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In situ observation of temperature-dependent atomistic and mesoscale oxidation mechanisms of aluminum nanoparticles

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Nano Research 2020年第1期13卷 183-187页

作者： Jing gao Jingyuan Yan beikai Zhao Ze Zhang Qian Yu Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China

Oxidation is a universal process causing metals’corrosion and *** intensive researches have been conducted for decades,the detailed atomistic and mesoscale mechanisms of metal oxidation are still not well *** using in situ environmental transmission electron microscopy(E-TEM)with atomic resolution,we revealed systematically the oxidation mechanisms of aluminum from ambient temperature to^600℃.It was found that an amorphous oxide layer formed readily once Al was exposed to air at room ***^150℃,triangle-shaped Al2O3 lamellas grew selectively on gas/solid(oxygen/amorphous oxide layer)interface,however,the thickness of the oxide layer slowly increased mainly due to the inward diffusion of *** the temperature further increased,partial amorphous-to-crystallization transition was observed on the amorphous oxide film,resulting in the formation of highly dense nano-cracks in the oxide ***^600℃,fast oxidation process was *** grew into terraces on the oxide/gas interface,indicating that the high temperature oxidation is controlled by the outward diffusion of *** or double/multi-layers of oxide nucleated at the corners of the terraces,forming denseγ’-Al2O3,which is a metastable oxide structure but may be stabilized at nanoscale.

关键词： in situ transmission electron microscopy(TEM) aluminum oxidation temperature diffusion

Natural anti-oxLDL IgM monoclonal antibody in the pathogenesis of atherosclerosis

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Journal of Geriatric Cardiology 2009年第1期6卷 42-48页

作者： Xuyang Feng Ruifen Xu Yan gao Haokao gao Zheng He Haichang Wang Department of Cardiology Xijing Hospital Xi''an 710032 China Department of Anesthesiology Stomatology Hospital the Fourth Military Medical University Xi''an 710000 P.R.China Department of Cardiology PLA No. 323 Hospital Xi''an 710054 P.R.China Department of Cardiology Xijing Hospital Xi''an 710032 China Department of Cardiology Xijing Hospital Xi''an 710032 China

Objective To explore the role and the possible molecular mechanisms of natural anti-oxLDL IgM monoclonal antibody played and involved in pathogenesis of atherosclerosis. Methods Natural anti-oxLDL IgM monoclonal antibody 3A6 was generated by using standard hybridoma production techniques. Influence of 3A6 on formation of foam cells was observed by Oil Red O staining and affinity of Na125I-conjugated oxLDL on the naive and LPS-activated macrophages. After LPS stimulation on macrophages, anti-TLR4 neutralizing mAb, p38MAPK specific inhibitor SB203580, NF-kB specific inhibitor PDTC or RNAi targeting Fcα/μ receptor (Fcamr) were applied, respectively. Results Natural anti-oxLDL IgM monoclonal antibody 3 A6 were found specifically inhibit the binding of CuoxLDL to naive macrophages but not the binding of CuoxLDL to LPS-activated macrophages. It also promoted the formation of CuoxLDL-mediated foam macrophages. 3A6 F(ab')2 or pre-incubation with un-related IgM inhibited the binding of 3A6/CuoxLDL complex to LPS-activated macrophages. LPS up-regulated the expression of Fcamr in macrophages in a dose- and time-dependent manner, which was attenuated by treatment with anti-TLR4. LPS induced the phosphorylation of p38MAPK and translocation of NF-kB p65, contributing to the up-regulated expression of Fcα/μ receptor in macrophages. Conclusions Natural anti-oxLDL IgM monoclonal antibody 3A6 specifically inhibited the binding of CuoxLDL to naive macrophages in vitro. However, LPS, through the Toll-like receptor (TLR)4 receptor, activated the p38MAPK and NF-kB pathways and up-regulated the expression of Fcα/μ receptor in macrophages, which promoted the binding of 3A6/CuoxLDL complex to macrophages through binding with Fc fragments and the formation of foam macrophages. Therefore, our findings provide a new explanation why bacterial infection deteriorates the pathogenesis of atherosclerosis.

