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Individual alcohol consumption by the population of Russia versus regional living conditions

Global Health Journal 2024年第1期8卷 24-31页

作者： Sergey A.Maksimov Svetlana A.Shalnova galina a.muromtseva Yuliya A.Balanova Svetlana E.Evstifeeva Anna V.Kapustina Oksana M.Drapkina National Medical Research Center for Therapy and Preventive Medicine Moscow 101990Russia

Background:There are substantial regional differences in drinking alcohol in Russia,both at the population and individual ***,the causes of these differences have not been studied ***:The goal of our study was to examine the effect of regional living conditions on individual alcohol consumption by the population of ***:For the analysis,we used data from a cross-sectional epidemiological study conducted in *** final analytical sample included 18,130 people aged 25-64 *** conducted the interviews face to face,based on which any drinking in the last year,as well as alcohol abuse,were considered as a *** abuse was recorded when the respondent consumed 5.75 or more grams of pure ethanol per day(75th percentile of average daily alcohol consumption among alcohol drinkers).The assessment of the regional living conditions was accomplished via integral indexing,which was previously performed based on publicly available data for *** were assessed using generalized scoring equations with unchanging standard *** associations were expressed by odds ratios(OR)and 95%confidence intervals(C).Results:Deterioration of social conditions and increase in demographic depression in the region of residence increased the odds of any drinking(OR 1.51,95%CI:1.33 to 1.72,P<0.001 and OR 1.22,95%CI:1.05 to 1.41,P=***9,respectively).The odds of alcohol abuse increased with the deterioration of social living conditions and the growth of the industrial development in the region:OR 1.35,95%CI:1.14 to 1.59,P<0.001 and OR 1.16,95%CI:1.05 to 1.28,P=0.002,***:Our analysis allowed assessing the impact of the regional living conditions on individual drinking alcohol in the population of Russia.

关键词： Alcohol Living environment Regional features Russia

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QUASIPERIODICITY OF TRANSCENDENTAL MEROMORPHIC FUNCTIONS

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Acta Mathematica Scientia 2024年第1期44卷 161-172页

作者：刘新玲刘凯 Risto KORHONEN galina FILIPUK Department of Mathematics Nanchang UniversityNanchang330031China Department of Physics and Mathematics University of Eastern FinlandP.O.Box 11180101JoensuuFinland Institute of Mathematics Faculty of MathematicsInformatics and MechanicsUniversity of WarsawBanacha 202-097WarsawPoland

This paper is devoted to considering the quasiperiodicity of complex differential polynomials,complex difference polynomials and complex delay-differential polynomials of certain types,and to studying the similarities... 详细信息

关键词： quasiperiodicity meromorphic functions complex delay-differential polynomials Nevanlinna theory

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Thermogravimetric,kinetic study and gas emissions analysis of the thermal decomposition of waste-derived fuels

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Journal of Environmental Sciences 2024年第3期137卷 155-171页

作者： Vadim V.Dorokhov galina S.Nyashina Pavel A.Strizhak Heat and Mass Transfer Laboratory National Research Tomsk Polytechnic University30 Lenin AvenueTomsk 634050Russia

A wide range of wastes can potentially be used to generate thermal and electrical *** co-combustion of several types of waste as part of water-containing waste-derived fuels is a promising method for their *** this research,we use thermogravimetric analysis and differential scanning calorimetry to study the thermal behavior and kinetics of coal slime,biomass,waste oils,and blends on their *** also analyze the concentrations of gaseous *** results show that biomass,oils,and coal slime significantly affect each other in the course of their co-combustion when added to slurry *** preparation of coal-water slurry based on slime and water reduced the ignition and burnout temperature by up to 16%.Adding biomass and waste oils additionally stimulated the slurry ignition and burnout,which occurred at lower *** to dry coal slime,threshold ignition temperatures and burnout temperatures decreased by 6%–9%and 17%–25%,***,the use of biomass and waste oils as part of slurries inhibited NOхand SO_(2)emission by 2.75 *** to the kinetic analysis,added biomass and waste turbine oil provide a 28%–51%reduction in the activation energy as compared to a coal-water slurry without additives.

关键词： Coal-water slurry Water-containing composite fuels Combustion Emission Kinetic TGA-DSC

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Structural Features of Nuclei in Leaf Mesophyll Cells of Salt-Tolerant Artemisia marschalliana

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CellBio 2024年第1期13卷 1-6页

作者： galina Semenova Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences Pushchino Russia

All nuclei in mesophyll cells of Artemisia marschalliana are located in vacuoles and occupy up to 90% of their volume. The ultrastructural organization of chromatin in nuclei shows different degrees of its decondensation, up to complete separation of DNA from histones. It is possible that the separation of DNA from histones enables Artemisia to grow in soils with high salinity.

