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Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles

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Bioactive Materials 2022年第1期7卷 74-84页

作者： Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.webster Behrooz Johari Hossein Danafar Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems DrohobychUkraineBakuAzerbaijan Department of Radiology School of Paramedical SciencesZanjan University of Medical SciencesZanjan45139-56184Iran Hacettepe University Department of ChemistryBeytepeAnkara06800Turkey Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjan45139-56184Iran Department of Pharmaceutical Nanotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Department of Surface Engineering The John Paul II Catholic University of Lublin20-950LublinPoland Drohobych Ivan Franko State Pedagogical University 82100DrohobychUkraine Department of Chemical Engineering Northeastern University360 Huntington AvenueBostonMA02115United States

Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer *** such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized ***,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray ***(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release *** designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal ***,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications.

关键词： Combination therapy Radiosensitizer Semiconductor Heterojunction Radioprotector

Therapeutic resistance in cancer: microRNA regulation of EgFR signaling networks

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Cancer Biology & Medicine 2013年第4期10卷 192-205页

作者： german g.gomez Jill Wykosky Ciro Zanca Frank B.Furnari webster K.Cavenee Ludwig Institute for Cancer Research University of California San Diego

Receptor tyrosine kinases(RTKs)such as the epidermal growth factor receptor(EgFR)regulate cellular homeostatic *** activates downstream signaling cascades that promote tumor cell survival,proliferation and *** of EgFR signaling as a consequence of overexpression,amplification and mutation of the EgFR gene occurs frequently in several types of cancers and many become dependent on EgFR signaling to maintain their malignant ***,concerted efforts have been mounted to develop therapeutic agents and strategies to effectively inhibit ***,limited therapeutic benefits to cancer patients have been derived from EgFR-targeted therapies.A well-documented obstacle to improved patient survival is the presence of EgFR-inhibitor resistant tumor cell variants within heterogeneous tumor cell ***,we summarize the mechanisms by which tumors resist EgFR-targeted therapies and highlight the emerging role of microRNAs(miRs)as downstream effector molecules utilized by EgFR to promote tumor initiation,progression and that play a role in resistance to EgFR *** also examine evidence supporting the utility of miRs as predictors of response to targeted therapies and novel therapeutic agents to circumvent EgFR-inhibitor resistance mechanisms.

关键词：表皮生长因子受体 microRNA 治疗药物癌症患者信号网络抗药性受体抑制剂受体酪氨酸激酶

Applications of active acoustics in particle technology

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Particuology 2010年第6期8卷 568-571页

作者： Clive E.Davies Stephen J.Tallon Emile S.webster Massey University Palmerston NorthNew Zealand Industrial Research Limited Lower HuttNew Zealand

Earlier work by the authors in which active sound pressure signals and impulsive pressure disturbances were used to measure flow rates in gas solid systems was briefly reviewed. Work in progress with an emerging techn... 详细信息

关键词： Flowrate measurement granular solids Helmholtz resonance Pneumatic conveying Volume measurement

THE CONTROL OF POLYMETHACRYLATE MOLECULAR STRUCTURE BY gROUP TRANSFER POLYMERIZATION

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Chinese Journal of Polymer Science 1990年第1期8卷 1-9页

作者： OWEN W. webster Central Research and Development Department E. I. Du Pont and CompanyP.O.Box 80328WilmingtonDelaware 19880-0328 USA

INTRODUCTION group transfer polymerization (gTP) is a method for controlling the structure of acrylic polymers in which reactive chain ends are covalentiy bound to a trimethylsilyl group. In the presence of a catalyst, monomer inserts into these chain ends between the silyl group and the last monomer unit. The process is illustrated by equation (1) for methyl methacrylate. gTP is a living polymerization, i. e., there is little or no chain termination and no chain transfer. A significant advantage of gTP is that it

关键词： PMMA EA gTP rate PBMA THE CONTROL OF POLYMETHACRYLATE MOLECULAR STRUCTURE BY gROUP TRANSFER POLYMERIZATION

gondwana Terrane Assembly in Northern Mozambique:A Snapshot of Crustal Processes in the Monapo Klippe

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地学前缘 2009年第S1期16卷 210-211页

作者： Meagan webster Jodie Miller Christie Rowe Department of geology Stellenbosch Universityc/o Merriman & Ryneveld Str. Department of geological Sciences University of Cape Town13 University Avenue

The Nampula Subprovince in Northern Mozambique is a Mesoproterozoic gneiss terrane with a Pan-African(523-550 Ma)amphibolite-facies met- amorphic *** province forms a pivotal part of the evolution and final assembly o... 详细信息

关键词： Monapo Complex Mozambique gondwana

Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations

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Chinese Journal of Cancer 2011年第1期30卷 5-12页

作者： Jill Wykosky Tim Fenton Frank Furnari webster K. Cavenee Ludwig Institute for Cancer Research University of California San Diego Department of Medicine University of California San Diego

Epidermal growth fac tor receptor (EgFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EgFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EgFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EgFR in human cancer. The genetic alterations of EgFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EgFR.