关键词： Atherosclerosis macrophage immunoglobulin M Toll-like receptor 4 oxidized low-density lipoprotein Fcα/μ receptor

Hydrochemical Characterization,Controlling Factors and Water Quality of Surface Water in Shandong Province,North China

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Journal of Earth Science 2024年第1期35卷 155-166页

作者： Ran An Jiutan Liu Zongjun gao Changsuo Li Yuming Peng School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China 801 Institute of Hydrogeology and Engineering Geology Shandong Provincial Bureau of Geology&Mineral ResourcesJinan 250014China Key Laboratory of Groundwater Resources and Environment Shandong Provincial Bureau of Geology&Mineral ResourcesJinan 250014China Shandong Engineering Research Center for Groundwater Environmental Protection and Remediation Jinan 250014China

In this study,90 surface water samples were collected from Shandong Province(SDP)in the dry and wet seasons and analyzed using statistical analysis,hydrochemical methods and water quality index(WQI).The content of main ions showed seasonal variations,with a higher average value in the dry season than in the wet *** points exhibiting high contents of the main chemical components were mainly distributed in areas southwest of SDP,north of Weifang,and around *** saturation index of carbonate minerals was greater than zero,while that of evaporite minerals was less than *** hydrochemical characteristics of surface water are mainly dominated by rock weathering as well as cation *** addition,surface water in SDP has significantly been affected by anthropogenic *** of the surface water could be classified as weakly alkaline soft-fresh water,with the hydrochemical types of SO_(4)·Cl-Ca·Mg and SO_(4)·*** terms of WQI,47.88% and 37.88% of the water samples in SDP were classified as poor water in the dry and wet seasons,*** the whole,the water quality is higher in the wet season than in the dry season,and surface water in SDP is generally suitable for agricultural irrigation.

关键词： surface water hydrochemical characteristics controlling factors water quality Shandong Province

D^2EA:Depict the Epidemic Picture of COVID-19

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Journal of Shanghai Jiaotong university(Science) 2020年第2期25卷 165-176页

作者： LIU Chenzhengyi ZHAO Jingwei LIU Guohang gao Yuannin gao Xiaofeng School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The outbreak of coronavirus disease 2019(COVID-19)has aroused a global *** release social panic and guide future schedules,this article proposes a novel mathematical model,the Delay Differential Epidemic Analyzer(D2EA),to analyze the dynamics of epidemic and forecast its future *** on the traditional Susceptible-Exposed-Infectious-Recovered(SEIR)model,the D2EA model innovatively introduces a set of quarantine states and applies both ordinary differential equations and delay differential equations to describe the transition between two *** variations of practical factors are further considered to reveal the true epidemic *** the experiment part,we use the D^2EA model to simulate the epidemic in Hubei *** to the collected real data as non-linear optimization,the D^2EA model forecasts that the accumulated confirmed infected cases in Hubei Province will reach the peak at the end of February and then steady *** also evaluate the effectiveness of the quarantine measures and schedule the date to reopen Hubei Province.

关键词： coronavirus disease 2019(COVID-19) epidemic model quarantine states Susceptible-Exposed-Infectious-Recovered(SEIR) delay differential equation non-linear optimization

Different El Niño Flavors and Associated Atmospheric Teleconnections as Simulated in a Hybrid Coupled Model

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Advances in Atmospheric Sciences 2024年第5期41卷 864-880页

作者： Junya HU Hongna WANG Chuan gao Rong-Hua ZHANG Key Laboratory of Ocean Circulation and Waves Institute of Oceanologyand Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Laoshan Laboratory Qingdao 266237China

A previously developed hybrid coupled model(HCM)is composed of an intermediate tropical Pacific Ocean model and a global atmospheric general circulation model(AGCM),denoted as *** this study,different El Niño flavors,namely the Eastern-Pacific(EP)and Central-Pacific(CP)types,and the associated global atmospheric teleconnections are examined in a 1000-yr control simulation of the *** HCMAGCM indicates profoundly different characteristics among EP and CP El Niño events in terms of related oceanic and atmospheric variables in the tropical Pacific,including the amplitude and spatial patterns of sea surface temperature(SST),zonal wind stress,and precipitation *** SST budget analysis indicates that the thermocline feedback and zonal advective feedback dominantly contribute to the growth of EP and CP El Niño events,*** to the shifts in the tropical rainfall and deep convection during EP and CP El Niño events,the model also reproduces the differences in the extratropical atmospheric responses during the boreal *** particular,the EP El Niño tends to be dominant in exciting a poleward wave train pattern to the Northern Hemisphere,while the CP El Niño tends to preferably produce a wave train similar to the Pacific North American(PNA)*** a result,different climatic impacts exist in North American regions,with a warm-north and cold-south pattern during an EP El Niño and a warm-northeast and cold-southwest pattern during a CP El Niño,*** modeling result highlights the importance of internal natural processes within the tropical Pacific as they relate to the genesis of ENSO diversity because the active ocean–atmosphere coupling is allowed only in the tropical Pacific within the framework of the HCMAGCM.

