检索结果-南通市图书馆

Thrombotic Thrombocytopenic Purpura in Pregnancy Presented with Stroke at 29 Weeks: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第3期14卷 359-364页

作者： Shamsa Kassam Jodie Lam gabrielle Baptiste Department of Women’s Health Luton and Dunstable University Hospital Bedfordshire Hospitals NHS Foundation Trust Luton UK

Thrombotic thrombocytopenic purpura (TTP) is a rare but acute, life-threatening condition which may be precipitated by pregnancy. This disorder that presents with thrombocytopenia, haemolytic anemia, and clinical consequences of microvascular thrombosis such as stroke. The exact cause is not known but it is associated with a deficiency of ADAMTS13 enzymes. Immune mediated TTP is more common and can present in pregnancy. The aim of this case is to bring awareness as many clinicians are unaware of this condition in pregnancy, its diagnosis may be missed or delayed, leading to fetal loss or serious maternal implications. In this case the patient presented at 29 weeks with stroke in Emergency department, referred to delivery suit for Obstetric review, with suspicion of Pre-eclampsia/HELLP. The diagnosis of TTP was achieved by a multidisciplinary team who worked tirelessly together. The patient was transferred to a Specialist Tertiary Care Centre for further management. The pregnancy continued until 33 weeks and 5 days. She underwent an emergency caesarean section for fetal distress. Steroids and Rituximab were continued postnatally. The outcome was favourable due to fast and efficient multidisciplinary care. Awareness of this rare but important condition can lead to recognition of clinical presentation, prompt diagnosis and appropriate management.

关键词： Thrombotic Thrombocytopenic Purpura Pregnancy Ischemic Stroke Caesarean Section

Risk of hepatitis B virus reactivation in cancer patients undergoing treatment with tyrosine kinase-inhibitors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第24期30卷 3052-3058页

作者： Bansi P Savaliya Ramin Shekouhi Fatima Mubarak Harsheen K Manaise Paola Berrios Jimenez gabrielle Kowkabany Reed A Popp Kyle Popp Emmanuel Gabriel Department of Surgery Medical Academy Named after SI Georgievsky of Vernadsky Crimean Federal UniversitySimferopol 295015CrimeaRussia Division of Plastic and Reconstructive Surgery Department of SurgeryUniversity of FloridaGainesvilleFL 32608United States Department of Surgery Aga Khan UniversityKarachi 74800SindhPakistan Department of Surgery Government Medical College and HospitalChandigarh 160030PunjabIndia Department of Surgery University of Puerto Rico School of MedicineSan Juan 00921Puerto Rico Department of Chemical and Biological Engineering University of AlabamaTuscaloosaAL 35487United States Department of Surgery University of Florida College of MedicineGainesvilleFL 32610United States Department of Surgery Florida State UniversityTallahasseeFL 32306United States Department of Surgery Mayo ClinicJacksonvilleFL 32224United States

This editorial commented on an article in the World Journal of Gastroenterology titled“Risks of Reactivation of Hepatitis B Virus in Oncological Patients Using Tyrosine Kinase-Inhibitors:Case Report and Literature Analysis”by Colapietro et *** this editorial,we focused on providing a more comprehensive exploration of hepatitis B virus reactivation(HBVr)associated with the usage of tyrosine kinase inhibitors(TKIs).It includes insights into the mechanisms underlying HBV reactivation,the temporal relationship between TKIs and HBV reactivation,and preventive *** aim is to understand the need for nucleos(t)ide analogs(NAT)and serial blood tests for early recognition of reactivation and acute liver injury,along with management *** are considered to be an intermediate(1%-10%)of *** guidelines stipulate that patients receiving therapy with high or moderate risks of reactivation or recent cancer diagnosis must have at least tested hepatitis B surface antigen,anti-hepatitis B core antigen(HBc),and anti-hepatitis B surface ***-HBc screening in highly endemic areas means people with negative tests should be vaccinated against *** or nucleotide analogs(NAs)like entecavir(ETV),tenofovir disoproxil fumarate(TDF),and tenofovir alafenamide(TAF)form the basis of HBV reactivation prophylaxis and treatment during ***,lamivudine,telbivudine,and adefovir are generally discouraged due to their reduced antiviral efficacy and higher risk of fostering drug-resistant viral ***,these less effective NAs may still be utilized in cases where ETV,TDF,and TAF are not feasible treatment options.

