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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang ai-ai gao Cheng Zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

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Nano Research 2024年第8期17卷 7365-7375页

作者： Huiwen Kang Danyang Huang Jiaru Jing Wei Zhang Lei Zhang Jingyu Wang Ziyan Liu Lin Han Ziyan Wang Lefeng Zhang ai gao Department of Occupational Health and Environmental Health School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China

Nanoplastics(NPs)can accumulate in the kidney and cause kidney injury,but the multi-organ interaction mechanism and preventive measures of kidney injury are still *** this study,in vivo(60μg/day,42 days)and in vitro(0.4μg/μL,24 h)exposure models of polystyrene nanoplastics(PS-NPs,80 nm)in mice and human kidney cortex proximal tubule epithelial cells(HK-2 cells)were established,*** study revealed that PS-NPs caused obvious pathological changes and impaired renal function in mice,which were related to lipid metabolism disorders mediated by intestinal ***-fatty acid synthase(Fasn)-docosahexaenoic acid(DHA)pathway may be one of the mechanisms of kidney injury in ***,we also found that melatonin attenuates PS-NPs-induced nephrotoxicity by modulating lipid metabolism disorders(represented by DHA)and affects Fasn *** conclusion,our study revealed the important role of intestinal flora-mediated lipid metabolism in PS-NPs-induced nephrotoxicity and preliminarily provided potential key gene targets and effective preventive measures for PS-NPs-induced nephrotoxicity.

关键词： nanoplastics nephrotoxicity lipid metabolism fatty acid synthase(Fasn) melatonin

Variation Characteristics of Root Traits of Different Alfalfa Cultivars under Saline-Alkaline Stress and their Relationship with Soil Environmental Factors

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 29-43页

作者： Tian-Jiao Wei Guang Li Yan-Ru Cui Jiao Xie Xing-ai gao Xing Teng Xin-Ying Zhao Fa-Chun Guan Zheng-Wei Liang Northeast Agricultural Research Center of China Jilin Academy of Agricultural SciencesChangchun130033China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun130102China

Soil salinization is the main factor that threatens the growth and development of plants and limits the increase of *** is of great significance to study the key soil environmental factors affecting plant root traits to reveal the adaptation strategies of plants to saline-alkaline-stressed soil *** this study,the root biomass,root morphological parameters and root mineral nutrient content of two alfalfa cultivars with different sensitivities to alkaline stress were analyzed with black soil as the control group and the mixed saline-alkaline soil with a ratio of 7:3 between black soil and saline-alkaline soil as the saline-alkaline treatment *** the same time,the correlation analysis of soil salinity indexes,soil nutrient indexes and the activities of key enzymes involved in soil carbon,nitrogen and phosphorus cycles was carried *** results showed that compared with the control group,the pH,EC,and urease(URE)of the soil surrounding the roots of two alfalfa cultivars were significantly increased,while soil total nitrogen(TN),total phosphorus(TP),organic carbon(SOC),andα-glucosidase activity(AGC)were significantly decreased under saline-alkaline *** was no significant difference in root biomass and root morphological parameters of saline-alkaline tolerant cultivar GN under saline-alkaline *** number of root tips(RT),root surface area(RS)and root volume(RV)of AG were reduced by 61.16%,44.54%,and 45.31%,respectively,compared with control *** ratios of K^(+)/Na^(+),Ca^(2+)/Na^(+)and Mg^(2+)/Na^(+)of GN were significantly higher than those of AG(p<0.05).The root fresh weight(RFW)and dry weight(RDW),root length(RL),RV and RT of alfalfa were positively regulated by soil SOC and TN,but negatively regulated by soil pH,EC,and URE(p<0.01).Root Ca^(2+)/Na+ratio was significantly positively correlated with soil TN,TP and SOC(p<0.01).The absorption of Mg and Ca ions in roots is significantly negatively regulated by soilβ-glucosidase ac

关键词： Saline-alkaline stress alfalfa root traits soil environmental factors correlation analysis

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-Na Cha Juan Yang Jin-ai gao Xin Lu Xiao-Long Chang Rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

Evidence-practice gap analysis in the role of tick in brucellosis transmission: a scoping review

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Infectious Diseases of Poverty 2024年第1期13卷 92-92页

作者： Rui Ma Chunfu Li ai gao Na Jiang Xinyu Feng Jian Li Wei Hu School of Life Sciences Inner Mongolia University Hohhot China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University-The University of Edinburgh Shanghai China Basic Medical College Guangxi University of Chinese Medical Nanning China Department of Infectious Diseases Huashan Hospital State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China

