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Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip

World Journal of Stem Cells 2023年第6期15卷 632-651页

作者： Arielly da Hora Alves Mariana Penteado Nucci Nicole Mastandrea Ennes do Valle Juliana Morais Missina Javier Bustamante Mamani gabriel nery albuquerque rego Olivia Furiama Metropolo Dias Murilo Montenegro Garrigós Fernando Anselmo de Oliveira Lionel Fernel Gamarra Hospital Israelita Albert Einstein São Paulo 05529-060São PauloBrazil Hospital das Clínicas HCFMUSP Faculdade de MedicinaUniversidade de São PauloSão Paulo 05403-010São PauloBrazil

BACKGROUND Induced pluripotent stem cells(iPSCs)show great ability to differentiate into any tissue,making them attractive candidates for pathophysiological *** rise of organ-on-a-chip technology in the past century has introduced a novel way to make in vitro cell cultures that more closely resemble their in vivo environments,both structural and *** literature still lacks consensus on the best conditions to mimic the blood-brain barrier(BBB)for drug screening and other personalized *** development of models based on BBB-on-achip using iPSCs is promising and is a potential alternative to the use of animals in *** To analyze the literature for BBB models on-a-chip involving iPSCs,describe the microdevices,the BBB in vitro construction,and *** We searched for original articles indexed in PubMed and Scopus that used iPSCs to mimic the BBB and its microenvironment in microfluidic *** articles were identified,wherein only 14 articles were finally selected according to the inclusion and exclusion *** compiled from the selected articles were organized into four topics:(1)Microfluidic devices design and fabrication;(2)characteristics of the iPSCs used in the BBB model and their differentiation conditions;(3)BBB-on-a-chip reconstruction process;and(4)applications of BBB microfluidic three-dimensional models using *** This study showed that BBB models with iPSCs in microdevices are quite novel in scientific *** technological advances in this area regarding the use of commercial BBB-on-a-chip were identified in the most recent articles by different research *** polydimethylsiloxane was the most used material to fabricate in-house chips(57%),whereas few studies(14.3%)adopted *** the models were constructed using a porous membrane made of diverse materials to separate the *** sources were divergent among the studies,but th

关键词： Induced pluripotent stem cells Cell differentiation Blood-brain barrier Neurovascular unit Organ-on-a-chip Microfluidic device

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Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno Filgueiras Joao Matias Ferreira Fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani gabriel nery albuquerque rego Lionel Fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

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Toxicological effects of mining hazard elements

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Energy Geoscience 2022年第3期3卷 255-262页

作者： Leonardo Lucas da Silva-rego Leonardo Augusto de Almeida Juciano Gasparotto Instituto de Ciencias Biomedicas-Universidade Federal de Alfenas AlfenasMinas GeraisRua Gabriel Monteiro da Silva700CEP:37130-001Centro-Alfenas/MGBrazil

Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural *** composed of various minerals vary according to the geological *** are raw materials for the conventional industries or fossil fuels for power *** can also be used in new *** mining industry triggers intense environmental *** exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health *** elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative ***,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the *** of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected *** review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the *** results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health.

关键词： Mining operation Toxicology Environmental impact Ecosystem Human health

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Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez Juan gabriel Alvarez-Gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

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Pseudocirrhosis after the Use of Taxanes and Bevacizumab in Metastatic Breast Cancer： Case Reports

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Journal of Pharmacy and Pharmacology 2017年第3期5卷 158-163页

作者： gabriel Lima Lopes Bruna Migliavacca Zucchetti Juliana Florinda de Mendoca rego Daniela de Freitas Ricardo Jose Marques ProOnco-Centro de Tratamento Oncologico Londrina 86050-190 Parana Brazil Department of Clinical Oneology Hospital Sirio-Libanes Sao Paulo 1308-050 Brazil Department of Clinical Oneology Universidade Federal do Rio Grande do Norte (UFRN) Natal 59300-000 Rio Grande do NorteBrazil Hospital do Coragao Sao Paulo 04004-030 Brazil

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