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Algorithm fusion to improve detection of lung cancer on chest radiographs

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International Journal of Intelligent Computing and Cybernetics 2012年第1期5卷 111-144页

作者： g.rg.ly Orbán gábor horváth Department of Measurement and Information Systems Budapest University of Technology and EconomicsBudapestHungary Intelligent Systems Research group Budapest University of Technology and EconomicsBudapestHungary

Purpose-the purpose of this paper is to show an efficient method for the detection of signs of early lung *** image processing algorithms are presented for different types of lesions,and a scheme is proposed for the combination of ***/methodology/approach-A computer aided detection(CAD)scheme was developed for detection of lung *** enables different lesion enhancer algorithms,sensitive to specific lesion subtypes,to be used *** image processing algorithms are presented for the detection of small nodules,large ones,and infiltrated *** outputs are merged,the false detection rate is reduced with four separated support vector machine(SVM)*** classifier input comes from a feature selection algorithm selecting from various textural and geometric features.A total of 761 images were used for testing,including the database of the Japanese Society of Radiological Technology(JSRT).Findings-the fusion of algorithms reduced false positives on average by 0.6 per image,while the sensitivity remained 80 per *** the JSRT database the system managed to find 60.2 per cent of lesions at an average of 2.0 false positives per *** effect of using different result evaluation criteria was tested and a difference as high as 4 percentage points in sensitivity was *** system was compared to other published ***/value-the study described in the paper proves the usefulness of lesion enhancement decomposition,while proposing a scheme for the fusion of ***,a new algorithm is introduced for the detection of infiltrated areas,possible signs of lung cancer,neglected by previous solutions.

关键词： Programming and algorithm theory Image processing Cancer Radiography Medical diagnosis Lung nodule Infiltrated area Chest radiograph Lung cancer Early detection

Omicron:increased transmissibility and decreased pathogenicity

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Signal Transduction and Targeted therapy 2022年第6期7卷 1865-1867页

作者： gábor Bálint Barbara Vörös-horváth Aleksandar Széchenyi Institute of Pharmaceutical Technology and Biopharmacy University of PécsFaculty of Pharmacy7624 PécsRókus u.2PécsHungary

three research papers were published recently to compare the virological properties of the Omicron variant with the earlier variants of concern(VOC).1,2,3 the SARS-CoV-2 B.1.1.529 variant,Omicron,was first detected in South Africa in October 2021 and has spread rapidly;within three months,it appeared in more than 87 countries.4 During the surveillance of the epidemiological data and mutations of earlier COVID-19 variants and Omicron,significant differences were revealed mainly in the reproduction rate and hospitalization.

关键词： Omi earlier reproduction

CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells

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World Journal of gastroenterology 2013年第17期19卷 2621-2628页

作者： János P Kósa Péter horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin horváth gábor Speer István Takács Zsolt Nagy Henrik horváth Péter Lakatos 1 st Department of Internal Medicine Semmelweis University Department of Organic Chemistry University of Szeged Department of Organic Chemistry Semmelweis University

AIM:the effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. the aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. MEthODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:these findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC.

关键词： Colorectal cancer CYP24A1 inhibition Vitamin D3 Tetralone derivatives Caco-2 cell culture

Iterative signal reconstruction of deliberately clipped SMT signals

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Science China(Information Sciences) 2014年第2期57卷 5-17页

作者： KOLLR Zsolt gAZDA Juraj horvth Pter VArgA Lajos KOCUR Duan Budapest University of Technology and Economics Technical University of Koice

Staggered MultiTone(SMT)is a modulation technique showing significantly reduced Adjacent Channel Leakage Ratio(ACLR)resulting in a more compact Power Spectrum Density(PSD)for the transmitted signal,than the well-known and already widely adopted Orthogonal Frequency Division Multiple Access(OFDMA)***,the unique spectral properties of an SMT signal could be degraded by a non-linear element(e.g.a Power Amplifier(PA))in the *** baseband clipping can be applied to the transmitted signal,reducing the notable high Peak-to-Average Power Ratio(PAPR).the objective of this paper is to give a brief introduction to the SMT scheme,with a special emphasis on deliberate clipping efects and their *** paper introduces two receiver-oriented iterative methods aiming at the restoration of the baseband Bit Error Rate(BER)performance of a non-clipped *** methods are evaluated and compared based on numerical *** paper concludes with the selection of a possible candidate for use in systems applying deliberately clipped SMT signals.

