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Effect of brimonidine tartrate on basophil activation in glaucoma patients

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 509-512页

作者： Eldar Rosenfeld Dana Barequet Gilad Rabina Sheila Langier Moshe Lazar gabi Shemesh Shimon Kurtz Shmuel Kivity Division of Ophthalmology Sourasky Medical CenterSackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Allergy and Immunology Sourasky Medical CenterSackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel

AIM:To evaluate the mechanism of which brimonidine tartrate 0.15%causes clinical ***:A prospective case-control study comparing 8 glaucoma patients with clinical hypersensitivity to brimonidine to a control group consisting 13 healthy *** samples were stimulated with brimonidine 0.15%,timolol 0.5%or brimonidine tartrate/timolol maleate 0.2%/0.5%.Premixed antibodies(CD63/FITC and aIgE/PE)were added for direct staining and whole-blood samples were lysed,fixed and analyzed by a flow *** basophil population was defined by high IgE cell *** was identified by the expression of the activation molecule ***:Basophil activation was not significant when comparing percent of activated basophils of patients and healthy controls after exposure to brimonidine(2.58%,2.45%,respectively,P=0.72).There was a significant suppression of basophil activation when a combination of brimonidine-timolol(0.87%)was compared to timolol(2.27%;P=0.012)and to brimonidine alone(2.58%;P=0.017).CONCLUSION:The results of our study do not support the hypothesis that brimonidine induces an immediate allergic *** activation was suppressed by the presence ofβ-blockers in patients hypersensitive to brimonidine and in healthy *** finding indicates that timolol suppress brimonidine drug reaction by a different mechanism.

关键词： glaucoma allergy hypersensitivity brimonidine timolol basophils

Trabeculectomy with Ex-PRESS implant versus Ahmed glaucoma valve implantation-a comparative study

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1415-1420页

作者： Michael Waisbourd Naomi Fischer Hadas Shalev Oriel Spierer Elad Ben Artsi Rony Rachmiel gabi Shemesh Shimon Kurtz Department of Ophthalmology Tel-Aviv Medical CenterAffiliated to the Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv 64239 Israel Wills Eye Glaucoma Research Center Philadelphia PA19107 USA

AIM：To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve（AGV） implantation. METHODS： Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart *** outcome measures were surgical failure and *** was defined as intraocular pressure（IOP）〉21 mm Hg or 〈5 mm Hg on two consecutive visits after 3mo,reoperation for glaucoma,or loss of light *** that had not failed were considered as complete success if they did not required supplemental medical ***： A total of 64 eyes from 57 patients were included： 31 eyes in the Ex-PRESS group and 33 eyes in the AGV *** mean follow-up time was 2.6 ±1.1y and 3.3±1.6y,*** in the AGV group had significantly higher baseline mean IOP（P =0.005）,lower baseline mean visual acuity（VA）（P =0.02）,and higher proportion of patients with history of previous trabeculectomy（P 〈0.0001）.Crude failure rates were 16.1%,n =5/31 in the Ex-PRESS group and 24.2%,n =8/33 in the AGV *** cumulative proportion of failure was similar between the groups,P =*** proportion of eyes that experienced postoperative complications was32.3% in the Ex-PRESS group and 60.1% in the AGV group（P =0.0229）.CONCLUSION： Trabeculectomy with Ex-PRESS implant and AGV implantation had comparable failure *** AGV group had more post-operative complications,but also included more complex cases with higher baselinemean IOP,worse baseline mean VA,and more previous glaucoma ***,the results are limited to the cohort included in this study.

关键词： Ex-PRESS glaucoma implant trabeculectomy Ahmed glaucoma valve implantation

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意大利工业区与华人的双重挑战

华侨华人历史研究 2011年第2期 9-16页

作者： gabi Dei Ottati 张铭意大利佛罗伦萨大学经济学院经济系中国华侨华人历史研究所北京100007

论文分析了全球性竞争压力对工业区适应机制的影响及工业区的竞争优势以及工业区内部形成的华人经济的潜在威胁,探讨了在新的条件下将这种威胁转化为新的发展机遇的可能性。认为华人经济的特殊优势使华人企业越来越活跃,但却使当地企业... 详细信息

