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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cellgeneration and functions in melanoma and ovarian cancer

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Signal Transduction and Targeted Therapy 2016年第1期1卷 1-9页

作者： Harshita B Gupta Curtis A Clark Bin Yuan gangadhara sareddy Srilakshmi Pandeswara Alvaro S Padron Vincent Hurez Jose Conejo-Garcia Ratna Vadlamudi Rong Li Tyler J Curiel Department of Medicine University of Texas Health Science CenterSan AntonioTXUSA The Graduate School of Biomedical Sciences University of Texas Health Science CenterSan AntonioTXUSA Department of Molecular Medicine University of Texas Health Science CenterSan AntonioTXUSA Department of Obstetrics and Gynecology University of Texas Health Science CenterSan AntonioTXUSA Tumor Microenvironment and Metastasis Program The Wistar InstitutePhiladelphiaPAUSA Cancer Therapy and Research Center University of Texas Health Science CenterSan AntonioTXUSA Department of Microbiology and Immunology University of Texas Health Science CenterSan AntonioTXUSA

As tumor PD-L1 provides signals to anti-tumor PD-1^(+)T cells that blunt their functions,αPD-1 andαPD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling ***,tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor cell proliferation and mTOR signals,among other important ***-initiating cells(TICs)generate carcinomas,resist treatments and promote *** show here that in murine B16 melanoma and ID8agg ovarian carcinoma cells,TICs express more PD-L1 versus *** PD-L1 in B16 and ID8agg cells by shRNA(‘PD-L1lo’)reduced TIC numbers,the canonical TIC genes nanog and pou5f1(oct4),and functions as assessed by tumorosphere development,immune-dependent and immune-independent tumorigenesis,and serial transplantability in ***,tumor PD-L1 sensitized TIC to interferon-γand rapamycin in ***-intrinsic PD-L1 similarly drove functional TIC generation,canonical TIC gene expression and sensitivity to interferon-γand rapamycin in human ES2 ovarian cancer ***,tumor-intrinsic PD-L1 signals promote TIC generation and virulence,possibly by promoting canonical TIC gene expression,suggesting that PD-L1 has novel signaling effects on cancer pathogenesis and treatment responses.

关键词： melanoma interferon initiating

Catalytic decomposition of CH_4 over Ni-Al_2O_3-SiO_2 catalysts:Influence of pretreatment conditions for the production of H_2

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Journal of Natural Gas Chemistry 2008年第2期17卷 113-119页

作者： Jangam Ashok gangadhara Raju Padigapati Shiva Reddy Machiraju Subrahmanyam Akula Venugopal Catalysis and Physical Chemistry Division Indian Institute of Chemical TechnologyTarnakaHyderabadIndia-500 607

This article reports the production of COx free hydrogen and carbon nanofibers by the catalytic decomposition of methane over Ni-Al2O3-SiO2 catalysts. The influence of reaction temperature, pretreatment temperature, and effect of reductive pretreatment on the decomposition of methane activity is investigated. The physico-chemical characteristics of fresh and deactivated samples were characterized using BET-SA, XRD, TPR, SEM/TEM, CHNS analyses and correlated with the methane decomposition results obtained. The Ni-Al-Si （4 ： 0.5 ： 1.5） catalyst reduced with hydrazine hydrate produced better H2 yields of ca. 1815 mol H2/mol Ni than the catalyst reduced with 5% H2/N2.

关键词： in situ reduction Ni-Al2O3-SiO2 catalyst methane decomposition hydrogen production carbon nanofibers

Effect of asymmetrical wall heat flux and wall temperature ratio on mixed convection in a vertical micro-porous-channel with internal heat generation

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Propulsion and Power Research 2020年第4期9卷 394-407页

作者： V.Leela K.N.Seetharamu Nagabhushanam Kotloni R.gangadhara Reddy PES University Bengaluru.Karnataka560085India RV Institute of Technology and Management.Bengaluru.Karnataka 560076India AMC Engineering College BengaluruKarnataka560083India

Mixed convective heat transfer in a vertical parallel plate micro-porous channel with internal heat generation and viscous dissipation,varying wall heat flux ratio and wall temperature ratio at the boundaries is investigated using the Darcy-Brinkman model under local thermal non-equilibrium *** solution for both fluid and solid temperature distributions are obtained by applying the finite element *** effect of pertinent parameters such as Brinkman number,Rayleigh number,Darcy number,inter-phase heat transfer coefficient,porosity scaled thermal conductivity ratio and solid internal heat generation are *** results indicate that the Nusselt number increases with the increase in the solid internal heat generation as well as Rayleigh number in both wall heat flux ratio and wall temperature ratio boundary *** is observed that with the quantitative increase in viscous dissipation parameter Br,Nusselt number Nu increases in the presence of internal heat generation and it decreases in the absence of internal heat generation,for a specific range of values of wall heat flux ratio and wall temperature *** this range Nu increases with the increase in Dr regardless of internal heat *** the cases,constant wall temperature and wall heat flux ratios,good correlation is observed in the results obtained with that of available in the literature.

