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氯化锂对人牙周膜干细胞增殖和成骨分化的影响

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牙体牙髓牙周病学杂志 2013年第1期23卷 12-16页

作者：安莹高丽娜杨昊张璟李蓓刘玲侠陈发明金岩第四军医大学口腔医学院陕西西安710032

目的:探讨Wnt/β-catenin通路激活剂—氯化锂(lithium chloride,liCl)对体外培养的人牙周膜干细胞(human periodontal ligament stem cells,hPDLSCs)增殖和成骨分化的影响。方法:低密度多克隆法分离培养人PDLSCs,分别与不同浓度的liCl(5、10、20、40 mmol/L)共同培养。分别检测各组细胞的增殖情况、碱性磷酸酶(alkaline phosphatase,ALP)活性、钙化结节形成量以及Col-1、OCN、Runx-2等成骨相关基因的表达水平。结果:liCl无促细胞增殖作用,且高浓度liCl能明显抑制细胞的增殖。浓度为5 mmol/L的liCl可促进hP-DLSCs成骨性分化,表现为提高细胞的ALP活性、促进钙化结节的形成、上调Col-1、OCN、Runx-2的mRNA表达水平,与对照组相比,差异均具有统计学意义(PliCl则对成骨分化具有抑制作用。结论:终浓度为5 mmol/L的liCl可明显促进hPDLSCs的成骨分化。

关键词：氯化锂牙周膜干细胞增殖分化

“劳动雇佣资本”公司治理范式的特征、适用环境和治理机制研究

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工业技术经济 2025年第1期44卷 3-11页

作者：高明华李扬北京师范大学经济与工商管理学院北京100875 北京师范大学公司治理与企业发展研究中心北京100875

在当今科技革命和产业变革方兴未艾的时代背景下,知识和技术成为经济增长和财富积累的主要驱动力,企业家等高能力人力资本作为知识和技术的载体,在企业的经营决策和创新创造中占据主导地位。同时,企业家人力资本的稀缺性和专用性及其风... 详细信息

在当今科技革命和产业变革方兴未艾的时代背景下,知识和技术成为经济增长和财富积累的主要驱动力,企业家等高能力人力资本作为知识和技术的载体,在企业的经营决策和创新创造中占据主导地位。同时,企业家人力资本的稀缺性和专用性及其风险承担能力和创造能力的提升使得企业家人力资本相对价格提高,财务资本相对价格降低,从而促使公司治理范式从“资本雇佣劳动”向“劳动雇佣资本”变革。高科技时代背景、资本市场完善导致的股权多元化以及企业较高的创新发展需求为“劳动雇佣资本”治理范式发展提供了适用环境。此外,“劳动雇佣资本”治理范式不仅会极大地激发企业家能力,也会引发企业各治理主体权益发生变化,进而能够通过提高治理效率和实现制度革新推动新质生产力的发展。

关键词：劳动雇佣资本资本雇佣劳动公司治理相对价格企业家能力人力资本稀缺性人力资本专用性新质生产力

Modeling and Analysis the Effects of EMP on the Balise System

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Computers, Materials & Continua 2019年第3期58卷 859-878页

作者： Zhiwei gao Shuai Zhang li hao Ning Cao Shijiazhuang Tiedao University 17 Northeast Second Inner RingShijiazhuang050043China College of Information Engineering Sanming UniversitySanmingChina.

Balise system is one kind of high-rate point-mode data transmission *** plays an indispensable role in Chinese Train Control System(CTCS),and it has been immigrated and widely used for passenger dedicated lines and high-speed ***,its working conditions directly affect train operation ***,the balise information transmission system(BITS)is based on the principle of electromagnetic induction,and the communication process is susceptible to external electromagnetic ***,it is vital to study the influence of transient signal interference on the balise *** paper builds the up-link model between the vehicle antena and the balise,and verifies the model’s correctness using finite-difference time-domain method and electromagnetic field *** paper analyzes the effect of electromagnetic pulses on the transponder’s uplink and simulates the coupled current under *** spectral distribution of the three types of pulse interference is analyzed according to relevant *** electromagnetic pulses have a strong energy distribution in the working frequency band of the up-link,which will generate in-band interference and bit *** will affect the balise communication and threaten the safety of train *** we know we are the first to analyze the effects of EMP on Chinese BITS,which will lay a foundation for the research of electromagnetic anti-interference or protection to highspeed railway.

关键词： Balise system BTM EMP electromagnetic anti-interference.

A Hybrid Level Set Optimization Design Method of Functionally Graded Cellular Structures Considering Connectivity

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Computers, Materials & Continua 2024年第4期79卷 1-18页

作者： Yan Dong Kang Zhao liang gao hao li The State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China Institute of Systems Engineering China Academy of Engineering PhysicsMianyang621900China

With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown ***,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular *** HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure ***,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both ***,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent *** method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology *** essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.

