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glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion

World Journal of gastroenterology 2014年第32期20卷 11406-11414页

作者： gilmara Pandolfo Zabot g.stavo franco carvalhal Norma Possa Marroni Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann Department of Surgery School of Medicine Pontifical Catholic University of Rio Grande do Sul Porto Alegre RS 90610-000 Brazil Department of gastroenterology School of Medicine Federal University of Rio Grande do Sul Porto Alegre RS 90035-903 Brazil Department of Pathology School of Medicine Pontifical Catholic University of Rio Grande do SulPorto Alegre RS 90610-000 Brazil

AIM: To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion (I/R).

关键词： Ischemia-reperfusion glutamine Lipid peroxidation Superoxide dismutase Nuclear factor-kappa beta Interleukin 6

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glutamine prevents oxidative stress in a model of portal hypertension

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World Journal of gastroenterology 2017年第25期23卷 4529-4537页

作者： gilmara Pandolfo Zabot g.stavo franco carvalhal Norma Possa Marroni Francielli Licks Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann Department of Surgery School of MedicinePontifical Catholic University of Rio Grande do Sul Department of gastroenterology School of MedicineFederal University of Rio Grande do Sul Department of Pathology School of MedicinePontifical Catholic University of Rio Grande do Sul

To evaluate the protective effects of glutamine in a model of portal hypertension (PH) induced by partial portal vein ligation (PPVL). METHODSMale Wistar rats were housed in a controlled environment and were allowed access to food and water ad libitum. Twenty-four male Wistar rats were divided into four experimental groups: (1) control group (SO) - rats underwent exploratory laparotomy; (2) control + glutamine group (SO + g) - rats were subjected to laparotomy and were treated intraperitoneally with glutamine; (3) portal hypertension group (PPVL) - rats were subjected to PPVL; and (4) PPVL + glutamine group (PPVL + g) - rats were treated intraperitoneally with glutamine for seven days. Local injuries were determined by evaluating intestinal segments for oxidative stress using lipid peroxidation and the activities of glutathione peroxidase (gPx), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) after PPVL. RESULTSLipid peroxidation of the membrane was increased in the animals subjected to PH (P group that received glutamine for seven days after the PPVL procedure showed levels of lipid peroxidation similar to those of the control groups (P > 0.05). The activity of the antioxidant enzyme gTx was decreased in the gut of animals subjected to PH compared with that in the control group of animals not subjected to PH (P group that received glutamine for seven days after the PPVL showed similar gTx activity to both the control groups not subjected to PH (P > 0.05). At least 10 random, non-overlapping images of each histological slide with 200 × magnification (44 pixel = 1 μm) were captured. The sum means of all areas, of each group were calculated. The mean areas of eNOS staining for both of the control groups were similar. The PPVL group showed the largest area of staining for eNOS. The PPVL + g group had the second highest amount of staining, but the mean value was much lower than that of the P

关键词： Portal hypertension Endothelial nitric oxide synthase glutamine glutathione peroxidase Inducible nitric oxide synthase Lipid peroxidation

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