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Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study

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World Journal of Clinical Cases 2021年第32期9卷 9722-9730页

作者： Beatrice D'Orazio girolamo geraci Fausto Famà g.oria terranova gaetano Di Vita Department of Surgical Oncological and Stomatological SciencesUniversity of PalermoPalermo 90100SicilyItaly Department of Human Pathology in Adulthood and Childhood"g.Barresi" University Hospital of MessinaMessina 98121SicilyItaly Department of Surgical Oncological and Stomatological SciencesPostgraduate Medical School in General SurgeryUniversity of PalermoPalermo 90100SicilyItaly

BACKgROUND Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure(CAF)with internal anal sphincter(IAS)hypertonia,but it is burdened by high-risk postoperative faecal incontinence(FI).Sphincter saving procedures have recently been reconsidered as treatments to overcome this *** most employed procedure is fissurectomy with anoplasty,eventually associated with pharmacological *** To evaluate whether fissurectomy and anoplasty with botulinum toxin injection improves the results of fissurectomy and anoplasty *** We conducted a case-control study involving 30 male patients affected by CAF with hypertonic IAS who underwent fissurectomy and anoplasty with V-Y cutaneous flap *** patients were divided into two groups:Those in group I underwent surgery alone,and those in group II underwent surgery and a botulinum toxin injection directly into the *** were followed up for at least 2 *** goals were to achieve complete healing of the patient and to assess the FI and recurrence rate along with manometry *** The intensity and duration of post-defecatory pain decreased significantly in both groups of patients starting with the first defecation,and this reduction was higher in group *** days after surgery,we achieved complete wound healing in all the patients in group II but only in 80%of the patients in group I(Pgroup,and both healed with conservative *** recorded one temporary and low-grade postoperative case of“de novo”*** parameters reverted to the normal range earlier for group II *** The injection of botulinum toxin A in association with fissurectomy and anoplasty with a V-Y advancement flap improves the results of surgery alone in patients affected by CAF with IAS hypertonia.

关键词： Proctology Fissurectomy Anoplasty Anal fissure Botulinum toxin

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建筑实践 2020年第5期 50-55页

作者： O.De Nooyer D.Piano S.Lafranconi P.Fang g.Boller E.ginocchio L.Jin Z.Kuehn M.Ottonello L.Peraita S.Polotti J.Jiang R.Raimondi M.Tokarnia V.Volpi B.Pignatti A.Pizzolato g.Semprini C.Zaccaria M.Abidos F.Cappellini D.Lange F.terranova 张超伦佐·皮亚诺建筑工作室

荟同深圳校区是荟同(Whittle School&Studios)在中国的第一个项目,它将成为世界一流城市中30个荟同校园的一员。这所新校区位于深圳市前海大湾开发区的中心区域,交通十分便利。其北部和东部都与新的城市公园接壤,周围是高达150m的住宅...

荟同深圳校区是荟同(Whittle School&Studios)在中国的第一个项目,它将成为世界一流城市中30个荟同校园的一员。这所新校区位于深圳市前海大湾开发区的中心区域,交通十分便利。其北部和东部都与新的城市公园接壤,周围是高达150m的住宅和商业塔楼。此校区预计容纳2,200名学生。

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