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Coronavirus disease-2019 and the intestinal tract:An overview

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World Journal of Gastroenterology 2021年第13期27卷 1255-1266页

作者： gabriela gama freire alberca Rosa Liliana Solis-Castro Maria Edith Solis-Castro Ricardo Wesley alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Departamento Académico de Medicina Humana Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal Microbiota Antibiotics

Intestinal inflammation and the microbiota:Beyond diversity

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World Journal of Gastroenterology 2022年第26期28卷 3274-3278页

作者： gabriela gama freire alberca Naiane Samira Souza Cardoso Rosa Liliana Solis-Castro Viviane Nakano Ricardo Wesley alberca Department of Microbiology Institute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the *** influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well *** the diversity in the microbiome,the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes,contributing to the induction of a proinflammatory environment.

关键词： Inflammation Microbiota Toxins Intestinal Ulcerative Colitis Cancer

Role of vitamin D deficiency and comorbidities in COVID-19

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World Journal of Virology 2022年第1期11卷 85-89页

作者： gabriela gama freire alberca Ricardo Wesley alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 04307-100Brazil Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 04307-100Brazil

Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)*** D deficiency is also common in patients with comorbidities that are associated with a poor COVID-19 *** ... 详细信息

关键词： COVID-19 SARS-CoV-2 Comorbidities Vitamin D

Sharp differentiation on the performance of plant functional groups across natural edges

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Journal of Plant Ecology 2019年第1期12卷 186-198页

作者： Evelyn da Fonseca Alecrim Bragion gabriela Aparecida Oliveira Coelho Flávia freire de Siqueira Maria Uriarte Eduardo van den Berg Department of Forest Engineering Federal University of LavrasCampus UniversitárioCaixa Postal 3037CEP 37200-000LavrasMGBrazil Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNYUSA

Aims Gallery forests within grasslands have natural edges with open envi-ronments and offer a unique opportunity to examine how species performances vary across environmental ***,we asked if demographic rates of tree functional groups varied along the edge,if we could explain differences in plant strategies and performance through functional traits and which traits increase growth and sur-vival in natural *** We examine mortality and recruitment within the first 10 m of nat-ural edges of eight gallery forests using demographic data from five annual *** defined a priori plant strategies using tree functional groups:light demanding,pioneer and shade *** Findings The shade-tolerant group had the lowest mortality rates and basal area(BA)loss,while pioneer and light-demanding species had similar behavior for these *** survival and growth of functional groups were affected differently by the distance from the *** pioneer group survived more near the edge,while light-demanding and shade-tolerant groups toward the forest *** groups had higher growth in the *** differences could be explained by functional traits since most species have an acquisition strategy:higher specific leaf area and growth,lower leaf dry matter con-tent,lighter stem density,deeper crowns and less slender *** traits enhanced ***,mortality selected both strategies,but in distinct edge’s *** study showed that the high diversity found in natural edges can be explained by a niche and functional perspective,where differences in functional traits lead to differential performance along the environmental gradient.

关键词： edges diversity gradient niche hypothesis SLA LDMC

Breast Cancer Paradox: High Curability versus High Mortality from a Gender Perspective

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Health 2019年第10期11卷 1257-1271页

作者： Maria gabriela Ribeiro Portella Virginia Dresch Maria Martha de Luna freire Ingrid Moraes de Siqueira Research Group Psychological Assessment Laboratory (CNPq) Niterói-RJ Brazil Department of Psychology Universidade Federal Fluminense (UFF) Niterói-RJ Brazil Department of Planning Health Universidade Federal Fluminense (UFF) Niterói-RJ Brazil.

Despite being considered a potentially curable disease, breast cancer is the most frequent cause of cancer death in women worldwide, establishing the following paradox: high curability versus high mortality. Among the conditions conducive to this situation, such as difficult access to diagnosis and treatment and social support by the State, there is the need to discuss the impact of women’s caregiving, the backbone of the female gender role, on self-care in health. Gender has a powerful effect on determining health status: it may limit different rates of exposure to certain risks, different patterns in the quest for treatment or differential impacts of the social and economic determinants of health. The study shows the results of a qualitative methodology with nine women aged 48 to 74 years with varying levels of schooling and socioeconomic status, who had breast cancer at some stage of adult life and who regularly attend a nongovernmental organization (NGO) to support women with breast cancer, in the city of Niterói (Rio de Janeiro, Brazil). The participants’ discourses evidenced the idea of the primacy of the caregiving, the idealized image of the warrior woman and their self-neglect and State’s care as elements of the potential impact on the choices of these women concerning self-care, and consequently in their experiences of illness.

关键词： Breast Cancer Gender Women’s Health

Larval habitat of <i>Ochlerotatus albifasciatus</i>(Diptera: Culicidae) in the southern edge of the Americas, Tierra del Fuego Island

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Open Journal of Animal Sciences 2013年第4期3卷 5-10页

作者： Nora Edith Burroni María Verónica Loetti María Cristina Marinone María gabriela freire Nicolás Schweigmann Arthropods Laboratory Department of Biodiversity and Experimental Biology Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina Institute of Biodiversity and Experimental and Applied Biology (IBBEA) UBA-CONICET Buenos Aires Argentina Mosquito Study Group Department of Ecology Genetics and Evolution Institute IEGEBA (CONICET-UBA) Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina Mosquito Study Group Department of Ecology Genetics and Evolution Institute IEGEBA (CONICET-UBA) Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina National Council of Scientific and Technological Research (CONICET) Buenos Aires Argentina