关键词： Hybrid level set method functionally graded cellular structure connectivity interpolated transition optimization design

Role of lateral growth on the structural properties of high temperature GaN layer

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Science China(Technological Sciences) 2009年第5期52卷 1242-1247页

作者： gao ZhiYuan hao Yue li PeiXian ZHANG JinCheng Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi’an 710071China

The role of lateral growth on the structural properties of high temperature (HT) GaN epitaxial layer has been investigated by means of transmission electron microscopy (TEM) and X-ray diffraction (XRD). Variations of the lateral growth rate of HT GaN in metal-organic chemical vapor deposition (MOCVD) can be obtained by changing the V/III ratio. It is found that under higher lateral growth rate, dislocation is easier to bend into subgrains away from c axis, and the position where bend occurs is closer to the buffer layer, however, dislocation density does not show to monotonically vary with increasing lateral growth rate. A model concerning the GaN growth dynamics and dislocation bending mechanics has been proposed to explain the correlation between lateral growth and the structural properties of GaN.

关键词： GaN lateral growth dislocation V/III

Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan hao liang Yong-Hong Tang li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Relationship between contact size and static friction:An approach for rigid crystalline surfaces

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Friction 2021年第3期9卷 502-512页

作者： hao CHEN Xinlei gao School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Relationship between contact size(A)and static friction(f)has been studied for rigid crystalline *** built a series of systems with two identical surfaces but different orientations and investigated the effects of the size and shape of the contact area on static *** these systems,there are numerous nontrivial commensurate *** results confirmed that the relationship between A and f was determined by both commensurability and shape of the *** commensurate contacts,f∝A independent of the *** incommensurate contacts,generally f∝A^(0) for regular shapes or f∝A^(1/4) for irregular shapes;however,in very few cases of regular shapes,f∝A^(1/2).Moreover,in above systems,commensurability of a contact can be easily changed by a perturbation of the misfit ***,if the perturbation caused by the lateral force and the deformation of the surface are considered(as is the case in real systems),further research is necessary.

关键词： static friction contact size numeric simulation rigid body

Research on active disturbance rejection control method for turbine blade tip clearance

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Science China(Technological Sciences) 2019年第10期62卷 1795-1804页

作者： WANG WeiMin Shao Xing li QiHang gao JinJi hao ZeRui Beijing Key Laboratory of Health Monitoring and Self-Recovery for High-End Mechanical Equipment Beijing University of ChemicalTechnologyBeijing100029China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China

Blade tip clearance(BTC) is one of the key factors affecting the efficiency and reliability of high performance turbomachinery such as heavy duty steam turbines, aircraft engines and other gas turbo machines. The self-adjusting ability of BTC according to the operation condition changing is important to meet the requirement of performance. In this paper, the principle and method of adjusting the BTC by controlling the axial displacement of the rotor were proposed and studied. The basic principle is that the BTC of the turbomachinery with a conical tail shroud will be affected by the axial displacement of rotor and thereby can be adjusted by controlling the axial position of rotor, which can be adjusted by the controllable oil pressure acting on the thrust bearing. To reach a higher control precision, lower noise and model perturbation, an adaptive quasi-sliding mode control(AQSMC) algorithm based on the disturbance observer(DOB) was designed, and numerical and experimental investigations were carried out. The numerical simulation results show that this algorithm can not only effectively suppress the disturbance, but also, compared with the general reaching law, effectively reduce the chattering and transient high gain switching effect of the closed-loop controller system and avoid the instability caused by the controller. Based on the DOB-AQSMC algorithm, the BTC was stabilized within 2 s with no overshoot and no misalignment in the test rig, and this algorithm achieves a better control performance than the proportion-integral-differential(PID) algorithm. These achievements can be used to push forward the intelligent turbomachinery development.

关键词： blade tip clearance turbomachinery active disturbance rejection control DOB-AQSM method

Modeling Impact of ROADM Intra-Node Add/Drop Contention on a Single Node lightpath Blocking Performance

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China Communications 2015年第1期12卷 89-98页

作者： gao li liU hao li Yongcheng SHEN Gangxiang School of Electronic and Information Engineering Soochow University Wuhan Research Institute of Posts and Telecommunications

We propose an analytical model to evaluate the lightpath blocking performance for a single ROADM node with intra-node add/drop contention,in which the number of lightpaths that can be added/dropped with the same wavelength is limited by the add/drop contention *** models of traffic load per nodal degree are considered to validate the effectiveness of the analytical *** simulation results show that the proposed analytical model is effective in predicting the performance for different values of add/drop contention factor C and for variable offered loads at the *** add/drop contention factor shows an important impact on the lightpath blocking performance and properly raising the contention factor can significantly improve the lightpath blocking *** the add/drop contention factor C exceeds a certain level,the performance of a ROADM with intra-node contention is close to that of a contentionless ROADM.

关键词： Reconfigurable optical add/ drop multiplexers (ROADMs) intra-node contention analytical model lightpath blocking