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Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

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Cellular & Molecular Immunology 2023年第10期20卷 1101-1113页

作者： SaloméS.Pinho Inês Alves Joana Gaifem gabriel A.Rabinovich i3S–Institute for Research and Innovation in Health University of Porto4200-135PortoPortugal ICBAS-School of Medicine and Biomedical Sciences University of Porto4050-313PortoPortugal Faculty of Medicine University of Porto4200-319PortoPortugal Laboratorio de Glicomedicina Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)C1428Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresC1428Ciudad de Buenos AiresArgentina

The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous *** of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses,whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections,but also influence cancer development and *** have emerged as essential components of homeostatic circuits,acting as fine-tuners of immunological responses and potential molecular targets for manipulation of immune tolerance and activation in a wide range of pathologic *** surface glycans,present in cells,tissues and the extracellular matrix,have been proposed to serve as“self-associated molecular patterns”that store structurally relevant biological *** responsibility of deciphering this information relies on different families of glycan-binding proteins(including galectins,siglecs and C-type lectins)which,upon recognition of specific carbohydrate structures,can recalibrate the magnitude,nature and fate of immune *** process is tightly regulated by the diversity of glycan structures and the establishment of multivalent interactions on cell surface receptors and the extracellular *** we review the spatiotemporal regulation of selected glycan-modifying processes including mannosylation,complex N-glycan branching,core 2 O-glycan elongation,LacNAc extension,as well as terminal sialylation and ***,we illustrate examples that highlight the contribution of these processes to the control of immune responses and their integration with canonical tolerogenic ***,we discuss the power of glycans and glycan-binding proteins as a source of immunomodulatory signals that could be leveraged for the treatment of autoimmune inflammation and chronic infection.

关键词： Immune response Inflammation Infection Glycans Glycosylation Glycan-binding proteins

Implementing a DIKW model on a deep mine cooling system

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International Journal of Mining Science and Technology 2019年第2期29卷 319-326页

作者： Jan gabriel Pretorius Marc John Mathews Philip Maré Marius Kleingeld Johann van Rensburg Centre for Research and Continued Engineering Development North-West University Pretoria 0081 South Africa TEMM International (Pty) Ltd

The South African mining industry has been experiencing increasing economic pressure. Deep mines also suffer from very hot workplaces, which leads to safety risks. These factors place stress on managers to reach their production targets while providing safe workplace conditions. The data information knowledge wisdom(DIKW) model, also known as the wisdom hierarchy, was implemented on a deep mine cooling system. This study aims to show that a simple model such as the DIKW model can assist managers in improving their deep mine cooling system's performance. The study found that the DIKW approach is a suitable approach for use on mine cooling systems to facilitate operational *** the DIKW approach to a case study on a mine cooling system created substantial awareness and facilitated a cooling duty improvement of 55% which relates to an increase of 5.3 MW of refrigeration. The results of this study indicate that the DIKW approach may be a suitable approach to optimise management on deep mines using their existing infrastructure.

关键词： DIKW Cooling system Mining Reporting

Outcomes after combined excisional goniotomy and manual small incision cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1707-1713页

作者： Daniela Alvarez-Ascencio gabriel Lazcano-Gomez Malik Y Kahook Department of Glaucoma Asociación Para Evitar la Ceguera en México(APEC)Mexico City 04030Mexico Department of Ophthalmology University of Colorado School of MedicineAuroraColorado 80145United States

AIM: To report the long-term outcomes of combined excisional goniotomy and manual small incision cataract surgery(MSICS).METHODS: This is a retrospective case series of patients with open angle glaucoma and visually significant cataracts that underwent combined excisional goniotomy and MSICS with one-year follow-up. The medical history, demographic information, and clinical characteristics of each case were recorded. Data regarding changes in vision, intraocular pressure(IOP), the number of glaucoma medications, and the evolution of the disease after surgery were reported. RESULTS: Three patients, with open angle glaucoma and cataracts underwent combined excisional goniotomy and MSICS without adverse events. All patients had improvement in vision compared to baseline measurements. The range of IOP at baseline was from 14 to 18 mm Hg and decrease to a range of 10 to 14 mm Hg after one year of follow-up. Additionally, two patients also decreased their dependence on IOP-lowering medications at the last follow up visit with one patient maintaining baseline level of medication ***: A combination of excisional goniotomy and MSICS illustrates both the safety and efficacy to treat patients with visually significant cataract and glaucoma. This procedure allows for a more cost-effective surgical approach that matches the needs of resource strained territories around the globe.

