检索结果-南通市图书馆

Prostate Health Index(phi)and its derivatives predict Gleason score upgrading after radical prostatectomy among patients with low-risk prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第4期24卷 406-410页

作者： Jia-Qi Yan Da Huang Jing-yi Huang Xiao-Hao Ruan Xiao-Ling Lin Zu-Jun Fang yi gao Hao-Wen Jiang yi-Shuo Wu Rong Na Dan-Feng Xu Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China.

To analyze the performance of the Prostate Health Index(phi)and its derivatives for predicting Gleason score(GS)upgrading between prostate biopsy and radical prostatectomy(RP)in the Chinese population,an observational,prospective RP cohort consisting of 351 patients from two medical centers was established from January 2017 to September *** reclassification was determined by the Gleason Grade Group(GG).The area under the receiver operating characteristic curve(AUC)and logistic regression(LR)models were used to evaluate the predictive performance of *** clinically low-risk patients with biopsy GG≤2,phi(odds ratio[OR]=1.80,95%confidence interval[95%CI]:1.14-2.82,P=0.01)and its derivative phi density(PHID;OR=2.34,95%CI:1.30-4.20,P=0.005)were significantly associated with upgrading to GG≥3 after RP,and the results were confirmed by multivariable *** results were observed in patients with biopsy GG of 1 for the prediction of upgrading to RP GG≥*** to the base model(AUC=0.59),addition of the phi or PHID could provide additional predictive value for GS upgrading in low-risk patients(AUC=0.69 and 0.71,respectively,both P<0.05).In conclusion,phi and PHID could predict GS upgrading after RP in clinically low-risk patients.

关键词： Gleason score Prostate Health Index prostate biopsy prostate cancer radical prostatectomy upgrading

Model Analysis of the Anthropogenic Aerosol Effect on Clouds over East Asia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2012年第1期5卷 1-7页

作者： gao yi ZHANG Mei-Gen LIU Xiao-Hong ZHAO Chun State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Pacific Northwest National Laboratory Richland Washington 99352 USA

A coupled meteorology and aerosol/chemistry model WRF-Chem （Weather Research and Forecast model coupled with Chemistry） was used to conduct a pair of simulations with present-day （PD） and preindustrial （P1） emissions over East Asia to examine the aerosol indirect effect on clouds. As a result of an increase in aerosols in January, the cloud droplet number increased by 650 cm-3 over the ocean and East China, 400 cm-3 over Central and Southwest China, and less than 200 cm-3 over North China. The cloud liquid water path （LWP） increased by 40-60 g m-2 over the ocean and Southeast China and 30 g m-2 over Central China; the LWP in- creased less than 5 g m-2 or decreased by 5 g m2 over North China. The effective radius （Re） decreased by more than 4 pm over Southwest, Central, and Southeast China and 2 pm over North China. In July, variations in cloud properties were more uniform; the cloud droplet number increased by approximately 250400 cm-3, the LWP increased by approximately 30-50 g m 2, and Re decreased by approximately 3 μm over most regions of China. In response to cloud property changes from PI to PD, shortwave （SW） cloud radiative m-2 over the ocean and 10 forcing strengthened by 30 W W m-2 over Southeast China, and it weakened slightly by approximately 2-10 W m-2 over Central and Southwest China in January. In July, SW cloud radiative forcing strengthened by 15 W m-2 over Southeast and North China and weakened by l0 W m-2 over Central China. The different responses of SW cloud radiative forcing in different regions was related to cloud feedbacks and natural variability.

关键词： WRF-Chem aerosol indirect effect cloud properties cloud radiative forcing

Effects of Pretreatment by the Flavanol Ampelopsin on Porcine Kidney Epithelial Cell Injury Induced by Hydrogen Peroxide

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2010年第4期9卷 598-604页

作者： TAN gao-yi ZHANG Min-hong FENG Jing-hai HAN Ai-yun ZHENG Shan-shan XIE Peng State Key Laboratory of Animal Nutrition Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

This study investigated the protective effects of ampelopsin on H2O2-induced oxidative injury in porcine kidney epithelial cell line, PK-15; cells were pretreated with medium containing 0, 15, 30, and 60 ug mL-1 ampelopsin, respectively, for 1 h prior to the addition of 100 umol L-1 H2O2. After 2 h, the cell viability, intracellular superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px） activity, cellular malondialdehyde （MDA） content, and DNA strand breakage were determined. Results showed that ampelopsin pretreatment did not modify the SOD and GSH-Px inactivation but significantly decreased MDA production; except for the medium dose （30 ug mL-1）, all the tested concentrations of ampelopsin did not significantly inhibit cell viability reduction and gave no influence on DNA damage. The results suggested that all the tested doses of ampelopsin pretreatment before H2O2 addition can protect PK-15 cell from H2O2-induced lipid peroxidation, which might not be mediated by the SOD and GSH-Px responsees. The appropriate dose of ampelopsin pretreatment prevents PK-15 cell from DNA damage and cell viability reduction.

