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Rifaximin.on.epigen.tics an. autophagy in.an.mal model of hepatocellular carcin.ma secon.ary to metabolic-dysfun.tion.associated steatotic liver disease

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World Journ.l of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Lon.o Melin. Belén.Kein.eski Brun. de Souza Basso gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolin. Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division.of Gastroen.erology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in.Gastroen.erology an. Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimen.al Laboratory of Hepatology an. Gastroen.erology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of In.lammatory an. n.oplastic Cells Universidade Federal do ParanáParaná81530900Brazil Departmen. of Gastroen.erology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Cien.ias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Un.t of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Cen.er of Biotechn.logy Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Departmen. of Morphological Scien.es Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Con.elho n.cion.l de Desen.olvimen.o Cien.ífico e Tecn.lógico(Cn.q) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUn. Prevalen.e of hepatocellular carcin.ma(HCC)is in.reasin.,especially in.patien.s with metabolic dysfun.tion.ssociated steatotic liver disease(MASLD).AIM To in.estigate rifaximin.RIF)effects on.epigen.tic/autophagy markers in.an.mals.METHODS Adult Sprague-Dawley rats were ran.omly assign.d(n.8,each)an. treated from 5-16 wk:Con.rol[stan.ard diet,water plus gavage with vehicle(Veh)],HCC[high-fat cholin. deficien. diet(HFCD),diethyln.trosamin.(DEn.in.drin.in. water an. Veh gavage],an. RIF[HFCD,DEn.an. RIF(50 mg/kg/d)gavage].Gen. expression.of epigen.tic/autophagy markers an. circulatin. miRn.s were obtain.d.RESULTS All HCC an. RIF an.mals developed metabolic-dysfun.tion.associated steatohepatitis fibrosis,an. cirrhosis,but three RIF-group did n.t develop HCC.Comparin. an.mals who developed HCC with those who did n.t,miR-122,miR-34a,tubulin.alpha-1c(Tuba-1c),metalloprotein.ses-2(Mmp2),an. metalloprotein.ses-9(Mmp9)were sign.fican.ly higher in.the HCC-group.The opposite occurred with Becn.,coactivator associated argin.n. methyltran.ferase-1(Carm1),en.an.er of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),an. p62/sequestosome-1(p62/SQSTM1)-protein.Comparin. with con.rols,Map1 Lc3b,Becn. an. Ezh2 were lower in.HCC an. RIF-groups(Pn.HCC compared to RIF(Pn.of Mmp9 was higher in.HCC in.relation.to the con.rol;the opposite was observed for p62/Sqstm1(Pn.of p62/SQSTM1 protein.was lower in.the RIF-group compared to the con.rol(P=0.024).There was n. differen.e amon. groups for Tuba-1c,Aldolase-B,alpha-fetoprotein.an. Mmp2(P>0.05).miR-122 was higher in.HCC,an. miR-34a in.RIF compared to con.rols(Pn.HCC compared to RIF,an. the in.erse was observed for miR-224(Pn. differen.e amon. groups regardin. miR-33a,miR-143,miR-155,miR-375 an. miR-21(P>0.05).COn.LUSIOn.RIF might have a possible ben.ficial effect on.preven.in./delayin. liver carcin.gen.sis through epigen.tic modulation.in.a rat model of MASLD

关键词： An.mal model Autophagy Epigen.tic Hepatocellular carcin.ma Metabolic dysfun.tion.associated steatotic liver disease Rifaximin

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Un.lateral rn.rr1-V5 tran.gen. expression.in.n.gral dopamin.rgic n.uron. mitigates bilateral n.uropathology an. behavioral deficits in.parkin.on.an.rats withα-syn.clein.pathy

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n.ural Regen.ration.Research 2024年第9期19卷 2057-2067页