Background Brucellosis is a zoonotic affiction instigated by bacteria belonging to the genus Brucella and is charac-terized by a diverse range of pervasiveness,multiple transmission routes,and serious *** is imperative to amal-gamate the current knowledge and identify gaps pertaining to the role of ticks in brucellosis *** We systematically searched China National Knowledge Infrastructure(CNKi),WanFang,Google Scholar,and PubMed on the topic published until April 23,*** procedure was performed in accordance with the Sys-tematic Reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR)*** selected articles were categorized across three major topic areas,and the potential data was extracted to describe evidence-practice gaps by two *** The search identifed 83 eligible studies for the final *** results highlighted the potential capacity of ticks in brucellosis transmission as evidenced by the detection of Brucella in 16 different tick *** pooled overall prevalence of Brucella in ticks was 33.87%(range:0.00-87.80%).The review also revealed the capability of Bru-cella to circulate in parasitic ticks'different developmental stages,thus posing a potential threat to animal and human *** evidence from in vitro rodent infection experiments has revealed that ticks possess the capability to transmit Brucella to uninfected animals(range:45.00-80.00%).Moreover,significant epidemiological associations have been found between the occurrence of brucellosis in animals and tick control in rangelands,which further suggests that ticks may serve as potential vectors for brucellosis transmission in ***,a mere three cases of human brucellosis resulting from potential tick bites were identified in search of global clinical case reports from 1963to *** It is imperative to improve the techniques used to identify Brucella in ticks,particularly by developing a novel,efficient,

关键词： Tick Brucella Detection Human infection Risk evaluation

g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)光催化剂协同降解苯扎贝特机理研究

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中国环境科学 2024年第5期44卷 2504-2513页

作者：尹泽高博熠刘愿强高爱舫河北地质大学水资源与环境学院河北石家庄050031 河北省水资源可持续利用与开发实验室河北省高校生态环境地质应用技术研发中心河北省水资源可持续利用与产业结构优化协同创新中心河北石家庄050031

利用贵金属Pd的等离子体共振效应和形貌可控Bi2WO6的光催化协同作用,通过低温水热法设计合成具有高效可见光活性的花状g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)异质结复合催化剂.在可见光照射下,异质结复合催化剂光催化降解BZF的去除率均高于g-C_(... 详细信息

利用贵金属Pd的等离子体共振效应和形貌可控Bi2WO6的光催化协同作用,通过低温水热法设计合成具有高效可见光活性的花状g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)异质结复合催化剂.在可见光照射下,异质结复合催化剂光催化降解BZF的去除率均高于g-C_(3)N_(4),g-C_(3)N_(4)/Bi_(2)WO_(6),Pd/g-C_(3)N_(4)和Bi_(2)WO_(6),其中,50%g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)对BZF的去除率为96%,是Pd/g-C_(3)N_(4)的1.8倍,g-C_(3)N_(4)和Bi_(2)WO_(6)的2.7倍.基于表征分析可知,g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)复合催化剂中Bi_(2)WO_(6)呈现中心辐射花状纳米结构,并与层状Pd/g-C_(3)N_(4)连接;贵金属Pd可作为电子传输的介质,促进g-C_(3)N_(4)和Bi_(2)WO_(6)Z型异质结构的形成,有利于协同提升可见光催化活性.淬灭实验和EPR表征证实了·OH是g-C_(3)N_(4)/Pd/Bi_(2)WO_(6)催化降解BZF的主要活性物质,LC-MS/MS分结果表明羟基化作用取代贝特链是BZF降解的主要路径.

关键词：苯扎贝特 Pd g-C_(3)N_(4) Bi_(2)WO_(6) 异质结

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小天体多节点着陆器强化学习任务规划方法

宇航学报 2024年第6期45卷 831-841页

作者：路思遥徐瑞高艾李朝玉王棒朱圣英李超博北京理工大学宇航学院北京100081 深空自主导航与控制工信部重点实验室(北京理工大学) 北京100081 上海卫星工程研究所上海201109

针对中国提出的小天体多节点着陆器节点运动强耦合,着陆规划过程复杂、执行易偏差、重新规划速度慢特点,提出一种多节点着陆器强化学习任务规划方法。该方法首先将状态空间规划逻辑模型描述为矩阵,利用模型矩阵将任务规划建模为马尔科... 详细信息

针对中国提出的小天体多节点着陆器节点运动强耦合,着陆规划过程复杂、执行易偏差、重新规划速度慢特点,提出一种多节点着陆器强化学习任务规划方法。该方法首先将状态空间规划逻辑模型描述为矩阵,利用模型矩阵将任务规划建模为马尔科夫过程,之后通过状态哈希的广度优先搜索算法筛选随机生成状态,生成有效多节点着陆器状态空间始末状态,构建虚拟状态空间训练环境,随机切换始末状态训练强化学习智能体,提升节点的规划适应能力,实现多种条件下的任务规划。对着陆任务进行仿真,实验表明训练后智能体成功完成所有测试任务,且规划效率比POPF3规划器更高,在方案频繁调整的短序列任务上规划速度优势更大,可以更好地应用于多节点着陆器的任务规划。

