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Wnt/Glycogen Synthase Kinase 3β/β-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection

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Chinese Medical Journal 2015年第17期128卷 2346-2353页

作者： Jin-Dong Liu Qian deng Huan-Huan Tian Yun-Ting Pang gan-lin deng Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical College Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical College Xuzhou Jiangsu 221004 China Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical College Xuzhou Jiangsu 221004 China

Background： Sevoflurane preconditioning （SP） has been shown to invoke potent myocardial protection in animal studies and clinical trials. However, the mechanisms underlying SP are complex and not yet well understood. We investigated the hypothesis that the cardioprotection afforded by SP is mediated via the Writ/glycogen synthase kinase 3β（GSK3β）/β-catenin signaling pathway. Methods： Two models were established： A Langendorffperfused rat heart model and the H9C2 cell hypoxia/reoxygenation model. Both rats and H9C2 cells were randomly divided into 6 groups as follows： S group, ischemia-reperfusion （I/R） group, DMSO group, IWP group, SP group, and SP ＋ IWP group. Hemodynamic parameters, lactate dehydrogenase （LDH） activity in coronary effluent and cell culture supernatant, and the infarct size were measured to evaluate myocardial ischemia-reperfusion injuries. To determine the activity of Wnt/GSK3β/β-catenin signaling pathway, the expressions of Wnt3a, phospho-GSK3β, and β-catenin were measured by Western blotting. Results： SP improved cardiac function recovery, reduced infarct size （18 ±2% in the SP group compared with 35 ± 4% in the 1/R group; P 〈 0.05）, decreased LDH activity in coronary effluent, and culture supematant. IWP-2, an inhibitor of Wnt, abolished the cardioprotection by SR In addition, Western blotting analysis demonstrated that the expressions of Wnt3a, phospho-GSK3β, and β-catenin significantly （P 〈 0.05） increased in the I/R group, compared with the S group; and compared to I/R group, SP significantly （P 〈 0.05） increased Wnt3a, phospho-GSK3 β, and β-catenin expressions. Pretreatment with IWP-2 significantly （P 〈 0.05） abolished SP-induced Wnt/GSK3β/β-catenin signaling activation. Conclusions： The results showed for the first time that cardioprotection afforded by SP may be mediated partly via the Wnt/GSK3β/β-catenin signaling pathway.

关键词： Cardioprotection Ischemia-reperfusion Injury Preconditioning Sevoflurane Wnt/Glycogen Synthase Kinase3β/β-catenin Signaling

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Broadband angular spectrum analog processors based on all-dielectric metasurfaces

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 188-190页

作者： lin deng Yongmin Liu Department of Electrical and Computer Engineering Northeastern UniversityBoston 02115USA Department of Mechanical and Industrial Engineering Northeastern UniversityBoston 02115USA

Digital signal processors are extensively used to execute mathematical operations and advanced computational tasks on digital ***,they suffer from several inherent limitations,including low speed,high energy consumption,and large memory requirements,because of the hardware bottleneck and the imperative conversion between digital and analogue signals.

关键词： dielectric spectrum hardware

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An angular blinking jamming method based on electronically controlled corner reflectors

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Journal of Systems Engineering and Electronics 2024年第2期35卷 330-338页

作者： gan lin WU Zehao WANG Xuesong LI Jianbing State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System National University of Defense TechnologyChangsha 410073China

Passive jamming is believed to have very good potential in countermeasure *** this paper,a passive angular blinking jamming method based on electronically controlled corner reflectors is *** amplitude of the incident wave can be modulated by switching the corner reflector between the penetration state and the reflection state,and the ensemble of multiple corner reflectors with towing rope can result in complex angle decoying *** of the decoying effect on corner reflectors’radar cross section and positions are analyzed and *** show that the angle measured by a monopulse radar can be significantly interfered by this method while the automatic tracking is employed.