作者： Bismark gatica-Garcia Michael J.Ban.on.Irma Alicia Martín.z-Dávila Luis O.Soto-Rojas David Reyes-Coron. Lourdes Escobedo Min.rva Maldon.do-Bern. ME Gutierrez-Castillo Arman.o J.Espadas-Alvarez Man.el A.Fern.n.ez-Parrilla Juan.U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valen.uela-Arzeta Claudia Lun.-Herrera Fran.isco E.Lopez-Salas Jaime San.oyo-Salazar Dan.el Martin.z-Fon. Departamen.o de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Departmen. of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogén.sis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicin. para la Educación.y Desarrollo y la In.estigación.Cien.ífica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico n.n.particle Therapy In.titute AguascalientesMéxico Departamen.o de Biocien.ias e In.en.ería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela n.cion.l de Medicin. y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamen.o de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamen.o de Biología Molecular y Biotecn.logía Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamen.o de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de n.n.cien.ias y n.n.tecn.logía Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkin.on.sm by un.lateral,in.ran.gralβ-sitosterolβ-D-glucoside admin.stration.in.rats is distin.uished in.that theα-syn.clein.in.ult begin. un.laterally but spreads bilaterally an. in.reases in.severity over time,thus replicatin. several clin.cal features of Parkin.on.s disease,a typicalα-syn.clein.pathy.As n.rr1 repressesα-syn.clein.we evaluated whether un.lateral tran.fected of rn.rr1-V5 tran.gen. via n.uroten.in.polyplex to the substan.ia n.gra on.day 30 after un.lateralβ-sitosterolβ-D-glucoside lesion.could affect bilateral n.uropathology an. sen.orimotor deficits on.day 30 post-tran.fection.This study foun. that rn.rr1-V5 expression.but n.t that of the green.fluorescen. protein.the n.gative con.rol)reducedβ-sitosterolβ-D-glucoside-in.uced n.uropathology.Accordin.ly,a bilateral in.rease in.tyrosin. hydroxylase-positive cells an. arborization.occurred in.the substan.ia n.gra an. in.reased tyrosin. hydroxylase-positive ramification. in.the striatum.In.addition.tyrosin. hydroxylase-positive cells displayed less sen.scen.e markerβ-galactosidase an. more n.uron.cytoskeleton.markerβIII-tubulin.an. brain.derived n.urotrophic factor.A sign.fican. decrease in.activated microglia(positive to ion.zed calcium-bin.in. adaptor molecule 1)an. n.urotoxic astrocytes(positive to glial fibrillary acidic protein.an. complemen. compon.n. 3)an. in.reased n.urotrophic astrocytes(positive to glial fibrillary acidic protein.an. S100 calcium-bin.in. protein.A10)also occurred in.the substan.ia n.gra.These effects followed the bilateral reduction.in.-syn.clein.aggregates in.the n.grostriatal system,improvin. sen.orimotor behavior.Our results show that un.lateral rn.rr1-V5 tran.gen. expression.in.n.gral dopamin.rgic n.uron. mitigates bilateral n.urodegen.ration.sen.scen.e an. loss of n.uron.cytoskeleton.an. tyrosin. hydroxylase-positive cells),n.uroin.lammation.activated microglia,n.urotoxic astrocytes),α-syn.clein.aggregation.an. sen.orimotor deficits.In.reased n.urotrophic astrocytes an. brain.derived n.urotrophic factor can.mediate t

关键词： A1 astrocytes A2 astrocytes gen. therapy microglia motor deficits n.n.particles n.urodegen.ration n.uroin.lammation sen.scen.e α-syn.clein.aggregates

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A Deep Dive in.o the Trajectory an. Tran.formation.of Fin.ech in.Colombia Through the Case of PTM Colombia-A Secon.ary Publication

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Proceedin.s of Busin.ss an. Econ.mic Studies 2024年第2期7卷 234-244页

作者： Yan.i gabriel Guacan.meÁlvarez Catalin. Medin. Ardila n.deska Gallardo Licháa Otilia Miladys Gil Hoyos Un.versity Corporation.of Saban.ta(Un.saban.ta) SabanetaColombia Remin.ton.Un.versity Corporation MedellínColombia

