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Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

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International Journal of Oral Science 2023年第1期15卷 76-86页

作者： Libo Liang Yi Li Binwu Ying Xinyan Huang Shenling liao Jiajin Yang ga liao General Practice Medical Center West China HospitalSichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Laboratory Medicine West China HospitalSichuan UniversityChengduChina West China School/Hospital of Stomatology Sichuan UniversityChengduChina Department of Information Management Department of Stomatology InformaticsWest China Hospital of StomatologySichuan UniversityChengduChina

Tongue squamous cell carcinoma is highly malignant and has a poor *** this study,we aimed to combine whole-genome sequencing,whole-genome methylation,and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma *** tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired *** multi-omics sequencing,differentially methylated intervals,methylated loop sites,methylated promoters,and transcripts were screened for variation in all paired *** were analyzed to determine biological processes in tongue squamous cell *** found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression *** annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade,which is associated with cancer progression and the development of drug resistance during *** prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype-gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical *** identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and ***,changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients.

关键词： squamous involvement signature

牙龈卟啉单胞菌促进阿尔茨海默病的机制研究进展

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口腔疾病防治 2024年第10期32卷 797-804页

作者：王玉洁彭显廖玍周学东口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙体牙髓病科四川成都610041 口腔疾病防治全国重点实验室国家口腔疾病临床医学研究中心、四川大学华西口腔医院四川成都610041

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病之一。牙龈卟啉单胞菌(Porphyromonas gingivalis,***)感染与AD密切相关。本文综述了***及其毒力因子在AD发生发展过程中的多重作用及其机制,旨在深入阐明两者之间的内... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病之一。牙龈卟啉单胞菌(Porphyromonas gingivalis,***)感染与AD密切相关。本文综述了***及其毒力因子在AD发生发展过程中的多重作用及其机制,旨在深入阐明两者之间的内在联系。***可通过多种途径与AD发生发展相关联。首先,***可以增加神经炎症、促进淀粉样蛋白和Tau蛋白沉积、破坏血脑屏障等途径参与AD病理进程。其次,***分泌的牙龈蛋白酶能增加血脑屏障通透性并进入脑内诱导病理损伤是其促进AD的重要机制。临床样本检测也支持***或其效应分子促进AD病理进展。因此,***可能是AD的一个环境易感因素或可调控的风险因素。目前***在AD中的确切作用机制和***与其他可能影响AD的因素之间的关联研究不明确。本文深入分析***促进AD的分子机制,为研制***相关的AD新型防治策略提供参考。

关键词：牙龈卟啉单胞菌阿尔茨海默病牙龈蛋白酶血脑屏障牙周炎神经退行性疾病淀粉样β蛋白

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The Oral Microbiome Bank of China

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International Journal of Oral Science 2018年第2期10卷 72-80页

作者： Xian Peng Xuedong Zhou Xin Xu Yuqing Li Yan Li Jiyao Li Xiaoquan Su Shi Huang Jian Xu ga liao IState Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of Cariology and EndodonticsWest China Hospital of StomatologySichuan UniversityChengduChina Single-Cell Center CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy GeneticsQingdao Institute of BioEnergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoShandongChina

The human microbiome project（HMP） promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database（HOMD） was established in the US. The HOMD includes 619 taxa in 13 phyla, and most of the microorganisms are from American populations. Due to individual differences in the microbiome, the HOMD does not reflect the Chinese oral microbial status. Herein, we established a new oral microbiome database—the Oral Microbiome Bank of China（OMBC,http：//***/ombc）. Currently, the OMBC includes information on 289 bacterial strains and 720 clinical samples from the Chinese population, along with lab and clinical information. The OMBC is the first curated description of a Chinese-associated microbiome; it provides tools for use in investigating the role of the oral microbiome in health and diseases, and will give the community abundant data and strain information for future oral microbial studies.