关键词： monopulse radar angular blinking jamming corner reflector amplitude-comparison angle measurement metasurface

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Multi-Fidelity Simulation of Gas Turbine Overall Performance by Directly Coupling High-Fidelity Models of Multiple Rotating Components

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Journal of Thermal Science 2024年第4期33卷 1357-1378页

作者： deng Weimin XU Yibing NI Ming WEI Zuojun gan Xiaohua REN Guangming Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055China School of Aerospace Engineering Tsinghua UniversityBeijing100084China Shenzhen Key Laboratory of Wide-Speed-Range and Variable-Density Continuous Wind Tunnel Shenzhen Science and Technology Innovation CommitteeShenzhen518000China

Multi-fidelity simulations incorporate computational fluid dynamics(CFD) models into a thermodynamic model,enabling the simulation of the overall performance of an entire gas turbine with high-fidelity *** iterative coupled methods rely on characteristic maps,while fully coupled methods directly incorporate high-fidelity ***,fully coupled methods face challenges in simulating rotating components,including weak convergence and complex *** address these challenges,a fully coupled method with logarithmic transformations was developed to directly integrate high-fidelity CFD models of multiple rotating *** developed fully coupled method was then applied to evaluate the overall performance of a KJ66 micro gas turbine across various off-design *** developed fully coupled method was also compared with the traditional iterative coupled ***,experimental data from ground tests were conducted to verify its *** convergence history indicated that the proposed fully coupled method exhibited stable convergence,even under far-off-design *** experimental verification demonstrated that the multi-fidelity simulation with the fully coupled method achieved high accuracy in off-design *** analysis revealed inherent differences in the coupling methods of CFD models between the developed fully coupled and traditional iterative coupled *** inherent differences provide valuable insights for reducing errors between the component-level model and CFD models in different coupling *** developed fully coupled method,introducing logarithmic transformations,offers more realistic support for the detailed and optimal design of high-fidelity rotating components within the overall performance platform of gas turbines.

关键词： multi-fidelity fully coupled method iterative coupled method gas turbine component-level model

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Memristor-based spiking neural networks:cooperative development of neural network architecture/algorithms and memristors

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Chip 2024年第2期3卷 62-78页

作者： Huihui Peng lin gan Xin Guo School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Inspired by the structure and principles of the human brain,spike neural networks(SNNs)appear as the latest generation of artificial neural networks,attracting significant and universal attention due to their remarkable low-energy transmission by pulse and powerful capability for large-scale parallel *** research on artificial neural networks gradually change from software simulation into hardware ***,such a process is fraught with *** particular,memristors are highly anticipated hardware candidates owing to their fastprogramming speed,low power consumption,and compatibility with the complementary metal–oxide semiconductor(CMOS)*** this review,we start from the basic principles of SNNs,and then introduced memristor-based technologies for hardware implementation of SNNs,and further discuss the feasibility of integrating customized algorithm optimization to promote efficient and energy-saving SNN hardware ***,based on the existing memristor technology,we summarize the current problems and challenges in this field.

关键词： Spike neural networks Hardware Memristor Algorithm Cooperative development

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Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang Shan-lin Li Guan-Hua gan Wen-Wen deng Yong-Sheng Chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

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A novel method for the green utilization of waste fried oil

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Particuology 2024年第1期84卷 1-11页

作者： gan Cheng Mengni Zhang Yang Lu Yanhui Zhang Bin lin Ee Von Lau College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo454003China Henan Key Laboratory for Green and Efficient Mining&Comprehensive Utilization of Mineral Resources Henan Polytechnic UniversityJiaozuo454003China Collaborative Innovation Center of Coal Work Safety and Clean High Efficiency Utilization Henan Polytechnic UniversityJiaozuo454003China School of Engineering Monash University MalaysiaSubang JayaSelangor47500Malaysia

Waste fried oil was studied to prepare three different types of detergent such as soap,liquid soap and soap powder via saponification *** preparation conditions of soap base were optimized by orthogonal *** specific preparation processes included waste fried oil treatment,orange peel extract preparation,saponification,demoulding and *** showed that the optimal con-ditions for saponification were as follows:ratio of pure waste fried oil to coconut oil=6∶4,alkali liquor(NaOH)mass fraction 30%,saponification temperature 70℃,orange peel extract concentration 15%.The mature soap was then used to make liquid soap and soap powder by surfactant(sodium dodecylbenzene sulfonate,coconut diethanol amide)addition,followed by *** prepared detergent conforms to the production standard of strong decontamination ability,possesses stable performance,is gentle to skin and non-toxic.

