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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu rong gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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Convergence in Distribution for Uncertain Random Sequences with Dependent Random Variables

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Journal of Systems Science & Complexity 2021年第2期34卷 483-501页

作者： gao rong AHMADZADE Hamed School of Economics and Management Hebei University of TechnologyTianjin 300401China Department of Mathematical Sciences University of Sistan and BaluchestanZahedanIran

Random variables and uncertain variables are respectively used to model randomness and uncertainty. While randomness and uncertainty always coexist in a same complex system. As an evolution of random variables and uncertain variables, uncertain random variable is introduced as a tool to deal with complex phenomena including randomness and uncertainty simultaneously. For uncertain random variables, a basic and important topic is to discuss the convergence of its ***, this paper focuses on studying the convergence in distribution for a sequence of uncertain random sequences with different chance distributions where random variables are not *** the result of this paper is a generalization of the existing literature. Relations among convergence theorems are studied. Furthermore, the theorems are explained by several examples.

关键词： Chance distribution convergence in distribution convergence in mean uncertain random variable

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On Stabilization of It Stochastic Time-Varying Systems

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Journal of Systems Science & Complexity 2017年第4期30卷 818-827页

作者： gao rong ZHANG Huanshui School of Control Science and Engineering Shandong UniversityJinan 250061China School of Mathematics and Statistics Science Ludong UniversityYantai 264025China

The stabilization with receding horizon control （RHC） of It5 stochastic time-varying systems is studied in this paper. Based on monotonically non-increasing of optimal cost and stochastic Lyapunov stability theory, a necessary and sufficient stabilization condition on the terminal weighting matrix is proposed, which guarantees the mean-square stability of the closed-loop system. The explicit receding horizon controller is obtained by employing stochastic maximum principle. Simulations demonstrate the effectiveness of the proposed method.

关键词： Mean-square stability receding horizon control stochastic time-varying system.

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On the Turán Density of Uniform Hypergraphs

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Acta Mathematicae Applicatae Sinica 2023年第3期39卷 638-646页

作者： An CHANG Guo-rong gao Center for Discrete Mathematics and Theoretical Computer Science Fuzhou UniversityFuzhou 350108China

Let p,q be two positive *** 3-graph F(p,q)is obtained from the complete 3-graph K_(p)^(3)by adding q new vertices and P_(q/2)new edges of the form vxy for which v∈V(K_p~3)and{x,y}are new *** frequently appears in many literatures on the Turán number or Turán density of *** this paper,we first construct a new class of r-graphs which can be regarded as a generalization of the 3-graph F(p,q),and prove that these r-graphs have the same Turán density under some ***,we investigate the Turán density of the F(p,q)for small p,q and obtain some new bounds on their Turán densities.

关键词： Hypergraph Turán density Bound

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Optimality conditions and duality for a class of nondifferentiable multiobjective generalized fractional programming problems

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 331-344页

作者： gao Ying rong Wei-dong School of Mathematical Sciences Inner Mongolia University Hohhot 010021 China

This paper studies a class of multiobjective generalized fractional programming problems, where the numerators of objective functions are the sum of differentiable function and convex function, while the denominators are the difference of differentiable function and convex function. Under the assumption of Calmness Constraint Qualification the Kuhn-Tucker type necessary conditions for efficient solution are given, and the Kuhn-Tucker type sufficient conditions for efficient solution are presented under the assumptions of （F, α, ρ, d）-V-convexity. Subsequently, the optimality conditions for two kinds of duality models are formulated and duality theorems are proved.

关键词： operations research multiobjective generalized fractional programming optimality condition duality theorem generalized convexity

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Extreme characteristics and causes of the drought event in the whole Yangtze River Basin in the midsummer of 2022

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Advances in Climate Change Research 2023年第5期14卷 642-650页

作者： Zhuo-Zhuo LYU Hui gao rong gao Ting DING Climate Studies Key Laboratory National Climate CenterChina Meteorological AdministrationBeijing 100081China Key Laboratory of Meteorological Disaster(KLME) Ministry of Education&Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China

Due to their huge socio-economic impacts and complex formation causes,extreme and continuous drought events have become the focus and nodus of research in recent *** the midsummer(July-August)of 2022,a severe drought event occurred in the whole Yangtze River Basin(YRB),*** that period,the precipitation in the upper,middle and lower reaches of the YRB dropped over 40%less than the 1961-2021 climatic mean,which had never happened ***,the temperature was the highest during *** record-breaking magnitude of less rainfall and high temperature directly led to the continuous development of this extreme drought *** atmospheric moisture budget analysis revealed that the YRB midsummer rainfall anomaly was dominated by the anomalous powerful vertical moisture advection,which was derived from the strongest descending motion over the whole YRB in the 2022 midsummer during *** western Pacific subtropical high(WPSH)during the midsummer remained stronger,more westward and lasted longer than the climatic *** a result,the whole YRB was controlled by a positive geopotential height *** evidence revealed that the anomalous subtropical zonal flow played a crucial role in inducing the extreme descent over the ***,the anomalous upper-tropospheric easterly flow over the YRB in 2022 is the strongest during 1981-2022,modulating the generation of the unprecedented descent anomaly over the *** likelihood that an integrated connection of severe drought in East Asia and flood in West Asia and northwestern South Asia would increase when the extremely strong easterly anomalies in the upper troposphere emerged and induced descending adiabatic flow on the eastern sides of the Tibetan *** results of this study can provide scientific insights into the predictability of extreme drought events and provide ways to improve predictions.