关键词： Hepatitis B virus Reactivation Chronic hepatitis B Tyrosine-kinase inhibitor Immunomodulators Immunosuppressant Nucleoside analogue Hemato-oncology

Association of Hypertension and Plant-based Dietary Patterns on Cognitive Impairment: A Nationwide Cohort Study in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Fang Liang Jialin Fu gabrielle Turner-McGrievy Yechuang Wang Kai Ding Jing Zeng Justin B Moore Rui Li Chengdu High-tech Zone Center for Diseases Control and Prevention School of Public Health Wuhan University Department of Implementation Science Division of Public Health Sciences Wake Forest School of Medicine Department of Health Promotion Education and Behavior Arnold School of Public Health University of South Carolina Columbia SC USA School of Nursing Wuhan University

This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet (PBD) patterns may modify the association. We analyzed 4485 elderly individuals with normal cognition at baseline from the Chinese Longitudinal Healthy Longevity Survey (2011-2018). Cognitive function was assessed by the Mini-mental State Examination (MMSE)， and cognitive impairment was defined as an MMSE score below 18 points. Diet patterns were assessed using the overall plant-based diet index (PDI)， healthful plant-based diet index (hPDI)， and unhealthful plant-based diet index (uPDI) derived from a simplified food frequency questionnaire (FFQ). Blood pressure was measured through physical examination. Cox proportional hazard regression and restricted cubic spline were performed. Participants with hypertension had an increased risk of cognitive impairment compared with normal group. The associations between hypertension and cognitive impairment were more pronounced among participants with lower PDI than those with higher PDI， among participants with lower hPDI than those with higher hPDI， and among participants with higher uPDI than those with lower uPDI. A healthful PBD pattern may attenuate hypertension-induced cognitive impairment， while an unhealthful PBD pattern may exacerbate hypertension-induced cognitive impairment in elderly. Adherence to healthful PBD pattern could be used to prevent or mitigate adverse neurological effects in the hypertensive population.

关键词：

The Support Systems and Coping Strategies of Infertile Women Attending the Out-Patient Consultation Unit of CHRACERH Yaoundé, Cameroon: A Cross-Sectional Study

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第6期14卷 869-887页

作者： Emenguele Pascale Mpono Fidelia Mbi Kobenge gabrielle Laure Mengne Etienne Belinga Jean Marie Kasia Thomas Obinchemti Egbe Department of Obstetrics and Gynecology CHRACERH Yaound Yaound Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon Department of Obstetrics and Gynecology Faculty of Health Sciences University of Bamenda Bamenda Cameroon Department of Obstetrics and Gynecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynecology Faculty of Health Sciences University of Buea Buea Cameroon

Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psychosocial aspects of the disease. Objectives: This study aimed to identify the support systems and coping strategies of infertile women attending the outpatient consultation unit of the Gynaecological Endoscopic Surgery and Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methods: A hospital-based cross-sectional study was conducted from the 14th of March to the 6th of April 2023 at CHRACERH Yaoundé. A total of 190 participants were recruited using a convenience sampling method. Data regarding socio-demographic characteristics, support systems and coping strategies were collected using a pretested questionnaire. Descriptive and analytic statistics were conducted using SPSS version 25. Results: The mean age of participants was 39.52 ± 7.64 years. The majority 78.9% of participants were workers (public, private sector, or traders) and were Christians 95.8%. The most common source of psychological support was from family 76.8 and husbands 72.63%. Most of the participants 89.5% resorted to prayer and getting busy 48.4% as a coping strategy. There was no statistically significant relationship between coping strategies and psychological disorders p > 0.05. Conclusion: The main support system of participants was family, husband, and friends. Prayer, getting busy and adoption were the most common coping strategies. There is a need for the Ministry of Public Health and other stakeholders to put in place other support systems and coping strategies (FELICIA) used elsewhere and provide adequate health education and infection control to prevent infertility in Cameroon.