The information about ecological topics of mosquitoes at the southernmost tip of South America is fragmentary and scarce. The present study evaluates lentic freshwater habitat located in the surroundings of main roads of the Argentine sector of Tierra del Fuego as larval habitat of Ochlerotatus albifasciatus, also analyzes the relationships between their presence and several environmental variables: water turbidity, percentage of gramineans, percentage of macrophytes, presence of crustaceous cyanobacteria, and filamentous chlorophyceans. Mosquito inmatures were collected with dip nets. A generalized linear model (GLM) with negative binomial error distribution was used to determine the effects of different variables of the water bodies on abundance of Oc. albifasciatus in the larval habitats. Collections were made in 45 lentic freshwater bodies. Preimaginal stages were found in 17.70% of the studied habitats. Oc. albifasciatus was the only culicid registered. The GLM explained 93.17% of the variability, and showed a negative relationship between the abundances of Oc. albifasciatus and water turbidity, and a positive relationship with percent-age of gramineans. The gramineans would improve food supply, because the plants are providing suitable substrate for different types of microbiota, a layer of leaves would protect eggs from extreme temperatures, and could help the larvae to hide from potential predators. The negative association between abundance of this species with water turbidity could be related to the presence of vegetation that favors retaining the substrate, reducing water turbidity.

关键词： Ochlerotatus Mosquitoes Larval Habitat Patagonia South America

Isolated Autoimmune Orchitis Due to IgG4 Hypersecretion Presenting as Tumor-Like Mass: Case Report and Review of Literature

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Open Journal of Urology 2022年第1期12卷 51-56页

作者： Francisco Marcos da Silva Barroso Flavio Antunes de Sousa Paloma Menezes de Souza Gustavo Lopes de Castro Katia Ramos Moreira Leite Monique freire Santana Roger Arthur da Cunha Alves gabriela Ayumi Owada Borges Juan Eduardo Rios Rodriguez Urology Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil General Surgery Service Santa Casa de Ribeir&#227 o Preto Ribeir&#227 o Preto Brazil Sã o Paulo University (USP) Ribeir&#227 o Preto Brazil Faculty of Medicine Federal University of Amazonas (UFAM) Manaus Amazonas Brazil Pathology Department Sírio-Libanes Hospital S&#227 o Paulo Brazil Faculty of Medicine S&#227 o Paulo University (USP) S&#227 o Paulo Brazil Patholgy Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil Dr. Heitor Vieira Dourado Tropical Medicine Foundation Manaus Amazonas Brazil Teaching and Research Department Oncology Center Control Foundation (FCECON) Manaus Amazonas Brazil Urology Service Hospital Pronto-Socorro 28 de Agosto Manaus Amazonas Brazil General Surgery Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil

Background: IgG4-related disease is a rare autoimmune condition that presents with lymphoplasmacytic infiltrate and fibrosis in the organ affected. Isolated testicle involvement is uncommon and there are only a few cases reported in the literature. Case Presentation: We report a case of isolated chronic orchitis due to IgG4 hypersecretion in a 61-year-old patient that evolved with asymptomatic tumor-like mass growth and was treated with left orchiectomy. Histopathological study revealed orchitis related to IgG4 hypersecretion disease. Conclusion: IgG4-related disease can be manifested as a multi or single-organ disorder. Most diagnoses are made after surgery with histopathological analysis. Most of the cases in literature stand out the difficulty in diagnosis and necessity of high suspicion due to this condition’s similarity with neoplasm presentation.

关键词： Orchitis IgG4-Related Disease Autoimmune Testicle Inflammatory

Immune response to Helicobacter pylori infection and gastric cancer development

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World Journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms

Molecular and serology methods in the diagnosis of COVID-19: An overview

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World Journal of Methodology 2022年第3期12卷 83-91页

作者： Marcel Silva Luz Ronaldo Teixeira da Silva Júnior Gabriella Almeida Santos de Santana gabriela SantosRodrigues Henrique de Lima Crivellaro Mariana Santos Calmon Clara Faria Souza Mendes dos Santos LuisGuilherme de Oliveira Silva Qesya Rodrigues Ferreira Guilherme Rabelo Mota Heloísa Heim Filipe AntônioFrança da Silva Breno Bittencourt de Brito Fabrício freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease-19(COVID-19)has become a pandemic,being a global health concern since December 2019 when the first cases were *** acute respiratory syndrome coronavirus 2,the COVID-19 causal agent,is aβ-coronavirus that has on its surface the spike protein,which helps in its virulence and pathogenicity towards the ***,effective and applicable diagnostic methods to this disease come as an important tool for the management of the *** use of the molecular technique PCR,which allows the detection of the viral RNA through nasopharyngeal swabs,is considered the gold standard test for the diagnosis of ***,serological methods,such as enzyme-linked immunosorbent assays and rapid tests,are able to detect severe acute respiratory syndrome coronavirus 2-specific immunoglobulin A,immunoglobulin M,and immunoglobulin G in positive patients,being important alternative techniques for the diagnostic establishment and epidemiological *** the other hand,reverse transcription loop-mediated isothermal amplification also proved to be a useful diagnostic method for the infection,mainly because it does not require a sophisticated laboratory apparatus and has similar specificity and sensitivity to ***,imaging exams provide findings of typical pneumonia,such as the ground-glass opacity radiological pattern on chest computed tomography scanning,which along with laboratory tests assist in the diagnosis of COVID-19.

关键词： COVID-19 Pandemic Diagnosis Polymerase chain reaction Molecular biology Serology