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考虑场地效应的多点地震动作用下边坡永久位移分析

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岩土工程学报 2025年第1期47卷 65-75页

作者：宋健潘驭航陆朱汐姬建张飞高玉峰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 河海大学土木与交通学院江苏南京210024

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土... 详细信息

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土条赋予不同的水平和竖向地震动时程,推导出一种考虑场地效应的圆弧和任意形状滑面的多点地震作用下边坡永久位移分析方法。通过与有限差分软件FLAC的数值模拟结果进行对比,验证了该方法能够合理考虑地震动的场地效应。通过研究不同分布形式的多点地震动及竖向地震动对边坡永久位移的影响,结果表明:场地效应引起的水平地震动放大以及多点地震动不同分布模式会导致整个滑体平均地震惯性力作用位置发生改变,从而影响地震作用下滑动体沿滑面的永久变形量,竖向地震动对边坡地震位移影响较小。将方法应用于Lexington土石坝震后变形案例分析,计算得到的坝坡地震永久位移与实际震后观测值相吻合,证明了考虑场地效应的重要性及本文方法的合理性。

关键词：地震边坡稳定性场地效应永久位移极限平衡条分法多点地震动

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science China(Life Sciences) 2025年第1期68卷 189-203页

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang yufeng gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan UniversityKunming650500China CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Medicine University of Massachusetts Chan Medical SchoolWorcester MA 01655USA Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou UniversityZhengzhou 450001China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for ***,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling *** exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling ***,we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling ***,mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2,inhibiting the recruitment of SHP-2 by *** together,our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling *** addition,our success in target recognition provides a paradigm of target identification and confirmation for natural products.

关键词： pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

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原料土液限对自密实固化土工程性质的影响

硅酸盐通报 2025年第1期44卷 360-367页

作者：徐婕梁剑辉齐乐龚英高玉峰河海大学岩土力学与堤坝工程教育部重点实验室南京210098

自密实固化土凭借就地取土、协同处置建筑垃圾、自流平、易泵送的优点在多种回填工程中得到了广泛应用。本文通过流动度试验、泌水率试验、湿密度试验、干缩试验和无侧限抗压强度试验,探究了原料土液限对自密实固化土性质的影响,并借助... 详细信息

自密实固化土凭借就地取土、协同处置建筑垃圾、自流平、易泵送的优点在多种回填工程中得到了广泛应用。本文通过流动度试验、泌水率试验、湿密度试验、干缩试验和无侧限抗压强度试验,探究了原料土液限对自密实固化土性质的影响,并借助自由水分离试验探讨了自由水含量对强度特征的作用机理。结果表明:在相同水泥掺量和掺水率条件下,以高液限黏土为原料土制成的自密实固化土新拌浆体流动度较低,固化后无侧限抗压强度较高;随着掺水率的增加,新拌浆体的流动度增长幅度基本保持不变,固化后的无侧限抗压强度降低幅度开始减少;任意龄期条件下,以高液限黏土为原料土制成的自密实固化土中自由水含量均较低。在7 d养护龄期时,以高液限黏土为原料土制成的自密实固化土中自由水含量仅为2.2%,而低液限黏土自密实固化土试样的自由水含量为11.7%。该研究成果揭示了不同原料土液限对自密实固化土中自由水含量的影响机制,可为工程实践中原料土的选择及其配比设计提供指导。

关键词：自密实固化土液限自由水流动度无侧限抗压强度

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Simulation of spatially correlated earthquake ground motions for engineering purposes

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Earthquake Engineering and Engineering Vibration 2011年第2期10卷 163-173页

作者： Wu Yongxin gao yufeng Li Dayong Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University Nanjing 210098 China Geotechnical Research Institute Hohai University Nanjing 210098 China Department of Civil Engineering Shandong University of Science and Technology Qingdao 266510 China

A new model to simulate spatially correlated earthquake ground motions is developed. In the model, the main factors that characterize three distinct effects of spatial variability, namely, the incoherency effect, the wave-passage effect and the site-response effect, are taken into account, and corresponding terms/parameters are incorporated into the well known model of uniform ground motions. Some of these terms/parameters can be determined by the root operation, and others can be calculated directly. The proposed model is first verified theoretically, and examples of ground motion simulations are provided as a further illustration. It is proven that the ensemble expected value and the ensemble auto-/cross-spectral density functions of the simulated ground motions are identical to the target spectral density functions. The proposed model can also be used to simulate other correlated stochastic processes, such as wave and wind loads.

关键词： ground motions simulation root operation incoherency effect wave-passage effect site-response effect

Effect of integrating memory on the performance of the fractional plasticity model for geomaterials

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Acta Mechanica Sinica 2018年第5期34卷 896-901页

作者： Yifei Sun yufeng gao Shunxiang Song Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China

A fractional plasticity model for geomaterials is proposed by using the fractional *** to the integral definition of the fractional derivative,the range of load memory for calculating the flow direction may influence the subsequent model ***,an investigation on the memory dependence of the model was *** was found that the load memory affected the stress-dilatancy behavior of the *** to the loss of memory from zero-to confiningstress states,slightly higher strain is reported,whereas an insignificant difference in the predicted deviator stress is ***,for engineering applications,starting the memory from the zero-stress state,which avoids mathematical complexity,is suggested.