关键词：表皮生长因子受体靶向治疗癌症人类酪氨酸激酶抑制剂信号转导通路恶性肿瘤临床治疗

Proteomic composition of the acrostyle＂ Novel approaches to identify cuticular proteins involved in virus-insect interactions

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Insect Science 2017年第6期24卷 990-1002页

作者： Craig graham webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest INRA UMR 0385 BGPI CIRAD-INRA-Montpellier SupAgro Campus International de Baillarguet Montpellier Cedex France

The acrostyle is a distinct anatomical region present on the cuticle at the inner face of the common food/salivary canal at the tip of aphid maxillary stylets. This conserved structure is of particular interest as it harbors the protein receptors of at least l plant virus, Cauliflower mosaic virus＇, and presumably has other roles in plant-insect interactions. Previously we reported immunolabeling of a highly conserved motif of cuticular proteins from the CPR family （named for the presence of a Rebers and Riddiford consensus） within the acrostyle. Here we report the development of novel tools to further study the proteomic composition of this region and to identify proteins involved in insect- virus interactions. Using a series of antibodies against cuticular proteins from the RR-2 subfamily, we identified additional peptides present within the acrostyle. Our results demonstrated that the acrostyle is a complex structure containing multiple domains of cuticular proteins accessible for interaction. In addition, an array of overlapping peptides,which covers the diversity of the majority of the RR-2 subfamily, was ~tevelopect as a generic tool to characterize cuticular protein/pathogen interactions. Upon probing this array with Cucumber mosaic virus particles, consensus peptide sequences from hybridizing peptides were identified. Use of these novel tools has extended our knowledge of the proteomic composition of insect maxillary stylets and identified sequences that could be involved in virus binding, thus contributing to further elucidation of the various properties and functions of the acrostyle.

关键词： acrostyle aphid cuticular protein immunolabeling peptide array stylet

Merriam-webster's Collegiate Dictionary, 11th Edition 11th ed.

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Cancer screening and management in the transgender population:Review of literature and special considerations for gender affirmation surgery

2003年

作者： Inc. Merriam-webster

ISBN: (数字)0877798095

ISBN: (纸本)9780877798095

Merriam webster is proud to announce the arrival of its most famous dictionary, now completely revised and updated. The features of the dictionary now include: 225,000 clear and precise definitions More than 40,000 word-use examples More than 7500 phrases and idions The Merriam webster Collegiate is a great learning too: It features a comprehensive coverage of all fields of knowledge 165,000 entries with correct spellings and pronunciations More than 700 illustrations, tables and diagrams for at-a-glance information The CD edition comes complete with the book and a free one year subscription to *** new Eleventh Edition of America's best-selling dictionary merges print, CD-ROM, and Internet-based formats to deliver unprecedented accessibility and flexibility at one affordable price. Fully revised print content features more than 225,000 clear and precise definitions and more than 10,000 words and meanings. Includes easily installable CD-ROM and free one-year subscription to new Collegiate Web *** first Merriam-webster's Collegiate Dictionary (M-W) was published in 1898, and the tenth edition had a copyright date of 1993. The eleventh edition brings many new words, a CD-ROM, and a free one-year subscription to Merriam-webster ***, which includes the text of the dictionary as well as the Collegiate Thesaurus, Collegiate Encyclopedia, and Merriam-webster's Spanish-English *** for the numbers. M-W has a paper file of 15,700,000 citations from which their lexicographers chose 10,000 new words, for a total of 165,000 entries and 225,000 definitions. There are 100,000 "changes" from the tenth edition. Users asked for more usage examples and idioms and phrases, so there are now 40,000 examples and a "significant" increase in idioms. There are 91,000 pronunciations, 33,000 etymologies, 2,700 illustrative quotations, 650 foreign words and phrases, and 700 *** the world rushes on, so does the time taken for w

关键词： English language

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World Journal of Clinical Oncology 2023年第7期14卷 265-284页

作者： Juliet C Panichella Sthefano Araya Siddhartha Nannapaneni Samuel g Robinson Susan You Sarah M gubara Maria T gebreyesus Theresa webster Sameer A Patel Alireza Hamidian Jahromi Lewis Katz School of Medicine Temple UniversityPhiladelphiaPA 19140United States Division of Plastic and Reconstructive Surgery Fox Chase Cancer CenterPhiladelphiaPA 19111United States Department of Plastic Surgery Temple UniversityPhiladelphiaPA 18045United States Division of Plastic and Reconstructive Surgery Temple University HospitalsPhiladelphiaPA 19140United States

BACKgROUND Literature focused on cancer screening and management is lacking in the transgender *** To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming(TgNC)*** We performed a systematic search of PubMed on January 5th,2022,with the following terms:“TgNC”,OR“transgender”,OR“gender non-conforming”,OR“gender nonbinary”AND“cancer screening”,AND“breast cancer”,AND“cervical cancer”,AND“uterine cancer”,AND“ovarian cancer”,AND“prostate cancer”,AND“testicular cancer”,AND“surveillance”,AND“follow-up”,AND“management”.70 unique publications were *** findings are discussed under“Screening”and“Management”*** Screening:Current cancer screening recommendations default to cis-gender ***,long-term genderaffirming hormone therapy and loss to follow-up from the gender-specific specialties contribute to a higher risk for cancer development and possible delayed *** only known screening guidelines made specifically for this population are from the American College of Radiology for breast ***:Prior to undergoing gender Affirmation Surgery(gAS),discussion should address cancer screening and management in the organs remaining in *** treatment in this population requires consideration for chemotherapy,radiation,surgery and/or *** of hormone therapy is decided on a case-by-case *** use of prophylactic vs aesthetic techniques in surgery is still *** When assessing transgender individuals for gAS,a discussion on the future oncologic risk of the sex-specific organs remaining in situ is *** management in this population requires a multidisciplinary approach while the care should be highly individualized with considerations to social,medical,surgical and gender affirming surgery related *** considerations have to

关键词： gender affirmation surgery gender affirming surgery Screening Management Transgender gender diverse