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Identification of novel genes associated with duck OASL in response to influenza A virus

Journal of Integrative Agriculture 2019年第7期18卷 1451-1459页

作者： WANG Xiao-xue LU Chang RONG En-guang HU Jia-xiang XING Yan-ling LIU Zheng-yu gao chu-ze LIU Jin-hua HUANG Yin-hua State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193P.R. China Key Laboratory of Animal Epidemiology and Zoonosis Ministry of Agriculture/College of Veterinary MedicineChina Agricultural UniversityBeijing 100193P.R.China

2′-5′-Oligoadenylate synthetase like protein(OASL) plays a key role in response to viral infections through selectively activating the OAS/RNase L or OASL/RIG-I signaling *** classic pathway of OASL is well-known,its regulated genes or co-actors are largely *** study the possible molecular mechanism of duck OASL(dOASL),we performed RNA-sequencing(RNA-seq) and immunoprecipitation and mass spectrometry(IP-MS) at the level of mRNA and protein,*** RNA-seq,we used DF1 cell lines(DF1 dO ASL+/+,DF1 cO ASL–/–,and DF1) with or without the CK/0513 H5 N1 virus(A/chicken/huabei/0513/2007) infection.1 737 differentially expressed genes(DEGs) were identified as candidate target genes regulated by *** Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and Weighted Correlation Network Analysis(WGCNA) were *** identified one important yellow co-expression module correlated with antiviral immune *** this module,Ankyrin repeat and FYVE domain containing 1(ANKFY1),harboring a BTB domain similar to the methyl CpG-binding protein 1(MBD1) which bound to OASL in human,was regulated by *** protein level,133 host proteins were ***,ANKFY1 was one of them binding to dOASL *** phylogenomic and chromosomal syntenic analysis demonstrated MBD1 was absent in birds,while mammals *** is suggested that OASL-ANKFY1 interaction might act as a compensatory mechanism to regulate gene expression in *** findings will provide a useful resource for the molecular mechanism research of dOASL.

关键词： duck OASL ANKFY1 compensatory mechanism influenza A virus

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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基于世界模拟的政治非稳态:Sora的智能影像生成与历史重塑

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 70-78页

作者：高奇琦台润泽华东政法大学政府管理学院上海201620 华东政法大学政治学研究院上海201620

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历... 详细信息

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历史真相和公众信任等带来挑战。文本介绍了Sora的技术背景,探讨了智能影像与虚假信息结合的风险。这一结合可能通过社会媒介影响公众信念和政治秩序,引发社会极化和分化。此外,在重塑历史记忆与认同时,可能导致信息的扭曲和伪造问题,或将社会推向政治非稳态。为应对技术带来的挑战,文本强调在迈向通用人工智能时代的过程中平衡技术创新与社会责任的重要性。通过深入分析Sora等智能影像生成的可能影响与挑战,提醒社会关注生成式人工智能技术的监管和伦理,确保技术发展的同时维护历史的真实性,保障社会福祉。

关键词： Sora 智能影像生成人工智能政治秩序

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主体结构荷载可控的新型组合式防护结构(Ⅱ)：影响因素及设计理念

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爆炸与冲击 2025年第1期45卷 011101-1-011101-12页

作者：方秦高矗孔祥振杨亚陆军工程大学爆炸冲击防灾减灾国家重点实验室江苏南京210007 内蒙古财经大学财政税务学院内蒙古呼和浩特010070

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响，充分发挥和合理利用泡沫混凝土良好的消波特性，首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响，并分析分层梯度泡沫混凝土在爆炸波... 详细信息

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响，充分发挥和合理利用泡沫混凝土良好的消波特性，首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响，并分析分层梯度泡沫混凝土在爆炸波作用下的消波特性。然后将组合式防护结构与采用中粗砂为分配层的传统成层式结构进行对比分析验证其优越性，在此基础上，总结凝练出组合式防护结构的主体结构荷载可控的设计理念。结果表明，利用泡沫混凝土材料较长的屈服平台和较低的波阻抗，以泡沫混凝土作为能量调控层，通过设计泡沫混凝土强度等级（密度等级）和厚度以及采用多层梯度泡沫混凝土，可使得作用于主体结构上的爆炸荷载峰值恰为泡沫混凝土屈服强度，实现对主体结构上荷载的可控设计，有效解决了中粗砂为分配层的传统成层式结构不易控制作用于主体结构上荷载的问题。研究结果可为抗新型钻地弹的防护设计提供重要参考。

关键词：泡沫混凝土组合式防护结构可控设计爆炸波消波

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Non-Gaussian Random Bi-matrix Models for Bi-free Central Limit Distributions with Positive Definite Covariance Matrices

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Acta Mathematica Sinica,English Series 2019年第12期35卷 1891-1905页

作者： Ming chu gao School of Mathematics and Information Science Baoji University of Arts and Sciences Department of Mathematics Louisiana College

In this paper,we construct random two-faced families of matrices with non-Gaussian entries to approximate a bi-free central limit distribution with a positive definite covariance *** prove that,under modest conditions weaker than independence,a family of random two-faced families of matrices with non-Gaussian entries is asymptotically bi-free from a two-faced family of constant diagonal matrices.

