment

Prescreening of large-effect markers with multiple strategies improves the accuracy of genomic prediction

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Journal of Integrative Agriculture 2024年第5期23卷 1634-1643页

作者： Keanning Li Bingxing An Mang Liang Tianpeng Chang Tianyu Deng Lili Du Sheng Cao Yueying Du Hongyan Li Lingyang Xu Lupei Zhang xue gao Junya LI Huijiang gao Laboratory of Molecular Biology and Bovine Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China College of Computer and Information Engineering Tianjin Agricultural UniversityTianjin 300384China College of Animal Science and Technology Qingdao Agricultural UniversityQingdao 266109China Tongliao Animal Agriculture Development Service Center Tongliao 028000China

Presently,integrating multi-omics information into a prediction model has become a ameliorate strategy for genomic selection to improve genomic prediction ***,we set the genomic and transcriptomic data as the training population data,using BSLMM,TWAS,and eQTL mapping to prescreen features according to |β_(b)|>0,top 1%of phenotypic variation explained(PVE),expression-associated single nucleotide polymorphisms(eSNPs),and egenes(false discovery rate(FDR)<0.01),where these loci were set as extra fixed effects(named GBLUP-Fix)and random effects(GFBLUP)to improve the prediction accuracy in the validation population,*** results suggested that both GBLUP-Fix and GFBLUP models could improve the accuracy of longissimus dorsi muscle(LDM),water holding capacity(WHC),shear force(SF),and pH in Huaxi cattle on average from 2.14 to 8.69%,especially the improvement of GFBLUP-TWAS over GBLUP was 13.66%for *** methods also captured more genetic variance than *** study confirmed that multi-omics-assisted large-effects loci prescreening could improve the accuracyofgenomic prediction.

关键词： multi-omics data features prescreening eQTL mapping Huaxi cattle genomic selection

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

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Journal of Pharmaceutical Analysis 2024年第1期14卷 86-99页

作者： Shengyou Li xue gao Yi Zheng Yujie Yang Jianbo gao Dan Geng Lingli Guo Teng Ma Yiming Hao Bin Wei Liangliang Huang Yitao Wei Bing Xia Zhuojing Luo Jinghui Huang Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi'an710032China

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid peroxidation. However, the molecular mechanisms of ferroptosis in the context of PNI and nerve regeneration remain unclear. Ferroportin (Fpn), the only known mammalian nonheme iron export protein, plays a pivotal part in inhibiting ferroptosis by maintaining intracellular iron homeostasis. Here, we explored in vitro and in vivo the involvement of Fpn in neuronal ferroptosis. We first delineated that reactive oxygen species at the injury site induces neuronal ferroptosis by increasing intracellular iron via accelerated UBA52-driven ubiquitination and degradation of Fpn, and stimulation of lipid peroxidation. Early administration of the potent arterial vasodilator, hydralazine (HYD), decreases the ubiquitination of Fpn after PNI by binding to UBA52, leading to suppression of neuronal cell death and significant acceleration of axon regeneration and motor function recovery. HYD targeting of ferroptosis is a promising strategy for clinical management of PNI.

关键词： Ferroptosis UBA52 Ferroportin Ubiquitination Hydralazine Peripheral nerve injury

Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-Yao Huang Ya-Ru Wang Jun Li Shi-Long Han Hao Xi Wen-xue gao Ying-Yu Cui Ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report

农地经营规模对农业碳排放的影响效应及地区异质性分析

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中国农机化学报 2024年第6期45卷 303-311页

作者：高雪吴丽丽东北大学秦皇岛分校经济学院河北秦皇岛066004 武汉工程大学管理学院武汉市430205

减少农业碳排放对于加快促进我国“双碳”目标的实现具有重要现实意义。利用固定效应模型、中介效应模型,采用2000—2022年省际面板数据,考察农地规模经营对农业碳排放的影响效应与作用机制,并进行地区异质性分析。研究发现:农地经营规... 详细信息

减少农业碳排放对于加快促进我国“双碳”目标的实现具有重要现实意义。利用固定效应模型、中介效应模型,采用2000—2022年省际面板数据,考察农地规模经营对农业碳排放的影响效应与作用机制,并进行地区异质性分析。研究发现:农地经营规模每扩大1%,农业的碳排放量将减少0.01%。其机制在于,农地经营规模通过农用化学品投入强度、农业技术进步、种植结构这三个中介变量来发挥作用。具体而言,农地经营规模每扩大1%,农用化学品投入强度将降低0.06%、农业技术进步增加0.69%、种植结构则呈“趋粮化”,而且这些变化有利于农业碳减排。分地区来看,农地经营规模扩大会显著降低东部地区、东北地区的农业碳排放,但会提升西部地区的农业碳排放。由此,促进我国农业低碳发展,要引导农业生产者适当扩大农地经营规模,降低化肥用量和采纳低碳生产技术。