关键词： Plasticity Fractional calculus Memory

Seismic-induced surficial failure of cohesive slopes using three-dimensional limit analysis:A case study of the Wangjiayan landslide in Beichuan, China

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 537-545页

作者： gao yufeng Liu Yang Geng Weijuan Zhang Fei Key Laboratory of the Ministry of Education for Geomechanics and Embankment Engineering College of Civil and Transportation EngineeringHohai UniversityNanjing 210098China Department of Civil Engineering Faculty of Civil Engineering and MechanicsJiangsu UniversityZhenjiang 212013China

A seismic-induced landslide is a common geological catastrophe that occurs in *** Wangjiayan landslide,which was triggered by the Wenchuan earthquake,is a typical case in *** Wanjiayan landslide caused many casualties and resulted in enormous property *** study constructs a simple surficial failure model based on the upper bound approach of three-dimensional(3D)limit analysis to evaluate the slope stability of the Wangjiayan case,while a traditional two-dimensional(2D)analysis is also conducted as a reference for comparison with the results of the 3D analysis.A quasi-static calculation is used to study the effect of the earthquake in terms of horizontal ground acceleration,while a parametric study is conducted to evaluate the critical cohesion of *** than employing a 3D analysis,using the 2D analysis yields an underestimation regarding the safety *** the Wangjiayan landslide,the difference in the factors of safety between the 3D and 2D analyses can reach 20%.The sliding surface morphology as determined by the 3D method is similar to actual morphology,and the parameters of both are also compared to analyze the reliability of the proposed 3D method.

关键词： landslide Wenchuan earthquake surficial failure limit analysis stability quasi-static

An analytical solution to the scattering of cylindrical SH waves by a partially filled semi-circular alluvial valley: near-source site effects

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Earthquake Engineering and Engineering Vibration 2015年第2期14卷 189-201页

作者： Zhang Ning gao yufeng Yang Jie Xu Changjie Geotechnical Research Institute Hohai University Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University Nanjing Hydraulic Research Institute Research Center of Coastal and Urban Geotechnical Engineering Zhejiang University

The earth’s surface irregularities can substantially affect seismic waves and induce amplifi cations of ground motions. This study investigates whether and how the source characteristics affect the site amplifi cation effects. An analytical model of a line source of cylindrical waves impinging on an alluvial valley is proposed to link the source and site. The analytical solution to this problem proves one aspect of the strong effect of source on site amplifi cation, i.e., the wave curvature effect. It is found that the site amplifi cation depends on the source location, especially under conditions of a small source-to-site distance. Whether the displacement is amplifi ed or reduced and the size of the amplifi cation or reduction may be determined by the location of the source. It is suggested that traditional studies of site responses, which usually ignore the source effect, should be further improved by combining the source with site effects.

关键词： site effects source effects wave function expansio

Fault diagnosis of wind turbine bearing based on stochastic subspace identification and multi-kernel support vector machine

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Journal of Modern Power Systems and Clean Energy 2019年第2期7卷 350-356页

作者： Hongshan ZHAO yufeng gao Huihai LIU Lang LI School of Electrical and Electronic Engineering North China Electric Power University

In order to accurately identify a bearing fault on a wind turbine, a novel fault diagnosis method based on stochastic subspace identification(SSI) and multi-kernel support vector machine(MSVM) is proposed. Firstly, the collected vibration signal of the wind turbine bearing is processed by the SSI method to extract fault feature vectors. Then, the MSVM is constructed based on Gauss kernel support vector machine(SVM) and polynomial kernel SVM. Finally, fault feature vectors which indicate the condition of the wind turbine bearing are inputted to the MSVM for fault pattern recognition. The results indicate that the SSI-MSVM method is effective in fault diagnosis for a wind turbine bearing and can successfully identify fault types of bearing and achieve higher diagnostic accuracy than that of K-means clustering, fuzzy means clustering and traditional SVM.

关键词： Wind turbine Bearing Fault diagnosis Stochastic subspace identification(SSI) Multi-kernel support vector machine(MSVM)

A note on near-field site amplification effects of ground motion from a radially inhomogeneous valley

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 707-718页

作者： Zhang Ning gao yufeng Wu Yongxin Zhang Fei Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University College of Civil and Transportation Engineering Hohai University

To improve the understanding of the near-field soil and topographic amplification effects, an analytical solution by the authors for the scattering of plane SH waves by a radially inhomogeneous semi-cylindrical valley is extended to the case of a line source of cylindrical SH waves. Upon confirmation of its accuracy with past exact solutions for a homogeneous and an inhomogeneous semi-cylindrical valley under far-field plane SH waves, the extended solution is used to calculate the ground motion amplification factors for both the homogeneous and inhomogeneous valleys subjected to near-field waves. A comprehensive parametric study is conducted with respect to the location of the wave source, the dimensionless frequency of the incident waves, and the inhomogeneity degree of the covering soil layer. It is found that more amplifications and reductions of ground motions will occur within a certain range in and around the valley as the sources are located further. Consistent with the far-field case, it is confirmed that an increase of the degree of inhomogeneity of the covering soil layer generally amplifies the ground motions significantly.

关键词： elastic SH-waves wave scattering and diffraction ground motion amplification valley canyon