关键词： Wallheat flux ratio Wallt emperatureratio Internal heat generation Mixed convection Viscous dissipation Local thermal non-equilibrium

Influence of soil density on gas permeability and water retention in soils amended with in-house produced biochar

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 593-602页

作者： Ankit Garg He Huang Weiling Cai Narala gangadhara Reddy Peinan Chen Yifan Han Viroon Kamchoom Shubham Gaurav Hong-Hu Zhu Department of Civil and Environmental Engineering Guangdong Engineering Center for Structure Safety and Health MonitoringShantou UniversityShantouChina Department of Civil Engineering Kakatiya Institute of Technology and ScienceWarangalIndia Department of Civil Engineering King Mongkut’s Institute of Technology LadkrabangBangkokThailand Department of Biology Science and Biology Technology Indian Institute of Technology GuwahatiGuwahatiIndia School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China

Biochar has been used as an environment-friendly enhancer to improve the hydraulic properties(*** and water retention)of ***,variations in densities alter the properties of the soil ebiochar *** density variations are observed in agriculture(loosely compacted)and engineering(densely compacted)*** influence of biochar amendment on gas permeability of soil has been barely investigated,especially for soil with different *** major objective of this study is to investigate the water retention capacity,and gas permeability of biochar-amended soil(BAS)with different biochar contents under varying degree of compaction(DOC)***-house produced novel biochar was mixed with the soil at different amendment rates(*** contents of 0%,5%and 10%).All BAS samples were compacted at three DOCs(65%,80%and 95%)in polyvinyl chloride(PVC)*** soil column was subjected to dryingewetting cycles,during which soil suction,water content,and gas permeability were measured.A simplified theoretical framework for estimating the void ratio of BAS was *** experimental results reveal that the addition of biochar significantly decreased gas permeability kg as compared with that of bare soil(BS).However,the addition of 5%biochar is found to be optimum in decreasing kg with an increase of DOC(i.e.k_(g,65%)>k_(g,80%)>k_(g,95%))at a relatively low suction range(<200 kPa)because both biochar and compaction treatment reduce the connected pores.

关键词： Biochar Degree of compaction(DOC) Gas permeability Soil water retention Wettingedrying cycle

An Experimental Study on the Response of Model Footings Resting on Reinforced Flyash Beds under Repeated Load

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Journal of Civil Engineering and Architecture 2014年第5期8卷 633-638页

作者： Shivaram gangadhara Honnagondanahalli Chikkaranganna Muddaraju Department of Civil Engineering Bangalore University Bangalore 560 056 India

In the present, investigation an attempt has been made to study the behavior of reinforced flyash beds under repeated loads by conducting carefully designed experiments. The main objective of the experiments conducted is to evaluate the beneficial effects of using flyash as a backfill material in the reinforced beds to resist the repeated loads. As no unique standard equipment is available for the application of repeated loads and to measure the response, different researchers have designed and fabricated different types of equipments for the testing. The repeated load of known intensity with waveform type and frequency is applied on the surface and embedded footing in unreinforced and reinforced flyash beds. The response of the flyash beds, in the form of settlement is measured using linear variable differential transducers. The experimental results clearly demonstrated that the provision of reinforcement in the flyash beds is effective in improving the performance of both surface and embedded footing under repeated loads.

关键词： Reinforced fly ash bed repeated loads cyclic resistance ratio settlement ratio.

The Response of Geopotential Height Anomalies to El Niño and La Niña Conditions and Their Implications to Seasonal Rainfall Variability over the Horn of Africa

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Atmospheric and Climate Sciences 2022年第2期12卷 475-492页

作者： Solomon Gunta Hejamady gangadhara Bhat Busnur Rachotappa Manjunatha Department of Physics College of Natural and Computational Sciences Wolaita Sodo University Wolaita Sodo Ethiopia Remote Sensing and Geo-Informatics Division Department of Marine Geology Faculty of Science and Technology Mangalore University Karnataka India

In this study, we unveil atmospheric circulation anomalies associated with the large-scale tropical teleconnections using National Center for Environmental Prediction (NCEP) reanalysis dataset. Composite analyses have been performed to know the impact of large-scale tropical circulations on the Horn of Africa. The composite analysis performed at the geopotential height of 850 Mb and 200 Mb, and precipitation rate (mm/day) during six strong El Niño and La Niña episodes revealed that the large-scale tropical variability induced climate anomalies in space and time. A substantial decrease in upper-level height (200 Mb) has been observed in the study area during El Niño composite years as compared to the La Niña years. During El Niño conditions, the upper-level divergence initiates low-level vertical motion, thereby enhancing convection, however, during La Niña composite years, nearly contrasting situations are noticed in Belg (February to May) season in Ethiopia. However, geopotential height anomalies at 850 Mb are above-normal during the strong El Niño years, suggesting suppressed convection due to vertical shrinking and enhancement of divergence at the lower level. Compared to the Belg (February to May), geopotential anomalies were generally positive during the Kiremt (June to September) season, thereby suppressing the rainfall, particularly in Southern Ethiopia and Northern Part of Kenya. In contrast, an increase in rainfall was observed during the Belg season (February to May).