关键词： clipping SMT iterative decoding nonlinear distortion PAPR

Biological treatment of chicken feather waste for improved biogas production

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Journal of Environmental Sciences 2011年第10期23卷 1747-1753页

作者： g.rg.ly Forgcs Saeid Alinezhad Amir Mirabdollah Elisabeth Feuk-Lagerstedt Ilona Srvri horvth School of Engineering University of Bors501 90 BorsSweden Department of Chemical and Biological Engineering Chalmers University of Technology412 96 GteborgSweden School of Engineering University of Boras501 90 BorsSweden

A two-stage system was developed which combines the biological degradation of keratin-rich waste with the production of biogas. Chicken feather waste was treated biologically with a recombinant Bacillus megaterium strain showing keratinase activity prior to biogas production. Chopped, autoclaved chicken feathers （4%, W/V） were completely degraded, resulting in a yellowish fermentation broth with a level of 0.51 mg/mL soluble proteins after 8 days of cultivation of the recombinant strain. During the subsequent anaerobic batch digestion experiments, methane production of 0.35 Nm3/kg dry feathers （i.e., 0.4 Nm3/kg volatile solids of feathers）, corresponding to 80% of the theoretical value on proteins, was achieved from the feather hydrolyzates, independently of the pre- hydrolysis time period of 1, 2 or 8 days. Cultivation with a native keratinase producing strain, Bacillus licheniformis resulted in only 0.25 mg/mL soluble proteins in the feather hydrolyzate, which then was digested achieving a maximum accumulated methane production of 0.31 Nm3/kg dry feathers. Feather hydrolyzates treated with the wild type B. megaterium produced 0.21 Nm3 CH4/kg dry feathers as maximum yield.

关键词： anaerobic digestion feather waste keratinase, Bacillus licheniformis Bacillus megaterium gene expression

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

the measurement of proprioceptive accuracy:A systematic literature review

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Journal of Sport and Health Science 2023年第2期12卷 219-225页

作者： Àron horváth Eszter Ferentzi Kristóf Schwartz Nina Jacobs Pieter Meyns Ferenc Köteles Doctoral School of Psychology ELTE Eötvös Loránd UniversityKazinczy street 23-27Budapest 1075Hungary Institute of Health Promotion and Sport Sciences ELTE Eötvös Loránd UniversityPrielle Kornélia Street 47-49Budapest 1117Hungary Rehabilitation Research(REVAL) Faculty of Rehabilitation SciencesUniversity of HasseltMartelarenlaan 42Hasselt 3500Belgium

Background:Proprioceptive accuracy refers to the individual’s ability to perceive proprioceptive information,that is,the information referring to the actual state of the locomotor system,which originates from mechanoreceptors located in various parts of the locomotor system and from tactile receptors located in the *** accuracy appears to be an important aspect in the evaluation of sensorimotor functioning;however,no widely accepted standard assessment *** this systematic review,our goal was to identify and categorize different methods that are used to assess different aspects of proprioceptive ***:A literature search was conducted in 5 different databases(PubMed,SPORTDiscus,PsycINFO,ScienceDirect,and SpringerLink).Results:Overall,1139 scientific papers reporting 1346 methods were included in this *** methods assess 8 different aspects of proprioception:(a)the perception of joint position,(b)movement and movement extent,(c)trajectory,(d)velocity,and the sense of(e)force,(f)muscle tension,(g)weight,and(h)*** apply various paradigms of psychophysics(i.e.,the method of adjustment,constant stimuli,and limits).Conclusion:As the outcomes of different tasks with respect to various body parts show no associations(i.e.,proprioceptive accuracy is characterized by site-specificity and method-specificity),the appropriate measurement method for the task needs to be chosen based on theoretical considerations and/or ecological validity.

关键词： Assessment Kinesthesia Motor control Proprioception Proprioceptive accuracy

Determination of relationships between thermal conductivity and material properties of rocks

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Journal of University of Science and Technology Beijing 2004年第4期11卷 297-301页

作者： Kazim grgülü Mining Engineering Dept. Cumhuriyet University58140-SivasTurkeynergy transfer between the adjacent parts of rocks in underground mines is widely influenced by the thermal conductivity of rocks. The relationships between the thermal conductivity and some material properties of rocks such as the uniaxial compressive strength unit mass tensile strength cohesion Young's modulus point load strength Schmidt rebound hardness Shore scleroscope hardness and toughness strength were investigated. The statistical analysis of the data obtained in laboratory tests shows that the thermal conductivity increases with increasing the uniaxial compressive strength unit mass tensile strength cohesion Young's modulus point load strength Schmidt rebound hardness and Shore scleroscope hardness and decreases with increasing the toughness strength.

Energy transfer between the adjacent parts of rocks in underground mines is widely influenced by the thermal conductivity of rocks. the relationships between the thermal conductivity and some material properties of rocks such as the uniaxial compressive strength, unit mass, tensile strength, cohesion, Young’s modulus, point load strength, Schmidt rebound hardness, Shore scleroscope hardness and toughness strength were investigated. the statistical analysis of the data obtained in laboratory tests shows that the thermal conductivity increases with increasing the uniaxial compressive strength, unit mass, tensile strength, cohesion, Young’s modulus, point load strength, Schmidt rebound hardness and Shore scleroscope hardness, and decreases with increasing the toughness strength.

关键词： thermal conductivity material properties underground mines

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)