关键词： excisional goniotomy microincisional glaucoma surgery manual small incision cataract surgery Kahook Dual Blade

Metallic nanostructures for efficient LED lighting

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Light(Science & Applications) 2016年第1期5卷 778-787页

作者： gabriel Lozano Said RK Rodriguez Marc A Verschuuren Jaime Gómez Rivas Instituto de Ciencia de Materiales de Sevilla Consejo Superior de Investigaciones Científicas-Universidad de Sevilla(CSIC-US)41092 SevillaSpain Laboratoire de Photonique et de Nanostructures(LPN) Centre National de la Recherche Scientifique(CNRS)91460 MarcoussisFrance Philips Research Laboratories 5656AE EindhovenThe Netherlands Dutch Institute for Fundamental Energy Research 5600 HH EindhovenThe Netherlands COBRA Research Institute Technical University of EindhovenEindhovenThe Netherlands

Light-emitting diodes(LEDs)are driving a shift toward energy-efficient ***,modifying the emission intensities,colors and directionalities of LEDs in specific ways remains a challenge often tackled by incorporating secondary optical *** nanostructures supporting plasmonic resonances are an interesting alternative to this approach due to their strong light–matter interaction,which facilitates control over light emission without requiring external secondary optical *** review discusses new methods that enhance the efficiencies of LEDs using nanostructured *** is an emerging field that incorporates physics,materials science,device technology and ***,we provide a general overview of state-of-the-art LED lighting,discussing the main characteristics required of both quantum wells and color converters to efficiently generate white ***,we discuss the main challenges in this field as well as the potential of metallic nanostructures to circumvent *** review several of the most relevant demonstrations of LEDs in combination with metallic nanostructures,which have resulted in light-emitting devices with improved *** also highlight a few recent studies in applied plasmonics that,although exploratory and eminently fundamental,may lead to new solutions in illumination.

关键词： light-emitting diodes nanophotonics plasmonics solid-state lighting

Evaluation of stress-control layout at the Subtropolis Mine,Petersburg,Ohio

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International Journal of Mining Science and Technology 2020年第1期30卷 77-83页

作者： Anthony Iannacchione Tim Miller gabriel Esterhuizen Brent Slaker Michael Murphy Natalie Cope Scott Thayer Department of Civil and Environmental Engineering University of PittsburghPittsburghPA 15216USA East Fairfield Coal Company North LimaOH 44452USA National Institute for Occupational Safety and Health(NIOSH) Pittsburgh Mining Research DivisionPittsburghPA 15236USA Mine Vision Systems Inc. PittsburghPA 1520USA

The Subtropolis room-and-pillar mine extracts the Vanport Limestone(Allegheny Formation,Pennsylvanian System)near Petersburg,*** instability problems associated with excessive concentrations of lateral stress caused the mine operator to implement a change in layout *** mining method has been identified as a stress control layout and has been used by other underground stone mines in the past with varying degrees of *** experience has shown that entry headings advance in the direction of the principal lateral stress,producing lower stress concentrations with better mining *** is important to minimize stress concentrations along the mining front,so an arrowshaped advance is *** technique advances more developments(headings)in a"good"direction and reduces developments(crosscuts)in the"bad direction."As is expected,the stress control layout enhances the potential for shear failures in *** is,therefore,important to focus crosscut engineering interventions that either:(a)lower stress concentrations(for example,an arched roof)or(b)enhance strength of the strata containing the shears(for example,rock reinforcement).This study focuses on observing strata conditions on a regular basis and monitoring the response of these strata to changing geologic and mining conditions through 3D Dynamic LiDAR scans.

关键词： Horizontal stress Stress-control layouts Underground stone mines

Image classification on smart agriculture platforms:Systematic literature review

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Artificial Intelligence in Agriculture

Artificial Intelligence in Agriculture 2024年第3期13卷 1-17页

作者： Juan Felipe Restrepo-Arias John W.Branch-Bedoya gabriel Awad Escuela de Ciencias Aplicadas e Ingeniería Universidad EAFIT050022 MedellínColombia Facultad de Minas Universidad Nacional de Colombia050041 Sede MedellínColombia

In recent years,smart agriculture has gained strength due to the application of industry 4.0 technologies in *** a result,efforts are increasing in proposing artificial vision applications to solvemany ***,many of these applications are developed *** academic works have proposed solutions integrating image classification techniques through IoT *** this reason,this paper aims to answer the following research questions:(1)What are themain problems to be solvedwith smart farming IoT platforms that incorporate images?(2)What are the main strategies for incorporating image classification methods in smart agriculture IoT platforms?and(3)What are the main image acquisition,preprocessing,transmission,and classification technologies used in smart agriculture IoT platforms?This study adopts a Systematic Literature Review(SLR)*** searched Scopus,Web of Science,IEEE Xplore,and Springer Link databases from January 2018 to July *** we could identify five domains corresponding to(1)disease and pest detection,(2)crop growth and health monitoring,(3)irrigation and crop protectionmanagement,(4)intrusion detection,and(5)fruits and plant *** are three types of strategies to integrate image data into smart agriculture IoT platforms:(1)classification process in the edge,(2)classification process in the cloud,and(3)classification process *** main advantage of the first is obtaining data in real-time,and its main disadvantage is the cost of *** the other hand,the main advantage of the second is the ability to process high-resolution images,and its main disadvantage is the need for high-bandwidth ***,themixed strategy can significantly benefit infrastructure investment,butmostworks are experimental.

