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2C-B的亚慢性毒性研究

哈尔滨商业大学学报（自然科学版） 2024年第3期40卷 266-272,280页

作者：张大雷杨波才志成洪玉于维彪廖林川黑龙江省公安厅刑事技术总队哈尔滨150008 哈尔滨商业大学药学院哈尔滨150076 四川大学华西基础医学与法医学院成都610041

研究4-溴-2,5-二甲氧基苯乙胺(4-bromo-2,5-dimethoxyphenethylamine,2C-B)的亚慢性毒性.通过对大鼠进行长期连续染毒,以体重变化、脏器系数、病理学检查及肝肾生化酶水平的影响探讨2C-B对机体造成损伤的情况.综合各指标结果分析长期服... 详细信息

研究4-溴-2,5-二甲氧基苯乙胺(4-bromo-2,5-dimethoxyphenethylamine,2C-B)的亚慢性毒性.通过对大鼠进行长期连续染毒,以体重变化、脏器系数、病理学检查及肝肾生化酶水平的影响探讨2C-B对机体造成损伤的情况.综合各指标结果分析长期服用2C-B会对心脏、肝脏、肺脏、肾脏、大脑产生损害,上述器官可能是2C-B毒性的靶器官.

关键词： 2C-B 亚慢性毒性脏器系数病理学检查肝肾生化酶水平

Acidity Modification of ZSM-5 for Methane Conversion in Co-feeding Method with MTA Reaction

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Chemical Research in Chinese Universities 2022年第4期38卷 1012-1017页

作者： YU Yue XI Zhixiang ZHOU Bingjie JIANG Binbo liao Zuwei YANG Yao WANG Jingdai HUANG Zhengliang SUN Jingyuan YANG Yongrong Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027P.R.China

Acidity plays a vital role in methane conversion by co-feeding method,which is one of the best strategies to improve the utilization and gentle the reaction conditions of *** this work,Zn,Ni,Mo,La,ga,Fe and Co-impregnated ZSM-5 zeolites have been prepared with the same substitutions to variate the acidities and tested in co-aromatization of methanol with *** is demonstrated that the new medium-strong acid sites formed by metal and strong acid sites are the key role to activate methane in ***-modified ZSM-5 catalyst is preferred to exhibit the best methane conversion of 12%,whose aromatic selectivity increases from 27.2%to 52.2%compared with that of ***,the addition of methane further improves the production of high-valued aromatics compared with methanol to aromatics(MTA)reaction.

关键词： Methane Methanol to aromatics(MTA) Co-reaction Acid site

Parentage Analysis of Dongfang No.2, a Hybrid of a Female gametophyte Clone of Laminaria japonica (Laminariales, Phaeophyta) and a Male Clone of L. longissima

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Journal of Ocean University of China 2008年第2期7卷 193-198页

作者： YANG Guanpin liao Meijie LI Xiaojie CONG Yizhou QU Shancun WANG Tongyong College of Marine Life Sciences Ocean University of China Qingdao 266003 P. R. China Shandong Oriental Ocean Sci-Tec Co. Ltd. Yantai 264003 P R. China Wendeng Fishery Technique Popularization Station of Shandong Province Wendeng 264400 P R. China

The cultivation of the first filial generation of monoploid gametophyte clones of different Laminaria species (hybrid Laminaria) is an effective way of utilizing heterozygous vigor (heterosis). A female gametophyte clone of L. japonica and a male gametophyte clone of L. longissima were hybridized, generating Dongfang No.2 hybrid Laminaria. The parentage of this hybrid Laminaria was determined using AFLP of total DNA, SNP of the ITS region of ribosomal RNA transcription unit and microsatellite DNA variation at two loci. In addition to 167 AFLP bands shared by Dongfang No.2, L. japonica and L. longissima, Dongfang No.2 hybrid Laminaria shared another 70 and 55 bands with L. japonica and L. longissima, respectively, which were obviously more than 11 bands shared by L. japonica and L. longissima. Dongfang No.2 held both ‘T’ and ‘C’ at position 847 of the ITS region, while ‘T’ at this position was specific for L. japonica and ‘C’ for L. longissima, respectively. Dongfang No.2 also held the microsatellite DNA alleles of two parents together at two microsatellite DNA marker loci. These observations clearly proved that Dongfang No.2 is a true hybrid of L. japonica and L. longissiuma. Unfortunately, the origin of the chloroplast of Dongfang No.2 was not determined based on the variation of RuBisCo spacer. More sequence variants of both ITS region and RuBisCo spacer were identified in Dongfang No.2 and most of them did not exist in either L. japonica or L. longissima. The unexpected variants may be due to the mutation of ga- metophyte clones occurring during their vegetative amplification.

