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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera gabriel carrasco-escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat

Valued gabriel quiver of a wedge product and semiprime coalgebras

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Frontiers of Mathematics in China 2013年第5期8卷 1157-1183页

作者： gabriel NAVARR0 Department of Computer Sciences and AI University of Granada E1 Greco s/n E-51002Ceuta Spain

We describe the valued gabriel quiver of a wedge product of coalgebras and study the category of comodules of a semiprime coalgebra. In particular, we prove that any monomial semiprime k-tame fc-tame coalgebra is string. We also prove a version of Eisenbud-Griffith theorem for coalgebras, namely, any hereditary semiprime strictly quasi-finite coalgebra is serial.

关键词： Wedge product semiprime coalgebras representation theory,valued gabriel quiver

Message from Deputy Editor-in-Chief gabriel M Leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： gabriel M Leung China CDC Weekly Dean of Medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

A case study on the efficacy of different roof bolting schemes in Lhoist North America’s Crab Orchard Mine

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International Journal of Mining Science and Technology 2020年第1期30卷 99-104页

作者： Reece Kurre gabriel Walton Stantec Consulting Services Inc. Walnut CreekCA 94597USA Department of Geology and Geological Engineering Colorado School of MinesGoldenCO 80401USA

Roof bolting has long been used in underground mines across the world to provide ground *** roof bolts are cheap and easy to install with the use of specialized machines as a part of the production cycle. Lhoist North America’s Crab Orchard Mine is an underground room and pillar limestone mine that uses mechanically anchored roof bolts for ground support. The mine currently employs two different roof bolting patterns: a standard 1.5 × 1.5 m pattern, and another 0.8 × 0.8 m pattern for use in areas with particularly hazardous roof conditions. The purpose of this study is to evaluate the relative effectiveness of each bolting pattern. A series of numerical models were created using Roc Science’s RS2. The models were based on a symmetrical section of the mine at its deepest point, and were modeled using generalized Hoek-Brown failure criterion along with a discrete fracture network. A series of sensitivity analyses were performed on the models by varying parameters such as joint friction angle, crack persistence, joint randomization, and tensile strength of the limestone. Based on the results of the original models and sensitivity analyses, it appeared that the standard bolting pattern provided sufficient roof support capacity under almost all the expected conditions at the mine, since safety factors below the design value of 1.5 were only found for individual bolts in a few of the worst test cases *** results can help improve the mine’s productivity and reduce operating costs without compromising safety.

关键词： Numerical modeling Mining Roof bolting Roof stability Analysis RocScience’s RS2 Underground stone

Atypical presentation of pseudomembranous colitis localized in adenomatous polyps

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World Journal of Gastroenterology 2013年第2期19卷 316-318页

作者： Cristian Hernández-Rocha Jonathan Barra-carrasco Ana María Guzmán Daniel Paredes-Sabja gabriel Lezcano Pablo Zoroquiaín Manuel lvarez-Lobos Department of Gastroenterology Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile Laboratory of Mechanisms of Bacterial Pathogenesis Department of Biological SciencesFaculty of Biological SciencesUniversidad Andrés BelloSantiago 6618000Chile Department of Clinical Laboratory Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile Department of Biomedical Sciences College of Veterinary MedicineOregon State UniversityCorvallisOR 97333United States Department of Anatomophatology Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile

The most frequent cause of pseudomembranous colitis is Clostridium difficile(***) *** type of colitis is characterized by an endoscopic pattern of numerous small,yellowish or whitish plaques diffusely distributed,which typically compromises the rectum extending to proximal ***,the pseudomembranes compromise only the transverse or right colon,but their exclusive localization over polyps has not been *** this case report we have described a patient with symptoms compatible with *** infection and positive for *** toxigenic *** examination showed two small polyps with a whitish surface,and histopathological analysis confirmed them to be pseudomembranes over tubular *** rest of the colonic mucosa was normal and no other cause was *** suggest that this particular distribution might be due to a higher affinity for dysplastic cells such as adenomatous polyps of colon by *** and/or its toxins.

关键词： Clostridium difficile Pseudomembranous colitis Adenomatous polyps Antibiotic-associated colitis Clostridium difficile infections

Gabor’s holography at sea

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Light(Science & Applications) 2019年第1期8卷 1004-1005页

作者： gabriel Popescu Quantitative Light Imaging Laboratory Department of Electrical and Computer EngineeringBeckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

In 1948,predating lasers by more than a decade,Gabor proposed a“new microscopic principle”,which was initially aimed at correcting spherical aberrations in electron *** the method has not produced an impact in its originally intended field,it opened a new direction,known as holography,in ***’s technique allows one to store phase information by recording on film the intensity of a field emerging at a certain distance from an object.

关键词： Gabor recording initially

Numerical study of solar absorption heat storage system applied to Bucharest city

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Building Simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad Adrian-gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral School Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions

GANscan:continuous scanning microscopy using deep learning deblurring

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Light(Science & Applications) 2022年第10期11卷 2378-2387页

作者： Michael John Fanous gabriel Popescu Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA

Most whole slide imaging(WSI)systems today rely on the"stop-and-stare"approach,where,at each field of view,the scanning stage is brought to a complete stop before the camera snaps a *** procedure ensures that each image is free of motion blur,which comes at the expense of long acquisition *** order to speed up the acquisition process,especially for large scanning areas,such as pathology slides,we developed an acquisition method in which the data is acquired continuously while the stage is moving at high *** generative adversarial networks(GANs),we demonstrate this ultra-fast imaging approach,referred to as GANscan,which restores sharp images from motion blurred *** allows us to complete image acquisitions at 30x the throughput of stop-and-stare *** method is implemented on a Zeiss Axio Observer Z1 microscope,requires no specialized hardware,and accomplishes successful reconstructions at stage speeds of up to 5000 μm/*** validate the proposed method by imaging H&E stained tissue *** method not only retrieves crisp images from fast,continuous scans,but also adjusts for defocusing that occurs during scanning within+/-5 μ*** a consumer GPU,the inference runs at<20 ms/image.

关键词： hardware continuous image