This research focuses on.an.lyzin. an. un.erstan.in. the evolution.an. impact of fin.ech compan.es in.Colombia,usin. PTM Colombia as a case study,a compan. that has un.ergon. a sign.fican. tran.formation.from its begin.in.s as a provider of physical recharges to its curren. position.as a comprehen.ive platform for digital fin.n.ial services.The curren. research uses a qualitative descriptive approach an. emphasizes un.erstan.in. the perception. an. experien.es in.the field of Fin.ech in.Colombia,particularly in.the case of PTM Colombia.The study revealed that adaptability an. customer orien.ation.have been.fun.amen.al in.the evolution.of PTM,allowin. the compan. to expan. its ran.e of services by actively listen.n. to the n.eds of its users an. adjustin. its strategies accordin.ly.In.addition.an.accelerated an. diversified growth of Fin.ech will be observed in.Colombia,particularly in.sectors such as credit an. paymen.s,driven.by a con.tan.ly advan.in. techn.logical en.iron.en. an. a regulatory framework that,although it presen.s challen.es,also offers opportun.ties for fin.n.ial in.ovation.This growth has impacted the tradition.l ban.in. sector,which,in.tead of bein. replaced by Fin.ech,is fin.in. n.w forms of collaboration.an. coexisten.e that ben.fit both parties an.,above all,the en. con.umer.In.con.lusion.the study highlights how Fin.ech in.Colombia,represen.ed by cases such as PTM,is redefin.n. the fin.n.ial lan.scape through the adoption.of advan.ed techn.logies,collaboration.with tradition.l ban.in.,an. stron. customer orien.ation.

关键词： Fin.n.ial techn.logy Fin.n.ial in.lusion Fin.ech ecosystem Fin.n.ial tran.formation

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Effect of Aspergillus n.ger prolyl en.opeptidase in.patien.s with celiac disease on.a lon.-term gluten.free diet

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World Journ.l of Gastroen.erology 2024年第11期30卷 1545-1555页

作者： Juan.Pablo Stefan.lo Verón.ca Segura Martin. Grizzuti Abel Heredia Isabel Comin. An. Floren.ia Costa Roberto Puebla María Paz Tempran. Son.a Isabel n.velon. gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elen. F Verdú Carolin. Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Departmen. of Microbiology an. Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Departmen. of Medicin. Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic an. Applied Research Group in.Immun.logy an. Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Departmen. of Medicin. Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicin. Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUn. The gluten.free diet(GFD)has limitation.,an. there is in.en.e research in.the developmen. of adjuvan. therapies.AIM To examin. the effects of orally admin.stered Aspergillus n.ger prolyl en.opeptidase protease(An.PEP)on.in.dverten. gluten.exposure an. symptom preven.ion.in.adult celiac disease(CeD)patien.s followin. their usual GFD.METHODS This was an.exploratory,double-blin.,ran.omized,placebo-con.rolled trial that en.olled CeD patien.s on.a lon.-term GFD.After a 4-wk run.in.period,patien.s were ran.omized to 4 wk of two An.PEP capsules(Gliadin.;AVI Research,LLC,Un.ted States)at each of three meals per day or placebo.Outcome en.poin.s were:(1)Average weekly stool gluten.immun.gen.c peptides(GIP)between.the run.in.an. en. of treatmen.s an. between.An.PEP an. placebo;(2)celiac symptom in.ex(CSI);(3)CeD-specific serology;an.(4)quality of life.Stool samples were collected for GIP testin. by ELISA every Tuesday an. Friday durin. run.in. an. treatmen.s.RESULTS Forty patien.s were ran.omized for the in.en.ion.to-treat an.lysis,an. three were excluded from the per-protocol assessmen..Overall,628/640(98.1%)stool samples were collected.GIP was un.etectable(n.65.6%of samples,an. n. differen.es between.treatmen. arms were detected.On.y 0.5%of samples had GIP con.en.ration. sufficien.ly high(>0.32μg/g)to poten.ially cause mucosal damage.Median.GIP con.en.ration.in.the An.PEP arm was 44.7%lower than.in.the run.in.period.On.-third of patien.s exhibitin. GIP>0.08μg/g durin. run.in.had lower or un.etectable GIP after An.PEP treatmen..Compared with the run.in.period,the proportion.of symptomatic patien.s(CSI>38)in.the An.PEP arm was sign.fican.ly lower(Pn.PEP did n.t result in.chan.es in.specific serologies.COn.LUSIOn.This exploratory study con.ucted in.a real-life settin. revealed high adheren.e to the GFD.The An.PEP treatmen. did n.t sign.fican.ly reduce the overall GIP stool con.en.ration.However,given.the observation.of a sign.fican.ly lower prevalen.e of patien.s with severe symptoms in.the An.P

关键词： Celiac disease Aspergillus n.ger prolyl en.oprotease Gluten.immun.gen.c peptides Trial Symptoms Real-life trial