关键词： hybrid Laminaria gametophyte clone heterosis Laminaria japonica Laminaria longissima

Single nucleotide polymorphisms of MAGE-A3 gene and its clinical implications in Chinese patients with non-small cell lung cancer(NSCLC)

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Chinese Journal of Cancer Research 2015年第3期27卷 301-308页

作者： Xue-Ning Yang Ling Huang Yu Chen She-Juan An Xu-Chao Zhang Ri-Qiang liao Jian Su Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong General Hospital& Guangdong Academy of Medical Sciences

Background： Available study revealed advanced tumors have a higher expression rate of MAGE-A3 gene which has a lot of single nucleotide polymorphism（SNP） loci with polymorphisms. This study aimed to analyze the allele frequency of SNP loci in MAGE-A3 gene and investigate the relationship between MAGE-A3 gene polymorphisms and clinical ***： Tumor samples of a cohort of 191 NSCLC patients were collected. EGFR m RNA expression were detected by q RT-PCR. SNPs in whole length of MAGE-A3 gene were detected by direct sequencing. Frequencies of the SNPs were correlated to gene expression, mutation status of EGFR and clinical ***： Sequencing analysis confirmed that allele frequencies of genotypes on SNP loci rs5970360, rs5925210, rs5970361, rs5925211 and rs35123853 were CC（0.681）/CT（0.319）, CC（0.660）/CG（0.340）, CC（0.681）/CA（0.319）, AA（0.984）/AT（0.016） and GG（1.000）/ga（0.000）, respectively, which were different from the frequencies and genotypes of MAGE-A3 in SNP database. Chi-square tests showed the EGFR mR NA expression level had significant correlation with the genotypes of SNP loci rs5970360 and rs5925210. But all frequencies of each MAGE-A3 SNPs were not found significantly different between EGFR mutant and wild type patients. MAGE-A3 gene polymorphisms had no significant effects on survival of NSCLC ***： Chinese patients with NSCLC had different SNP patterns of MAGE-A3 in comparison with those in international SNP database. These MAGE-A3 SNP loci might have not prognostic significance. MAGE-A3 SNP loci rs5970360 and rs5925210 might be predictive for EGFR m RNA expression levels and helpful to the selection of patients for epidermal growth factor receptor（EGFR） targeted immunotherapy.

关键词： MAGE-A3 epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) single nucleotide polymorphism (SNP)

Paleoproterozoic Nb-enriched meta-gabbros in the Quanji Massif,NW China:Implications for assembly of the Columbia supercontinent

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Geoscience Frontiers 2018年第2期9卷 577-590页

作者： Fan-Xi liao Neng-Song Chen M.Santosh Qin-Yan Wang Song-Lin Gong Chuan He Hassan Abdelsalam Mustafa Institute of Geophysics and Geomatics China University of GeosciencesWuhan 430074China School of Earth Sciences China University of GeosciencesWuhan 430074China International Research Center for Geology and Resources along the Silk Roads China University of GeosciencesWuhan 430074China State Key Lab of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Centre for Tectonics Resources and ExplorationDepartment of Earth SciencesUniversity of AdelaideSA 5005Australia School of Earth Sciences and Resources China University of Geosciences Beijing29 Xueyuan RoadBeijing 100083China School of Earth Sciences Zhejiang UniversityHangzhou310027China Three Gorges Geological Hazards Research Center Ministry of EducationChina University of GeosciencesWuhan 430074China Faculty of Science University of KordofanEL ObeidP.O 160Sudan

Diverse models have been proposed for the role of the Tarim Craton within the Paleoproterozoic Columbia supercontinent assembly. Here we report a suite of-1.71 ga Nb-enriched meta-gabbro lenses in the eastern Quanji Massif, within the Tarim Craton in NW China. The meta-gabbroic rocks have Nb contents of 11.5-16.4 ppm with Nb/La ratios varying from 0.84 to 1.02((Nb/La)_N = 0.81-0.98) and Nb/U ratios from 38.0 to 47.2. They show low SiO_2(45.1-48.5 wt.%) and MgO(5.96-6.81 wt.%) and Mg#(Mg# = Mg/(Mg + Fe) = 43.5-47.7), high FeO^t(13.0-15.7 wt.%) and moderate Ti02(1.70-2.51 wt.%).with tholeiitic affinities. These rocks possess low fractionated REE patterns without obvious Eu anomalies(Eu/Eu~* = 0.87-1.02). Their primitive mantle-normalized elements patterns display significant Zr-Hf troughs, positive Nb anomalies, weak negative Ti and P anomalies, and high contents of Rb and Ba,resembling Nb-enriched basalts generated in arc-related tectonic settings. Their arc-like geochemical signatures together with whole rock εNd(t) values of 0.4-2.1 and corresponding old T_(DM)(2.22-2.37 ga)as well as(^(143)Nd/^(144)Nd)_t and(^(87)Sr/^(86)Sr)t(t = 1712 Ma) values of 0.5104-0.5105 and 0.7030-0.7058,respectively, suggest that their precursor magma originated from mantle wedge peridotite metasomatised by subduction-derived melts. The results from our study reveal subduction along the eastern periphery of the Tarim Craton and marginal outgrowth continuing to ~1.7 ga within the Columbia supercontinent.

