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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Protection of cement-soil reinforced regions for adjacent running tunnels during pit excavation

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岩石力学与工程学报 2018年第A01期37卷 3674-3685页

作者： WANG Li zheng gang School of Civil Engineering Tianjin University School of Civil and Safety Engineering Dalian Jiaotong University

In pit excavation,cement is introduced into ground by deep mixing method to form an improved soil raft below final formation level to diminish deflection of retaining wall and effect on surrounding *** to complicated site conditions and improper workmanship,there are always some regions left untreated in the embedded improved soil *** this work,Several schemes of cement-soil mixed piles arrangement are modeled in order to discuss the effect of different cement-soil reinforced regions on protection for adjacent running *** element results show that:when lateral regions above tunnels are not enhanced by cement-soil mixed piles,effect of enlarging vertical enhanced regions around tunnels on diminishing lateral displacement of tunnel is really small;enhancing the lateral regions next to retaining wall is more effective in reducing the deflection of tunnel and retaining wall;uplifting of tunnel under the middle pit mainly depends on lateral reinforced regions and lateral displacements of retaining wall;as cement-soil mixed piles near retaining wall in east pit are removed during east pit excavation,effect of cement-soil mixed piles in east pit on reducing the final wall deflection can be neglected;upward shaft resistances are exerted along left side of diaphragm wall during excavation,which helps to reduce the wall deflection;positive effect of single-head cement-soil mixed piles in east pit is to decreasing the uplifting of soil inside east ***-head cement-soil mixed piles arranged in"T"shape decrease the effect of east pit excavation on tunnels under middle pit apparently.

关键词： mining engineering deep mixing method cement-soil mixed piles pit excavation deflection uplifting

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BRITTON CHANCE AND THE THERANOSTIC BEACON DEVELOPMENT AT PENN

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 483-485页

作者： gang zheng Department of Medical Biophysics University of Toronto Canada

In the summer of 2000,while I was vacationing in China and getting ready to start my career in industry,I got a call from Jerry Glickson to check if I would be interested in joining the Penn Molecular Imaging *** was very persuasive and he drew an interesting outline of the work,including the opportunity to work with one of the greatest scientific minds in the *** could I say no to work with Britton Chance,aka"BC"?

关键词： Optical imaging photodynamic therapy chlorophyll cancer

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囊体扩张主动控制桩基水平变形机理分析

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岩土工程学报 2025年第1期47卷 85-95页

作者：黄建友闫宇涛刁钰郑刚李凯贾建伟刘永超天津大学建筑工程学院天津300072 滨海土木工程结构与安全教育部重点实验室(天津大学) 天津300072 中国建筑第五工程局有限公司湖南长沙410004 中国建筑第六工程局有限公司天津300457 天津建城基业集团有限公司天津300301

囊体扩张是一种新型地下结构变形主动控制技术,然而其在桩基变形控制机理方面尚未深入研究。采用有限元软件探究了囊体扩张控制桩基水平变形机理,分析了囊体扩张引起桩基和土体变形特性以及囊体-土体-桩体之间相互作用。结果表明:扩张直... 详细信息

囊体扩张是一种新型地下结构变形主动控制技术,然而其在桩基变形控制机理方面尚未深入研究。采用有限元软件探究了囊体扩张控制桩基水平变形机理,分析了囊体扩张引起桩基和土体变形特性以及囊体-土体-桩体之间相互作用。结果表明:扩张直径0.5 m的囊体对直径为1.2 m的桩可产生最大5.5 mm水平变形,控制效率为60%,囊体扩张对桩基水平变形控制效果良好。囊体扩张会引起邻近土体产生较大的超孔隙水压力,而孔压消散会导致土体压缩而降低桩基控制效率。当扩张距离较小时,桩径对囊体扩张控制效果影响显著。囊体扩张对桩径为0.4~1.6m的桩均有一定的变形控制效果,尤其适用于小直径桩基的变形控制。随扩张直径的增大,桩基最大水平位移近乎呈线性增大。此外,桩基水平变形随扩张距离增大而减小,但由于扩张对周围孔隙水压力影响范围有限,导致控制效率呈增大趋势。双排囊体扩张控制变形中“遮拦效应”和“反力效应”明显,控制桩基变形应遵循“先远后近,逐排扩张”的原则,以提高控制效果。