关键词： Bi-free central limit distributions non-Gaussian random matrices asymptotic bi-freeness

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The 2-pebbling Property for Dense Graphs

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Acta Mathematica Sinica,English Series 2013年第3期29卷 557-570页

作者： ze Tu gao Jian Hua YIN Department of Mathematics College of Information Science and Technology

Given a distribution of pebbles on the vertices of a connected graph G, a pebbling move on G consists of taking two pebbles off one vertex and placing one on an adjacent vertex. The pebbling number f（G） is the smallest number m such that for every distribution of m pebbles and every vertex v, a pebble can be moved to v. A graph G is said to have the 2-pebbling property if for any distribution with more than 2f（G） - q pebbles, where q is the number of vertices with at least one pebble, it is possible, using pebbling moves, to get two pebbles to any vertex. Snevily conjectured that G（s, t） has the 2- pebbling property, where G（s, t） is a bipartite graph with partite sets of size s and t （s 〉 t）. Similarly, the ~,pebbling number fl（G） is the smallest number m such that for every distribution of m pebbles and every vertex v, ~ pebbles can be moved to v. Herscovici et al. conjectured that fl（G） ≤ 1.5n ＋ 8l -- 6 for the graph G with diameter 3, where n = IV（G）I. In this paper, we prove that if s ≥ 15 and G（s,t）

关键词： Pebbling number 2-pebbling property bipartite graph

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Admissible Solutions of Systems of Complex Partial Difference Equations on C^n

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 297-306页

作者： Ling-yun gao ze-mei ZHENG Department of Mathematics Jinan University Guangzhou

In a recent papers,some authors applied Nevanlinna theory to prove some results on complex difference equations reminiscent of the classical Malmquist theorem in complex differential equations. We will mainly investigate Malmquist theorem of a type of systems of complex partial difference equations on Cn,improvements and extensions of such results are presented in this paper.

关键词： Malmquist type meromorphic solution value distribution partial difference equations

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Bio-inspired self-folding strategy to break the trade-off between strength and ductility in carbon-nanoarchitected materials

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npj Computational Materials 2020年第1期6卷 1558-1564页

作者： Xiangzheng Jia ze Liu Enlai gao Department of Engineering Mechanics School of Civil EngineeringWuhan UniversityWuhanHubei 430072China

Graphene possesses extraordinary mechanical,electronic,and thermal properties,thus making it one of the most promising building blocks for constructing macroscopic high performance and multifunctional ***,the common material strength–ductility paradox also appears in the carbon-nanoarchitected materials and some of the key mechanical performance,for example,the tensile strength of graphene-based materials,are still far lower than that of *** by the exceptional mechanical performance of silk protein benefiting from the conformations of folded structures as well as their transitions,this work proposed a topological strategy to yield graphene-based materials with ultrahigh ductility while maintaining decent tensile strength by self-folding graphene *** drastically improved mechanical performance of graphene-based materials is attributed to the exploitation of shearing,sliding,and unfolding deformation at the self-folded *** dynamics simulations show that both modulating self-folded length and engineering interface interaction can effectively control the strength,ductility,and the ductile failure of van der Waals interfaces among the self-folded structures,where interfacial shearing,sliding,and unfolding open channels to dissipate mechanical *** on the insights into the atomic-scale deformation by molecular dynamics simulations,the underlying mechanism of deformation and failure of these materials is finally discussed with a continuum mechanics-based *** findings bring perceptive insights into the microstructure design of strong-yet-ductile materials for load-bearing engineering applications.

关键词： strength ductility deformation

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Maps on Positive Cones of C^(*)-algebras

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Acta Mathematica Sinica,English Series 2023年第3期39卷 387-398页

作者： Ming chu gao Gui Mei AN Department of Mathematics Louisiana Christian UniversityPinevilleLA 71359USA School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071P.R.China

We prove that a surjective map(on the positive cones of unital C^(*)-algebras)preserves the minimum spectrum values of harmonic means if and only if it has a Jordan *-isomorphism extension to the whole *** represent weighted geometric mean preserving bijective maps on the positive cones of prime C^(*)-algebras in terms of Jordan *-isomorphisms of the *** also characterize order isomorphisms and orthoisomorphisms of the projection lattice of the von Neumann algebra of all bounded linear operators on a Hilbert space,answering an open question arisen by ***,we give a description for Fuglede-Kadison determinant preserving maps on the positive cone of a finite von Neumann algebra and improve Gaal and Nayak’s work on this topic.

关键词： Operator means preserving maps positive cones projection lattices Fuglede-Kadison Determinants

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Manufacture and characteristics of Al2O3 composite coating on steel substrate by SHS process

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Rare Metals 2019年第7期38卷 704-712页

作者： Hai-Dong gao ze-Hua Wang Jia Shao College of Mechanics and Materials Hohai University

Many steel components are needed to be reinforced on their surface to have a high abrasive resistance and corrosion resistance. Based on self-propagating hightemperature synthesis, a process to making Al2O3 composite coatings on mild steel substrate in atmospheric environment with the help of simple auxiliary facilities was developed successfully. A pre-coated bilayer coating was employed. The effects of Fe content in pre-coated transition layer on phase composition, porosity and interfacial bon ding were studied using scanning electron microscopy (SEM), energy-dispersive spectrum (EDS) and X-ray diffraction (XRD). The thermal shock resistance and abrasive resistance were investigated. When Fe content changes from 0 wt% to 50 wt%, the bond quality at first becomes better and then worse gradually. When Fe content is less 20 wt%, there is a small gap between the transition layer and the substrate;when Fe contents are 30 wt% and 40 wt%, working layer, the transition layer and the substrate bond together well. The working layer is mainly composed of Al2O3, Fe-Cr and Al(Cr)2O3 phases and has a dense structure with porosity of less than 1 %. The coating has a good thermal shock resistance and abrasive resistance. The abrasive resistance of the working layer is about ten times that of the substrate.

关键词： Al2O3 composite coating Self-propagating high-temperature synthesis Interfacial bonding Thermal shock resistance Abrasive resistance

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