关键词： ampelopsin PK-15 cell antioxidation hydrogen peroxide

Tunable catalytic activity of gadolinium-doped ceria nanoparticles for pro-oxidation of hydrogen peroxide

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第9期13卷 2384-2392页

作者： Anuja Bhalkikar Tai-Sing Wu Tamra J.Fisher Anandakumar Sarella Dawei Zhang yi gao Yun-Liang Soo Chin Li Cheung Department of Chemistry University of Nebraska-LincolnLincolnNE 68588USA Department of Physics "National Tsing Hua University"Hsinchu 30013TaiwanChina Nebraska Center for Materials and Nanoscience University of Nebraska-LincolnLincolnNEB 68588USA Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China "National Synchrotron Radiation Research Centre" Hsinchu 30076TaiwanChina

We report a study of the roles of gadolinium(lll)(Gd3+)dopants in influencing the catalytic activity of gadolinium-doped ceria nanoparticles towards the pro-oxidation of hydrogen peroxide to hydroxyl *** doped ceria nanoparticles with dopant concentrations of 0.6 wt.%,3 wt.%,and 6 wt.%Gd^3+were synthesized using an ozone-mediated method for tuning their catalytic *** Gd dopants were found to foster an increase in the percentage of Ce^3+ions in the doped ceria *** reaction kinetic study revealed that the relationship between the overall reaction rates and the Gd dopant concentrations in our doped materials followed a volcano-like *** contrast,the apparent activation energy values of these Gd-doped ceria nanoparticles were found to be positively associated with the concentrations of Gd *** overall catalytic activity trend was attributed to the interplay between the promotion and degradation effects of the Gd dopants on the properties of doped ceria nanoparticles.

关键词： ceria cerium oxide gadolinium pro-oxidation hydrogen peroxide hydroxyl radicals ozone

Technology for high performance TRIP steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2012年第7期55卷 1823-1826页

作者： LI Lin gao yi ZHU NaQiong HE YanLin LIU RenDong HE ZhongPing SHI Wen ZHANG Mei Material School Shanghai UniversityShanghai 200072China Anshan Iron and Steel Group Corporation Anshan 114009China

Thermodynamics of martensite transformation in low alloy TRIP steel was *** follows from the calculation that ε phase might be formed at above room temperature in the low Mn *** steel was therefore prepared according to the estimation *** volume fraction of retained austenite(above 20%) containing 1.37%C was obtained in the steel after continuous annealing *** test showed that the ultimate strength of the steel was 1248 MPa,elongation rate 25%,the product of strength and elongation rate 31200 MPa%,reaching the grade of the third generation automobile *** detection indicated that after tensile test there existed ' martensite while TEM revealed that ε martensite also existed in the ***-toughening of the steel was thus raised due to the effect of transformation induced plasticity of two kinds of *** addition,the phase stability of carbonitrates containing V was estimated and the complex micro-alloying effect was applied to the steel to control the size of austenite(about 1 μm) and enhance the stability of austenite.

关键词： TRIP steel ε martensite ' martensite complex micro-alloying

Three-dimensional concentration field imaging in a swirling flame via endoscopic volumetric laser-induced fluorescence at 10-kHz-rate

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2020年第10期63卷 2163-2168页

作者： WANG Qian LIU HeCong LIU XunChen WANG SiRui FU Chen WANG GuoQing gao yi CAI WeiWei QI Fei Key Laboratory of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China

Optical combustion diagnostics are indispensable tools to investigate flame dynamics and excavate in-situ quantities of flames,such as velocity,temperature,concentration of key intermediates and pressure without introducing probe *** example,velocity and flame temperature can be obtained using techniques such as particle image velocimetry,coherent anti-Stokes Raman scattering spectroscopy,Rayleigh scattering and tunable diode laser absorption spectroscopy,respectively.

关键词： scattering laser concentration

Modified tungsten oxide as a binder-free anode in lithium-ion battery for improving electrochemical stability

在线全文

学校读者我要写书评

暂无评论

Tungsten 2022年第4期4卷 356-369页

作者： Jia-Bin Hou Ke Zhang Jin-Hua Xiao Zi-Qi Xu Wen-Jing gao Xin-yi gao Si-Ke Zhou Ze-Zhou Jiao Meng-Ru yi Yan-Hong yin Zi-Ping Wu Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China Chongyi Zhangyuan Tungsten Co. LtdGanzhou341000China Ganzhou Key Laboratory of Advanced Metals and Functional Materials Ganzhou341000China

