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Petroleum Science 2019年第6期16卷 1471-1478页

作者： Yuvarajan Devarajan Dineshbabu Munuswamy Beemkumar Nagappan ganesan subbiah Department of Mechanical Engineering Madanapalle Institute of Technology&ScienceMadanapalleIndia Department of Mechanical Engineering Panimalar Engineering CollegeChennaiIndia Department of Mechanical Engineering Jain UniversitySchool of Engineering and TechnologyBangaloreIndia Department of Mechanical Engineering Sathyabama Institute of Science and TechnologyChennaiIndia

This work examines the effect of butanol as an oxygenated additive to lower carbon monoxide,smoke,nitrogen oxide and hydrocarbon emissions and to improve the performance aspects of Calophyllum inophyllum(Punnai)***,oil-cooled compression ignition engines are employed in this *** Punnai biodiesel(P100)is blended with butanol at 10%and 20%by volume and labelled as B10 P90 and B20 P80,*** and alkaline catalyst(KOH)were used for the transesterification process for biodiesel *** transesterification technique yielded 88%biodiesel from raw Punnai *** tests resulted in lower CO,smoke,NO_x and HC emissions when fuelled with both butanol blends when compared to *** addition,BSFC(brake-specific fuel consumption)reduced and BTE(brake thermal effciency)increased with the inclusion of butanol blends(B10 and B20)to neat Punnai biodiesel.

关键词： Butanol Punnai biodiesel Nitrogen oxide Carbon dioxide Engine

High-fidelity model to predict heat transfer enhancement for liquid film boiling on uniform micro-structured wicking surfaces

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National Science Review 2024年第6期11卷 93-95页

作者： Vishwanath ganesan Mohammad Jalal Inanlu Nenad Miljkovic Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Materials Research Laboratory University of Illinois Urbana-Champaign International Institute for Carbon Neutral Energy Research (WPI-I2CNER) Kyushu University Institute for Sustainability Energy and Environment (iSEE)University of Illinois Urbana-Champaign

The field of thermal management in highpower electronic devices is a critical area of study, focusing on the efficient dissipation of heat to prevent device overheating and failure [1]. A key aspect of this field is understanding the dynamics of thin liquid film boiling, both on uniform and non-uniform micro-structured wicking surfaces, which can significantly enhance the heat transfer effectiveness[2].

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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang Hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

An Imperative Role of Fetal Autopsy in Previable Fetuses-Amniotic Deformity Adhesions,Mutilations Complex

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Maternal-Fetal Medicine 2024年第3期6卷 134-140页

作者： Harini Devi JKA Nidhya ganesan Umamaheswari Gurusamy Department of Pathology PSG Institute of Medical Sciences and ResearchPeelameduCoimbatore 641004India

Objective:To identify the occurrence of the amniotic deformity adhesions,mutilation(ADAM)complex and imperative role of fetal autopsy in diagnosing this ***:A retrospective descriptive study spanning nine years,from January 2014 to January 2022,was conducted at the Department of Pathology within a tertiary care hospital in South *** study focused on analyzing the clinical presentation,prenatal ultrasonogram,and morphological features of fetuses with the ADAM complex,limb body wall complex,or amniotic ***:Among the 438 fetuses assessed during the study period,five fetuses showed features of the ADAM complex(0.01%).The most frequent gestational age observed was 12–18 weeks andmost fetuseswere *** common anomaly encountered was limb defects,followed by abdominal and cranial ***:The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk *** pathologist plays a crucial role in understanding the complexities of the ADAM *** antenatal imaging and therapies offer potential for prevention through improved counseling.