关键词： Infertility Coping Strategies Support Systems Mental Health Women

In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第5期15卷 653-663页

作者： Rafaela Viana Vieira gabrielle Caroline Peiter Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Universidade Federal do Paraná Campus ToledoToledo 85919-899Brazil Universidade Tecnológica Federal do Paraná Campus ToledoParaná85902-490Brazil Universidade Federal da Bahia Instituto Multidisciplinar em Saúde-Campus Anísio TeixeiraVitória da Conquista 45029-094Brazil Universidade Federal do Paraná-Setor Palotina Programa de Pós-graduação em BiotecnologiaPalotina 85950-000Brazil

BACKGROUND Colonization with Helicobacter pylori(***)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in *** have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking ***-induced cell differentiation to prevent the onset and/or progression of tumors has not been *** type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using ***,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA *** To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of *** In this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem *** phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate *** *** three-dimensional structure model of the CagA oncoprotein of ***(receptor)was obtained through molecular modeling using computational tools from the I-Tasser platform,employing the threading *** primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRaSP online *** the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock Vina v.1.2.0 *** sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involvi

关键词： CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis

Multi-Compartment SCFA Quantification in Human

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2024年第6期15卷 177-200页

作者： Jérémy Monteiro Antoine Lefèvre Diane Dufour-Rainfray Adeline Oury gabrielle Chicheri Laurent Galineau Hélène Blasco Lydie Nadal-Desbarats Patrick Emond Imaging Brain & Neuropsychiatry iBraiN U1253 Universit de Tours INSERM MetaboHub Tours Tours France CHRU de Tours Service de Mdecine Nuclaire in Vitro Tours France Service de Biochimie et Biologie Molculaire CHRU Tours France

Short-chain fatty acids (SCFA) play an important role in human biochemistry. They originate primarily from the digestive system through carbohydrates microbial fermentation. Most SCFA produced in the colon are absorbed by the intestinal wall and enter the bloodstream to be distributed throughout the body for multiple purposes. At the intestinal level, SCFA play a role in controlling fat storage and fatty acid metabolism. The effects of these beneficial compounds therefore concern overall health. They facilitate energy expenditure and are valuable allies in the fight against obesity and diabetes. SCFA are also involved in the regulation of the levels of several neurotransmitters such as GABA (γ-aminobutyric acid), glutamate, serotonin, dopamine, and norepinephrine. Their role is also highlighted in many inflammatory and neurodegenerative diseases such as Alzheimer’s disease (AD) or Parkinson’s disease (PD). To have a realistic picture of the distribution of SCFA in different biological compartments of the human body, we propose to study SCFA simultaneously in five human biological samples: feces, saliva, serum, cerebrospinal fluid (CSF), and urine, as well as in Dried Blood Spot (DBS). To evaluate their concentration and repeatability, we used 10 aliquots from pooled samples, analyzed by 3-nitrophenylhydrazine (3-NPH) derivation and liquid chromatography coupled with high sensitivity mass spectrometry (LC-QqQ-MS). We also evaluated the SCFA assay on Dried Blood Spot (DBS). In this work, we adapted the pre-analytical parts for each sample to be able to use a common calibration curve, thus facilitating multi-assay quantification studies and so being less time-consuming. Moreover, we proposed new daughter ions from the same neutral loss (43 Da) to quantify SCFAs, thus improving the sensitivity. In conclusion, our methodology, based on a unique calibration curve for all samples for each SCFA, is well-suited to quantified them in a clinical context.

关键词： LC-MS 3-Nitrophenylhydrazine Short-Chain Fatty Acids Human Biological Samples Quantification

The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第9期19卷 1012-1029页

作者： Sophie Curio gabrielle T.Belz The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandWoolloongabbaQLD4102Australia

Cancer is a complex disease,and despite incredible progress over the last decade,it remains the leading cause of death *** cancers,including hepatocellular carcinoma(HCC),and liver metastases are distinct from other cancers in that they typically emerge as a consequence of long-term low-grade *** the mechanisms that underpin inflammation-driven tissue remodeling of the hepatic immune environment is likely to provide new insights into much needed treatments for this devastating *** 1 innate lymphoid cells(ILCs),which include natural killer(NK)cells and ILC1s,are particularly enriched in the liver and thought to contribute to the pathogenesis of a number of liver diseases,including *** cells are an attractive,but underexplored,therapeutic target in hepatic disease due to their role in immunosurveillance and their ability to recognize and eliminate malignant ***1s are closely related to and share many phenotypic features with NK cells but are less well ***,their utility in immunotherapeutic approaches is not yet well ***,we review our current understanding of ILCs in cancer with a particular focus on liver and liver-related diseases.

