检索结果-南通市图书馆

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Bulging Performance and Quality Control of Aluminum Alloy Tailor-welded Overlapping Sheets Based on Interface Friction

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 258-264页

作者： gao Tiejun gao Bowen LI Weijie ZHANG Jiabin College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Shenyang Aerospace Xinguang Group Co.L td. Shenyang 110043China

In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping *** the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded *** this work,the bulging process of the tailor-welded overlapping sheets was taken as the research *** alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental *** results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming *** increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.

关键词： tailor-welded sheets overlapping sheet bulging interface friction weld seam stress

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

椎体成形术治疗急性崩裂性胸腰椎骨折

中国骨伤 2008年第1期21卷 7-9页

作者：高景春宓士军刘长林唐山市丰润区人民医院河北唐山064000

目的:探讨椎体成形术治疗急性崩裂性胸腰椎骨折的可行性。方法:采用椎体成形术治疗急性胸腰椎崩裂骨折58例,其中男38例,女20例;年龄38～70岁,平均56.8岁。伤椎节段:T113例,T1218例,L129例,L25例,L33例。将适合单纯椎体成形术治疗的病例... 详细信息

目的:探讨椎体成形术治疗急性崩裂性胸腰椎骨折的可行性。方法:采用椎体成形术治疗急性胸腰椎崩裂骨折58例,其中男38例,女20例;年龄38～70岁,平均56.8岁。伤椎节段:T113例,T1218例,L129例,L25例,L33例。将适合单纯椎体成形术治疗的病例分为3型(Ⅰ型:椎体成形术安全型;Ⅱ型:椎体成形术风险型;Ⅲ型:椎体成形术边缘型)。本组58例为Ⅰ～Ⅲ型病例:Ⅰ型26例,Ⅱ型21例,Ⅲ型11例。结果:58例中术后1～3d可按预定时间下床活动者53例。随访1～2.5年,平均1年4个月,症状完全缓解55例,其中可从事日常劳动39例,可从事家务劳动16例,完全缓解率95%。部分缓解3例,表现活动后仍觉轻度腰痛,生活可自理,部分缓解率5%。结论:椎体成形术治疗急性崩裂胸腰椎骨折,尽管有一定的风险性,但仍是一个很好的治疗方法。

关键词：椎体成形术崩裂性胸腰椎骨折

基于MATLAB的准实时背景噪声计算分析软件研制

在线全文

学校读者我要写书评

暂无评论

地震研究 2013年第2期36卷 231-237页

作者：王俊缪发军詹小艳高景春江苏省地震局江苏南京210014 河北省地震局河北石家庄050021

针对目前我国省级区域数字测震台网所运行的JOPENS系统,利用Matlab语言开发了采用功率谱概率密度函数的背景噪声计算分析软件。实现了对数字地震台网的数据记录质量、观测系统的健康状态以及背景噪声源变化的准实时监控,计算结果的有效... 详细信息

针对目前我国省级区域数字测震台网所运行的JOPENS系统,利用Matlab语言开发了采用功率谱概率密度函数的背景噪声计算分析软件。实现了对数字地震台网的数据记录质量、观测系统的健康状态以及背景噪声源变化的准实时监控,计算结果的有效频带范围为90s～35Hz,对信号的最小分辨率约为0.012Hz。软件根据功能需求进行模块化设计,并通过TaskContral定时任务控制终端来进行控制和管理,以减少各模块之间的相互联系,从而保证软件运行的持久和稳定。2011年1月在江苏省数字地震台网进行实际部署,运行情况和实际效能均良好。

关键词：测震台网数据记录质量背景噪声源功率谱概率密度函数 JOPENS系统

CT导引下经皮穿刺骨水泥注射治疗骨盆部位溶骨病变9例

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2010年第8期14卷 1467-1470页

作者：宓士军高景春赵士军周广军高万旭孙敬宇唐山市丰润区人民医院河北省唐山市064000

背景：骨盆是溶骨肿瘤常见发生部位,经皮骨水泥注射到病灶部位能达到稳定骨折,减轻疼痛甚或治疗肿瘤的作用,但骨水泥泄漏能引起严重并发症。目的：探讨应用CT导引下经皮穿刺骨水泥注射治疗9例骨盆部位溶骨病变的方法以及治疗效果。方法... 详细信息

