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Capacitive actuation and switching of add–drop graphene-silicon micro-ring filters

Photonics Research 2017年第6期5卷 274-278页

作者： TOMMASO CASSESE MARCO ANGELO GIAMBRA VITO SORIANELLO gabriele de angelis MICHELE MIDRIO MARIANNA PANTOUVAKI JORIS VAN CAMPENHOUT INGE ASSELBERGHS CEDRIC HUYGHEBAERT ANTONIO D'ERRICO MARCO ROMAGNOLI Scuola Superiore Sant'Anna-Te CIP Institute CNIT-Consorzio Nazionale Interuniversitario per le Telecomunicazioni CNIT-Consorzio Nazionale Interuniversitario per le Telecomunicazioni Università degli Studi di Udine Imec Ericsson Research

We propose and experimentally demonstrate capacitive actuation of a graphene–silicon micro-ring add/drop filter. The mechanism is based on a silicon–SiO_2–graphene capacitor on top of the ring waveguide. We show the capacitive actuation of the add/drop functionality by a voltage-driven change of the graphene optical absorption. The proposed capacitive solution overcomes the need for continuous heating to keep tuned the filter's in/out resonance and therefore eliminates "in operation" energy consumption.

关键词： MRR drop graphene-silicon micro-ring filters Capacitive actuation and switching of add

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Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy

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World Journal of Gastroenterology 2008年第29期14卷 4643-4651页

作者： Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de angelis Giuseppe Corritore Fabrizio Bossa Vito Annese U.U. O.O. di Gastroenterologia ed Endoscopia Ospedale IRCCS-CSSSan Giovanni Rotondo (Fg) 71013 Italy Cattedra di Gastroenterologia Università di PadovaPadova 35122 Italy Clinica Pediatrica Università "La Sapienza" Roma 00185 Italy Cattedra di Gastroenterologia Università di NapoliNapoli 80131 Italy Clinica Pediatrica Università di Napoli Napoli 80131 Italy Unità di Gastroenterologia Ospedale "Sacco" Milano 20157 Italy Clinica Pediatrica Università di Palermo Palermo 90128 Italy Clinica Pediatrica Università di Parma Parma 43100 Italy

AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age ded in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population.

关键词： Inflammatory bowel disease Crohn'sdisease Ulcerative colitis Genetic predisposition Autophagy-related 16-like 1 Interleukin 23 receptor Genome-wide association study Pediatric inflammatorybowel disease

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Hot electrons in water: injection and ponderomotive acceleration by means of plasmonic nanoelectrodes

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Light(Science & Applications) 2017年第1期6卷 744-751页

作者： Pierfrancesco Zilio Michele Dipalo Francesco Tantussi gabriele C Messina Francesco de angelis Istituto Italiano di Tecnologia 16163GenovaItaly

We present a theoretical and experimental study of a plasmonic nanoelectrode architecture that is able to inject bunches of hot electrons into an aqueous *** this approach,electrons are accelerated in water by ponderomotive forces up to energies capable of exciting or ionizing water *** ability is enabled by the nanoelectrode structure(extruding out of a metal baseplate),which allows for the production of an intense plasmonic hot spot at the apex of the structure while maintaining the electrical connection to a virtually unlimited charge *** electron injection is experimentally monitored by recording the current transmitted through the water medium,whereas the electron acceleration is confirmed by observation of the bubble generation for a laser power exceeding a proper *** understanding of the complex physics involved is obtained via a numerical approach that explicitly models the electromagnetic hot spot generation,electron-by-electron injection via multiphoton absorption,acceleration by ponderomotive forces and electron-water interaction through random elastic and inelastic *** model predicts a critical electron density for bubble nucleation that nicely matches the experimental findings and reveals that the efficiency of energy transfer from the plasmonic hot spot to the free electron cloud is much more efficient(17 times higher)in water than in a *** of their high kinetic energy and large reduction potential,these proposed wet hot electrons may provide new opportunities in photocatalysis,electrochemical processes and hot-electron driven chemistry.

关键词： hot electrons hydrated electrons lightwave electronics plasmonics ponderomotive acceleration strong-field photoemission water breakdown

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Needle-based confocal endomicroscopy in the discrimination of mucinous from non-mucinous pancreatic cystic lesions

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World Journal of Gastrointestinal Endoscopy 2021年第11期13卷 555-564页

作者： Helga Bertani Raffaele Pezzilli Flavia Pigo Mauro Bruno Claudio de angelis Guido Manfredi gabriele delconte Rita Conigliaro Elisabetta Buscarini Gastroenterology and Digestive Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41124Italy department of Internal Medicine Policlinico S.Orsola MalpighiBologna 40121Italy Gastroenterology and Digestive Endoscopy Unit AOU Cittàdella Salute e della ScienzaUniversity of TurinTurin 10100Italy Gastroenterology and Digestive Endoscopy department Ospedale MaggioreCrema 26013Italy department of Diagnostic Endoscopy and Endoscopic Surgery Istituto Nazionale TumoriMilano 20019Italy

BACKGROUND Pancreatic cystic lesions(PCLs)are considered a precursor of pancreatic ***-based confocal endomicroscopy(nCLE)is an imaging technique that enables visualization of the mucosal layer to a micron *** application has demonstrated promising results in the distinction of *** study evaluated the utility of nCLE in patients with indeterminate PCLs undergoing endoscopic ultrasound fine-needle aspiration(EUS-FNA)to distinguish mucinous from non-mucinous *** To evaluate the accuracy of nCLE in indeterminate PCLs undergoing EUS-FNA to distinguish mucinous from non-mucinous *** Patients who required EUS-FNA between 2015 and 2017 were enrolled *** EUS-FNA,confocal imaging,analyses of the tumor markers carcinoembryonic antigen and amylase,and cytologic examination were *** patients were followed for at least 12 mo and underwent laboratory testing and computed tomography scanning or magnetic resonance *** videos were independently reviewed by 6 observers to reach a final diagnosis(mucinous vs non-mucinous)based on criteria derived from previous studies;if there was disagreement>20%,a final diagnosis was discussed after consensus *** sensitivity,specificity,and accuracy of nCLE were *** events were *** Fifty-nine patients were included in this *** diagnoses were derived from surgery in 10 patients,cytology in 13,and imaging and multidisciplinary team review in *** patients were excluded from final diagnosis due to problems with nCLE ***-six patients were included in the final *** sensitivity,specificity,and accuracy of nCLE were 80%[95%confidence interval(CI):65-90],100%(95%CI:72-100),and 84%(95%CI:72-93),*** acute pancreatitis occurred in 5%.CONCLUSION EUS-nCLE performs better than standard EUS-FNA for the diagnosis of indeterminate PCL.

关键词： Needle-based confocal endomicroscopy Pancreatic cystic lesion Pancreatic adenocarcinoma Endoscopic ultrasound Endoscopic ultrasound fine-needle aspiration Intraductal papillary mucinous neoplasm Serous cyst adenoma

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