关键词： Inflammation Tumor ILC subsets Cytokines Progenitors

A computational framework for improving genetic variants identification from 5,061 sheep sequencing data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第6期14卷 2332-2344页

作者： Shangqian Xie Karissa Isaacs gabrielle Becker Brenda M.Murdoch Department of Animal Veterinary&Food SciencesUniversity of IdahoMoscowIDUSA Superior Farms CaliforniaUSA

Background Pan-genomics is a recently emerging strategy that can be utilized to provide a more comprehensive characterization of genetic *** calling is routinely used to combine identified variants across multiple related ***,the improvement of variants identification using the mutual support information from mul-tiple samples remains quite limited for population-scale *** In this study,we developed a computational framework for joint calling genetic variants from 5,061 sheep by incorporating the sequencing error and optimizing mutual support information from multiple samples’*** variants were accurately identified from multiple samples by using four steps:(1)Probabilities of variants from two widely used algorithms,GATK and Freebayes,were calculated by Poisson model incorporating base sequencing error potential;(2)The variants with high mapping quality or consistently identified from at least two samples by GATK and Freebayes were used to construct the raw high-confidence identification(rHID)variants database;(3)The high confidence variants identified in single sample were ordered by probability value and controlled by false discovery rate(FDR)using rHID database;(4)To avoid the elimination of potentially true variants from rHID database,the vari-ants that failed FDR were reexamined to rescued potential true variants and ensured high accurate identification *** results indicated that the percent of concordant SNPs and Indels from Freebayes and GATK after our new method were significantly improved 12%-32%compared with raw variants and advantageously found low frequency variants of individual sheep involved several traits including nipples number(GPC5),scrapie pathology(PAPSS2),sea-sonal reproduction and litter size(GRM1),coat color(RAB27A),and lentivirus susceptibility(TMEM154).Conclusion The new method used the computational strategy to reduce the number of false positives,and simulta-neously improve the identifi

关键词： Computational framework Genetic variants Multiple samples Sheep

Fast action on short-lived climate pollutants and nature-based solutions to help countries meet carbon neutrality goals

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2022年第4期13卷 564-577页

作者： Xiaopu SUN Pu WANG Tad FERRIS Hui LIN gabrielle DREYFUS Bai-He GU Durwood ZAELKE Yi WANG Institute for Governance&Sustainable Development Washington DC20016USA Institutes of Science and Development Chinese Academy of SciencesBeijing 100190China School of Public Policy and Management University of Chinese Academy of SciencesBeijing 100049China Department of Physics Georgetown UniversityWashington DC20057USA Bren School of Environmental Science&Management University of California Santa BarbaraSanta Barbara CA 93106USA

Scientific studies show that fast actions to reduce near-term warming are essential to slowing self-reinforcing climate feedbacks and avoiding irreversible tipping *** cutting CO_(2) emissions only marginally impacts near-term warming,This study identifies two of the most ffective mitigation strategies to limit near-term warming beyond CO_(2) mitigation,namely reducing short-lived climate pollutants(SLCPs)and promoting targeted nature-based solutions(NbS),and comprehensively reviews the latest scientifie progress in these *** show that quickly reducing SLCP emissions,particularly hydrofuorocarbons(HFCs),methane,and black carbon,from ll relevant sectors can avoid up to 0.6℃ of warming by ***,promoting targeted NbS that protect and enhance natural carbon sinks ncluding in forests,wetlands,grasslands,and agricultural lands,can avoid emssions of 23.8 Gt of CO_(2)e per year in 2030,without jeopardizing food security and *** on the scientific evidence,we provided a series of policy recommendations on SLCPs and NbS,including:1)implementing the Kigali Amendment to reduce HFC emissions;2)deploying cost-effective,sector-based measures to reduce methane and black carbon emissions;and 3)implementing targeted NbS to protect and enhance existing carbon sinks and shifting away from forest-burning *** fast-acting strategies on SLCPs and NbS will play a key role in securing the most avoided warming in the near-term and help countries meet their mid-century carbon neutrality ***,we proposed future research topics,including:improving measurement and monitoring systems and techniques for SLCP emissions;developing and improving assessments of marginal abatement costs for SLCP mitigation in dfferent sectors;better quantifying the avoided warming potential from protecting dfferent types of natural carbon sinks by 2030,2050,and over longer periods;and identifying whether there are any biomass types for energy sources that

关键词： Non-CO_(2)mitigation Short-lived elimate pollutants Climate feedbacks and tipping points Near-term warming Methane Hydrofuorocarbons(HFCs) Black carbon Nature-based solutions(NbS)