论文分析了全球性竞争压力对工业区适应机制的影响及工业区的竞争优势以及工业区内部形成的华人经济的潜在威胁,探讨了在新的条件下将这种威胁转化为新的发展机遇的可能性。认为华人经济的特殊优势使华人企业越来越活跃,但却使当地企业日益萎缩。这反过来又促使当地经济整体进行转型;华人企业家的某些优势在于其跨地区和跨国网络;华人移民对其祖籍国潜在商业伙伴的能力和品德有深度了解,如果能发挥中介作用,意大利当地企业就能使其工业生产及产品销售国际化。

关键词：意大利华人研究工业区华人经济华人企业

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磁珠富集法分离柿微卫星标记

西北农林科技大学学报（自然科学版） 2008年第5期36卷 97-102页

作者：阮小凤 gabi Krczal 杨勇西北农林科技大学园艺学院陕西杨凌712100 莱茵兰普法尔茨州植物研究所 67435 Neustadt/Weinstraβe德国

【目的】分离柿属植物的微卫星标记,为柿种质资源的分类、进化等遗传研究奠定基础。【方法】提取磨盘柿（Diospyros kaki）基因组DNA后,用EcoRⅠ和MesⅠ2种内切酶酶切并连接接头,再用接头特异引物进行PCR扩增。扩增产物与生物素标记的... 详细信息

【目的】分离柿属植物的微卫星标记,为柿种质资源的分类、进化等遗传研究奠定基础。【方法】提取磨盘柿（Diospyros kaki）基因组DNA后,用EcoRⅠ和MesⅠ2种内切酶酶切并连接接头,再用接头特异引物进行PCR扩增。扩增产物与生物素标记的（GA）15和（AC）15探针杂交,杂交复合物用链亲和素包裹磁珠进行结合,得到单链DNA目标片段,经PCR扩增,连接pGEM-T载体,转化入感受态大肠杆菌,得到微卫星富集小插入片段DNA文库。用Colony-PCR法筛选阳性克隆,进行测序分析。【结果】测序96个克隆,54个含微卫星序列,24个为有效微卫星序列,其中完美型（perfect）9个,占37.5%;非完美型（imperfect）7个,占29.2%;混合型（compound）8个,占33.3%（。GA）n重复最为常见。21条含微卫星序列已登录GenBank（Accession Number：EF567396～EF567416）。成功设计21对引物,经初步筛选,14对表现出多态性。【结论】试验方法分离柿基因组微卫星简便有效,得到的多态性引物可用于柿种质资源的遗传研究。

关键词：柿微卫星磁珠富集

Sirolimus-induced drug fever and ciclosporin-induced leukencephalopathia with seizures in one liver transplant recipient

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World Journal of Gastroenterology 2007年第45期13卷 6090-6093页

作者： Doris Schacherer Martina Zeitoun Roland Büttner Cornelia Gelbmann Aiman Obed Hans-Jürgen Schlitt Jürgen Schlmerich gabi I Kirchner Department of Internal MedicineⅠ University of Regensburg Regensburg 93042 Germany Department of Surgery University of Regensburg Regensburg 93042 Germany

We describe the first case of sirolimus-induced drug fever in a female liver transplant recipient, with a history of hepatitis C-induced end-stage liver cirrhosis in 1999. In 2005, six years after transplantation, she developed calcineurin inhibitor-induced renal function impairment. Immunosuppression was switched from tacrolimus to sirolimus. Two days after the intake of sirolimus, she developed daily fever spikes, but no infectious focus was found. Antibiotic therapy had no influence on the fever. After fourteen days, sirolimus was switched back to tacrolimus and the fever disappeared. In history, the patient developed ciclosporin-induced generalized seizures eleven days after liver transplantation, followed by the development of a motoric speech disorder. Magnetic resonance imaging (MRI) findings were consistent with leucoencephalopathy, therefore immunosuppressive therapy was changed from ciclosporin to tacrolimus and the neurologic symptoms improved significantly. Our case is the first reported case of sirolimus-induced drug fever. In addition, the patient showed the rare occurrence of ciclosporin-induced leukencephalopathy with seizures.

关键词： Liver transplantation Immunosuppression Side effects

Global Paleogeography through the Proterozoic and Phanerozoic:Goals and Challenges

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Acta Geologica Sinica(English Edition) 2019年第S1期93卷 59-60页

作者： James G.OGG Christopher R.SCOTESE HOU Mingcai CHEN Anqing gabi M.OGG ZHONG Hanting Institute of Sedimentary Geology State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology)Chengdu 610059China PALEOMAP Project 134 DodgeEvainstonIllinois 60202USA Geologic TimeScale Foundation 1224 N.SalisburyWest LafayetteIndiana 47906US4

Paleogeography is the merger of lithology,depositional environments,tectonic plate movements,topography,climate patterns and ecosystems(reefs,vegetation)through time(e.g.,Scotese,2014,2016,2017;Blakey,2019).The construction of paleogeographic maps using tectonic plate reconstructions requires a multi-year community effort that shares databases,standards and computer projection methods.

