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Picotesla-sensitivity microcavity optomechanical magnetometry

Light(Science & Applications) 2024年第11期13卷 2835-2846页

作者： Zhi-Gang Hu Yi-Meng gao Jian-Fei Liu Hao Yang Min Wang Yuechen Lei Xin Zhou Jincheng Li Xuening Cao Jinjing Liang Chao-Qun Hu Zhilin Li Yong-Chang Lau Jian-Wang Cai bei-bei Li beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Physics Beihang UniversityBeijing 100191China Songshan Lake Materials Laboratory Dongguan 523808 GuangdongChina

Cavity optomechanical systems have enabled precision sensing of magnetic fields,by leveraging the optical resonance-enhanced readout and mechanical resonance-enhanced *** studies have successfully achieved mass-produced and reproducible microcavity optomechanical magnetometry(MCOM)by incorporating Terfenol-D thin films into high-quality(Q)factor whispering gallery mode(WGM)***,the sensitivity was limited to 585 pT Hz^(−1/2),over 20 times inferior to those using Terfenol-D *** this work,we propose and demonstrate a high-sensitivity and mass-produced MCOM approach by sputtering a FeGaB thin film onto a high-Q SiO2 WGM *** studies are conducted to explore the magnetic actuation constant and noise-limited sensitivity by varying the parameters of the FeGaB film and SiO2 *** magnetometers with different radii are fabricated and *** utilizing a microdisk with a radius of 355μm and a thickness of 1μm,along with a FeGaB film with a radius of 330μm and a thickness of 1.3μm,we have achieved a remarkable peak sensitivity of 1.68 pT Hz^(−1/2)at 9.52 *** represents a significant improvement of over two orders of magnitude compared with previous studies employing sputtered Terfenol-D ***,the magnetometer operates without a bias magnetic field,thanks to the remarkable soft magnetic properties of the FeGaB ***,as a proof of concept,we have demonstrated the real-time measurement of a pulsed magnetic field simulating the corona current in a high-voltage transmission line using our developed *** high-sensitivity magnetometers hold great potential for various applications,such as magnetic induction tomography and corona current monitoring.

关键词： particles. magnetometer film

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Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats

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World Journal of Gastroenterology 2016年第16期22卷 4136-4148页

作者： Dan-Dan gao Jia Fu Bo Qin Wen-Xiang Huang Chun Yang bei Jia Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University

AIM: To investigate the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus containing either HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF).METHODS: The recombinant adenoviruses containing HIL-6 and/or HGF were constructed. We established an ACLF model, and rats were randomly assigned to control, model, Ad-GFP, Ad-HIL-6, Ad-HGF or Ad-HGF-HIL-6 group. We collected serum and liver tissue samples to test pathological changes, biochemical indexes and molecular biological ***: Attenuated alanine aminotransferase, prothrombin time, high-mobility group box 1 (HMGB1), endotoxin, tumour necrosis factor (TNF)-α and interferon-γ were observed in the Ad-HGF-, Ad-HIL-6- and Ad-HGF-HIL-6-treated rats with ACLF. Likewise, reduced hepatic damage and apoptotic activity, as well as reduced HMGB1 and Bax proteins, but raised expression of Ki67 and Bcl-2 proteins and Bcl-2/Bax ratio were also observed in the Ad-HGF-, Ad-HIL-6- and Ad-HGF-HIL-6-treated rats with ACLF. More significant changes were observed in the Ad-HGF-HIL-6 treatment group without obvious side effects. Furthermore, caspase-3 at the protein level decreased in the Ad-HIL-6 and Ad-HGF-HIL-6 treatment groups, more predominantly in the latter ***: This study identifies that the protective efficacy of Ad-HGF-HIL-6 is more potent than that of Ad-HGF or Ad-HIL-6 in ACLF rats, with no significant side effects.

关键词： Acute-on-chronic liver failure Recombinant adenovirus Hyper-interleukin-6 Hepatocyte growth factor Inflammatory cytokines

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A Cell Solid Structure of cis-1,3-Cyclohexanedicarboxylic Acid and Its Complex Crystal with 4,4'-Dipyridine

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有机化学 2004年第Z1期24卷 51-52页

作者： gao,Wei YU,Kai-bei ZHU,Jin DENG,Jin-Gen Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

Carboxylic acids are important in crystal engineering because they can form strong and directional O-H…O hydrogen bonds as dimmer and catmer.[1] The dicarboxylic acids (not containing other hydrogen bonding groups) generally form the extended line structure interlinked through dimmer,[2] except that oxalic acid forms both the β-oxalic acid linked by dimmer (finite synthon) and the a-oxalic acid by catmer[3] (infinite synthon). A new molecular packing structure of cis-1,3-cyclohexanedicarboxylic acid (CHDA), which is different from line structure,[4] was gotten (P1/2, Figure 1). The novel structure has dimmer and catmer hydrogen bond pairs in the crystal and the hydrogen bond length of O-H…O is 0.268 nm in catmer and 0.264 nm in dimmer. The bond angles of O=C-O vary from 123.1° to 123.8° in catmer and from 123.1° to 122.0° in dimmer comparing with the ones in line structure.……

关键词： oxalic acid hydrogen bonding crystal engineering molecular packing novel structure hydrogen bonds bond length

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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A molecular framework for signaling crosstalk between jasmonate and ethylene in anthocyanin biosynthesis,trichome development,and defenses against insect herbivores in Arabidopsis