关键词： Waste fried oil Detergent Saponification Decolorization

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Mean-square exponential stability of stochastic Volterra systems in infinite dimensions

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Science China(Information Sciences) 2024年第10期67卷 298-314页

作者： lin FU Shiguo PENG Feiqi deng Quanxin ZHU School of Automation Guangdong University of Technology School of Automation Science and Engineering South China University of Technology Key Laboratory of Computing and Stochastic Mathematics(Ministry of Education) School of Mathematics and StatisticsHunan Normal University

Over the past decade, the study of stability theory in integro-differential systems has grown significantly owing to their relevance in solving physical and engineering problems, such as viscoelasticity and thermo-viscoelasticity in materials with memory properties. This paper concentrates on a class of infinite-dimensional stochastic integro-differential systems. We establish the well-posedness of the system and identify mild solutions to the system and an abstract stochastic Cauchy problem. This identification is identified by employing a semigroup approach combined with Yosida approximation. We derive sufficient conditions that ensure the mean-square exponential stability of mild solutions to the system boils down to the boundedness of a certain function and a norm estimate for the stochastic part. These conditions are implemented through the semigroup approach and the composition operator method. Illustrative examples are provided and the obtained theoretical results are validated by numerical simulations.

关键词： stochastic integro-differential equations mean-square exponential stability stochastic distributed parameter systems Hardy space composition operators

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Rational design and energy catalytic application of high-loading single-atom catalysts

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Rare Metals 2024年第10期43卷 4844-4866页

作者： Zi-Wei deng Yue Liu Jie lin Wen-Xing Chen Energy and Catalysis Center School of Materials Science and EngineeringBeijing Institute of Technology Ningbo Institute of Materials Technology and Engineering Chinese Academy of Science

It is well known that single-atom catalysts(SACs)have become a hot topic in the field of catalysis due to their advantages such as 100% metal atom utilization efficiency,high catalytic activity and selectivity compared with conventional catalysts and nanocatalysts. However, the isolated metal atoms on SACs have thermodynamic instability and tend to agglomerate, which limit their catalytic ***, it is of great significance to synthesize stable and high-loading single-atom catalysts(HLSACs). In this paper,we review the research progress of HLSACs from two aspects:design and application. Firstly, we comprehensively introduce the synthesis strategies of HLSACs, namely, top-down and bottom-up methods. Secondly, we overview the application status of HLSACs in three fields: electrocatalysis, thermal catalysis and photocatalysis. Finally, we summarize the development prospects and challenges of HLSACs.

关键词： Design Electrocatalysis High-loading single-atom catalysts Photocatalysis Thermal catalysis

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Effect of Oxygen-Rich Combustion on Flame Propagation of Syngas in a Half-Open Pipe at Elevated Temperatures

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Journal of Thermal Science 2024年第5期33卷 1920-1934页

作者： LI Ningning deng Haoxin XU Zhuangzhuang YAN Mengmeng WEI Shengnan SUN Guangzhen WEN Xiaoping gan Haowen WANG Fahui School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454003China

The investigation of syngas flame propagation has great benefits for the effective use of gas *** essay sets out to study the flame propagation of premixed oxygen-rich combustion(oxygen enrichment coefficient in volumeΩ:0.21,0.27,0.32,0.37)of syngas(H_(2):CO=2:8)in half-closed rectangular ducts at elevated temperatures(T:300 K,400 K,500 K)and evaluate the effects of initial temperature and oxygen enrichment coefficient on the LBV from sensitivity analysis and kinetic *** paper presents the effect of the expansion effect on laminar burning velocity for the first time,and separates the effect of the expansion effect on laminar burning velocity by a new *** shows that as the initial temperature goes up,the faster the exponential growth phase of the flame front velocity,the slower the slow growth *** smaller and earlier the maximum flame front velocity arrives,the slower the average flame speed *** the oxygen enrichment coefficient goes up,the peak value of the flame front velocity gradually ***-rich combustion and increasing initial temperature inhibit flame propagation in a half-open tube,but promote laminar burning velocity,which increases the key chemical bond and adiabatic flame *** net reaction rate shows that oxygen-rich combustion mainly promotes the combustion reaction of H_(2)(R2).However,increasing the initial temperature mainly promoted the oxidation of CO(R29).Analysis of the reaction path showed that oxygen-rich combustion and increased initial temperature promoted the reaction of H_(2)and CO with key chemical bonds,increased OH concentration,and inhibited OH cracking reaction.

关键词： gas turbines oxyfuel combustion numerical simulation combustion kinetics fire and flame

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