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Distribution.an. Relation.of Primes with Tesla n.mbers 3, 6, an. 9

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Journ.l of Applied Mathematics an. Physics 2024年第4期12卷 1021-1027页

作者： Javier Men.oza-n.varrete Huetzin.Perez Ismael Ojeda Victor Verdugo gabriel Lun. San.oval Ricardo Jimen.z Garcia Jaime Alvarez Departametn. de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI Departamen.o de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico Departamen.o de In.en.eria In.ustrial en.Man.factura Universidad Estatal de Sonora Navojoa M&#233xico Departamen.o de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guan.juato M&#233xico

This work presen.s a differen. approach to twin.primes, an.approach from the perspective of the Tesla n.mbers an. gives a refresh an. n.w observation.of twin.primes that could lead us to an.an.wer to the Twin.Prime Con.ecture problem. We expose a peculiar relation.between.twin.primes an. the gen.ration.of prime n.mbers with Tesla n.mbers. Tesla n.mbers seem to be presen. in.so man. domain. like time, vibration.an. frequen.y [1], an. the space between.twin.primes is n.t the exception. Let us say that twin.primes are more than.just prime n.mbers plus 2 or min.s 2, an. Tesla n.mbers are more in.olved with twin.primes than.we thin., an. hopefully, this approach give us a better un.erstan.in. of the distribution.of the twin.pairs.

关键词： Tesla n.mbers Prime n.mber Twin.Prime n.mbers Twin.Pair

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The n.kola Tesla Con.tan. an. Its Relation.to the Circumferen.e In.cribed in.a Square

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Journ.l of Applied Mathematics an. Physics 2024年第1期12卷 277-283页

作者： Javier Men.oza n.varrete José Ismael Ojeda Campaña Huetzin.Perez gabriel Lun.-San.oval Victor Verdugo Ricardo Jimén.z Garcia Departamen.o de Matemáticas CBTis 256 DGETI Cabo San Lucas México División.de In.en.ería en.Sistemas Computacion.les Tecnológico Nacional de México/ITES de Los Cabos Cabo San Lucas México DCI Departamen.o de Física Médica Universidad de Guanajuato León México Departamen.o de In.en.ería In.ustrial en.Man.factura Universidad Estatal de Sonora Navojoa México Departamen.o de Eléctrica-Electrón.ca Tecnológico Nacional de México Campus Mexicali Mexicali México

This research work relates the surface of a square an. the area circumscribed by a circle, resultin. in.a value called n.kola Tesla con.tan.. This con.tan. starts with the calculation.of the areas of the square an. the in.cribed circle, givin. a ratio of 9/40 an. from which a residual area of the area proportion. of the geometric figures described is obtain.d. Plottin. smooth curves, particularly those in.roun. shapes, can.be represen.ed efficien.ly with the use of n.kola Tesla con.tan., reducin. complex mathematical calculus.

关键词： Tesla n.mbers Prime n.mber Circle Bin.ry Area

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Tran.arterial embolization.is an.acceptable bridgin. therapy to hepatocellular carcin.ma prior to liver tran.plan.ation

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World Journ.l of Tran.plan.ation 2024年第2期14卷 126-134页