As the anode active substance of lithium ions battery(LIB),the low conductivity/ion diffusivity and large volume changes of tungsten oxide(WO_(3))lead to its serious polarization during the lithiation/delithiation process,decreasing the cycling *** address these challenges,a binder-free anode consisting of nitrogen-doped tungsten oxide nanosheets,encapsulated in carbon layers(N-doped WO_(3)@CL)and entangled with carbon nanotubes macro-films(CMF),was successfully synthesized through a combination of hydrothermal and online assembly *** with the pristine tungsten oxide entangled with carbon nanotubes macro-films(WO_(3)@CMF),the synthesized N-doped WO_(3)@CL@CMF as a binder-free LIB anode demonstrated better electrochemical performance,which could be attributed to(1)surface defects of WO_(3)created by N dopant providing more channels to improve Li^(+)diffusion,(2)the N-doped WO_(3)@CL with a flower-like structure shortening the diffusion length of Li^(+)ions and further leading to high Li^(+)incorporation,and(3)carbon layers and carbon nanotubes synergistically alleviating the large volume change of the N-doped WO_(3)@CL@CMF electrode during the charging and discharging *** present study offers insights into employing nitrogen dopant and a carbon matrix to mediate the conductivity and wrapped structure in the WO_(3)semiconductor powder,which provides an important strategy for large-scale design of the binder-free LIB anode with high performance.

关键词： Tungsten oxide Nitrogen-doped Carbon layers Carbon nanotubes Binder-free anode

Open-source algorithm and software for computed tomography-based virtual pancreatoscopy and other applications

在线全文

学校读者我要写书评

暂无评论

Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 239-249页

作者： Haofan Huang Xiaxia Yu Mu Tian Weizhen He Shawn Xiang Li Zhengrong Liang yi gao School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China Laboratory for Imaging Research and Informatics State University of New YorkStony BrookNY 11794USA Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies Shenzhen 518060China Marshall Laboratory of Biomedical Engineering Shenzhen 518060China Peng Cheng Laboratory Shenzhen 518066China

Pancreatoscopy plays a significant role in the diagnosis and treatment of pancreatic ***,the risk of pancreatoscopy is remarkably greater than that of other endoscopic procedures,such as gastroscopy and bronchoscopy,owing to its severe *** comparison,virtual pancreatoscopy(VP)has shown notable ***,because of the low resolution of current computed tomography(CT)technology and the small diameter of the pancreatic duct,VP has limited clinical *** this study,an optimal path algorithm and super-resolution technique are investigated for the development of an open-source software platform for VP based on 3D *** proposed segmentation of the pancreatic duct from the abdominal CT images reached an average Dice coefficient of 0.85 with a standard deviation of *** to the excellent segmentation performance,a fly-through visualization of both the inside and outside of the duct was successfully reconstructed,thereby demonstrating the feasibility of *** addition,a quantitative analysis of the wall thickness and topology of the duct provides more insight into pancreatic diseases than a fly-through *** entire VP system developed in this study is available at https://***/gaoyi/***.

关键词： Pancreatic cancer Pancreatic duct segmentation Virtual pancreatoscopy 3D Slicer

Therapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2015年第1期11卷 74-82页

作者： Hong-Fang Ding Hui Zhang Hui-Fang Ding Dong Li Xin-Hao yi Xin-yi gao Wei-Wei Mou Xiu-Li Ju Department of Pediatrics Qilu HospitalShandong UniversityJinan 250012China Department of Pediatrics Shengli Oil Field Central HospitalDongying 257034China Department of Neurology Qingdao Municipal HospitalQingdao 266000China

Background:Oxidative stress is involved in the development of hypoxic-ischemic brain damage(HIBD).In this study,we investigated the therapeutic efcts of placenta-derived mesenchymal stem cells(PD-MSCs)and explored the N F-E2-related factor-2/heme oxygenase-1(Nrf2/HO-1)signaling pathway in treating ***:P7 rats were subjected to hypoxic-ischemic brain injury and randomly divided into four groups(control,HIBD,HIBD+PD-MSCs,and HIBD+fbroblasts).Forty-eight hours after the induction of HIBD,5×10^(5)of PD-MSCs were injected into cerebral tissue in the HIBD+PD-MSCs group,while the same dose of fibroblas ts were injected in the HIBD+fibroblasts *** Water Maze,gross and pathological changes were tested at *** level of malondialdehyde(MDA)was detected in rats'***-PCR and western blot analysis were used to evaluate the changes of Nrf2/***:The HIBD group showed significantly longer escape latency and a lower frequency of original platform crossing in the Morris Water M laze compared with the control *** receiving PD MSCs showed significant improvement of *** pathological changes were evident after HIBD,but ameliorated in the PD-MSCs *** with the control group,HO-1 and Nrf2 were up-regulated at gene and protein levels in the HI brain,beginning at 6 hours and peaking at 48 hours(P<0.05).The expression of HO-1 and Nrf2 in the PD-MSCs treatment group was more pronounced than in the HBD group(P<0.01).PD MSCs also decreased MDA production in the brain ***:These results demonstrate that PD-MSCs have neuroprotective effect during the treatment of HIBD and that the mechanism may be partly due to alleviating oxidative stress.

关键词： hypoxia-ischemia mesenchymal stem cells neonatal rat oxidative stress