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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Valued gabriel quiver of a wedge product and semiprime coalgebras

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Frontiers of Mathematics in China 2013年第5期8卷 1157-1183页

作者： gabriel NAVARR0 Department of Computer Sciences and AI University of Granada E1 Greco s/n E-51002Ceuta Spain

We describe the valued gabriel quiver of a wedge product of coalgebras and study the category of comodules of a semiprime coalgebra. In particular, we prove that any monomial semiprime k-tame fc-tame coalgebra is string. We also prove a version of Eisenbud-Griffith theorem for coalgebras, namely, any hereditary semiprime strictly quasi-finite coalgebra is serial.

关键词： Wedge product semiprime coalgebras representation theory,valued gabriel quiver

Message from Deputy Editor-in-Chief gabriel M Leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： gabriel M Leung China CDC Weekly Dean of Medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

A case study on the efficacy of different roof bolting schemes in Lhoist North America’s Crab Orchard Mine

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International Journal of Mining Science and Technology 2020年第1期30卷 99-104页

作者： Reece Kurre gabriel Walton Stantec Consulting Services Inc. Walnut CreekCA 94597USA Department of Geology and Geological Engineering Colorado School of MinesGoldenCO 80401USA

Roof bolting has long been used in underground mines across the world to provide ground *** roof bolts are cheap and easy to install with the use of specialized machines as a part of the production cycle. Lhoist North America’s Crab Orchard Mine is an underground room and pillar limestone mine that uses mechanically anchored roof bolts for ground support. The mine currently employs two different roof bolting patterns: a standard 1.5 × 1.5 m pattern, and another 0.8 × 0.8 m pattern for use in areas with particularly hazardous roof conditions. The purpose of this study is to evaluate the relative effectiveness of each bolting pattern. A series of numerical models were created using Roc Science’s RS2. The models were based on a symmetrical section of the mine at its deepest point, and were modeled using generalized Hoek-Brown failure criterion along with a discrete fracture network. A series of sensitivity analyses were performed on the models by varying parameters such as joint friction angle, crack persistence, joint randomization, and tensile strength of the limestone. Based on the results of the original models and sensitivity analyses, it appeared that the standard bolting pattern provided sufficient roof support capacity under almost all the expected conditions at the mine, since safety factors below the design value of 1.5 were only found for individual bolts in a few of the worst test cases *** results can help improve the mine’s productivity and reduce operating costs without compromising safety.

关键词： Numerical modeling Mining Roof bolting Roof stability Analysis RocScience’s RS2 Underground stone

Gabor’s holography at sea

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Light(Science & Applications) 2019年第1期8卷 1004-1005页

作者： gabriel Popescu Quantitative Light Imaging Laboratory Department of Electrical and Computer EngineeringBeckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

In 1948,predating lasers by more than a decade,Gabor proposed a“new microscopic principle”,which was initially aimed at correcting spherical aberrations in electron *** the method has not produced an impact in its originally intended field,it opened a new direction,known as holography,in ***’s technique allows one to store phase information by recording on film the intensity of a field emerging at a certain distance from an object.

关键词： Gabor recording initially

Numerical study of solar absorption heat storage system applied to Bucharest city

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Building Simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad Adrian-gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral School Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions

GANscan:continuous scanning microscopy using deep learning deblurring

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Light(Science & Applications) 2022年第10期11卷 2378-2387页

作者： Michael John Fanous gabriel Popescu Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA

Most whole slide imaging(WSI)systems today rely on the"stop-and-stare"approach,where,at each field of view,the scanning stage is brought to a complete stop before the camera snaps a *** procedure ensures that each image is free of motion blur,which comes at the expense of long acquisition *** order to speed up the acquisition process,especially for large scanning areas,such as pathology slides,we developed an acquisition method in which the data is acquired continuously while the stage is moving at high *** generative adversarial networks(GANs),we demonstrate this ultra-fast imaging approach,referred to as GANscan,which restores sharp images from motion blurred *** allows us to complete image acquisitions at 30x the throughput of stop-and-stare *** method is implemented on a Zeiss Axio Observer Z1 microscope,requires no specialized hardware,and accomplishes successful reconstructions at stage speeds of up to 5000 μm/*** validate the proposed method by imaging H&E stained tissue *** method not only retrieves crisp images from fast,continuous scans,but also adjusts for defocusing that occurs during scanning within+/-5 μ*** a consumer GPU,the inference runs at<20 ms/image.

关键词： hardware continuous image

Modeling behaviors of a coal pillar rib using the progressive S-shaped yield criterion

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 484-492页

作者： Sankhaneel Sinha gabriel Walton Colorado School of Mines GoldenCO80401USA

Spalling of pillar ribs has been a major hazard in the mining industry for *** the absence of rib support guidelines,accidents have continued to occur in recent *** effective support guidelines requires a complete understanding of complex pillar damage *** models represent a convenient tool for analyzing this problem,but the behavior of such models is dependent of the choice of the constitutive *** this study,a recently proposed constitutive model was used to simulate the rib fracturing process in a longwall chain pillar at West Cliff *** calibration,the model was able to capture the rib displacement profiles for multiple locations of the longwall face and the stress evolution 4 m into the *** rib bolts in the model were found to be yielding over 60% of their length under the headgate loading *** model also predicted a steady damage accumulation in the rib for certain face locations,which is consistent with the description of the rib at the *** was localized along the upper part of the pillar and underscored the role that the dirt band played in controlling rib deterioration at the *** ability of the numerical model to replicate field measurements provides confidence in the capabilities of the new constitutive ***,the need of using multi-point calibration is highlighted by comparing the results of the calibrated model to an alternative model calibrated to a smaller amount of data.

关键词： S-shaped yield criterion Coal pillar Back-analysis Numerical modeling

Integration of three-dimensional continuum model and two-dimensional bonded block model for studying the damage process in a granite pillar at the Creighton Mine,Sudbury,Canada

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 275-288页

作者： Sankhaneel Sinha gabriel Walton Geology and Geological Engineering Colorado School of MinesGoldenCO80401USA

Bonded blockmodel(BBM)has shownpotential in replicating rockmass behavior aswell as the rockesupport interactionmechanism,but their practical application is limited totwo dimensions due to the high associated computational *** allow for the use of BBM in simulating three-dimensional(3D)problems,this study proposes an integrated 3D continuumetwo-dimensional(2D)discontinuum approach,in context of rock pillars.A cross-section of a granite pillar was simulated using a BBM with a load path from a calibrated mine-scale FLAC^(3D)*** support as employed in the mine was also incorporated in different stages during the *** was calibrated by varying the input parameters until the displacements at six locations within the pillarmatchedthosemeasuredby amulti-point borehole extensometer(MPBX)inthe *** calibratedmodel was subsequently used to understand how the support and load path influenced the damage evolution in the *** shear component of the load pathwas found to have amajor effect on the severity and extent of the damaged *** the support density was increased in the model,the lateral displacements along the pillar walls were significantly suppressed in a somewhat unpredictable *** explained by the interaction between the supports and the damaged regions at the corners,which ultimately modified the stresses along the pillar *** amount of displacement reduction obtained by increasing the support density illustrates the potential of BBMto be used as a support design tool.

关键词： Bonded block model(BBM) Rock pillars Supports Continuum-discontinuum integration