关键词：囊体扩张桩基变形控制机理分析

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Dynamics of rotator chain with dissipative boundary

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Frontiers of physics 2014年第4期9卷 511-518页

作者： Pu Ke Zhi-gang zheng Department of Physics and the Beijing Hong Kong Singapore Joint Center for Nonlinear and Complex Systems (Beijing) Beijing Normal University Beijing 100875 China

We study the deternfinistic dynanfics of rotator chain with purely mechanical driving on the boundary by stability analysis and numerical sinmlation. Globally synchronous rotation, clustered synchronous rotation, and split synchronous rotation states are identified. In particular, we find that the single-peaked wariance distribution of angular momenta is the consequence of the deterministic dynamics. As a result, the operational definition of temperature used in the previous studies on rotator chain should be revisited.

关键词： rotator chain energy conduction

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Effects of phase change material(PCM)-based nanocomposite additives on thermal decomposition and burning characteristic of high energy propellants containing RDX

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Defence Technology（防务技术） 2022年第4期18卷 557-566页

作者： En-fa Fu Na Sun zheng-gang Xiao Key Laboratory of Special Energy Materials Ministry of Education School of Chemical Engineering Nanjing University of Science and Technology

A kind of phase change material(PCM)-based nanocomposite was prepared and added into high energy propellants containing RDX as additives to investigate its effect on thermal decomposition and burning characteristic of high energy *** effect of PCM-based nanocomposites on thermal decomposition of high energy propellants is investigated by TG/DSC-FTIR-MS *** to the delayed protection effect(PCM-based nanocomposites can absorb lots of heat at the range of certain temperature when it undergoes structure change or phase transitions)of PCM-based nanocomposites under the thermal decomposition condition,the thermal stability of high energy propellants modified with PCMbased nanocomposites is *** the same time,the concentration of N2,NO2,H2O and CO_(2)is increased during thermal decomposition of high energy propellants whereas NO and CO is *** burning gaseous products and burning characteristic of high energy propellants are studied by the combination of closed bomb test and Fourier transform infrared *** main burning gaseous products are N2,CO_(2),CO,H2O,CH4,*** the high energy propellant modified with PCM-based nanocomposites,the concentration of CH4is increased while CO,CO_(2) and H2O is decreased under the high-pressure burning *** progressivity factor of high energy propellants is increased by22.2%compared with the control sample while the maximum pressure is merely decreased 1.25%after the addition of the PCM-based nanocomposite,thus PCM-based nanocomposites can be used to adjust the burning process and improve the burning progressivity of high energy *** study is expected to boost the practical application of PCM-based nanocomposite to the propellant formulation and effectively control the burning characteristic of high energy propellants.

关键词： Phase change material Propellants Nanocomposite Thermal decomposition Burning

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Rapid detection to long ship wake in synthetic aperture radar satellite imagery

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Journal of Oceanology and Limnology 2019年第5期37卷 1523-1532页

作者： CHEN Peng LI Xiunan zheng gang Second Institute of Oceanography Ministry of Natural Resources

The maritime administrative department employs synthetic aperture radar (SAR) satellite remote sensing technology to obtain evidence of illegal discharge of ships. If the ship is discharged during navigation, it forms a long dark wake on the SAR image due to the suppression of the Bragg wave by the oil fi lm. This study investigates key techniques for rapid detection of long ship wakes, thereby providing law enforcement agencies with candidate ships for possible discharge. This paper presents a rapid long ship wake detection method that uses satellite imaging parameters and the axial direction of the ship in images to determine the potential detection area of the wake. Then, the threshold of long ship wake detection is determined using statistical analysis, the area is binarized, and isolated points are removed using a morphological filter operator. The method was tested with ENVISAT Synthetic Aperture Radar and GF-3 SAR data, and results showed that the method was eff ective, and the overall accuracy of the decision reaches 71%. We present two innovations;one is a method that draws a Doppler shift curve, and uses the SAR imaging parameters to determine the detection area of the long wake to achieve rapid detection and reduce the image detection area. The other is where a classical linear fitting method is used to quickly and accurately determine whether the detected dark area is a long ship wake and realizes the twisted long ship wake detection caused by the sea surface flow field, which is otherwise diffi cult to detect by the traditional Radon and Hough transform methods. This method has good suppression performance for the dark spot false alarm formed by low speed wind region or upward flow. The method is developed for maritime ship monitoring system and will promote the operational application of maritime ship monitoring system.