关键词：农地经营规模农业技术进步农业碳排放地区异质性

Application of alginate in inflammatory bowel disease

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Biomedical Engineering Communications 2024年第2期3卷 10-16页

作者： Rui-xue Kang Ying Zhuang Ming-Jie Liu Qi Han Wei-Li Zhang Wei-Yu Fan xue gao Jia-Zheng Zhou Jian-Bin Zhang Collage of Pharmacy Dalian Medical UniversityDalian 116044China Laboratory Animal Center Dalian Medical UniversityDalian 116044China

Inflammatory bowel disease(IBD)represents a chronic inflammatory condition profoundly impacting the gastrointestinal *** prevalence has markedly risen in both developed and developing nations over recent *** the absence of definitive etiological elucidation,therapeutic strategies predominantly revolve around pharmacological interventions aimed at symptom ***(AG)is a polysaccharide of marine origin that has garnered significant attention due to its inherent biocompatibility,pH sensitivity,and *** exploration within drug delivery systems for IBD treatment stems from its natural sourcing,non-cytotoxic nature,and economic ***,AG demonstrates facile interpolymeric cross-linking,facilitating the formation of a cohesive network conducive to sustained drug release ***-based carrier systems for sustained drug release,and targeted drug delivery have been widely *** article reviews the pathogenesis of IBD and the current drugs,AG-based drug delivery systems and their properties in alleviating *** prospect of further development of AG in the field of biopharmaceutical and drug delivery is prospected.

关键词： alginate inflammatory bowel disease drug delivery

Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy

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Genes & Diseases 2024年第4期11卷 61-64页

作者： xue gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang Jinyuan Yang Yijin Chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang Yongyi Yuan Pu Dai College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic Diseases State Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China Beijing Key Lab of Hearing Impairment Prevention and Treatment Chinese PLA Medical SchoolBeijing 100853China Department of Otolaryngology PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关键词： auditory maintain potential

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中国式乡村体育现代化的内涵与推进路径

体育文化导刊 2024年第3期 8-15页

作者：高雪婷曹莉曲阜师范大学体育科学学院山东曲阜273165 山东师范大学体育学院济南250358

运用实地调研、文献资料、逻辑分析等方法,对中国式乡村体育现代化的内涵、现实困境与推进路径进行研究。内涵:促进村民主动健康,推进体育人口现代化;优化体育产业结构,筑牢乡村经济根基;弘扬乡村体育文化,助力村民精神富裕;贯彻落实生... 详细信息

运用实地调研、文献资料、逻辑分析等方法,对中国式乡村体育现代化的内涵、现实困境与推进路径进行研究。内涵:促进村民主动健康,推进体育人口现代化;优化体育产业结构,筑牢乡村经济根基;弘扬乡村体育文化,助力村民精神富裕;贯彻落实生态体育,打造绿色宜居乡村;统筹城乡体育融合,保障服务均衡可及。现实困境:体育人才匮乏和培养短板,体育产业转型与升级困难,体育文化互动与生产薄弱,生态体育空间与发展隐患,体育资源统筹与服务失衡。推进路径:培养“两懂两爱”体育人才,夯实乡村全民健康基础;创新聚合产业结构升级,科技赋能产业高质量发展;坚定文化自信自强自觉,驱动文化传承创造转化;推进生态体育绿色回归,赋能乡村宜居生活变革;健全乡村体育治理体系,促进体育服务平等共享。

关键词：中国式现代化乡村体育乡村体育现代化

电商直播情境下即时评论信息特性对顾客粘性的影响研究——基于情绪认知理论

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管理评论 2024年第3期36卷 119-131页

作者：焦媛媛高雪杜军南开大学商学院天津300071 天津大学管理与经济学部天津300072

在电商直播竞争激烈的背景下,如何留住顾客已成为其获取长期收益的主要难题,但现有研究聚焦于短期顾客行为的探讨,关于顾客粘性的探索十分匮乏。并且,现有研究大多分析了主播对顾客的影响,但顾客也会通过弹幕功能发布“即时评论信息”,... 详细信息

在电商直播竞争激烈的背景下,如何留住顾客已成为其获取长期收益的主要难题,但现有研究聚焦于短期顾客行为的探讨,关于顾客粘性的探索十分匮乏。并且,现有研究大多分析了主播对顾客的影响,但顾客也会通过弹幕功能发布“即时评论信息”,并对其他顾客产生重要影响。同时,相关研究探索了顾客认知因素的作用,顾客的情绪反应仍有待进一步讨论。因此,本文运用质性研究方法,识别出电商直播情境下即时评论信息包含同步性、诊断性、娱乐性、契合性和创新性这五种信息特性;进而以情绪认知理论为基础,构建“即时评论信息特性→情绪反应→顾客粘性”研究模型,揭示即时评论信息特性对顾客粘性的影响及其内在机理,为电商直播留住顾客提供实践启示。

关键词：电商直播顾客粘性即时评论信息特性情绪认知理论信息需求层次模型