关键词： Amniotic band syndrome ADAM complex Previable fetus Fetal autopsy

Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients

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World Journal of Diabetes 2024年第1期15卷 24-33页

作者： Rupak Desai Nishanth Katukuri Sumaja Reddy Goguri Azra Kothawala Naga Ruthvika Alle Meena Kumari Bellamkonda Debankur Dey Sharmila ganesan Minakshi Biswas Kuheli Sarkar Pramoda Prattipati Shaylika Chauhan Independent Researcher Independent ResearcherAtlantaGA 30079United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Medicine Chalmeda Anand Rao Institute of Medical SciencesTelangana 505001India Department of Medicine Jawaharlal Nehru Medical CollegeBelgaum 590010India Department of Medicine Narayana Medical CollegeAndhra PradeshNellore 524003India Department of Medicine Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research FoundationVijaywada 521286India Department of Medicine Medical College KolkataKolkata 700073India Department of Medicine P.E.S.Institute of Medical Sciences and ResearchAndhra Pradesh 517425India Department of Medicine Shaheed Ziaur Rahman Medical CollegeBogra 5800Bangladesh Department of Medicine College of Medicine and J.N.M HospitalKalyani 741235India Department of Medicine Jawaharlal Nehru Medical College IndiaKarnatakaBelagavi 590010India Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States

BACKGROUND Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events(MACCE).However,the relationship between prediabetes and MACCE in atrial fibrillation(AF)patients has not been extensively ***,this study aimed to establish a link between prediabetes and MACCE in AF *** To investigate a link between prediabetes and MACCE in AF *** We used the National Inpatient Sample(2019)and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes,excluding *** primary outcome was MACCE(all-cause inpatient mortality,cardiac arrest including ventricular fibrillation,and stroke)in AF-related *** Of the 2965875 AF-related hospitalizations for MACCE,47505(1.6%)were among patients with *** prediabetes cohort was relatively younger(median 75 vs 78 years),and often consisted of males(56.3%vs 51.4%),blacks(9.8%vs 7.9%),Hispanics(7.3%vs 4.3%),and Asians(4.7%vs 1.6%)than the non-prediabetic cohort(P<0.001).The prediabetes group had significantly higher rates of hypertension,hyperlipidemia,smoking,obesity,drug abuse,prior myocardial infarction,peripheral vascular disease,and hyperthyroidism(all P<0.05).The prediabetes cohort was often discharged routinely(51.1%vs 41.1%),but more frequently required home health care(23.6%vs 21.0%)and had higher *** adjusting for baseline characteristics or comorbidities,the prediabetes cohort with AF admissions showed a higher rate and significantly higher odds of MACCE compared to the non-prediabetic cohort[18.6%vs 14.7%,odds ratio(OR)1.34,95%confidence interval 1.26-1.42,P<0.001].On subgroup analyses,males had a stronger association(aOR 1.43)compared to females(aOR 1.22),whereas on the race-wise comparison,Hispanics(aOR 1.43)and Asians(aOR 1.36)had a stronger association with MACCE with prediabetes vs whites(aOR 1.33)and blacks(aOR 1.21).CONCLUSION This population-

关键词： Prediabetes Atrial fibrillation Cardiovascular disease risk Major adverse cardiovascular and cerebrovascular events Stroke Mortality

Knowledge and attitude on childhood cancer survivorship among healthcare trainees:a multicentre study from India

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Family Medicine and Community Health 2024年第S2期12卷 34-43页

作者： Amritesh Grewal Bhavik Bansal Chetanya Mittal Hardik Gupta Archana Sasi Prasanth ganesan Aashima Dabas Puneet Sahi Lakshmi Ramamoorthy Hmar Thiak Lalthanthuami Jaikumar Ramamoorthy Arwachi Sindhu Suyash Arora Anumeha Bhukya Muthumani Hepzibah Kanchana Devi Karthick Krishnamurthy Sanjeet K Rai Nikhil Mehta Komal Antil Sameer Bakhshi Shuvadeep Ganguly Medical Student All India Institute of Medical SciencesNew DelhiDelhiIndia Department of Medical Oncology Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew DelhiDelhiIndia Department of Medical Oncology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Department of Pediatrics Lok Nayak HospitalNew DelhiDelhiIndia Department of Pediatrics Maulana Azad Medical CollegeNew DelhiDelhiIndia College of Nursing Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Medical Student Maulana Azad Medical CollegeNew DelhiDelhiIndia Department of Surgical Disciplines All India Institute of Medical SciencesNew DelhiDelhiIndia Department of Dermatology and Venereology All India Institute of Medical SciencesNew DelhiDelhiIndia College of Nursing All India Institute of Medical SciencesNew DelhiDelhiIndia