关键词：任务规划强化学习多节点着陆器状态空间

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乌珠穆沁羊肉品质研究进展

饲料研究 2024年第11期47卷 165-169页

作者：苏湘潭刘叶青张高威杨光王科高爱琴内蒙古农业大学动物科学学院内蒙古自治区草食家畜饲料工程技术研究中心内蒙古呼和浩特010018

乌珠穆沁羊具有个体大、产肉多和抗逆性强等特点,所产羊肉因肉质鲜美、营养丰富,而广受消费者喜爱。文章从牧草特点和乌珠穆沁羊多脊椎特性两个方面对乌珠穆沁羊概况展开分析。在肉质特性方面,从饲粮营养因素、肌纤维特点及脂质3个方面... 详细信息

乌珠穆沁羊具有个体大、产肉多和抗逆性强等特点,所产羊肉因肉质鲜美、营养丰富,而广受消费者喜爱。文章从牧草特点和乌珠穆沁羊多脊椎特性两个方面对乌珠穆沁羊概况展开分析。在肉质特性方面,从饲粮营养因素、肌纤维特点及脂质3个方面进行归纳总结,分析其影响机制,并着重探究肌内脂肪含量、脂肪酸种类和不饱和脂肪酸氧化程度与乌珠穆沁羊肉营养价值的内在联系,通过乌珠穆沁羊自身滋味呈味物质和挥发性风味化合物的代谢积累,解释说明羊肉滋味丰富、无膻味的具体原因。文章系统性分析乌珠穆沁羊肉风味独特、营养丰富的成因,以期为进一步探究肉品质调控机制网络研究提供参考。

关键词：乌珠穆沁羊肉品质肌纤维脂肪酸风味物质

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基于大气成分观测网的山西省近地面O3体积分数分布特征

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环境科学 2024年第2期45卷 655-667页

作者：李莹王淑敏裴坤宁闫世明孙鸿娉张逢生高兴艾山西省气象科学研究所中国气象局温室气体及碳中和监测评估中心山西分中心太原030006 山西省人工增雨防雷技术中心太原030006

利用山西省6个大气成分观测站2019年3月至2020年2月的反应性气体O_(3)、NO、NO_(2)和NO_(x)连续观测资料以及同期气象资料,采用统计分析和后向轨迹分析等方法,对山西近地面O_(3)体积分数变化特征及影响因素进行了对比研究.结果表明,6个... 详细信息

利用山西省6个大气成分观测站2019年3月至2020年2月的反应性气体O_(3)、NO、NO_(2)和NO_(x)连续观测资料以及同期气象资料,采用统计分析和后向轨迹分析等方法,对山西近地面O_(3)体积分数变化特征及影响因素进行了对比研究.结果表明,6个站的O_(3)体积分数一般在4~9月较高,10月至翌年3月较低,研究期内山西南部的晋城和临汾2站的O_(3)日最大8h体积分数滑动平均值φ(MDA8O_(3))超标最严重,其次是北部的五台山、朔州和大同3站,中部的太原站O_(3)污染较轻.对比城市站和高山站发现,两类站点的O_(3)体积分数季节变化虽都表现为:夏季>春季>秋季>冬季,但前者主要受前体物NO_(x)光化学反应的影响,后者的NO_(x)并不是产生高体积分数O_(3)的主要来源;两类站点的O_(3)日变化谱型截然相反,城市站O_(3)小时平均体积分数的峰谷值分别出现在15:00和06:00,而高山站分别出现在20:00和10:00,分别比城市站滞后了约5 h;此外城市站的O_(3)日振幅明显大于高山站.就城市站而言,相较日照时数、降水量和总云量,气温对O_(3)体积分数的影响更为显著;白天的NO_(2)体积分数直接影响O_(3)的日振幅大小,尽管太原站O_(3)的光化学生成潜力也较高,由于被高体积分数的NO滴定消耗,O_(3)体积分数为城市站中最低;各城市站高体积分数的O_(3)对应低体积分数的NO_(x),低NO_(x)以NO_(2)为主,高NO_(x)的贡献则主要来自NO,在较高NO_(x)体积分数时,O_(3)基本上完全被消耗.影响全部站点O_(3)体积分数升高的地面风主要来自东南、南和西南方向,特定的风速条件将导致站点O_(3)体积分数增加.站点地理位置不同会引起大气污染物输送作用的差异,而来自华北平原和汾渭平原高浓度O_(3)的水平输送很可能是造成山西各站点O_(3)体积分数升高的共同原因.

关键词： O_(3)体积分数前体物NO_(x) 城市站高山站气团输送