检索结果-南通市图书馆

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代医学科学（英文） 2024年第4期44卷 726-734页

作者： Liang WANG Ping WANG Bing LIU Hui ZHANG Cheng-cheng WEI Ming XIONG gang luo Miao WANG Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China

Objective:This study aimed to investigate the role of the long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)in the epithelial-mesenchymal transition(EMT)of bladder cancer cells and the potential ***:Cell invasion,migration,and wound healing assays were conducted to assess the effects of MEG3 on the invasive and migratory capabilities of bladder cancer *** expression levels of E-cadherin were measured using Western blotting,RT-qPCR,and dual luciferase reporter *** immunoprecipitation and pull-down assays were performed to investigate the interactions between MEG3 and its downstream ***:MEG3 suppressed the invasion and migration of bladder cancer cells and modulated the transcription of *** binding of MEG3 to the zinc finger region of the transcription factor Snail prevented its ability to transcriptionally repress ***,MEG3 suppressed the phosphorylation of extracellular regulated protein kinase(ERK),c-Jun N-terminal kinase(JNK),and P38,thereby decreasing the expression of Snail and stimulating the expression of ***:MEG3 plays a vital role in suppressing the EMT in bladder cancer cells,indicating its potential as a promising therapeutic target for the treatment of bladder cancer.

关键词： Snail bladder cancer epithelial-mesenchymal transition long noncoding RNA maternally expressed gene 3

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

右心发育不良综合征胎儿心脏介入治疗进展

中华儿科杂志 2024年第6期62卷 583-586页

作者：罗刚泮思林青岛大学附属妇女儿童医院心脏中心青岛266034

右心发育不良综合征表现为右心室、三尖瓣和(或)肺动脉瓣发育不良,右心发育不良程度决定远期预后。胎儿肺动脉瓣成形术可改变疾病的自然病史,促进右心继续发育,利于生后双心室循环。本文对心脏介入治疗右心发育不良综合征胎儿的进展进... 详细信息

右心发育不良综合征表现为右心室、三尖瓣和(或)肺动脉瓣发育不良,右心发育不良程度决定远期预后。胎儿肺动脉瓣成形术可改变疾病的自然病史,促进右心继续发育,利于生后双心室循环。本文对心脏介入治疗右心发育不良综合征胎儿的进展进行综述。

关键词：心脏介入治疗自然病史肺动脉瓣右心发育不良综合征发育不良远期预后双心室右心室

在线全文

学校读者我要写书评

暂无评论

清儒礼学研究中的“礼意”追求

湖南大学学报（社会科学版） 2024年第2期38卷 16-24页

作者：林存阳罗刚中国社会科学院古代史研究所北京100101 中国社会科学院大学历史学院北京102488

在礼学的发展过程中,“礼意”受到治礼者的重视。“礼意”源自“礼义”,可看作是对“礼”的义理或意蕴的诠释。作为记载礼学内容的“礼文”经层累的构建而愈密,“礼意”经层累的构建而愈精。历代的礼学研究均注重寻求“礼意”,也关注到... 详细信息

在礼学的发展过程中,“礼意”受到治礼者的重视。“礼意”源自“礼义”,可看作是对“礼”的义理或意蕴的诠释。作为记载礼学内容的“礼文”经层累的构建而愈密,“礼意”经层累的构建而愈精。历代的礼学研究均注重寻求“礼意”,也关注到了“礼文”和“礼意”的关系。清儒在治礼过程中格外关注对“礼意”的寻求,主张“通礼文之穷”以寻求蕴藏在“礼文”背后的“礼意”,并呈现出清初“礼时为大”、清中期“即器明道”、晚清“会通汉宋”的阶段性特征。对“礼意”的寻求与阐发,既是一种治“礼”的方法,也是一种治“礼”的理念,更是一种治“礼”的目的,展现了清儒“通经明道”的立学旨趣及“以礼经世”的礼治思想。

关键词：清儒礼学礼意礼义通经明道以礼经世

Electric field dependence of spin qubit in a Si-MOS quantum dot

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第6期33卷 248-253页

作者：马荣龙倪铭周雨晨孔真真王桂磊刘頔罗刚曹刚李海欧郭国平 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Origin Quantum Computing Company Limited Hefei 230026China

Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum ***, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.

关键词： silicon-based quantum computing valley electric-dipole spin resonance

在线全文

学校读者我要写书评

暂无评论

清儒论“伪儒”的三重考量

古代文明（中英文） 2024年第3期18卷 130-139,160页

作者：林存阳罗刚中国社会科学院中国历史研究院古代史研究所北京100101 中国社会科学院大学北京100101 中国社会科学院大学历史学院北京102488

清儒从“学道”与“事功”的考量出发,努力辨别“真儒”与“伪儒”,主张“真儒”以“明道”为安身立命之所,以“明学术、正人心”为目的,以“经世致用”为现实考量。清儒对“伪儒”的批判与对“真儒”的追求彰显了清代儒者对正统儒学的... 详细信息

清儒从“学道”与“事功”的考量出发,努力辨别“真儒”与“伪儒”,主张“真儒”以“明道”为安身立命之所,以“明学术、正人心”为目的,以“经世致用”为现实考量。清儒对“伪儒”的批判与对“真儒”的追求彰显了清代儒者对正统儒学的传承与践履、自我净化的诉求以及回归传统儒家学术的努力。

关键词：伪儒明道学术经世致用

Majorana tunneling in a one-dimensional wire with non-Hermitian double quantum dots