关键词： Smart agriculture Artificial vision Internet of things Artificial intelligence

Policy-Making and the Effect on Public and Private Incubator Programs in Israel:A Qualitative Comparative Analysis Study

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Policy-Making and the Effect on Public and Private Incubator...

作者： gabriel(Georgi) Rijinachvili 上海交通大学

学位级别：硕士

The aim of this thesis is to analyze policies and approach and their effect on private and public incubator programs in *** this analysis,a division of the public and private sector will *** thesis will also review the concept of innovation and entrepreneurial passion due to the fact that it is a key component for the vast incubator programs phenomena in *** technological incubators are subject to the laws of the Office of the Chief Scientist,whereas private incubators which also operate in Israel established by private bodies and free of the conditions and regulations that government incubators are obligated to comply *** thesis analyzes the influence of Israel’s incubator policies and will try comparing their *** methodology consists of four case-studies,qualitative analysis of two private sector incubators and two of the public sector incubators,government policies regarding incubation initiative and a ***,the results expose if the incubator policies are effective for public incubators in Israel and also reveal how existing policy frameworks affects on the encouragement of the state for technological *** conclusion,this thesis focuses on technological innovation and the encouragement of the Government and the Innovation Authority,formerly the Chief *** such as technological incubators,incentives for start-ups will be *** research hopes to provide a clear insight of the effectiveness of the existing policies regarding incubation programs and seeks to recommend a change in policies,due to the fast-growing phenomena of the establishment of incubators in the Start-up Nation.

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Evaluating the Potential of Exporting Natural Gas in Tanzania

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Evaluating the Potential of Exporting Natural Gas in Tanzani...

作者： CHRISTINA gabriel KESSY 中国石油大学（北京）

学位级别：硕士

Recently,Tanzania has experience great volume of natural gas discoveries on its main land and its offshores *** oil and gas exploration in Tanzania is not new,the rapid pace of discoveries over the past few years has not been matched by the development of an adequate framework within which to govern this particular sector;both in the interest of Tanzania as well as the interests of international *** study aimed to evaluate the potential of exporting natural in *** this evaluation the main focus was on the future demand for natural gas and to analyse the competitiveness of exporting natural gas from Tanzania.A dynamic econometric model Partial Adjustment Model（PAM）was used to understand the natural gas demand and to forecast the demand of natural gas from year *** results showed that there is a positive relationship between natural gas consumption,urban population,and electricity consumption per ***,there exist a negative relationship between natural gas consumption and the industry output *** forecasts results were conducted into three scenarios high,base and low case scenario each case with a total estimated demand for natural gas to be 6.13 TCF,2.9 TCF and 0.789 *** natural gas supply is estimated to be 40.07 TCF（holding the assumption that 70% of the total discoveries is recoverable）.Tanzania competitive advantage strength mainly lies on the demand *** order to utilize its advantage Tanzania has to first strengthen its factor conditions and formulate the firm’s strategies and structure to win the rivals in the market.

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Diabetes in French Guiana,adapting national standards of therapeutic education and care to the amazonian challenge

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World Journal of Diabetes 2021年第2期12卷 98-107页

作者： Nadia Sabbah gabriel Carles Magalie Demar Mathieu Nacher Endocrinology Diabetology Nutrition Centre Hospitalier Andree RosemonCayenne 97300French Guiana Department of Obstetrics and Gynaecology Centre Hospitalier Franck JolySt Laurent Du Maroni 97320French Guiana Department of Laboratory University of French GuianaCayenne 97300French Guiana Department of Medicine COREVIH Centre Hospitalier Andree RosemonCayenne 97300French Guiana

French Guiana is a territory located more than 7000 km from *** is also the largest French territory,with almost 84000 km2 and 90%of it is covered by *** municipalities are isolated due to the scarcity of transportation and the poor road *** population is extremely diverse ethnically and culturally,and includes more than thirty ethnic *** is high because it is one of the richest countries in the area bordering northern Brazil,Suriname,Guyana,and as a result of socio-economic crises in some other countries such as Haiti,and it has permeable natural *** and obesity,are emerging issues,with double the prevalence of Mainland France,whereas infectious diseases,such as HIV,take second *** and educational management are challenging because they require the adaptation of tools and treatments to the multiculturalism and precariousness often encountered in these *** French and European recommendations are unsuited to the needs of the territory and must take into account the epidemiological,sociological and cultural parameters of these populations in order to provide appropriate and graded management of diabetes in the French Amazon.

关键词： French Guiana Diabetes mellitus Ethnicity Consensus workshops Poverty Immigration