关键词： hybrid coupled model tropical Pacific Ocean global atmosphere Eastern/Central-Pacific El Niño atmospheric teleconnections

Multichannel adaptive signal detection: basic theory and literature review

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Science China(Information Sciences) 2022年第2期65卷 5-44页

作者： Weijian LIU Jun LIU Chengpeng HAO Yongchan gao Yong-Liang WANG Wuhan Electronic Information Institute Department of Electronic Engineering and Information Science University of Science and Technology of China State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences School of Electronic Engineering Xidian University

Multichannel adaptive signal detection uses test and training data jointly to form an adaptive detector to determine whether a target exists. The resulting adaptive detectors typically possess constant false alarm rate(CFAR) properties; thus, no additional CFAR processing is required. In addition, a filtering process is also not required because the filtering function is embedded in the adaptive detector. Adaptive detection typically exhibits better detection performance than the filtering-then-CFAR detection *** has been approximately 35 years since the first multichannel adaptive detector was proposed by Kelly in 1986. However, there are few overview articles on this topic. Thus, in this study, we present a tutorial overview of multichannel adaptive signal detection with an emphasis on the Gaussian background. We discuss the main design criteria for adaptive detectors, investigate the relationship between adaptive detection and filtering-then-CFAR detection techniques, investigate the relationship between adaptive detectors and adaptive filters, summarize typical adaptive detectors, present numerical examples, provide a comprehensive literature review, and discuss potential future research tracks.

关键词： constant false alarm rate multichannel signal signal mismatch statistical distribution subspace signal

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On the Present Leisure Anomalies in China —— Based on the Marxist Concept of Leisure

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学术界 2014年第11期 298-302页

作者： gao Yan Lü Lizhi College of Humanities and Social Sciences Nanjing University of Aeronautics and Astronautics Department of Social Sciences Yancheng Institute of Technology Institute of Higher Education Nanjing University of Aeronautics and Astronautics

According to the Marxist ideology,leisure is a state of survival based on free time,and its value orientation is to promote the all-round development of the people. How-ever,at present,leisure is restricted by consumption in people’s daily life in China and there are such phenomena as ceded leisure,materialized leisure and displayed leisure. How can the people really have the leisure time and w onderful life? The government shall direct people correctly relax through leisure education,regulate the development of the leisure industry to meet people’s needs concerning leisure,and supervise the mass media to guide people to have proper leisure consumption.

关键词： Marxism the concept of leisure Consumerism consumption anomalies of leisure government responsibilities

基于生态安全格局的国土空间生态修复关键区域识别——以吉林省松原市为例

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中国环境科学 2022年第6期42卷 2779-2787页

作者：曹秀凤刘兆顺李淑杰高振君孙贝雯李莹雪吉林大学地球科学学院吉林长春130012

为了在生态文明建设背景下,从生态系统完整性和结构连通性角度识别生态修复关键区域,以吉林省松原市为研究区,综合运用MSPA分析、景观连通性评价和电路理论,构建生态安全格局,识别松原市国土空间生态修复关键区域.结果表明:松原市共识... 详细信息

为了在生态文明建设背景下,从生态系统完整性和结构连通性角度识别生态修复关键区域,以吉林省松原市为研究区,综合运用MSPA分析、景观连通性评价和电路理论,构建生态安全格局,识别松原市国土空间生态修复关键区域.结果表明:松原市共识别生态源地9处,面积为787.95km^(2),以水域及草地为主,对区域生态安全起着至关重要的作用;识别生态廊道23条,一级廊道16条,二级廊道7条,全长1458.18km;基于生态安全格局识别松原市国土空间生态修复关键区域,包括生态夹点16处,面积180.70km^(2),生态障碍点24处,面积298.11km^(2).综合分析生态修复关键区域空间分布和土地利用现状,并提出针对性生态修复策略.

关键词：生态安全格局国土空间生态修复 MSPA 电路理论松原市

应用Simpson法评价针刺穴位联合药物治疗胆囊炎的临床疗效

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中国实用医刊 2011年第8期38卷 9-10页

作者：曹子洋吕培瑾高伟张蓓蓓耿拮泰山医学院附属聊城市第二人民医院山东临清252600

目的应用Simpson法测量技术评价针刺穴位联合药物治疗胆裳炎的临床疗效。方法对42例胆囊炎患者应用针刺穴位联合药物治疗，采用脂餐试验，采集胆囊长轴切面声像图，应用改良Simpson法直接测量脂餐前后两纽胆囊的客积，并统计胆囊排空率... 详细信息

目的应用Simpson法测量技术评价针刺穴位联合药物治疗胆裳炎的临床疗效。方法对42例胆囊炎患者应用针刺穴位联合药物治疗，采用脂餐试验，采集胆囊长轴切面声像图，应用改良Simpson法直接测量脂餐前后两纽胆囊的客积，并统计胆囊排空率。结果治疗后较治疗前胆囊收缩功能明显提高，胆囊张力减低、胆囊回声减少或消失、胆囊壁厚度变薄，经统计学处理差异有统计学意义（P〈0．05）。结论改良Simpson法测量胆囊容积简便易行，可用于针刺穴位联合药物治疗胆囊炎的临床疗效评价。

关键词： Simpson法针刺穴位药物胆囊炎胆囊收缩功能