关键词： Nb-enriched gabbros Geochemistry Quanji Massif Tarim Craton Columbia supercontinent

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基于物联网的温室大棚环境监控系统设计方法

农业工程学报 2016年第11期32卷 233-243页

作者：廖建尚广东交通职业技术学院计算机工程学院广州510650

目前农业物联网通信协议尚不统一。为了更好地封装和传输农业信息,提出一种适用于农业物联网的通信协议AGCP(agricultural greenhouses communication protocol)。利用AGCP协议结合物联网架构完成了基于物联网架构的农业大棚监控系统的... 详细信息

目前农业物联网通信协议尚不统一。为了更好地封装和传输农业信息,提出一种适用于农业物联网的通信协议AGCP(agricultural greenhouses communication protocol)。利用AGCP协议结合物联网架构完成了基于物联网架构的农业大棚监控系统的设计,重点完成了感知层中协调器和节点终端的信息采集以及设备控制的软硬件设计,并详细设计了光照控制模块、温度控制模块和灌溉控制模块,最后进行了系统测试和分析。试验表明,该系统能有效监测温室大棚的空气温度、湿度、二氧化碳以及土壤湿度等农业环境信息,并能进行相应设备的自动控制,验证了AGCP协议在农业物联网的有效性以及构建系统的可行性。

关键词：温室大棚传感器设计物联网通信协议自动监控系统

Modulating the threshold voltage of oxide nanowire field-effect transistors by a ga^＋ ion beam

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Nano Research 2014年第11期7卷 1691-1698页

作者： Wenqing Li Lei liao Xiangheng Xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei Wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang Department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education Wuhan UniversityWuhan 430072 China

In this paper, we report a method to change the threshold voltage of SnO2 and In2O3 nanowire transistors by ga^＋ ion irradiation. Unlike the results in earlier reports, the threshold voltages of SnO2 and In2O3 nanowire field-effect transistors （FETs） shift in the negative gate voltage direction after ga^＋ ion irradiation. Smaller threshold voltages, achieved by ga^＋ ion irradiation, are required for high-performance and low-voltage operation. The threshold voltage shift can be attributed to the degradation of surface defects caused by ga＋ ion irradiation. After irradiation, the current on/off ratio declines slightly, but is still close to -106. The results indicate that ga^＋ ion beam irradiation plays a vital role in improving the performance of oxide nanowire FETs.

关键词： nanowire field-effect transistor ion irradiation threshold voltage

Concise Modeling of Amorphous Dual-gate In-ga-Zn-O Thin-Film Transistors for Integrated Circuit Designs

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Chinese Physics Letters 2018年第2期35卷 93-96页

作者： Can Li Cong-Wei liao Tian-Bao Yu Jian-Yuan Ke Sheng-Xiang Huang Lian-Wen Deng School of Physics and Electronics Central South University

An analytical model for current-voltage behavior of amorphous In-ga-Zn-O thin-film transistors（a-IGZO TFTs）with dual-gate structures is *** unified expressions for synchronous and asynchronous operating modes are derived on the basis of channel charges,which are controlled by gate *** is proven that the threshold voltage of asynchronous dual-gate IGZO TFTs is adjusted in proportion to the ratio of top insulating capacitance to the bottom insulating capacitance（C_（TI）/C_（BI））.Incorporating the proposed model with Verilog-A,a touch-sensing circuit using dual-gate structure is investigated by SPICE *** shows that the touch sensitivity is increased by the dual-gate IGZO TFT structure.

关键词： TFT Concise Modeling of Amorphous Dual-gate In-ga-Zn-O Thin-Film Transistors for Integrated Circuit Designs Zn

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基于时间反演和单站天线的导体目标微波成像

西南交通大学学报 2011年第3期46卷 451-455页

作者：钟选明廖成西南交通大学电磁场与微波技术研究所四川成都610031

为克服强散射体环境、多径效应等因素对目标成像的影响,利用时间反演法的自适应聚焦特性,研究了导体目标微波成像算法.将需要成像的目标轮廓用有限项三角级数逼近,散射问题用时域有限差分法模拟,逆散射问题转换成受限制的优化问题,引入... 详细信息

为克服强散射体环境、多径效应等因素对目标成像的影响,利用时间反演法的自适应聚焦特性,研究了导体目标微波成像算法.将需要成像的目标轮廓用有限项三角级数逼近,散射问题用时域有限差分法模拟,逆散射问题转换成受限制的优化问题,引入遗传算法优化待求的三角级数的系数,仅用单站天线完成多散射体环境中二维导体目标的图像重建.为验证算法的有效性,对2个算例进行了数值仿真.

关键词：时间反演遗传算法微波成像逆散射