关键词： The Oral Microbiome

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人工智能+口腔正畸远程诊疗系统创新与实践

中国数字医学 2024年第9期19卷 14-20页

作者：廖健谢磊李峥峥周逸梅全淑琪任建鹏陈若石赵志河廖玍李娟四川大学华西口腔医院成都610041 成都玻尔兹曼智贝科技有限公司

为提高口腔正畸诊疗的效率和质量,针对当前口腔正畸治疗工作中存在的专业水平不足、医疗资源分配不均以及治疗时效性不强等问题,采用人工智能、大数据、云计算等先进技术,创新性地开发了口腔正畸远程诊疗系统,设计了其架构和主要功能模... 详细信息

为提高口腔正畸诊疗的效率和质量,针对当前口腔正畸治疗工作中存在的专业水平不足、医疗资源分配不均以及治疗时效性不强等问题,采用人工智能、大数据、云计算等先进技术,创新性地开发了口腔正畸远程诊疗系统,设计了其架构和主要功能模块,以提供智能诊断分析、治疗方案建议和远程诊疗服务。选取某基层医疗机构,将人工智能+口腔正畸远程诊疗系统付诸实践,并对其效果进行了评估。应用结果显示,该机构在应用此系统后,诊疗方案的准确性与患者满意度方面显著提升,同时医务人员的工作难度也明显降低,充分验证了系统设计的实用性和重要价值。

关键词：人工智能口腔正畸远程诊疗诊疗系统

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Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus

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International Journal of Oral Science 2014年第1期6卷 22-26页

作者： Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng ga liao Hong-Xia Dan Qian-Ming Chen College of Stomatology Chongqing Medical University Chongqing Research Center for Oral Diseases and Biomedical Science State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Our previous salivary study had demonstrated an apparent T helper 2 （Th2）-predominance in saliva of oral lichen planus （OLP） patients and suggested a potential of salivary interleukin-4 （IL-4） as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-γ （IFN-γ） and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP （40 of the erythematous/ulcerative form and 20 of the reticular form） were recruited for this study, with 40 age-sex-matched healthy volunteers as control group. IFN-γ and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-γ/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-γ and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine- predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP.

关键词： oral lichen planus saliva serum T helper cytokines

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口腔医学领域人工智能研究前沿和热点分析

中国循证医学杂志 2022年第6期22卷 684-691页

作者：唐莉徐欣廖玍口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院成都610041 四川大学华西口腔医院牙体牙髓病科成都610041 四川大学华西生物医学大数据中心成都610041

目的对口腔医学领域人工智能研究的前沿和热点进行分析。方法计算机检索Web of Science数据库核心合集,收集相关研究文献,检索时限为建库至2021年。利用CiteSpace软件进行文献计量学分析。结果口腔医学领域人工智能的研究总体呈上升... 详细信息

目的对口腔医学领域人工智能研究的前沿和热点进行分析。方法计算机检索Web of Science数据库核心合集,收集相关研究文献,检索时限为建库至2021年。利用CiteSpace软件进行文献计量学分析。结果口腔医学领域人工智能的研究总体呈上升趋势,相关研究产出最多的国家是美国。除口腔综合性期刊以外,主要发文期刊为口腔颌面外科学、口腔正畸学和口腔影像学专科期刊。过去10年内,口腔医学领域人工智能研究的主要方向是深度学习和机器人手术;研究的主要数据是口腔影像学资料;口腔头颈部肿瘤尤其是口腔癌是口腔医学领域人工智能研究的热点前沿,人工智能算法模型在辅助口腔疾病诊断和治疗方案决策方面具有潜在医疗价值和经济价值,经口机器人手术在口腔头颈部肿瘤治疗中表现优秀。结论近10年来,口腔医学领域人工智能研究激增,数字化、智能化是口腔医学研究的热点和前沿。

关键词：人工智能口腔医学机器人手术可视化分析文献计量学

Honokiol:a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells

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International Journal of Oral Science 2011年第1期3卷 34-42页

作者： Xi-rui Chen Rui Lu Hong-xia Dan ga liao Min Zhou Xiao-yu Li Ning Ji Pharmacology and Toxicology Program Faculty of Art and Science University of Toronto Ontario Canada State Key Laboratory of Oral Diseases West China School of Stomatology Sichuan University Chengdu 610041 China