作者： gabriel Lazzarotto-da-Silva Lean.ro A Scaffaro Mauricio Faren.en. Lucas Prediger Rafaela K Silva Flávia Hein. Feier Tomaz J M Grezzan.-Filho Pablo D Rodrigues Alexan.re de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pin.o Kruel Marcio Fern.n.es Chedid Departmen. of Liver Tran.plan. an. Hepatobiliary Surgery Un.t Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departmen. of In.erven.ion.l Radiology Un.t Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departmen. of Gastroen.erology an. Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUn. Hepatocellular carcin.ma(HCC)is an.aggressive malign.n. n.oplasm that requires liver tran.plan.ation.LT).Despite patien.s with HCC bein. prioritized by most organ.allocation.systems worldwide,they still have to wait for lon. periods.Locoregion.l therapies(LRTs)are employed as bridgin. therapies in.patien.s with HCC awaitin. LT.Although largely used in.the past,tran.arterial embolization.TAE)has been.replaced by tran.arterial chemoembolization.TACE).However,the superiority of TACE over TAE has n.t been.con.isten.ly shown.in.the literature.AIM To compare the outcomes of TACE an. TAE in.patien.s with HCC awaitin. LT.METHODS All con.ecutive patien.s with HCC awaitin. LT between.2011 an. 2020 at a sin.le cen.er were in.luded.All patien.s un.erwen. LRT with either TACE or TAE.Some patien.s also un.erwen. percutan.ous ethan.l in.ection.PEI),con.om-itan.ly or in.differen. treatmen. session..The choice of LRT for each HCC n.dule was determin.d by a multidisciplin.ry con.en.us.The primary outcome was waitlist dropout due to tumor progression.an. the secon.ary outcome was the occurren.e of adverse even.s.In.the subset of patien.s who un.erwen. LT,complete pathological respon.e an. post-tran.plan. recurren.e-free survival were also assessed.RESULTS Twelve(18.5%)patien.s in.the TACE group(on.y TACE an. TACE+PEI;n.65)an. 3(7.9%)patien.s in.the TAE group(on.y TAE an. TAE+PEI;n.38)dropped out of the waitlist due to tumor progression.P log-ran. test=0.29).Adverse even.s occurred in.8(12.3%)an. 2(5.3%)patien.s in.the TACE an. TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patien.s in.the TACE group an. 29(76.3%)of the 38 patien.s in.the TAE group un.erwen. LT(P=0.818).Amon. these patien.s,complete pathological respon.e was detected in.7(14.6%)an. 9(31%)patien.s in.the TACE an. TAE groups,respectively(P=0.145).Post-LT,HCC recurred in.9(18.8%)an. 4(13.8%)patien.s in.the TACE an. TAE groups,respectively(P=0.756).Posttran.plan. recurren.e-free survival was similar between.the groups(P log-ran. test=0.71).COn.L

关键词： Hepatocellular carcin.ma Tran.arterial embolization Tran.arterial chemoembolization Liver tran.plan.ation Locoregion.l therapy Bridgin.

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GDn. to the rescue:GDn. delivery effects on.motor n.uron. an. n.rves,an. muscle re-in.ervation.after peripheral n.rve in.uries

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n.ural Regen.ration.Research 2022年第4期17卷 748-753页

作者： Alberto F.Cin.rón.Colón.gabriel Almeida-Alves Julian. M.Van.yseghem John.M.Spitsbergen Biological Scien.es Departmen. Western Michigan UniversityKalamazooMIUSA

Peripheral n.rve in.uries common.y occur due to trauma,like a traffic acciden..Peripheral n.rves get severed,causin. motor n.uron.death an. poten.ial muscle atrophy.The curren. golden.stan.ard to treat peripheral n.rve lesion.,especially lesion. with large(≥3 cm)n.rve gaps,is the use of a n.rve autograft or reimplan.ation.in.cases where n.rve root avulsion. occur.If n.t ten.ed early,degen.ration.of motor n.uron. an. loss of axon.regen.ration.can.occur,leadin. to loss of fun.tion.Although surgical procedures exist,patien.s often.do n.t fully recover,an. quality of life deteriorates.Peripheral n.rves have limited regen.ration.an. it is usually mediated by Schwan. cells an. n.urotrophic factors,like glial cell lin.-derived n.urotrophic factor,as seen.in.Wallerian.degen.ration.Glial cell lin.-derived n.urotrophic factor is a n.urotrophic factor kn.wn.to promote motor n.uron.survival an. n.urite outgrowth.Glial cell lin.-derived n.urotrophic factor is upregulated in.differen. forms of n.rve in.uries like axotomy,sciatic n.rve crush,an. compression.thus creatin. great in.erest to explore this protein.as a poten.ial treatmen. for peripheral n.rve in.uries.Exogen.us glial cell lin.-derived n.urotrophic factor has shown.positive effects in.regen.ration.an. fun.tion.l recovery when.applied in.experimen.al models of peripheral n.rve in.uries.In.this review,we discuss the mechan.sm of repair provided by Schwan. cells an. upregulation.of glial cell lin.-derived n.urotrophic factor,the latest fin.in.s on.the effects of glial cell lin.-derived n.urotrophic factor in.differen. types of peripheral n.rve in.uries,delivery systems,an. complemen.ary treatmen.s(electrical muscle stimulation.an. exercise).Un.erstan.in. an. overcomin. the challen.es of proper timin. an. glial cell lin.-derived n.urotrophic factor delivery is paramoun. to creatin. n.vel treatmen.s to ten. to peripheral n.rve in.uries to improve patien.s'quality of life.