关键词： Meso- and Ultrastructure of Mesophyll Decondensation of Nuclear Chromatin Artemisia marschalliana

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Potential of the Arkhangelsk seismic network for European Arctic monitoring

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Earthquake Science 2024年第5期37卷 434-444页

作者： galina Antonovskaya Yana Konechnaya Ekaterina Morozova Yana Mikhailova Eugenia Shakhova N.Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences Arkhangelsk 163002Russia Geophysical Survey of the Russian Academy of Sciences ObninskKaluga region 249034Russia

The Arkhangelsk Seismic Network(ASN)of the *** Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences,founded in 2003,includes 10 permanent seismic stations located on the coasts of the White,Barents,and Kara Seas and on the Arctic archipelagos of Novaya Zemlya,Franz Josef Land,and Severnaya *** network is registered with the International Federation of Digital Seismograph Networks and the International Seismological *** used not only ASN data to process earthquakes but also the waveforms of various international seismic *** 13,000 seismic events were registered using ASN data for 2012-2022,and for 5,500 of them,we determined the parameters of the earthquake epicenters from the European *** spatial distribution of epicenters shows that the ASN monitors not only the main seismically active zones but also weak seismicity on the shelf of the Barents and Kara *** representative magnitude of ASN was ML,rep=*** level of microseismic noise has seasonal variations that affect the registration capabilities of each station included in the ASN and the overall sensitivity of the network as a *** summer,the sensitivity of the ASN decreased owing to the increasing microseismic and ambient noises,whereas in winter,the sensitivity of the ASN increased significantly because of the decrease.

关键词： European Arctic Arkhangelsk Seismic Network seismic monitoring seismic network registration capabilities

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Soil Cover in the Eastern Part of the Dried Bed of the Aral Sea

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Journal of Geoscience and Environment Protection 2024年第6期12卷 30-37页

作者： galina Stulina Kamaladin Idirisov International Fund for the Aral Sea Saving Interstate Coordination Water Commission Scientific-Information Center (SIC ICWC) Tashkent Uzbekistan International Innovation Centre of Priaralie (IICAS) Nukus Karakalpakstan

The greatest environmental disaster in Central Asiathe drying up of the Aral Seahas led to the formation of a new terrain, extending over 2.7 million hectares in Uzbekistan. This newly formed terrain is dynamically developing, with emerging soil formations replacing bottom sediments. This paper analyzes the results of a study on soil formation in the eastern part of the dried-up seabed, focusing on the influence of natural processes occurring there.

关键词： Aral Sea Environmental Dried Seabed Soil Cover

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Passive seismic investigation of intraplate earthquakes epicentral zones in the North of Russia as one of the ways to understand their source mechanics

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Journal of Earth Science 2024年

作者： Konstantin Danilov galina Antonovskaya Irina Basakina Eugenia Shakhova Natalia Kapustian N.Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences

Studying the inner structure of intraplate earthquakes originating in aseismic areas， which are poorly covered by seismic networks or as historical earthquakes is usually the only way to get knowledge about their source mechanisms that is partially important to deeper understand intraplate geodynamics. The epicentral zones of earthquakes are situated in hard-to-reach areas， so， using active seismic methods for such purposes is unreasonable or even impossible because of high cost and logistical difficulties. We are presenting a way to join using different passive seismic methods， which allows us to get sufficient information about geological environment structure for such task solutions. As an example， we investigated the inner structure of platform earthquake epicentral zone originated up north of Russia. We used four passive seismic methods: microseismic sounding method， passive seismic interferometry， HVSR method， and microseismic activity method. We show that passive seismic data， recoded in the same installation and processed by these different methods， can provide sufficient information about structure of studied environment， needed to explain source mechanism. In sum， the hypocenter zone is presented by intersection of vertical faults and a lateral fractured zone in the middle crust. Results were confirmed by comparison with results by active seismic methods.

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Prognostic and predictive role of immune microenvironment in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 643-652页

作者： Olesya Kuznetsova Mikhail Fedyanin Larisa Zavalishina Larisa Moskvina Olga Kuznetsova Alexandra Lebedeva Alexey Tryakin galina Kireeva Gleb Borshchev Sergei Tjulandin Ekaterina Ignatova Department of Chemotherapy Federal State Budgetary Institution(N.N.Blokhin National Medical Research Center of Oncology)of the Ministry of Health of the Russian FederationMoscow 115478Russia Department of Pathology Russian Medical Academy of Continuous Professional EducationMoscow 123242Russia OncoAtlas LCC Moscow 115478Russia Federal State Budgetary Institution“National Medical and Surgical Center named after N.I.Pirogov”of the Ministry of Health of the Russian Federation Moscow 105203Russia STOONCO:Science and Technology in Oncology Moscow 115478Russia

Colorectal cancer(CRC)represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death *** traditional classification of CRC is based on pathomorphological and molecular character-istics of tumor cells(mucinous,ring-cell carcinomas,etc.),analysis of mechanisms of carcinogenesis involved(chromosomal instability,microsatellite instability,CpG island methylator phenotype)and mutational statuses of commonly altered genes(KRAS,NRAS,BRAF,APC,etc.),as well as expression signatures(CMS 1-4).It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in *** to the latest data,the immune microenvironment can also be predictive of the response to immune checkpoint *** this review,we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.

关键词： Immunoscore Immune microenvironment Colorectal cancer Gastrointestinal cancers Predictive biomarkers Digital pathology

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PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR V.BATOROV ALISA D.INESHINA TATIANA A.ARISTOVA VERA V.DENISOVA SVETLANA A.SIZIKOVA DARIA S.BATOROVA galina Y.USHAKOVA EKATERINA Y.SHEVELA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia V.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparatively assessed with flow cytometry in PD-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negative and positive CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusive regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

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Olefin Polymerization Behavior of Titanium(IV) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim F.Magomedov Svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia V.Nelyubina Evgenii K.Golubev Maria D.Evseeva Viktor G.Vasil'ev galina G.Nikiforova Mikhail I.Buzin Vyacheslav S.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(IV) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

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