Honokiol （HNK） is a small organic molecule purified from magnolia species and has demonstrated anticancer activities in a variety of cancer cell lines; however, its effect on oral squamous cell carcinoma （OSCC） cells is unknown. We investigated the antitumor activities of HNK on OSCC ceils in vitro for the first time. The inhibitory effects of HNK on the growth and proliferation of OSCC cells were demonstrated via in vitro 3-（4,5-dimethyl thiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） and propidium iodide （PI） assays, and the apoptotic cells were investigated by the observation of morphological changes and detection of DNA fragmentation via PI, TdT-mediated dUTP-biotin nick end labeling （TUNEL）, and DNA ladder assays, as well as flow cytometry assay. The results showed that HNK inhibited the growth and proliferation of OSCC cells in vitro in a time and dose-dependent manner. The inhibitory effect was associated with the cell apoptosis induced by HNK, evidenced by the morphological features of apoptotic cells, TUNEL-positive cells and a degradation of chromosomal DNA into small internucleosomal fragments. The study also demonstrated here that the inhibition or apoptosis mediated by 15 μ***-1 or 20 μ***-1 of HNK were more stronger compared with those of 20 μg-mL-1 5-fluorouracil （5-Fu, the control） applied to OSCC cells, when the ratio of OSCC cell numbers were measured between the treatment of different concentrations of HNK to the 5-Fu treatment for 48 h. HNK is a promising compound that can be potentially used as a novel treatment agent for human OSCC.

关键词： honokiol oral squamous cell carcinoma anticancer apoptosis

Is hemostatic agent effective and safe in minimally invasive partial nephrectomy?

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Chinese Medical Journal 2022年第17期135卷 2116-2118页

作者： Qiong Guo Yifei Lin Chenyang Zhang Fangqun Leng Youlin Long Yifan Cheng Liu Yang Liang Du Jin Huang ga liao Medical Device Regulatory Research and Evaluation Center West China HospitalSichuan UniversityChengduSichuan 610041China Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengduSichuan 610041China Precision Medicine Center West China HospitalSichuan UniversityChengduSichuan 610041China Department of Urology West China HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China West China School of Public Health Sichuan UniversityChengduSichuan 610041China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Medical Big Data Center Sichuan UniversityChengduSichuan 610041China Department of Information Management West China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Department of Stomatology Informatics West China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

To the Editor:Renal cell carcinoma(RCC)is one of the top *** cancers in *** nephrectomy(PN)is the standard treatment forsmall RCc.i2In recent decades,minimally invasive PN,including robotic-assisted partial nephrectomy(RAPN)and laparoscopic partial nephrectomy(LPN),has been considered as a viable alternative for open PN due to its less invasive approach.

关键词： invasive nephrectomy viable

Hybrid vibration isolation optimization of a flexible manipulator based on neural network agent model

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Chinese Journal of Aeronautics 2024年第5期37卷 482-505页

作者： Yongxin ZHANG Liang LI Dingguo ZHANG Wei-Hsin liao Xian GUO School of Science Nanjing University of Science and TechnologyNanjing 210094China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

Segmented Active Constrained Layer Damping(SACLD)is an intelligent vibration-damping structure,which could be applied to the sectors of aviation,aerospace,and transportation engineering to reduce the vibration of flexible ***,machine learning technology is widely used in the engineering field because of its efficient multi-objective *** dynamic simulation of a rotational segmental flexible manipulator system is presented,in which enhanced active constrained layer damping is carried out,and the neural network model of Genetic Algorithm-Back Propagation(ga-BP)algorithm is *** suppression and structural optimization of the SACLD manipulator model are studied based on vibration mode and damping *** modal responses of the SACLD manipulator model at rest and rotation are *** addition,the four model indices are optimized using the ga-BP neural network:axial incision size,axial incision position,circumferential incision size,and circumferential incision ***,the best model for vibration suppression is obtained.

关键词： Machine learning Vibration suppression Flexible manipulator Segmented active constrained layer damping Structural optimization