背景：骨盆是溶骨肿瘤常见发生部位,经皮骨水泥注射到病灶部位能达到稳定骨折,减轻疼痛甚或治疗肿瘤的作用,但骨水泥泄漏能引起严重并发症。目的：探讨应用CT导引下经皮穿刺骨水泥注射治疗9例骨盆部位溶骨病变的方法以及治疗效果。方法：在CT导引下,首先确定进针点和进针角度,按照病灶的大小和扫描的层数,计算病灶的容积,估计骨水泥的注射剂量。然后使用自行设计的三维穿刺导向器引导穿刺,按照手术前计算的容积略少于计算量0.2~0.5mL注射骨水泥到骨盆溶骨破坏部位,充填满意后退出穿刺针。对穿刺的准确性、注射剂量、临床效果以及并发症进行观察和探讨。结果与结论：全部病例完成5个月~4年,平均1.5年随访。手术后1~48h症状缓解,完全缓解6例,部分缓解2例,轻微缓解1例。手术后CT扫描无病灶周围泄漏。提示经皮穿刺骨水泥注射是治疗不适应手术切除的骨盆溶骨病变的有效方法,具有安全、见效快、创伤小等优点。

关键词：骨水泥溶骨病变 CT导引骨盆成形术生物材料

CT测量穿刺路径在指导椎体成形术穿刺中的应用价值

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2011年第3期14卷 279-282页

作者：刘长林宓士军高景春河北省唐山市丰润区人民医院 064000

目的探讨CT测量穿刺路径在指导椎体成形术穿刺中的安全性及对椎体成形术疗效的影响.方法对248例胸腰椎骨折（365个伤椎节段）患者行经皮穿刺椎体成形术治疗,伤椎穿刺前全部行穿刺路径CT测量标定,应用导向器导引穿刺行椎体成形术,并观... 详细信息

目的探讨CT测量穿刺路径在指导椎体成形术穿刺中的安全性及对椎体成形术疗效的影响.方法对248例胸腰椎骨折（365个伤椎节段）患者行经皮穿刺椎体成形术治疗,伤椎穿刺前全部行穿刺路径CT测量标定,应用导向器导引穿刺行椎体成形术,并观察疗效.结果 365个椎体节段均穿刺成功,穿刺成功率为100.00%.穿刺路径与CT标定相符合者323节段,穿刺符合率为88.49%;42节出现明显偏差,不符合率达11.51%.随访6～12个月,248例行椎体成形术患者中,术后症状完全缓解224例（90.32%）,部分缓解24例（9.68%）,有效率为100.00%.结论单侧穿刺椎体成形术中CT测量穿刺路径是必要的,可提高手术安全性,获得良好的治疗效果.

关键词：体层摄影术,螺旋计算机椎体成形术穿刺路径

在线全文

学校读者我要写书评

暂无评论

高职学生就业预期调查研究

天津职业院校联合学报 2014年第4期16卷 86-90页

作者：高春静高凤敏天津科技大学天津300457

随着我国高校毕业生的逐年增加,大学生就业压力日渐突出。就业是民生之本,是社会安定和谐的基础。大学生就业问题,不仅关系到大学生本人及其家庭的安定幸福,也关系到大学生的权利与尊严,还关系到高校的生存与发展。做好毕业生的跟踪调... 详细信息

随着我国高校毕业生的逐年增加,大学生就业压力日渐突出。就业是民生之本,是社会安定和谐的基础。大学生就业问题,不仅关系到大学生本人及其家庭的安定幸福,也关系到大学生的权利与尊严,还关系到高校的生存与发展。做好毕业生的跟踪调查和就业预期调查,及时了解就业动态、就业形势及企业的需求等,根据调查结果调整就业指导教育,为教学改革提供依据,为毕业生搭建良好的就业平台十分必要。