关键词： Geopotential Height Composite Analysis ENSO Atmospheric Circulations NCEP Reanalysis Tropical SST Anomalies Teleconnections Belg Kiremt

基于主动加热光纤法的毛细阻滞入渗模型试验研究

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岩土工程学报 2021年第1期43卷 147-155,I0004,I0005页

作者：王家琛朱鸿鹄王静曹鼎峰苏立君 Narala gangadhara Reddy 南京大学地球科学与工程学院江苏南京210023 中国科学院山地灾害与地表过程重点实验室四川成都610041 中山大学土木工程学院广东广州510275 印度理工学院布巴内斯瓦尔分校基础设施学院印度布巴内斯瓦尔752050

毛细阻滞效应是多层、不同粒径非饱和土入渗过程中的一个自然现象。为了探究多层土水分入渗的毛细阻滞过程,设计了室内模型试验,采用主动加热光纤法(AHFO法)对多层土的水分迁移进行试验,并结合频域反射法(FDR法)和直接观测法作为验证。... 详细信息

毛细阻滞效应是多层、不同粒径非饱和土入渗过程中的一个自然现象。为了探究多层土水分入渗的毛细阻滞过程,设计了室内模型试验,采用主动加热光纤法(AHFO法)对多层土的水分迁移进行试验,并结合频域反射法(FDR法)和直接观测法作为验证。试验结果表明:相较于FDR法和直接观测法,AHFO法对降雨入渗所产生的毛细阻滞现象具有较好的观测效果,可观测出水分运移的更多细节;运用FDR法,对AHFO传感器进行原位标定,曲线拟合精度R2均大于0.93,具有较高的体积含水率监测准确度;毛细阻滞层对降雨入渗具有明显的阻滞效应,即存储屏障上部入渗和减少水分向下部水体渗出。相关研究结论为毛细阻滞现象研究以及土壤水分场监测提供了一种新的监测方法。

关键词：毛细阻滞主动加热光纤法砂土模型试验降雨入渗

Association of Meloidogyne incognita and Fusarium chlamydosporum causing with wilt complex in Northern Karnataka on Coleusforskohlii

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Journal of Agricultural Science and Technology 2009年第8期3卷 49-52页

作者： Devappa V Kumar B Nagaraj R. gangadhara Naik, B Ravindra H. Kamanna B. C. Shamrao Jahagirdar Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad 580005. India Department of Plant Pathology and Microbiology College of Agriculture Navile Campus Shimoga 5 77204 India

A pot culture experiment was carried out to study the interaction of Melodogyne incognita and Fusarium chlamydosporurn on Coleus forskohlii. The nematode multiplication was adversely affected when fungus was inoculated prior to nematode. Simultaneous inoculation of nematode and fungus as well as nematode followed by fungus seven days later, caused 85.5 per cent root rot disease and significant reduction in plant growth as well as nematode multiplication when compared to the inoculation fungus alone or fungus inoculation prior to nematode.

关键词： Meloidogvne incognita: Fusarium chlamydosporum Coleus forskohli disease complex

Screening of genotypes for their resistance againstMeloidogyne incognita and Fusarium chlamydosporum causing wilt complex on Coleusforskohlii Briq.

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Journal of Agricultural Science and Technology 2009年第12期3卷 16-18页

作者： Devappa V. Kumar B. gangadhara Naik. Nagaraja.R. Ravindra H. Kamanna B.C. Jahagirdar.S. L.Hegde Department of Plant Pathology College of Agriculture University of Agricultural Sciences Dharwad 580005 India Department of Plant Pathology and Microbiology College of Agriculture Shimoga 577204 India

A pot culture experiment was carried out for the Screening of 11 popular genotypes against to Meloidogyne incognita and Fusarium chlamydosporum wilt complex on Coleus forskohlii. Genotype viz., yellow tubers and Rabakavi local showed resistant reaction, Orange tuber and Nimbanur local showed moderately resistant reaction. Rest of the seven genotvDes showed suscentible reactions.

关键词： Coleus genotypes Meloidogyne incognita Fusarium chlamydosporum Coleus forskohlii