关键词： electrical muscle stimulation exercise glial cell lin.-derived n.urotrophic factor glial cell lin.-derived n.urotrophic factor delivery motor n.uron n.rve gap n.urotrophic factor peripheral n.rve in.ury Schwan. cells skeletal muscle atrophy

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Use of recycled con.rete aggregates in.asphalt mixtures for pavemen.s:A review

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Journ.l of Traffic an. Tran.portation.En.in.erin.(En.lish Edition. 2022年第5期9卷 725-741页

作者： Juan.gabriel Bastidas-Martín.z Fredy Alberto Reyes-Lizcan. Hugo Alexan.er Ron.ón.Quin.an. Faculty of En.in.erin. Universidad Piloto de ColombiaBogotáDC 110231Colombia Faculty of En.in.erin. Pontificia Universidad JaverianaBogotáDC 110131Colombia Facultad del Medio Ambien.e y Recursos n.turales Universidad Distrital Francisco Joséde CaldasBogotáDC 110131Colombia

Large quan.ities of n.tural aggregates(n.)are required in.the man.facturin. of asphalt mixtures for pavemen.s.The extraction.of n. gen.rates high en.iron.en.al impacts that n.gatively affect en.iron.en.al preservation.an. con.ervation.Diverse altern.tive materials obtain.d in.con.truction.an. demolition.processes in.civil con.truction.worked have been.studies as possible replacemen.s for n.,with the purpose of reducin. these en.iron.en.al impacts.The foregoin. study presen.s a state of kn.wledge review referrin. to the use of recycled con.rete aggregates(RCA)when.these are used in.the man.facturin. of asphalt mixtures(main.y hot-mix asphalt HMA type).En.iron.en.al aspects are presen.ed,as well as possible ben.fits an. limitation. of usin. RCA as replacemen.s for n. in.asphalt mixtures.However,it is n.t possible to establish a behavior pattern.sin.e the characteristics of the RCA are very heterogen.ous an. vary from the origin.l source of the con.rete.It is highlighted from the literature that RCA has a wide poten.ial for use in.the man.facture of asphalt mixtures,sin.e in.most studies,the mixtures with these materials comply the quality requiremen.s con.emplated by the con.truction.specification.,main.y in.low-volume roads.Addition.lly,based on.the literature review,some recommen.ation. an. suggestion. are presen.ed for future research.

关键词： Recycled con.rete aggregates Asphalt mixtures Mechan.cal properties Volumetric composition

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Hepatobiliar man.festation. in.in.lammatory bowel disease: A practical approach

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World Journ.l of Hepatology 2022年第2期14卷 319-337页

作者： Paulin. n.ñez F Fabiola Castro gabriel Mezzan. Rodrigo Quera Diego Diaz Loren. Castro Un.versidad de los An.es Inflammatory Bowel Disease ProgramDigestive Disease CenterSantiago 7600976RMChile In.lammatory Bowel Disease Program Hospital San Juan de DiosUniversidad de ChileSantiago 7701230RMChile Un.versidad de los An.es Hepatology ProgramDigestive Disease CenterSantiago 7600976RMChile Departmen. of Gastroen.erology Hospital del Salvador/Universidad de ChileSantiago 7600976RMChile Un.versidad de los An.es Santiago 770976RMChile

In.lammatory bowel diseases(IBD)are associated with various hepatobiliary disorders.They can.occur at an. momen. in.the course of the disease or associated with the treatmen..The prevalen.e of liver dysfun.tion.can.reach up to 50%in.differen. studies.n.n.lcoholic fatty liver disease is con.idered the most common.hepatobiliary complication.in.IBD,while primary sclerosin. cholan.itis is the most specific.Man.gemen. of hepatic man.festation. in.IBD in.olves a multidisciplin.ry approach that in.ludes a high in.ex of suspicion.an. join. man.gemen. with hepatologists.The medical con.ron.ation.with abn.rmal liver tests must in.lude an.exhaustive study to determin. if these pattern. can.be related to IBD,associated diseases or to the therapies used.

关键词： Extrain.estin.l man.festation. In.lammatory bowel disease Sclerosin. primary cholan.itis Hepatic steatosis Liver toxicity

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