关键词：高职毕业生就业预期调查

在线全文

学校读者我要写书评

暂无评论

妊娠合并卵巢恶性肿瘤11例临床分析

中国实用妇科与产科杂志 2019年第12期35卷 1354-1359页

作者：王春阳高景春金仙玉王惠华周慧韩璐大连医科大学附属大连市妇产医院暨大连市妇幼保健院妇科辽宁大连116033 大连医科大学附属第一医院辽宁大连116011 大连市中心医院辽宁大连116033 大连市妇女儿童医疗中心辽宁大连116037 瓦房店市中心医院辽宁瓦房店116300

目的探讨妊娠合并卵巢恶性肿瘤的临床特点、诊疗方案及临床结局。方法回顾性分析2005年10月至2018年12月大连医科大学附属大连市妇产医院暨大连市妇幼保健院等5所医院收治的11例妊娠合并卵巢恶性肿瘤患者的临床资料。结果妊娠合并卵巢... 详细信息

目的探讨妊娠合并卵巢恶性肿瘤的临床特点、诊疗方案及临床结局。方法回顾性分析2005年10月至2018年12月大连医科大学附属大连市妇产医院暨大连市妇幼保健院等5所医院收治的11例妊娠合并卵巢恶性肿瘤患者的临床资料。结果妊娠合并卵巢恶性肿瘤的发生率为0.05‰(11/241770)。11例患者中,7例为卵巢原发性恶性肿瘤,其中手术未分期1例、Ⅰ期5例、ⅢC期1例。7例卵巢原发性恶性肿瘤患者中,1例ⅢC期患者放弃妊娠,另6例患者均选择保证胎儿存活的前提下终止妊娠。11例患者中,4例为转移性肿瘤,其中3例手术治疗,均要求保胎放弃恶性肿瘤治疗。11例患者共获得9例新生儿,早产儿4例,其中1例于出生后5min死亡,余8例新生儿均健康存活。结论妊娠合并卵巢恶性肿瘤部分缺乏特异性临床症状,联合各项辅助检查有助于诊断,术中冰冻病理、术后石蜡病理可明确诊断及分期,应警惕转移性肿瘤可能;治疗应根据诊断时的妊娠状态、肿瘤病理类型和分期、患者及家属意愿制定个体化方案。

关键词：妊娠卵巢恶性肿瘤结局

Some evidences for earthquake occurrence in the shallow crust in some areas of North China and Southwest China

在线全文

学校读者我要写书评

暂无评论

Acta Seismologica Sinica(English Edition) 2001年第4期14卷 456-465页

作者：胡新亮刁桂苓高景春张四昌张学民李钦祖秦清娟朱振兴张彦清 1. Seismological Bureau of Hebei Province 050021 Shijiazhuang China

The parameters of hypocentral location are important fundamental data for the study of seismology and the earth interior physics; among them, the focal depth is a very important one but can hardly be measured with higher precision. With the increase of seismic stations in number, the heightening of observation quality and the improvement of determination method, such a situation has been changed much. In this paper, the results of hypocentral location and re-location by 7 small-aperture digital seismic station networks at Tangshan, Zhangbei and Huailai of Hebei Province, Datong of Shanxi Province and Jianchuan, Luquan and Yao'an of Yunnan Province are used. Using these results together with those of focal depth inversion by far-field data of some individual large shocks in corresponding areas and those re-determined by the Linfen telemetered seismic network of Shanxi Province, a comparison with the results of focal depth determination in the past earthquake catalogues is made. It is found out that the focal depths determined by the small-aperture seismic networks are basically distributed in the range from the earth surface to ten-odd kilometers underground. In contrast, the focal depths determined in the past are mostly distributed at the depth range from the earth surface to 30 km underground. Besides, there is a difference of 50% to 100% between the average values of the two cases, which is quite an obvious one. From the result of analysis, it is considered that the results determined by the small-aperture seismic networks may be closer to the reality of focal depths distribution. That is to say, earthquakes in the above-mentioned areas should be distributed in the shallow part of the crust. The causes that lead to the above situation are discussed preliminarily, and some suggestions and measures for improving the precision of focal depth determination are put forward.

关键词： North China region Southwest China region focal depth shallow crust