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Journal of Integrative Plant Biology 2022年第9期64卷 1770-1788页

作者： Susheng Song bei Liu Junqiao Song Shihai Pang Tianxue Song Shang gao Yue Zhang Huang Huang Tiancong Qi College of Life Sciences Capital Normal Universityand Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental ImprovementBeijing100048 China School of Life Sciences Tsinghua UniversityBeijing100084 China

The phytohormones ethylene(ET)and jasmonate(JA)regulate plant development,growth,and defense responses;however,the molecular basis for their signaling crosstalk is ***,we show that JA-ZIM-domain(JAZ)proteins,which repress JA signaling,repress trichome initiation/branching and anthocyanin accumulation,and inhibit the transcriptional activity of the basic helix-loop-helix(bHLH)-MYBmembers(GLABRA3(GL3)-GL1 and TRANSPARENT TESTA 8(TT8)-MYB75)of WD-repeat/bHLH/MYB(WBM)*** ET-stabilized transcription factors ETHYLENEINSENSITIVE3(EIN3)and EIN3-LIKE1(EIL1)were found to bind to several members of WBM complexes,including GL3,ENHANCER OF GLABRA3(EGL3),TT8,GL1,MYB75,and TRANSPARENT TESTA GLABRA1(TTG1).This binding repressed the transcriptional activity of the b HLH-MYB proteins and inhibited anthocyanin accumulation,trichome formation,and defenses against insect herbivores while promoting root hair ***,the JA-activated b HLH members GL3,EGL3,and TT8 of WBM complexes were able to interact with and attenuate the transcriptional activity of EIN3/EIL1 at the HOOKLESS1 promoter,and their overexpression inhibited apical hook ***,this study demonstrates a molecular framework for signaling crosstalk between JA and ET in plant development,secondary metabolism,and defense responses.

关键词： anthocyanin defense ethylene EIN3 jasmonate JAZs trichome WD-repeat/bHLH/MYB complexes

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Clerodane-type Diterpene Glycosides from Dicranopteris pedata

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Natural Products and Bioprospecting 2021年第5期11卷 557-564页

作者： bei‑bei gao Yu‑Fei Ou Qin‑Feng Zhu Zhi‑Ping Zhou Zhen‑Tao Deng Meng Li Qin‑Shi Zhao Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologyYunnan UniversityYunnan650091 KunmingPeople’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Pharmacy Guizhou Medical UniversityGuian New AreaGuizhou 550025China

Three new clerodane-type diterpene glycosides,(5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]cleroda-3,13(16),14-diene(1),(5R,6S,8R,9S,10R,13S)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol(2),(5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol(3),together with two known compounds 4 and 5 were isolated from Dicranopteris *** structures of these compounds were elucidated by detailed spectroscopic analysis,and the absolute configuration of compound 2 was determined by ECD *** addition,compound 1 exhibited weak inhibitory activities against SMMC-7721,MCF-7 and SW480.

关键词： Dicranopteris pedata Clerodane-type diterpene glycosides ECD

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Constraint-induced movement therapy enhances AMPA receptor-dependent synaptic plasticity in the ipsilateral hemisphere following ischemic stroke

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Neural Regeneration Research 2021年第2期16卷 319-324页

作者： Jian Hu Pei-Le Liu Yan Hua bei-Yao gao Yu-Yuan Wang Yu-Long Bai Chan Chen Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina

Constraint-induced movement therapy(CIMT)can promote the recovery of motor function in injured upper limbs following stroke,which may be associated with upregulation ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)at synapses in the ipsilateral sensorimotor cortex in our previous ***,AMPAR distribution is tightly regulated,and only AMPARs on the postsynaptic membrane can mediate synaptic *** speculated that synaptic remodeling induced by movement-associated synaptic activity can promote functional recovery from *** test this hypothesis,we compared AMPAR expression on the postsynaptic membrane surface in a rat model of ischemic stroke induced by middle cerebral artery occlusion(MCAO)with versus without CIMT,which consisted of daily running wheel training for 2 weeks starting on day 7 after *** results showed that CIMT increased the number of glutamate receptor(Glu R)2-containing functional synapses in the ipsilateral sensorimotor cortex,and reduced non-Glu R2 AMPARs in the ipsilateral sensorimotor cortex and hippocampal CA3 *** addition,CIMT enhanced AMPAR expression on the surface of post-synaptic membrane in the ipsilateral sensorimotor cortex and ***,CIMT promotes the recovery of motor function of injured upper limbs following stroke by enhancing AMPAR-mediated synaptic transmission in the ischemic *** findings provide supporting evidence for the clinical value of CIMT for restoring limb movement in stroke *** experimental procedures and protocols were approved by the Department of Laboratory Animal Science of Fudan University,China(approval No.201802173 S)on March 3,2018.

关键词： brain experiment injury plasticity regeneration repair stroke synapse

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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Low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

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Journal of Energy Chemistry 2025年第1期100卷 458-468页

作者： Peng Zhu Cun Liu Yiren Yu Guoshu gao Yumeng Zhao Xiongfu Zhang Guodong Liu Guohui Yang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. Here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silicalite-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive colloidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classical oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles facilitated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-scale production of ZSM-5 nanosheets was successfully carried out in a 3 L highpressure autoclave, yielding samples consistent with those from laboratory-scale synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Scale-up synthesis Aromatic alkylation

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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu gao Xiaofan Jiang Kangyi Yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

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