关键词： Paleogeography GPlates Asia China databases

从芽外植体到温室栽培——甜樱桃和酸樱桃30周快繁技术(英文)

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西南农业大学学报（自然科学版） 2001年第3期23卷 230-232页

作者：王永清 gabi Krczal 四川农业大学园艺系四川雅安625014 ZentrumGruneGentechnik

甜樱桃 (Prunusavium)和酸樱桃 (Prunuscerasus)分步微繁技术 ,此技术涵盖了微繁全过程所需的全套技术 ,包括外植体和培养基的制备方法 ,各个阶段的培养技术及培养基配方、试管苗炼苗和移栽等 ,采用这一技术体系 ,可在 30周内完成从芽... 详细信息

甜樱桃 (Prunusavium)和酸樱桃 (Prunuscerasus)分步微繁技术 ,此技术涵盖了微繁全过程所需的全套技术 ,包括外植体和培养基的制备方法 ,各个阶段的培养技术及培养基配方、试管苗炼苗和移栽等 ,采用这一技术体系 ,可在 30周内完成从芽外植体建立到温室植株的全过程。此外 ,还提出了进一步改进该技术体系的建议 ,如调整总氮量及NO3-/NH4 +比率 ,添加蔗糖以外的其他碳源。

关键词：微型繁殖组织培养甜樱桃酸樱桃

Numerical Investigation of Effective Heat Conductivity of Fluid in Charging Process of Thermal Storage Tank

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Open Journal of Fluid Dynamics 2015年第1期5卷 39-50页

作者： Hadi Taheri Ferdinand P. Schmidt Martin gabi Institute of Fluid Machinery Department of Mechanical Engineering Karlsruhe Institute of Technology Karlsruhe Germany

This paper presents a numerical case study of heat transfer mechanisms during the charging process of a stratified thermal storage tank applied in a specific adsorption heat pump cycle. The effective thermal conductivity of the heat transfer fluid during the charging process is analyzed through CFD simulations using Unsteady Reynolds-averaged Navier-Stokes equations (URANS). The aim of the study is to provide an equivalent thermal conductivity for a one-dimensional storage tank model to be used in a system simulation of the complete adsorption heat pump cycle. The influence of the turbulent mixing and also the advection effect due to fluid bulk motion are investigated. The results show that in the case considered here, the turbulence effect on the effective thermal conductivity is more considerable than the advection effect.

关键词： Thermal Storage Tank Stratification Pipe Effective Thermal Conductivity

New Development of Port Structures Design and Construction

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Journal of Shipping and Ocean Engineering 2011年第3期1卷 150-157页

作者： S. gabi M. Doubrovsky A. Belakrouf Department of Civil Engineering University of Tizi-Ouzou Hasnaoua 15000 Algeria Sea River Ports and Waterways Department Odessa National Maritime University Odessa 65029 Ukraine Department of Civil Engineering University of Boumerdes Boumerdes 35000 Algeria

Some new innovative constructions and technologies for improvement of port structures are worked out and discussed. The aims of innovations are to increase structures＇ reliability, to decrease cost of construction and maintenance, to simplify technology and cost of building. For these purposes either some main bearing elements or structures in whole are modified or improved. In particular different improved waterfront constructions as well as retaining walls and coastal protection （gravity, piled, sheet piling, etc.） for use in various soil conditions are outlined. One of them incorporates trapezoidal blocks forming columns, each block in the column contacts the others either with smaller or larger bases. Another design incorporates blocks that are constructed with holes ran through the centres of gravity of the blocks. Rigid cylinder element running through the holes of several adjacent blocks allows them to be joined forming large size units, The structure consisting of wedge form retaining wall is original but simple to construct, Some new designs based on perfection of sheet-piling walls （sheet piles with curvilinear cross-section having a form of semi-rings） are proposed for different applications. Proposals on modernization of some traditional structures and technologies are discussed.

关键词： Port structures sheet-piling walls coastal protection.