关键词： Yangtze River Basin Midsummer extreme drought Atmospheric circulations Zonal flow Water vapour budget Subtropical high

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American Barrier Option Pricing Formulas for Currency Model in Uncertain Environment

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Journal of Systems Science & Complexity 2022年第1期35卷 283-312页

作者： gao rong LIU Kaixiang LI Zhiguo LANG Liying School of Economics and Management Hebei University of TechnologyTianjin 300401China School of Management Science and Engineering Chongqing Technology and Business UniversityChongqing 400067China Hebei University of Technology Tianjin 300401China

Option pricing problem is one of the central issue in the theory of modern *** currency model has been put forward under the foundation of uncertainty theory as a tool to portray the foreign exchange rate in uncertain finance *** paper uses uncertain differential equation involved by Liu process to dispose of the foreign exchange *** an American barrier option of currency model in uncertain environment is *** important of all,the authors deduce the formulas to price four types of American barrier options for this currency model in uncertain environment by rigorous derivation.

关键词： Barrier option currency model option pricing uncertain process

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A necessary and sufficient stabilization condition for discrete time-varying stochastic systems with multiplicative noise

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Control Theory and Technology 2016年第2期14卷 151-158页

作者： rong gao Xiaohua LIU Huanshui ZHANG School of Control Science and Engineering Shandong University Jinan Shandong 250061 China School of Mathematics and Statistics Science Ludong University Yantai Shandong 264025 China

This paper investigates a fundamental problem of stabilization for time-varying multiplicative noise stochastic systems. A necessary and sufficient stabilization condition is presented based on the receding horizon approach. The explicit time-varying controller is designed if the condition is satisfied. The presented results are new to the best of our knowledge.

关键词： Receding horizon control time-varying stochastic system mean-square stability multiplicative noise

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RIVERINE INORGANIC CARBON DYNAMICS:OVERVIEW AND PERSPECTIVE

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Chinese Geographical Science 2006年第2期16卷 183-191页

作者： YAO Guan-rong gao Quan-zhou School of Geographical Science and Planning SUN Yat-Sen University Guangzhou 510275 P. R. China

Inorganic carbon, the great part of the riverine carbon exported to the ocean, plays an important role in the global carbon cycle and ultimately impacts the coupled carbon-climate system. An overview was made on both methods and results of the riverine inorganic carbon researches. In addition to routine in situ survey, measurement and calculation, the direct precipitation method and the gas evolution technique were commonly used to analyze dissolved inorganic carbon in natural water samples. Soil CO2, carbonate minerals and atmospheric CO2 incorporated into riverine inorganic car- bon pool via different means, with bicarbonate ion being the dominant component. The concentration of inorganic carbon, the composition of carbon isotopes （8^13C and △^14C）, and their temporal or spatial variations in the streams were controlled by carbon input, output and changes of carbon biogeochemistry within the riverine system. More accurate flux es- timation, better understanding of different influential processes, and quantitative determination of various inputs or outputs need to be well researched in future.

关键词： riverine inorganic carbon dissolved inorganic carbon dynamics flux

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Generalized Empirical Likelihood Inference in Semiparametric Regression Model for Longitudinal Data

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Acta Mathematica Sinica,English Series 2008年第12期24卷 2029-2040页

作者： gao rong LI Ping TIAN Liu Gen XUE College of Applied Sciences Beijing University of Technology Beijing 100022 P. R. China School of Finance and Statistics East China Normal University Shanghai 200241 P. R. China Department of Mathematics Xuchang University Xuchang 461000 P. R. China

In this paper, we consider the semiparametric regression model for longitudinal data. Due to the correlation within groups, a generalized empirical log-likelihood ratio statistic for the unknown parameters in the model is suggested by introducing the working covariance matrix. It is proved that the proposed statistic is asymptotically standard chi-squared under some suitable conditions, and hence it can be used to construct the confidence regions of the parameters. A simulation study is conducted to compare the proposed method with the generalized least squares method in terms of coverage accuracy and average lengths of the confidence intervals.

关键词： longitudinal data semiparametric regression model empirical likelihood confidence region

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