Background The proportion of childhood cancer survivors(CCS)in low/middle-income countries(LMICs)is *** often develop several physical and psycho-social long-term adverse effects,with unique healthcare *** healthcare providers(primary care physicians(PCPs)),especially in LMICs,are often not equipped to handle survivorship *** study aimed to assess knowledge,and attitude among trainee healthcare providers concerning major issues of paediatric survivorship *** A multi-centre,cross-sectional,questionnaire-based study was conducted among nursing and medical undergraduate students,and postgraduate medical residents across three tertiary-care teaching hospitals in India—All India Institute of Medical Sciences,New Delhi;Jawaharlal Institute of Postgraduate Medical Education and Research,Puducherry;and Maulana Azad Medical College,New Delhi.A questionnaire with total of 24 questions(14 knowledge-based and 10 attitude-based)was finalised after validation by expert review and *** major domains covered in the questionnaire included knowledge and attitude regarding long-term adverse effects and psychosocial,employment-related issues faced by the *** was administered to the study participants *** knowledge-based questions had true/false responses(scored as 0 or 1 if incorrect or correct,respectively).Attitude-based questions were scored as 5-point Likert *** Total 898 responses were collected(median age:21 years,64%(576/898)female).Among the respondents,44%were undergraduate medical students,42%were nursing students and 14%were postgraduate medical *** mean(SD)of knowledge score was 8.72(2.04)(out of 14).On multivariable analysis,only discipline of training predicted knowledge scores regarding survivorship *** medical residents(9.08)as well as undergraduate medical students(8.85),had significantly higher mean knowledge scores than nursing students(8.47)(p=0.004).Two questions were

关键词： centre handle false

BRCA1,PARP,and 53BP1:conditional synthetic lethality and synthetic viability

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分子细胞生物学报:英文版 2011年第1期3卷 66-74页

作者： Amal Aly Shridar ganesan Cancer Institute of New Jersey Robert Wood Johnson Medical School-UMDNJ195 Little Albany StreetNew BrunswickNJ 08903USA

BRCA1 plays a critical role in the regulation of homologous recombination(HR)-mediated DNA double-strand break ***1-deficient cancers have evolved to tolerate loss of BRCA1 *** renders them vulnerable to agents,such as PARP inhibitors,that are conditionally‘synthetic lethal’with their underlying repair *** studies demonstrate that BRCA1-deficient cells may acquire resistance to these agents by partially correcting their defect in HR-mediated repair,either through reversion mutations in BRCA1 or through‘synthetic viable’loss of *** findings and their clinical implications will be reviewed in this article.

关键词： DNA repair BRCA1 53BP1 PARP

Performance Analysis of a Heterogeneous Network Employing DAPSK Based OFDMA-PON

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China Communications 2023年第3期20卷 128-145页

作者： Priyadharshini Rajasekaran Geetha ganesan Department of Electronics and Communication Engineering Sri Venkateswara College of EngineeringSriperumbudur 602117Tamil NaduIndia Department of Electronics and Communication Engineering College of Engineering GuindyAnna UniversityChennai 600025Tamil NaduIndia

