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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya gao Shuyue li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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石墨烯增强环氧树脂基复合材料的研究进展

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塑料工业 2018年第9期46卷 1-5,87页

作者：田晋高立齐泽昊张翠平辛昊谭业发陆军工程大学研究生院江苏南京210007

环氧树脂基复合材料在工程领域中的应用日趋广泛,为了进一步提高其理化性能和力学性能,以满足苛刻工况条件下工程应用的要求,运用石墨烯作为增强体改性环氧树脂取得了良好的增强效果,并显示出了极大的应用前景。在介绍石墨烯及其衍生物... 详细信息

环氧树脂基复合材料在工程领域中的应用日趋广泛,为了进一步提高其理化性能和力学性能,以满足苛刻工况条件下工程应用的要求,运用石墨烯作为增强体改性环氧树脂取得了良好的增强效果,并显示出了极大的应用前景。在介绍石墨烯及其衍生物结构和性能特点的基础上,阐述了石墨烯的功能化改性及其与聚合物树脂的复合方法,重点叙述了石墨烯改性环氧树脂复合材料的研究概况,并展望了石墨烯/环氧树脂复合材料的发展前景。

关键词：复合材料环氧树脂石墨烯研究进展

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin Pei Xing Yin Xinyi li Yi hao Mengru Zhang Meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du hao You Junfeng Huang Mudong Tu Hua li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： X ray photoelectron spectroscopy

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Controllably elevating the initial Coulombic efficiency of li3VO4 anode via a facile electrode pre-lithiation technique for lithium-ion batteries

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Science China Chemistry 2025年

作者： haoyue liang Xingguo Zhong Guxin Huang Wenpan liu Yao liu Shuhao Wang Deyu Wang hao liu hao Wang Tianyou Zhai Huiqiao li State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Shenzhen Research Institute of Huazhong University of Science and Technology Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education) School of Optoelectronic Materials &Technology Jianghan University Centre for Clean Energy Technology Faculty of Science University of Technology Sydney Yichang Brunp Recycling Technology Co. Ltd.

li3VO4has been a promising insertion anode material for li-ion batteries,which has high theoretical capacity (up to～600 mAh g-1) and safe li insertion voltage （0.5–1 V ***/li+）.However,the low initial Coulombic efficiency （ICE） has always been the bottleneck limiting its ***,we propose a facile pre-lithiation method to controllably elevate the ICE by the post-treatment of the prepared li3VO4composite electrode based on an immersion *** this process,the whole electrode was immersed in the liquid li source,via which the ICE of the li3VO4electrode can be controllably elevated from 80%to over 100%within 5 min of *** than the traditional powder treatment for pre-lithiation,this process we proposed minimizes the impact of pre-lithiation on the battery assembly ***,we further investigated the effect of this pre-lithiation process on the functional components in the *** the first time the ICE of li3VO4electrode was elevated to 100%.As a result,the initial reversible capacity of liFePO4||li3VO4full cell was improved from 44.0 to146.3 m Ah g-1,demonstrating the feasibility and great potential of the process.

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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回流孔径对磁力驱动离心泵内部流动的影响分析

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灌溉排水学报 2017年第11期36卷 70-78页

作者：高振军李浩刘建瑞段福义苏华山常浩三峡大学机械与动力学院水电机械设备设计与维护湖北省重点实验室湖北宜昌443000 江苏大学流体机械工程技术研究中心江苏镇江212013 中国农业科学院农田灌溉研究所/河南省节水农业重点实验室河南新乡450002

为研究回流孔径变化对磁力驱动离心泵内部流场及水力性能的影响,分别以6、8、10 mm等3种不同回流孔径的磁力驱动离心泵模型,通过定常、非定常以及流热耦合等数值计算与外特性试验相结合的方法,开展了回流孔径变化对磁力驱动离心泵外特... 详细信息

为研究回流孔径变化对磁力驱动离心泵内部流场及水力性能的影响,分别以6、8、10 mm等3种不同回流孔径的磁力驱动离心泵模型,通过定常、非定常以及流热耦合等数值计算与外特性试验相结合的方法,开展了回流孔径变化对磁力驱动离心泵外特性、内部流场、温度场以及压力脉动特性的影响规律研究。结果表明,(1)回流孔径的变化对磁力驱动离心泵的扬程、效率及泵内部流场的影响较小,其中随着回流孔径的增大,磁力驱动离心泵扬程及效率呈下降趋势;(2)回流孔径的变化对冷却循环流道内的流场、温度场以及压力脉动性能的影响较大,其中随着回流孔径的增大,冷却循环流场内的压力分布逐渐减小,湍动能分布呈增大的趋势,冷却循环流道的冷却效果逐渐变强,另外回流孔径变化对传播进入冷却循环流场的压力脉动强度影响较小,对冷却循环流场内的压力脉动衰减速度影响较大。综上可知,回流孔径变化对泵内流场的影响较小,对冷却循环流道内的流动特性影响较大。

关键词：磁力驱动离心泵回流孔径数值模拟内部流动特性压力脉动特性流热耦合

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基于NOM-Hybrid DEA和Meta-frontier的效率模型研究

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广西科技大学学报 2015年第4期26卷 97-102页

作者：高李昊马璐金山广西科技大学管理学院广西柳州545006

利用NOM-Hybrid DEA理论对共同边界(Meta-frontier)框架进行了重建,使得新框架能够处理带负值的径向与非径向的变量问题,从而求得技术差距率(TGR),结果表明新框架模型是有效的.在算例分析中,出现了瑕疵点,给出了一定程度的解释,但是仍... 详细信息

利用NOM-Hybrid DEA理论对共同边界(Meta-frontier)框架进行了重建,使得新框架能够处理带负值的径向与非径向的变量问题,从而求得技术差距率(TGR),结果表明新框架模型是有效的.在算例分析中,出现了瑕疵点,给出了一定程度的解释,但是仍然需要进一步研究,尝试将共同边界框架分析(Meta-frontier frameworks analysis)理论进一步扩展,使得该理论能够更加广泛地在实际中应用,并且测量更加精确可靠,进而在经济分析和管理应用中发挥更大作用.

关键词：共同边界 NOM-Hybrid DEA 技术差距率

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