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第1期33卷 686-691页

作者：牛鹏斌罗洪刚 Institute of Solid State Physics Shanxi Datong Universityand Shanxi Provincial Key Laboratory of Microstructural Electromagnetic Functional MaterialsDatong 037009China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Beijing Computational Science Research Center Beijing 100084China

The combination of non-Hermitian physics and Majorana fermions can give rise to new effects in quantum transport systems. In this work, we investigate the interplay of PT-symmetric complex potentials, Majorana tunneling and interdot tunneling in a non-Hermitian double quantum dots system. It is found that in the weak-coupling regime the Majorana tunneling has pronounced effects on the transport properties of such a system, manifested as splitting of the single peak into three and a reduced 1/4 peak in the transmission function. In the presence of the PT-symmetric complex potentials and interdot tunneling, the 1/4 central peak is robust against them, while the two side peaks are tuned by them. The interdot tunneling only induces asymmetry, instead of moving the conductance peak, due to the robustness of the Majorana modes. There is an exceptional point induced by the union of Majorana tunneling and interdot tunneling. With increased PT-symmetric complex potentials, the two side peaks will move towards each other. When the exceptional point is passed through, these two side peaks will disappear. In the strong-coupling regime, the Majorana fermion induces a 1/4 conductance dip instead of the three-peak structure. PT-symmetric complex potentials induce two conductance dips pinned at the exceptional point. These effects should be accessible in experiments.

关键词： Majorana fermion non-Hermitian quantum dot parity–time symmetry exceptional point

鲜水河断裂带地震矩亏损的空间分布及2022年泸定M 6.8级地震

在线全文

学校读者我要写书评

暂无评论

地球科学 2024年第2期49卷 425-436页

作者：尹力周本刚任治坤罗纲中国地震局地质研究所地震动力学国家重点实验室北京100029 武汉大学测绘学院湖北武汉430079

2022年9月5日泸定M 6.8级地震发生在鲜水河断裂带南端的磨西断裂.该地震的发震机制以及未来该断裂段是否仍会发生强震是值得关注的科学问题.拟从地震能量积累与释放的角度来解释该地震的发震原因以及鲜水河断裂带未来的发震潜力.通过对... 详细信息

2022年9月5日泸定M 6.8级地震发生在鲜水河断裂带南端的磨西断裂.该地震的发震机制以及未来该断裂段是否仍会发生强震是值得关注的科学问题.拟从地震能量积累与释放的角度来解释该地震的发震原因以及鲜水河断裂带未来的发震潜力.通过对比地震矩积累与释放的时空分布,发现地震大都发生在地震矩亏损的段落,并有填补地震矩亏损的趋势.此外,鲜水河断裂带至今存在3个显著的地震矩亏损段,均具发生6.5级以上地震的潜力.1786年康定M 7.6级地震发生之后,经过两百多年时间的积累,足以发生M 6.5级以上地震,而泸定M 6.8级地震仅释放了磨西断裂上部分的地震矩亏损,未来该断裂段仍具有发生强震的可能.

关键词：地震矩亏损鲜水河断裂带泸定M 6.8级地震地震危险性分析

在线全文

学校读者我要写书评

暂无评论

习近平文化思想引领高校文化建设的思考

淮阴师范学院学报（哲学社会科学版） 2024年第2期46卷 109-117,215页

作者：罗刚淮阴师范学院教育科学学院江苏淮安223300

习近平文化思想对高校文化建设的价值意蕴在于提供了强大的思想武器、有效的方法论和科学的行动指南。习近平文化思想引领高校文化建设的理论逻辑不仅在于能提高对文化建设重要性的认识,还在于深化了对高校文化的方向、结构和层次的认识... 详细信息

习近平文化思想对高校文化建设的价值意蕴在于提供了强大的思想武器、有效的方法论和科学的行动指南。习近平文化思想引领高校文化建设的理论逻辑不仅在于能提高对文化建设重要性的认识,还在于深化了对高校文化的方向、结构和层次的认识,高校要文化育人、文化治校、文化强国;高校文化建设的目标逻辑在于以文化育人,培养高素质人才;高校文化建设的价值逻辑在于以科研优势传承和创新中华优秀传统文化;高校文化建设的行动逻辑在于内外兼修,发挥高校文化优势。高校教育工作者需要提升文化自觉,推动高校文化的高质量发展,做到强化理论武装,筑牢理想信念,坚守初心使命,砥砺精神品格;加强内容创新,构建中国特色的校园文化内容体系,既要提炼文化育人素材,凸显中华民族精神与爱国主义教育,激发学生民族自豪感,又要凸显文化特色,推动中华优秀传统文化创造性转化和创新性发展;增进文化传播,塑造高校文化品牌。做到扩大开放合作,既要面向区域,也要面向世界,还要注重塑造学科创新品牌。

关键词：习近平文化思想高校文化建设价值意蕴基本逻辑行动方略

聚三氟氯乙烯合成、改性与加工技术国内专利综述

在线全文

学校读者我要写书评

暂无评论

有机氟工业 2024年第2期 58-64页

作者：罗钢湖南株洲宏大高分子材料有限公司湖南省特种工程塑料工程技术研究中心湖南株洲412007

基于中国专利文献,对聚三氟氯乙烯(PCTFE)合成、改性与加工技术发展现状进行梳理总结,旨在帮助国内相关企业和研究机构了解该领域的专利技术,指导聚三氟氯乙烯技术创新,提升聚三氟氯乙烯专利质量。

关键词：聚三氟氯乙烯合成改性加工