Recent mobile broadband networks require heterogeneous networks supporting high capacity on demand.A hybrid Fiber-Wireless(Fi-Wi)access network integrating Differential Amplitude and Phase Shift Keying(DAPSK)based-Orthogonal Frequency Division Multiple Access(OFDMA)Passive Optical Network(PON)and 4G wireless network using Radio over Fiber(Ro F)technique is *** proposed heterogeneous network is simulated,and the performance is analyzed in terms of Bit Error Rate(BER),Error Vector Magnitude(EVM),Capacity,and Spectral *** proposed network is simulated considering a higher data rate of 10 and 25 Gbps,and the effect of system parameters like Laser Power,Fiber Length,and Number of users is *** results show that a higher network capacity of 720 Gbps with an average capacity of about 45 Gbps and a higher spectral efficiency of 4.85 bps/Hz is achieved for the multi-user heterogeneous network link with sixteen *** minimum value of optical power sufficient to achieve the desired BER is found to be-6 *** suitability of the proposed integrated architecture in supporting multiple services is analyzed by considering different services at each *** spectral efficiency of the multi-service link varies from 3 to 4 bps/Hz.

关键词： DAPSK OFDMA PON RoF Spectral ef-ficiency

Minimum Spanning Trees Across Well-Connected Cities and with Location-Dependent Weights

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Communications in Mathematics and Statistics 2022年第1期10卷 1-50页

作者： Ghurumuruhan ganesan Institute of Mathematical Sciences HBNIChennaiIndia

Consider n nodes{X_(i)}_(1≤i≤n) independently and identically distributed(i.i.d.)across N cities located within the unit square *** city is modelled as an r_(n)×r_(n)square,and MSTC_(n)denotes the weighted length of the minimum spanning tree containing all the n nodes,where the edge length between nodes X_(i)and X_(j)is weighted by a factor that depends on the individual locations of X_(i)and X_(j).We use approximation methods to obtain variance estimates for MSTC_(n)and prove that if the cities are well connected in a certain sense,then MSTC_(n)appropriately centred and scaled converges to zero in *** the above proof techniques we also study MST_(n),the length of the minimum weighted spanning tree for nodes distributed throughout the unit square S with location-dependent edge *** this case,the variance of MST_(n)grows at most as a power of the logarithm of n and we use a subsequence argument to get almost sure convergence of MST_(n),appropriately centred and scaled.

关键词： Minimum spanning tree Well-connected cities Location-dependent edge weights

Chloride-Bridged Dimeric SalphenZr(IV) Cobaltate Catalyst Unleashes the Potential of Base-Free Carbonylative Polymerization for Biodegradable PHAs

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Chinese Journal of Chemistry 2023年第24期41卷 3560-3566页

作者： Vinothkumar ganesan Sungho Yoon Department of Chemistry Chung Ang University84 Heukseok-roDongjak-guSeoul06974 Republic of Korea

Poly(3-hydroxyalkanoates) (PHAs) are a promising class of biodegradable polymers,exhibiting properties comparable to traditional petroleum-based ***,the widespread commercialization of PHAs is hindered by the absence of an efficient and economically viable catalytic system,impeding their competitiveness against non-biodegradable *** an effort to address this challenge,we present a study on a newly developed chloro-bridged dimeric salphen zirconium cobaltate complex for the direct synthesis of PHAs via carbonylative polymerization of *** catalytic system demonstrates favorable activity under mild reaction conditions,enabling complete monomer conversion and an impressive 92% selectivity towards PHA *** meticulous control experiments and mechanistic studies,we have gained crucial insights into the polymerization ***,our findings challenge the prevailing notion of sequential ring-opening polymerization of in-situ generated β-lactones as the primary ***,we demonstrate that the polymerization predominantly proceeds through direct co-polymerization of epoxide and carbon monoxide,unveiling a unique and efficient mechanism for PHA synthesis.

关键词： C1 building blocks Chloro bridged salphenZr(IV)dimer Homogeneous catalysis Carbonylation Carbonylative polymerization Biodegradable polymer Poly(3-hydroxyalkanoates)