关键词： marine pollution illegal discharge linear fi t oil spill synthetic aperture radar (SAR) long ship wake

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Propagation dynamics on the Fermi-Pasta-Ulam lattices

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Frontiers of physics 2013年第3期8卷 349-355页

作者： Zong-Qiang Yuan Zhi-gang zheng Department of Physics and the Beijing Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Beijing) Beijing Normal University Beijing 100875 China

The spatiotemporal propagation of a momentum excitation on the finite Fermi-Pasta-Ulam lattices is investigated. The competition between the solitary wave and phonons gives rise to interesting propagation behaviors. For a moderate nonlinearity, the initially excited pulse may propagate co- herently along the lattice for a long time in a solitary wave manner accompanied by phonon tails. The lifetime of the long-transient propagation state exhibits a sensitivity to the nonlinear parameter. The solitary wave decays exponentially during the final loss of stability, and the decay rate varying with the nonlinear parameter exhibits two different scaling laws. This decay is found to be related to the largest Lyapunov exponent of the corresponding Hamiltonian system, which manifests a transition from weak to strong chaos. The mean-free-path of the solitary waves is estimated in the strong chaos regime, which may be helpful to understand the origin of anomalous conductivity in the Fermi-Pasta Ulam lattice.

关键词： Fermi-Past-Ulam model solitary wave low-dimensional heat conduction

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Hierarchical cluster-tendency analysis of the group structure in the foreign exchange market

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Frontiers of physics 2013年第4期8卷 451-460页

作者： Xin-Ye Wu Zhi-gang zheng Department of Physics and the Beijing-Hong Kong Singapore Joint Center for Nonlinear and Complex Systems Beijing Normal University Beijing 100875 China

A hierarchical cluster-tendency （HCT） method in analyzing the group structure of networks of the global foreign exchange （FX） market is proposed by combining the advantages of both the minimal spanning tree （MST） and the hierarchical tree （HT）. Fifty currencies of the top 50 World GDP in 2010 according to World Bank＇s database are chosen as the underlying system. By using the HCT method, all nodes in the FX market network can be ＂colored＂ and distinguished. We reveal that the FX networks can be divided into two groups, i.e., the Asia-Pacific group and the Pan-European group. The results given by the hierarchical cluster-tendency method agree well with the formerly observed geographical aggregation behavior in the FX market. Moreover, an oil-resource aggregation phenomenon is discovered by using our method. We find that gold could be a better numeraire for the weekly-frequency FX data.

关键词： foreign-exchange market hiergrchical cluster-tendency method hierarchical tree,minimum spanning tree

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Radiative Decay Bc → Ds*γ in the Technicolor with a Massless Scalar Doublet Model

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Communications in Theoretical Physics 2002年第7期38卷 47-52页

作者： CAO Yi-gang JIAO zheng-Kuan Department of Physics Zhejiang University Hangzhou 310027 China Department of Physics Zhejiang University Hangzhou 310027 China

Applying perturbative QCD, we study the process Bc → Dsγ in the technicolor with a massless scalar doublet model (TCMLSM). There are mainly two mechanisms contributing to the Bc → D*sγ process. One proceeds through the short distance b → sγ transition and the other through weak annihilation accompanied by a photon *** find that, compared with the standard model, the modification of Bc → D*sγ from πρ (the physical pions in the TCMLSM) is so small that can be neglected for the allowed mass ofπρ. The weak-annihilation contribution is found to be about one order larger than that of the electromagnetic penguin diagrams.

关键词： perturbative QCD, technicolor, massless scalar doublet model

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